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| 1 | Carboniferous Post-collisional Rift Volcanism of the Tianshan Mountains, Northwestern China显示文摘The Tianshan Carboniferous post-collisional rift volcanic rocks occur in northwestern China as a large igneous province. Based on petrogeochemical data, the Tianshan Carboniferous post-collisional rift basic lavas can be classified into two major magma types: (1) the low-Ti/Y type situated in the eastern-central Tianshan area, which exhibits low Ti/Y (<500), Ce/Yb (<15) and SiO2 (43-55%), and relatively high Fe2O3T (6.4-11.5%); (2) the high-Ti/Y type situated in the western Tianshan area, which has high Ti/Y (>500), Ce/Yb (>11) and SiO2 (49-55%), and relatively low Fe2O3T (5.8-7.8%). Elemental data suggest that chemical variations of the low-Ti/Y and high-Ti/Y lavas cannot be explained by fractional crystallization from a common parental magma. The Tianshan Carboniferous basic lavas originated most likely from an OIB-like asthenospheric mantle source (87Sr/86Sr(t) ≈ 0.703-0.705, εNd(t) ≈ +4 to +7). The crustal contamination and continental lithospheric mantle have also contributed significantly to the formation of the basic lavas of the Tianshan Carboniferous post-collisional rift. The silicic lavas were probably generated by partial melting of the crust. The data of this study show that spatial petrogeochemical variations exist in the Carboniferous post-collisional rift volcanics province in the Tianshan region. Occurrence of the thickest volcanics dominated by tholeiitic lavas may imply that the center of the mantle-melting anomaly (mantle plume) was in the eastern Tianshan area at that time. The basic volcanic magmas in the eastern Tianshan area were generated by a relatively high degree of partial melting of the mantle source around the spinel-garnet transition zone, whereas the alkaline basaltic lavas are of the dominant magma type in the western Tianshan area, which were generated by a low degree of partial melting of the mantle source within the stable garnet region, thus the basic lavas of the western Tianshan area might have resulted from relatively thick lithosphere and low geothermal gradient. | XIA Linqi, XU Xueyi, XIA Zuchun, LI Xiangmin, MA Zhongping and WANG Lishe Xi’an Institute of Geology and Mineral Resources, China Geological Survey, Xi’an, Shaanxi 710054 E-mail: geologyx@pub.xaonline.com. Liu Shuchun and Liu Xinzhu | 2003 | Acta Geologica Sinica(English Edition)2003，77，3： | 49 |
| 2 | Reassessment of petrogenesis of Carboniferous—Early Permian rift-related volcanic rocks in the Chinese Tianshan and its neighboring areas显示文摘The Carboniferous Early Permian rill-related volcanic successions.covering large areas in the Chinese Tianshan and its adjacent areas.make up a newly recognized important Phanerozoic large igneous province in the world.which can be further divided into two sub-provinces:Tianshan and Tarim. The regional unconformity of Lower Carboniferous upon basement or pre-Carboniferous rocks.the ages (360—351 Ma) of the youngest ophiolite and the peak of subduction metamorphism of high pressure-low temperature metamorphic belt and the occurrence of Ni-Cu-bearing mafic-ultramatic intrusion with age of—352 Ma and A-type granite with age of~358 Ma reveal that the final closure of the Paleo Asian Ocean might lake place in the Early Mississippian.Our summation shows that at least four criteria.being normally used to identify ancient asthenosphere upwelling(or mantle plumes),are met for this large igneous province:(1) surface uplift prior to magmatism:(2) being associated with continental ifting and breakup events:(3) chemical characteristics of asthenosphere(or plume) derived basalts;(4) close links to large-scale minerali/alion and the uncontaminaled basalts,being analogous to those of many 'ore-bearing' large igneous provinces.display Sr-Nd isotopic variations between plume and EMI geochemical signatures.These suggest that a Carboniferous asthenosphere upwelling and an Early Permian plume played the central role in the generation of the Tianshan—Tarim(central Asia) large igneous province. | Linqi Xia Xueyi Xu Xiangmin Li Zhongping Ma Zuchun Xia | 2012 | Geoscience Frontiers2012，3，4： | 30 |
| 3 | 深度数字阅读推广的内容营销机制研究显示文摘[目的/意义]针对推广信息缺乏用户化设计等问题,提出一种基于内容营销理论来促进深度数字阅读推广效果提升、激发用户的深度数字阅读行为的新思路。[方法/过程]聚焦于推广信息视角,借鉴内容营销理论,结合深度数字阅读推广的内涵和特征,构建深度数字阅读推广的内容营销机制。[结果/结论]基于内容营销的深度数字阅读推广机制的特点主要体现在重视推广信息的设计、创建和传播,同时对目标用户、推广对象、推广主体、推广渠道、推广策略、推广评价等要素进行重塑;以推广信息为纽带,通过有价值的内容实现目标用户和推广对象的强关联,并以推广渠道、推广策略为支撑。 | 马坤坤 茆意宏 Xiangmin Zhang Hermina Anghelescu 朱玲玲 | 2020 | 图书情报工作2020，64，8： | 23 |
| 4 | Collision free 4D path planning for multiple UAVs based on spatial refined voting mechanism and PSO approach显示文摘In this paper, a four-dimensional coordinated path planning algorithm for multiple UAVs is proposed, in which time variable is taken into account for each UAV as well as collision free and obstacle avoidance. A Spatial Refined Voting Mechanism(SRVM) is designed for standard Particle Swarm Optimization(PSO) to overcome the defects of local optimal and slow convergence.For each generation candidate particle positions are recorded and an adaptive cube is formed with own adaptive side length to indicate occupied regions. Then space voting begins and is sorted based on voting results, whose centers with bigger voting counts are seen as sub-optimal positions. The average of all particles of corresponding dimensions are calculated as the refined solutions. A time coordination method is developed by generating specified candidate paths for every UAV, making them arrive the same destination with the same time consumption. A spatial-temporal collision avoidance technique is introduced to make collision free. Distance to destination is constructed to improve the searching accuracy and velocity of particles. In addition, the objective function is redesigned by considering the obstacle and threat avoidance, Estimated Time of Arrival(ETA), separation maintenance and UAV self-constraints. Experimental results prove the effectiveness and efficiency of the algorithm. | Yang LIU Xuejun ZHANG Yu ZHANG Xiangmin GUAN | 2019 | Chinese Journal of Aeronautics2019，32，6： | 20 |
| 5 | Mid—Late Neoproterozoic rift-related volcanic rocks in China:Geological records of rifting and break-up of Rodinia显示文摘Early Cambrian and Mid-Late Neoproterozoic volcanic rocks in China are widespread on several Precambrian continental blocks,which had aggregated to form part of the Rodinia supercontinent by ca.900 Ma.On the basis of petrogeochemical data,the basic lavas can be classified into two major magma types:HT(Ti/Y>500) and LT(Ti/Y<500) that can be further divided into HT1 (Nb/La>0.85) and HT2(Nb/La≤0.85),and LT1(Nb/La>0.85) and LT2(Nb/La≤0.85) subtypes, respectively.The geochemical variation of the HT2 and LT2 lavas can be accounted for by lithospheric contamination of asthenosphere-(or plume-) derived magmas,whereas the parental magmas of the HT1 and LT1 lavas did not undergo,during their ascent,pronounced lithospheric contamination.These volcanics exhibit at least three characteristics:(1) most have a compositional bimodality;(2) they were formed in an intracontinental rift setting;and(3) they are genetically linked with mantle plumes or a mantle surperplume.This rift-related volcanism at end of the MidNeoproterozoic and Early Cambrian coincided temporally with the separation between AustraliaEast Antarctica,South China and Laurentia and between Australia and Tarim,respectively. The Mid—Late Neoproterozoic volcanism in China is the geologic record of the rifting and break-up of the supercontinent Rodinia. | Linqi Xia Zuchun Xia Xueyi Xu Xiangmin Li Zhongping Ma | 2012 | Geoscience Frontiers2012，3，4： | 18 |
| 6 | Land Use Effects on Soil Organic Carbon, Microbial Biomass and Microbial Activity in Changbai Mountains of Northeast China显示文摘Land use changes are known to alter soil organic carbon(SOC) and microbial properties, however, information about how conversion of natural forest to agricultural land use as well as plantations affects SOC and microbial properties in the Changbai Mountains of Northeast China is meager. Soil carbon content, microbial biomass carbon(MBC), basal respiration and soil carbon mineralization were studied in five selected types of land use: natural old-growth broad-leaved Korean pine mixed forest(NF); spruce plantation(SP) established following clear-cutting of NF; cropland(CL); ginseng farmland(GF) previously under NF; and a five-year Mongolian oak young forest(YF) reforested on an abandoned GF, in the Changbai Mountains of Northeast China in 2011. Results showed that SOC content was significantly lower in SP, CL, GF, and YF than in NF. MBC ranged from 304.4 mg/kg in CL to 1350.3 mg/kg in NF, which was significantly higher in the soil of NF than any soil of the other four land use types. The SOC and MBC contents were higher in SP soil than in CL, GF, and YF soils, yielding a significant difference between SP and CL. The value of basal respiration was also higher in NF than in SP, CL, GF, and YF. Simultaneously, higher values of the metabolic quotient were detected in CL, GF, and YF soils, indicating low substrate utilization of the soil microbial community compared with that in NF and SP soil. The values of cumulative mineralized carbon and potentially mineralized carbon(C0) in NF were significantly higher than those in CL and GF, while no significant difference was observed between NF and SP. In addition, YF had higher values of C0 and C mineralization rate compared with GF. The results indicate that conversion from NF into agricultural land(CL and GF) uses and plantation may lead to a reduction in soil nutrients(SOC and MBC) and substrate utilization efficiency of the microbial community. By contrast, soils below SP were more conducive to the preservation of soil organic matter, which was reflected in the comparison of microbial indicators among CL, GF, and YF land uses. This study can provide data for evaluating soils nutrients under different land use types, and serve as references for the rational land use of natural forest in the study area. | FANG Xiangmin WANG Qingli ZHOU Wangming ZHAO Wei WEI Yawei NIU Lijun DAI Limin | 2014 | Chinese Geographical Science2014，24，3： | 16 |
| 7 | Relationships between Basic and Silicic Magmatism in Continental Rift Settings:A Petrogeochemical Study of Carboniferous Post-collisional Rift Silicic Volcanics in Tianshan,NW China显示文摘Petrogeochemical data are reported for silicic volcanic rocks from the Tianshan Carboniferous rift, with the aim of discussing the petrogenesis of silicic magmas. Incompatible element vs. incompatible element diagrams display smooth positive trends for the Tianshan Carboniferous rift-related volcanic rocks; the isotope ratios of the silicic lavas [87Sr/86Sr(t)=0.69988–0.70532; εNd(t)=4.76–8.00; 206Pb/204Pb(t)=17.435–18.017; 207Pb/204Pb(t)=15.438–15.509; 208Pb/204Pb(t) = 37.075–37.723] encompass those of the basic lavas. These data suggest a genetic link between rhyolites and basalts, but are not definitive in establishing whether silicic rocks are related to basalts through fractional crystallization or partial melting. Geochemical modeling of incompatible vs. compatible elements excludes the possibility that silicic melts are generated by the melting of basaltic rocks, and indicates a derivation by fractional crystallization plus moderate assimilation of wall rocks (AFC) starting from intermediate rocks to silicic rocks. Continuous AFC from basalt to rhyolite, with small rates of crustal assimilation, best explains the geochemical data. The presence or absence of bimodal volcanism (the “Daly Gap”) might be related to cooling rates of magma chambers. In central and eastern Tianshan, the crust was thinner and the cooling rates of the magma chamber within the crust were greater. These conditions resulted in a rapid fall in temperature within the magma reservoir and caused a narrow temperature interval over which intermediate melts formed, effectively reducing the volume of the intermediate melts. | XIA Linqi XIA Zuchun XU Xueyi LI Xiangmin MA Zhongping WANG Lishe | 2005 | Acta Geologica Sinica(English Edition)2005，79，5： | 14 |
| 8 | Triptolide Inhibits Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression in Human Colon Cancer and Leukemia Cells显示文摘Triptolide ( TP ),繁体中文药,被报导了在在几人的肿瘤 celllines.This 研究的肿瘤的活动调查的自体免疫的疾病和施加的反的治疗有效在人的结肠癌房间( SW114 )的 TP 的反肿瘤效果 andmyelocytic 白血病( K562 ),并且阐明可能的分子的机制 involved.SW114 和 K562cells 与 TP ( 0,5,10,20 ,或 50 ng/ml )的不同剂量被对待。房间生存能力被 3- 估计[4,5-dimethylthiazol-2-yl ]-2,5-diphenyltetrazolium 溴化物(MTT ) 。结果证明 TP 以一种剂量依赖者方式禁止了两根肿瘤房间线的增长。为了推进,调查它的机制,产品前列腺素 E2 (PGE2 ) 和氮的氧化物(没有) 被连接酶的免疫吸着剂试金(ELISA ) 测量。我们的数据证明 TP 强烈禁止了生产没有并且有这些的 PGE2.Consistent 结果,表示可诱导合酶(i NOS ) 和 cyclooxygenase-2 (COX-2 ) 都不在 mRNA 水平和蛋白质表示水平两个都是起来调整的由即时 RT-PCR 并且西方的弄污出现。这些结果显示煽动性的因素 COX-2 和 i NOS 活动的抑制能涉及 TP 的 antitumormechanisms。 | Xiangmin TONG~# Shui’er ZHENG~# Jie JIN Lifen ZHU Yinjun LOU and Hangping YAO Institute of Hematologic Disease,Department of Hematology,First Affiliated Hospital,Medical School,Zhejiang University,Hangzhou 310003,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，2： | 12 |
| 9 | A hybrid distributed-centralized conflict resolution approach for multi-aircraft based on cooperative co-evolutionary显示文摘Conflict resolution(CR)plays a crucial role in safe air trafc management(ATM).In this paper,we propose a new hybrid distributed-centralized tactical CR approach based on cooperative co-evolutionary named the CCDG(cooperative co-evolutionary with dynamic grouping)strategy to overcome the drawbacks of the current two types of approaches,the totally centralized approach and distributed approach.Firstly,aircraft are divided into several sub-groups based on their interdependence.Besides,a dynamic grouping strategy is proposed to group the aircraft to better deal with the tight coupling among them.The sub-groups are adjusted dynamically as new conflicts appear after each iteration.Secondly,a fast genetic algorithm(GA)is used by each sub-group to optimize the paths of the aircraft simultaneously.Thirdly,the aircraft’s optimal paths are obtained through cooperation among diferent sub-groups based on cooperative co-evolutionary(CC).An experimental study on two illustrative scenarios is conducted to compare the CCDG method with some other existing approaches and it is shown that CCDG which can get the optimal solution efectively and efciently in near real time,outperforms most of the existing approaches including Stratway,the fast GA,a general evolutionary path planner,as well as three well-known cooperative co-evolution algorithms. | ZHANG XueJun GUAN XiangMin HWANG Inseok CAI KaiQuan | 2013 | Science China(Information Sciences)2013，56，12： | 12 |
| 10 | Aircraft conflict resolution method based on hybrid ant colony optimization and artificial potential field显示文摘Dear editor, With the significant growth of the civil aviation industry and especially its rapid development in booming economies such as that of China,air traffic flow is drastically increasing,leading to greater congestion around airport terminal areas and in busy airspace [i].The substantial increase in air traffic flow has intensified the risk of violating safe separation regulations,endangering the airspace operational safety.Furthermore,as the result of this significant growth has resulted in problems such as longer delays,which increase fuel consumption and cost the airline industry billions of dollars every year [2,3]. | Huaxian LIU Feng LIU Xuejun ZHANG Xiangmin GUAN Jun CHEN Pascal SAVINAUD | 2018 | Science China(Information Sciences)2018，61，12： | 11 |
| 11 | A survey of safety separation management and collision avoidance approaches of civil UAS operating in integration national airspace system显示文摘Recent years have witnessed a booming of the industry of civil Unmanned Aircraft System(UAS).As an emerging industry,the UAS industry has been attracting great attention from governments of all countries and the aviation industry.UAS are highly digitalized,informationized,and intelligent;therefore,their integration into the national airspace system has become an important trend in the development of civil aviation.However,the complexity of UAS operation poses great challenges to the traditional aviation regulatory system and technical means.How to prevent collisions between UASs and between UAS and manned aircraft to achieve safe and efficient operation in the integrated operating airspace has become a common challenge for industry and academia around the world.In recent years,the international community has carried out a great amount of work and experiments in the air traffic management of UAS and some of the key technologies.This paper attempts to make a review of the UAS separation management and key technologies in collision avoidance in the integrated airspace,mainly focusing on the current situation of UAS Traffic Management(UTM),safety separation standards,detection system,collision risk prediction,collision avoidance,safety risk assessment,etc.,as well as an analysis of the bottlenecks that the current researches encountered and their development trends,so as to provide some insights and references for further research in this regard.Finally,this paper makes a further summary of some of the research highlights and challenges. | Xiangmin GUAN Renli LYU Hongxia SHI Jun CHEN | 2020 | Chinese Journal of Aeronautics2020，33，11： | 10 |
| 12 | Forest Carbon Storage and Tree Carbon Pool Dynamics under Natural Forest Protection Program in Northeastern China显示文摘The Natural Forest Protection(NFP) program is one of the Six Key Forestry Projects which were adopted by the Chinese Government since the 1980s to address important natural issues in China. It advanced to protecting and restoring the structures and functions of the natural forests through sustainable forest management. However, the role of forest carbon storage and tree carbon pool dynamics since the adoption of the NFP remains unknown. To address this knowledge gap, this study calculated forest carbon storage(tree, understory, forest floor and soil) in the forest region of northeastern(NE) China based on National Forest Inventory databases and field investigated databases. For tree biomass, this study utilized an improved method for biomass estimation that converts timber volume to total forest biomass; while for understory, forest floor and soil carbon storage, this study utilized forest type-specific mean carbon densities multiplied by their areas in the region. Results showed that the tree carbon pool under the NFP in NE China functioned as a carbon sink from 1998 to 2008, with an increase of 6.3 Tg C/yr, which was mainly sequestrated by natural forests(5.1 Tg C/yr). At the same time, plantations also acted as a carbon sink, reflecting an increase of 1.2 Tg C/yr. In 2008, total carbon storage in forests covered by the NFP in NE China was 4603.8 Tg C, of which 4393.3 Tg C was stored in natural forests and 210.5 Tg C in planted forests. Soil was the largest carbon storage component, contributing 69.5%–77.8% of total carbon storage; followed by tree and forest floor, accounting for 16.3%–23.0% and 5.0%–6.5% of total carbon storage, respectively. Understory carbon pool ranged from 1.9 to 42.7 Tg C, accounting for only 0.9% of total carbon storage. | WEI Yawei YU Dapao Bernard Joseph LEWIS ZHOU Li ZHOU Wangming FANG Xiangmin ZHAO Wei WU Shengnan DAI Limin | 2014 | Chinese Geographical Science2014，24，4： | 9 |
| 13 | A strategic flight conflict avoidance approach based on a memetic algorithm显示文摘Conflict avoidance(CA) plays a crucial role in guaranteeing the airspace safety. The current approaches,mostly focusing on a short-term situation which eliminates conflicts via local adjustment,cannot provide a global solution. Recently,long-term conflict avoidance approaches,which are proposed to provide solutions via strategically planning traffic flow from a global view,have attracted more attentions. With consideration of the situation in China,there are thousands of flights per day and the air route network is large and complex,which makes the long-term problem to be a large-scale combinatorial optimization problem with complex constraints. To minimize the risk of premature convergence being faced by current approaches and obtain higher quality solutions,in this work,we present an effective strategic framework based on a memetic algorithm(MA),which can markedly improve search capability via a combination of population-based global search and local improvements made by individuals. In addition,a specially designed local search operator and an adaptive local search frequency strategy are proposed to improve the solution quality. Furthermore,a fast genetic algorithm(GA) is presented as the global optimization method. Empirical studies using real traffic data of the Chinese air route network and daily flight plans show that our approach outperformed the existing approaches including the GA based approach and the cooperative coevolution based approach as well as some well-known memetic algorithm based approaches. | Guan Xiangmin Zhang Xuejun Han Dong Zhu Yanbo Lv Ji Su Jing | 2014 | Chinese Journal of Aeronautics2014，27，1： | 8 |
| 14 | A large-scale multi-objective flights conflict avoidance approach supporting 4D trajectory operation显示文摘Recently, the long-term conflict avoidance approaches based on large-scale flights scheduling have attracted much attention due to their ability to provide solutions from a global point of view. However, current approaches which focus only on a single objective with the aim of minimizing the total delay and the number of conflicts, cannot provide controllers with variety of optional solutions, representing different tradeoffs. Furthermore, the flight track error is often overlooked in the current research. Therefore, in order to make the model more realistic, in this paper, we formulate the long-term conflict avoidance problem as a multi-objective optimization problem, which minimizes the total delay and reduces the number of conflicts simultaneously. As a complex air route network needs to accommodate thousands of flights, the problem is a large-scale combinatorial optimization problem with tightly coupled variables, which make the problem difficult to deal with. Hence,in order to further improve the search capability of the solution algorithm, a cooperative co-evolution(CC)algorithm is also introduced to divide the complex problem into several low dimensional sub-problems which are easier to solve. Moreover, a dynamic grouping strategy based on the conflict detection is proposed to improve the optimization efficiency and to avoid premature convergence. The well-known multi-objective evolutionary algorithm based on decomposition(MOEA/D) is then employed to tackle each sub-problem. Computational results using real traffic data from the Chinese air route network demonstrate that the proposed approach obtained better non-dominated solutions in a more effective manner than the existing approaches, including the multi-objective genetic algorithm(MOGA), NSGAII, and MOEA/D. The results also show that our approach provided satisfactory solutions for controllers from a practical point of view. | Xiangmin GUAN Xuejun ZHANG Renli LV Jun CHEN Weiszer MICHAL | 2017 | Science China(Information Sciences)2017，60，11： | 8 |
| 15 | Fluid inclusion, siliceous rock geochemistry of Shewushan lateritic gold deposit, Hubei Province, eastern China: Implication for the genesis of primary orebody显示文摘The Shewushan gold deposit is located 16 km southwest of Jiayu County, Hubei Province, eastern China, which is the largest lateritic gold deposit in Asia, consisting of a series of mineralized faults containing gold grades of 1.0–19.5 g/t set within a larger, lower-grade(0.2–1.0 g/t) zone. According to the fluid inclusions study, the homogenization temperature ranges from 70–350℃, and concentrates between 140–220℃. The laser Rama results show that the CO2 and CH4 exist in mineralized fluid. In addition, the major and trace element and REE geochemical data show that the genesis of the siliceous rocks is hydrothermal genesis, formed by mineralized fluid bearing SiO2 transmitted along faults to the surface, and replace the carbonate rocks to begin deposition. Primary gold mineralization is attributed to hydrothermal activity that followed the main period of tectonic deformation of the Indosinian orogeny, which caused the regional detachment regime in southeast Hubei. The reversed fold and the fault system formed the fluid migration channel in the Shewushan area. EPMA results show that Au exists in arsenopyrite(850×10-6–1550×10-6 Au) and pyrite(470×10-6–1340×10-6 Au). Therefore, based on the above results and combined with the field observation, we suggest that the genesis of primary orebody in Shewushan deposit is carlin type, while not weathered residual type. | WANG Minfang ZHENG Youye XU Rongke LIU Yunguang XIAO Fan CHENG Shanwen SUN Xiangmin | 2014 | Chinese Journal Of Geochemistry2014，33，1： | 6 |
| 16 | Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage显示文摘Asparaginyl endopeptidase (AEP ) 是有为在 P1 地点的天门冬素残余的偏爱的 endo/lysosomal 半胱氨酸 endopeptidase 并且在像使用费的受体 3/7/9 的成熟起一个重要作用。AEP 被知道为催化激活在酸的 pH 经历 autoproteolytic 成熟。这里,我们描述 AEP 酶原的水晶结构和 AEP 的成熟形式。在 AEP 和 caspases 之间的结构的比较在关键残余的作文并且在催化机制揭示了类似。Mutagenesis 研究作为为肽底层的劈开是必要的残余识别了 N44, R46, H150, E189, C191, S217/S218 和 D233。在成熟期间, AEP 的帽子领域的 autoproteolytic 劈开在核心领域上开创存取到活跃地点。出人意料地,一个中间的 autoproteolytic 成熟阶段被发现在近似 pH 4.5 在哪个部分激活的 AEP 能被颠倒回到它的酶原形式。这个唯一的特征被 AEP pH4.5 (AEP 在 pH 被成熟 4.5 并且在 pH 结晶 8.5 ) ,在哪个破肽契约被重新绑扎,结构被转变回到它的酶原形式。另外, AEP 禁止者 cystatin C 能被充分激活的 AEP 消化,但是不能被激活的组织蛋白酶消化。因此,我们第一次证明 cystatins 可以为活跃地点通过底层竞争调整 AEP 的活动。 | Lixia Zhao Tian Hua Christopher Crowley Heng Ru Xiangmin Ni Neil Shaw Lianying Jiao Wei Ding Lu Qu Li-Wei Hung Wei Huang Lei Liu Keqiang Ye Songying Ouyang Genhong Cheng Zhi-Jie Liu | 2014 | Cell Research2014，24，3： | 6 |
| 17 | Strategic flight assignment approach based on multi-objective parallel evolution algorithm with dynamic migration interval显示文摘The continuous growth of air traffic has led to acute airspace congestion and severe delays, which threatens operation safety and cause enormous economic loss. Flight assignment is an economical and effective strategic plan to reduce the flight delay and airspace congestion by reasonably regulating the air traffic flow of China. However, it is a large-scale combinatorial optimization problem which is difficult to solve. In order to improve the quality of solutions, an effective multi-objective parallel evolution algorithm(MPEA) framework with dynamic migration interval strategy is presented in this work. Firstly, multiple evolution populations are constructed to solve the problem simultaneously to enhance the optimization capability. Then a new strategy is proposed to dynamically change the migration interval among different evolution populations to improve the efficiency of the cooperation of populations. Finally, the cooperative co-evolution(CC) algorithm combined with non-dominated sorting genetic algorithm II(NSGA-II) is introduced for each population. Empirical studies using the real air traffic data of the Chinese air route network and daily flight plans show that our method outperforms the existing approaches, multiobjective genetic algorithm(MOGA), multi-objective evolutionary algorithm based on decomposition(MOEA/D), CC-based multi-objective algorithm(CCMA) as well as other two MPEAs with different migration interval strategies. | Zhang Xuejun Guan Xiangmin Zhu Yanbo Lei Jiaxing | 2015 | Chinese Journal of Aeronautics2015，28，2： | 6 |
| 18 | A critical epitope in CD147 facilitates memory CD4^(+) T-cell hyper-activation in rheumatoid arthritis显示文摘The abnormal activation of CD4^(+)CD45RO+memory T(Tm)cells plays an important role in the pathogenesis of rheumatoid arthritis(RA).Previous studies have shown that CD147 participates in T-cell activation.However,it remains unclear whether CD147 is involved in abnormal Tm-cell activation in RA patients.In this study,we demonstrated that CD147 was predominantly upregulated in Tm cells derived from RA patients.The anti-CD147 mAb 5A12 specifically inhibited Tm-cell activation and proliferation and further restrained osteoclastogenesis.Using a structural–functional approach,we depicted the interface between 5A12 and CD147.This allowed us to identify two critical residues,Lys63 and Asp65,as potential targets for RA treatment,as the double mutation K63A/D65A inhibited Tm-cell activation,mimicking the neutralization by 5A12.This study provides not only a theoretical basis for a“CD147-Tm/Osteoclast-RA chain”for the potential prevention and treatment of RA or other T-cell-mediated autoimmune diseases but also a new target for related drug design and development. | Na Guo Sheng Ye Kui Zhang Xiaoling Yu Hongyong Cui Xiangmin Yang Peng lin Minghua Lv Jinlin Miao Yang Zhang Qing Han Rongguang Zhang Zhinan Chen Ping Zhu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 19 | A Formation Reconfiguration Algorithm for Multi-UAVs Based on Distributed Cooperative Coevolutionary with an Adaptive Grouping Strategy显示文摘The Formation reconfiguration problem plays a crucial role in the implementation of complex t asks for multiple unmanned aerial vehicles,which attracted increasing attention in the past decade.Taking into consideration the control parame ters and time discretization of the multi-UAVs in the 3 Dimensional(3-D)space,the formation reconfiguration problem can be formulated as a large-scale combinatorial optimization problem with complex constraints and tight couplings between variables.The problem results in the reduction in efficiency and effectiveness using classic bio-inspired algorithms.In this paper,a formation reconfiguration method based on cooperative coevolutionary algorithm is proposed along with a new decomposition strategy to improve the optimization capability and prevent premature convergence.In the proposed approach,variables of multi-UAV are divided into several sub-groups based on an adaptive grouping strategy.The proposed strategy groups the variables in order to better deal with the tight coupling among them,taking into account the variables'variance and multi-UAVs characteristics of the formation reconfiguration problem.Therefore,each sub・group can adopt the Self-adaptive differential evolution strategy with neighborhood search(SaNSDE)with the aim to optimize the UAV's control inputs using multithreaded programming.SaNSDE contributes to calculating the results in a fully distributed and paralleled manner.Optimal solution is then obtained through cooperation and coordina tion with all subcomponents.Simulation results based on extreme scenarios adopted by previous researches demonstrate that the proposed algorithm out performed the existing approaches including Par ti cle swarm optimization(PSO),Differential evolution(DE),and the cooperative coevolution algorithms with different well-known grouping strategies. | LIU Huaxian LIU Feng ZHANG Xuejun GUAN Xiangmin CHEN Jun | 2020 | Chinese Journal of Electronics2020，29，5： | 5 |
| 20 | Structural basis for termination of AIM2-mediated signaling by p202显示文摘 | Heng Ru Xiangmin Ni LixiaZhao Christopher Crowle Wei Ding Li-Wei Hung Neil Shaw Genhong Cheng Zhi-Jie Liu | 2013 | Cell Research2013，23，6： | 5 |
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