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| 1 | Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure显示文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a'tonifying qi and detoxification'('TQD')group(72 patients);and(3)a'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the'TQD'group were given a TCM formula'tonifying qi and detoxification'and general internal medicine treatment;patients in the'TTK'group were given a TCM formula of'TTK'and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,'TQD',and'TTK'groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the'TTK'group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the'TQD'group and'TTK'group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the'TQD'group and one case of gastrointestinal side effect in the'TTK'group.CONCLUSION:Treatment with'TTK'improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored. | Han-Min Li Zhi-Hua Ye Jun Zhang Xiang Gao Yan-Ming Chen Xin Yao Jian-Xun Gu Lei Zhan Yang Ji Jian-Liang Xu Ying-He Zeng Fan Yang Lin Xiao Guo-Guang Sheng Wei Xin Qi Long Qing-Jing Zhu Zhao-Hong Shi Lian-Guo Ruan Jia-Yao Yang Chang-Chun Li Hong-Bin Wu Sheng-Duo Chen Xin-La Luo | 2014 | World Journal of Gastroenterology2014，20，48： | 20 |
| 2 | Soil contamination with antibiotics in a typical peri-urban area in eastern China: Seasonal variation, risk assessment, and microbial responses显示文摘The prevalence and persistence of antibiotics in soils has become an emerging environmental issue and an increasing threat to soil security and global public health. The problem is more severe in areas undergoing rapid urbanization; however, the ecological risks of antibiotics,seasonal variability, and associated soil microbial responses in peri-urban soils have not been well-explored. The seasonal soil sampling campaigns were conducted in a typical peri-urban watershed in eastern China to investigate distribution of antibiotics. The results demonstrated higher mean concentrations of most antibiotic compounds in winter than in summer in periurban soils. The seasonal variations of norfloxacin, enrofloxacin, and ciprofloxacin were more significant than those of other antibiotics, due to their higher migration ability and bioavailability.An ecological risk assessment demonstrated that chlortetracycline, ciprofloxacin, doxycycline,and ofloxacin can pose high risks to soil microorganisms. Furthermore, the coexistence of multiple antibiotics obviously poses higher risks than individual compounds. A redundancy analysis demonstrated that tetracyclines mainly showed negative correlations with Firmicutes and Chloroflexi, and quinolones showed obviously negative correlations with Acidobacteria,Gemmatimonadetes, and Nitrospirae, suggesting potential inhibition from antibiotics on biological activities or biodegradation processes. However, the persistence of antibiotics in soil results in a significant decrease in bacterial diversity and a change in dominant species.Our results provide an overview of the seasonal variability of antibiotics and the associated effects on bacterial communities in peri-urban soils. The results can provide scientific guidance on decreasing soil contamination with antibiotics to enhance soil security in similar areas. | Fangkai Zhao Lei Yang Liding Chen Qian Xiang Shoujuan Li Long Sun Xinwei Yu Li Fang | 2019 | Journal of Environmental Sciences2019，31，5： | 19 |
| 3 | Hydrogeochemical and Isotopic Evidence for Flow Paths of Karst Waters Collected in the Heshang Cave,Central China显示文摘Understanding of hydrological processes in caves is important to help us interpret paleoclimate records from speleothems. In this study,we integrated hydrogeological and hydrogeochemical properties to characterize the hydraulic behavior of karst waters in the Heshang Cave,Central China. Using geological and topographical analyses,we identified regional watershed boundaries and hydrogeological connections that were controlled by anticlinal geometry and faults. Water samples were collected from the Heshang Cave and potential recharge sites. Geochemical data of c(Sr2+)/c(Ca2+) and c(Mg2+)/c(Ca2+) ratios suggest that the drainage system in Heshang Cave consists of two flow paths. For vadose waters,including drip water and rimstone pool water,c(Sr2+)/c(Ca2+) ratio ranges from 0.000 6 to 0.001 1,and c(Mg2+)/c(Ca2+) ratio ranges from 0.97 to 1.1,indicating that recharge was mainly from rainfall infiltration through the overlying Cambrian dolomite stratum. In contrast,slope current and underground river waters have higher c(Sr2+)/c(Ca2+) ratios(values from 0.002 2 to 0.002 8),and lower c(Mg2+)/c(Ca2+) ratios(values from 0.50 to 0.64). These waters show homogeneous isotopic composition(δ18O:-7.15‰–-6.95‰; δD:-52.73‰–-51.31‰),implying recharge of allogeneic water from the Xiaoer River via karst conduits that pass through Ordovician limestone and Cambrian dolomite stratum. | Xiang Long Ziyong Sun Aiguo Zhou Deliang Liu | 2015 | Journal of Earth Science2015，26，1： | 18 |
| 4 | Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients显示文摘BACKGROUND The methylated septin 9(mSEPT9) assay was the first blood-based test approved by the United States Food and Drug Administration as a colorectal screening test.However, the diagnostic and prognostic role of preoperative mSEPT9 for colorectal cancer(CRC) in Chinese patients is still unknown.AIM To improve the understanding of diagnostic and prognostic factors, serum m SEPT9 was detected in Chinese CRC patients.METHODS A retrospective analysis of 354 cases, of which 300 had CRC and 54 were normal,was performed in China. Patients' characteristics, treatments, and laboratory data, including age, the date of surgery, Union for International Cancer Control(UICC) stages, distant metastasis(M), and so on, were collected. Methylation levels of SEPT9 were quantified by quantitative, methylation-specific polymerase chain reaction before surgery. In addition, the effects of mSEPT9 on the occurrence and prognosis of 330 CRC cases from The Cancer Genome Atlas(TCGA) database were evaluated using bioinformatics analyses. Potential prognostic factors for overall survival(OS) and progression-free survival(PFS)were evaluated by Kaplan-Meier univariate analysis.RESULTSIn Chinese CRC patients, positive mSEPT9 was strongly associated with advanced UICC stages, deeper invasion by the primary tumor, and more distant metastasis. Methylation levels of SEPT9 were stage-dependent and showed a stepwise increase in UICC stages(I–IV), primary tumor categories(T1–T4),regional node categories(N0–N2), and distant metastasis categories(M0–M1).The patients with positive mSEPT9 showed a tendency toward lower PFS. After analyzing TCGA clinical data, the high mSEPT9 group was found to be obviously correlated only with more distant metastasis. The patients with high mSEPT9 levels showed a tendency toward lower OS. Besides, nine meaningful mSEPT9 sites were found to provide guidance for the follow-up studies.CONCLUSION MSEPT9 analysis may add valuable information to current tumor staging. Serum m SEPT9 in Chinese CRC patients appears to offer promising novel prognostic markers and might be considered for monitoring CRC recurrence. | Xue Yang Zhi-Jie Xu Xi Chen Shuang-Shuang Zeng Long Qian Jie Wei Mei Peng Xiang Wang Wan-Li Liu Hong-Ying Ma Zhi-Cheng Gong Yuan-Liang Yan | 2019 | World Journal of Gastroenterology2019，25，17： | 16 |
| 5 | Tribological properties of laser cladding TiB_2 particles reinforced Ni-base alloy composite coatings on aluminum alloy显示文摘To improve the wear resistance of aluminum alloy frictional parts, Ti B_2 particles reinforced Ni-base alloy composite coatings were prepared on aluminum alloy 7005 by laser cladding. The microstructure and tribological properties of the composite coatings were investigated. The results show that the composite coating contains the phases of Ni Al, Ni_3Al, Al_3Ni_2, TiB_2, TiB, TiC, CrB, and Cr_(23)C_6.Its microhardness is HV_(0.5)855.8, which is 15.4 % higher than that of the Ni-base alloy coating and is 6.7 times as high as that of the aluminum alloy. The friction coefficients of the composite coatings are reduced by 6.8 %–21.6 % and 13.2 %–32.4 % compared with those of the Ni-base alloy coatings and the aluminum alloys, while the wear losses are 27.4 %–43.2 % less than those of the Ni-base alloy coatings and are only 16.5 %–32.7 % of those of the aluminum alloys at different loads. At the light loads ranging from 3 to 6 N, the calculated maximum contact stress is smaller than the elastic limit contact stress. The wear mechanism of the composite coatings is micro-cutting wear, but changes into multi-plastic deformation wear at 9 N due to the higher calculated maximum contact stress than the elastic limit contact stress. As the loads increase to 12 N, the calculated flash temperature rises to 332.1 °C.The composite coating experiences multi-plastic deformation wear, micro-brittle fracture wear, and oxidative wear. | Long He Ye-Fa Tan Xiao-Long Wang Qi-Feng Jing Xiang Hong | 2015 | Rare Metals2015，34，11： | 14 |
| 6 | Three dimensional velocity structure and accurate earthquake location in Changning–Gongxian area of southeast Sichuan显示文摘In order to understand the crustal structure and tectonic background of the Changning–Gongxiang area, southeastern Sichuan Province, where a series of moderate-to-strong earthquakes occurred in recent years, we utilized the seismic phase data both from a local dense array and from the regional seismic networks;we used the tomoDD program to invert for the high-resolution three-dimensional velocity structure within the depth range of 0–10 km and for accurate hypocentral locations in this area. We analyzed the seismogenic structures for the events of Xingwen M5.7 in 2018 and Gongxian M5.3 and Changning M6.0 in 2019. The results show that:(1) widespread lateral inhomogeneity exists in the velocity structure of the study area, and the location of the velocity anomaly is largely consistent with known structures. In the range of distinguishable depth, the inhomogeneity decreases with increasing depth, and the velocity structure anomalies in some areas are continuous in depth;(2) earthquakes occurred in clusters, showing the characteristics of zonal folding trends in the NW-SE and NE-SW directions;the focal depth in the area is generally shallow in both the sedimentary cap and the crystalline basement. The seismogenic structures of small earthquake clusters are different in size and occurrence in different sections, and the clusters occurred mostly in regions with high P-or S-wave velocities;(3) synthesis of a variety of data suggests that the seismogenic structures of the Xingwen M5.7 and Changning M6.0 earthquakes are associated with slip faults that trend NW-SE in, respectively, the south wing and the axis of the Changning–Shuanghe anticline, while that of the Gongxian M5.3 earthquake is associated with thrust faults that trend N-S in the Jianwu syncline region. The dynamic sources of the three earthquakes are all from the SE pushing of the Qinghai–Tibet block on the Sichuan basin;(4) the risk of future strong earthquakes in this area must be reevaluated in light of the facts(a)that in recent years, moderate-to-strong earthquake swarms have occurred frequently in southeast Sichuan;(b) that the complex structural area exhibits the easy-to-trigger characteristic, and(c) that the small-scale faults in this area are characterized by the phenomenon of stress 'lock and release'. | Feng Long ZhiWei Zhang YuPing Qi MingJian Liang Xiang Ruan WeiWei Wu GuoMao Jiang LongQuan Zhou | 2020 | Earth and Planetary Physics2020，4，2： | 13 |
| 7 | Role of pyroptosis in inflammation and cancer显示文摘Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures,resulting in the release of cellular contents that can activate strong inflammatory and immune responses.Pyroptosis,an innate immune response,can be triggered by the activation of inflammasomes by various influencing factors.Activation of these inflammasomes can induce the maturation of caspase-1 or caspase-4/5/11,both of which cleave gasdermin D to release its N-terminal domain,which can bind membrane lipids and perforate the cell membrane.Here,we review the latest advancements in research on the mechanisms of pyroptosis,newly discovered influencing factors,antitumoral properties,and applications in various diseases.Moreover,this review also provides updates on potential targeted therapies for inflammation and cancers,methods for clinical prevention,and finally challenges and future directions in the field. | Xiang Wei Feng Xie Xiaoxue Zhou Yuchen Wu Haiyan Yan Ting Liu Jun Huang Fangwei Wang Fangfang Zhou Long Zhang | 2022 | Cellular & Molecular Immunology2022，19，9： | 11 |
| 8 | Effect of intramuscular injection of hepatocyte growth factor plasmid DNA with electroporation on bleomycin-induced lung fibrosis in rats显示文摘背景到目前为止,为肺的纤维变性没有有效处理。这研究的目的是决定是否,并且调查可能的 mechanisms.Methods hepatocyte 生长因素(HGF ) 的肌内的注射 plasmid DNA 由在 vivo, electroporation 能在老鼠阻止导致 bleomycin 的肺的纤维变性二十只男 Wistar 老鼠随机被划分成四个组:控制组(组 C ) ,模型组(组 M ) ,早干预组(组) 和迟了的干预组(组) 。组 M,并且 intratracheally 与 bleomycin 被灌输,然后注射了 plasmid pcDNA3.1-hHGF 在白天 7, 14 和 21 上组织。组在白天 14 和 21 上接受了象组一样的一样的处理。所有老鼠在在 bleomycin 注射以后的白天 28 上被打死。我们与 ELISA 方法在老鼠检测了人 HGF 表示并且用 hematoxylin 曙红估计了肺织物的病理学的纤维变性分数(他) 并且染色的 Massion。转变生长 factor-1 ( TGF-1 )的 mRNA 表示, cycloxygenase-2 ( COX-2 ),并且在老鼠的老鼠 HGF 肺的实质被 RT-PCR.Immunohistochemistry 评估,西方的弄污被执行决定在 plasmid pcDNA3.1-hHGF 能表示的肺 parenchyma.Results 转变 TGF-1 和 COX-2 的蛋白质表示在 NIH3T3 房间和 hHGF 蛋白质的 hHGF 被分泌进文化媒介。hHGF 蛋白质的表示能在组在四头肌肌肉,血浆和肺被监视并且。组的肺的纤维变性层次并且显然比 TGF-1 蛋白质的组 M (P0.05 ).Expression 的低,在肺织物的 mRNA 显著地在组并且与组 M (P0.05 ) 相比被减少。HGF 和 COX-2 mRNA 的表示的水平在组是更高的,比在 plasmid 的组 M (P0.05 ).Conclusions 注射,进有 electroporation 的骨胳的肌肉的 pcDNA3.1-hHGF 在导致 bleomycin 的肺纤维变性的治疗有一个潜在的角色。外长的 HGF 可以禁止 TGF-1 的表示并且调整在原子能委员会和间充质的成纤维细胞之间的串音。 | LONG Xiang XIONG Sheng-dao XIONG Wei-ning XU Yong-jian | 2007 | Chinese Medical Journal2007，，16： | 10 |
| 9 | Selenium Supplementation Alleviates Autoimmune Thyroiditis by Regulating Expression of Th1/Th2 Cytokines显示文摘Selenium (Se) is an essential trace element.Autoimmune thyroid diseases (AITD) are destructive inflammatory or anti-receptor autoimmune diseases characterized by reactivity to self-thyroid antigens.However,the effects of Se on the cytokines in AITD are still unclear.So we researched the role of Selenium (Se) and Th1/Th2 cytokine productions in the pathogenesis of autoimmune thyroid diseases (AITD).The data shown that high Se intake reduced the autoantibody titers and alleviated the | TAN Long SANG Zhong Na SHEN Jun WU Yun Tang YAO Zhai Xiao ZHANG Jin Xiang ZHAO Na ZHANG Wan Qi | 2013 | Biomedical and Environmental Sciences2013，26，11： | 10 |
| 10 | Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy: A National Multicenter Study in China显示文摘 | Hua Yang Xiao-Chuan Li Chen Yao Jing-He Lang Hang-Mei Jin Ming-Rong Xi Gang Wang Lu-Wen Wang Min Hao Yan Ding Jie Chen Jian-Qing Zhang Lu Han Cheng-Xiu Guo Xiang Xue Yan Li Jian-Hua Zheng Man-Hua Cui Huai-Fang Li Guang-Shi Tao Long Chen Su-Min Wang An-Wei LU Ze-Hua Huang Qing Liu Ya-Li Zhuang Xiang-Hua Huang Gen-Hai Zhu Ou-Ping Huang Li-Na Hu Mu-Jun Li Hong-Lin Zhou Jing-Hui Song Lan Zhu | 2017 | Chinese Medical Journal2017，，22： | 10 |
| 11 | Generation of ready to use (RTU) products over China based on Landsat series data显示文摘Earth observation community has entered into the era of big data.Family of Landsat sensors have collected massive medium resolution satellite images,which are valuable for long-term land surface monitoring.In order to significantly reduce the magnitude of data processing for remote sensing data users,Landsat-based Ready to Use(RTU)products have been produced.Main RTU products,including orthorectified products,land surface reflectance,land surface temperature,large-area mosaic image,and standard image map products,are described.The resulting Landsat RTU products are hosted on the RSGS earth observation data sharing web site for free download(http://gffzz959b1a8e74bf485dhuq0uc0nf9oxw6u6k.ffgz.tsg.suse.edu.cn/rtu/).These new products will provide consistent,standardized,multi-decadal image data for robust land cover change detection and monitoring across the Earth sciences.In the coming years,CASEarth DataBank system will be constructed,which is an intelligent data service platform for providing not only the RTU products from multi-source satellite data,but also big earth data analysis methods. | Guojin He Zhaoming Zhang Weili Jiao Tengfei Long Yan Peng Guizhou Wang Ranyu Yin Wei Wang Xiaomei Zhang Huichan Liu Bo Cheng Bo Xiang | 2018 | Big Earth Data2018，2，1： | 8 |
| 12 | Impact of an innovative tuberculosis financing and payment model on health service utilization by tuberculosis patients in China:do the poor fare better than the rich?显示文摘Background:Tuberculosis(TB)prevalence is closely associated with poverty in China,and poor patients face more barriers to treatment.Using an insurance-based approach,the China-Gates TB program Phase II was implemented between 2012 and 2014 in three cities in China to improve access to TB care and reduce the financial burden on patients,particularly among the poor.This study aims to assess the program effects on service use,and its equity impact across different income groups.Methods:Data from 788 and 775 patients at baseline and final evaluation were available for analysis respectively.Inpatient and outpatient service utilization,treatment adherence,and patient satisfaction were assessed before and after the program,across different income groups(extreme poverty,moderate poverty and non-poverty),and in various program cities,using descriptive statistics and multi-variate regression models.Key stakeholder interviews were conducted to qualitatively evaluate program implementation and impacts.Results:After program implementation,the hospital admission rate increased more for the extreme poverty group(48.5 to 70.7%)and moderate poverty group(45.0 to 68.1%),compared to the non-poverty group(52.9 to 643%).The largest increase in the number of outpatient visits was also for the extreme poverty group(4.6 to 5.7).The proportion of patients with good medication adherence increased by 15 percentage points in the extreme poverty group and by ten percentage points in the other groups.Satisfaction rates were high in all groups.Qualitative feedback from stakeholders also suggested that increased reimbursement rates,easier reimbursement procedures,and allowance improved patients'service utilization.Implementation of case-based payment made service provision more compliant to clinical pathways.Conclusion:Patients in extreme or moderate poverty benefited more from the program compared to a non-poverty group,indicating improved equity in TB service access.The pro-poor design of the program provides important丨essons to other TB programs in China and other countries to better address TB care for the poor. | Di Dong Wei-Xi Jiang Qian Long Fei Huang Hui Zhang Jia-Ying Chen Li Xiang Qiang Li Sheng-Lan Tang Henry Lucas | 2019 | Infectious Diseases of Poverty2019，8，3： | 8 |
| 13 | Disparity in reimbursement for tuberculosis care among different health insurance schemes: evidence from three counties in central China显示文摘Background:Health inequity is an important issue all around the world.The Chinese basic medical security system comprises three major insurance schemes,namely the Urban Employee Basic Medical Insurance(UEBMI),the Urban Resident Basic Medical Insurance(URBMI),and the New Cooperative Medical Scheme(NCMS).Little research has been conducted to look into the disparity in payments among the health insurance schemes in China.In this study,we aimed to evaluate the disparity in reimbursements for tuberculosis(TB)care among the abovementioned health insurance schemes.Methods:This study uses a World Health Organization(WHO)framework to analyze the disparities and equity relating to the three dimensions of health insurance:population coverage,the range of services covered,and the extent to which costs are covered.Each of the health insurance scheme’s policies were categorized and analyzed.An analysis of the claims database of all hospitalizations reimbursed from 2010 to 2012 in three counties of Yichang city(YC),which included 1506 discharges,was conducted to identify the differences in reimbursement rates and out-of-pocket(OOP)expenses among the health insurance schemes.Results:Tuberculosis patients had various inpatient expenses depending on which scheme they were covered by(TB patients covered by the NCMS have less inpatient expenses than those who were covered by the URBMI,who have less inpatient expenses than those covered by the UEBMI).We found a significant horizontal inequity of healthcare utilization among the lower socioeconomic groups.In terms of financial inequity,TB patients who earned less paid more.The NCMS provides modest financial protection,based on income.Overall,TB patients from lower socioeconomic groups were the most vulnerable.Conclusion:There are large disparities in reimbursement for TB care among the three health insurance schemes and this,in turn,hampers TB control.Reducing the gap in health outcomes between the three health insurance schemes in China should be a focus of TB care and control.Achieving equity through integrated policies that avoid discrimination is likely to be effective. | Yao Pan Shanquan Chen Manli Chen Pei Zhang Qian Long Li Xiang Henry Lucas | 2016 | Infectious Diseases of Poverty2016，5，1： | 7 |
| 14 | Model predictions for behaviors of sand-nonplastic-fines mixtures using equivalent-skeleton void-ratio state index显示文摘It is a challenge to suggest a constitutive model for describing the stress-strain behavior of sand-fines mixtures due to that these granular mixtures exhibited very complex behaviors at different densities, pressures and fines contents. In this study, an elastoplastic constitutive model within the framework of the bounding surface plasticity and critical state theories was proposed for sand-nonplastic-fines mixtures by using the concept of the equivalent-skeleton void ratio and equivalent-skeleton void-ratio state index. The proposed model with a set of material constants calibrated from a few tests could be used to model the fines-dependent and state-dependent behaviors of the sand-nonplastic-fines mixture including the strain- softening and volumetric-expansion behaviors in the drained triaxial compression tests, and also the effects of fines content on the critical state lines in both the deviatoric stress versus mean effective stress and the void ratio versus mean effective stress planes. | XIAO Yang SUN YiFei LIU HanLong XIANG Jia MA QiFeng LONG LeiHang | 2017 | Science China(Technological Sciences)2017，60，6： | 7 |
| 15 | Are free anti-tuberculosis drugs enough? An empirical study from three cities in China显示文摘Background:Tuberculosis(TB)patients in China still face a number of barriers in seeking diagnosis and treatment.There is evidence that the economic burden on TB patients and their households discourages treatment compliance.Methods:A cross-sectional study was conducted in three cities of China.Patients were selected using probability proportional to size(PPS)cluster sampling of rural townships or urban streets,followed by list sampling from a patient register.Data were collected using a questionnaire survey,key informant interviews and focus group discussions with TB patients to gain an understanding of the economic burden of TB and implications of this burden for treatment compliance.Results:A total of 797 TB patients were surveyed,of which 60 were interviewed in-depth following the survey.More than half had catastrophic health expenditure.TB patients with higher household incomes were less likely to report non-compliance(OR 0.355,95%CI 0.140–0.830)and patients who felt that the economic burden relating to TB treatment was high more likely to report non-compliance(OR 3.650,95%CI 1.278–12.346).Those who had high costs for transportation,lodging and food were also more likely to report non-compliance(OR 4.150,95%CI 1.804–21.999).The findings from the qualitative studies supported those from the survey.Conclusion:The economic burden associated with seeking diagnosis and treatment remains a barrier for TB patients in China.Reducing the cost of treatment and giving patients subsidies for transportation,lodging and food is likely to improve treatment compliance.Improving doctors’salary system to cut off the revenue-oriented incentive,and expanding current insurance’s coverage can be helpful to reduce patients’actual burden or anticipated burden.Future research on this issue is needed. | Shanquan Chen Hui Zhang Yao Pan Qian Long Li Xiang Lan Yao Henry Lucas | 2015 | Infectious Diseases of Poverty2015，4，1： | 7 |
| 16 | Effect of mean arterial pressure change by norepinephrine on peripheral perfusion index in septic shock patients after early resuscitation显示文摘Background:The peripheral perfusion index(PI),as a real-time bedside indicator of peripheral tissue perfusion,may be useful for determining mean arterial pressure(MAP)after early resuscitation of septic shock patients.The aim of this study was to explore the response of PI to norepinephrine(NE)-induced changes in MAP.Methods:Twenty septic shock patients with pulse-induced contour cardiac output catheter,who had usual MAP under NE infusion after early resuscitation,were enrolled in this prospective,open-label study.Three MAP levels(usual MAP-10 mmHg,usual MAP,and usual MAP+10 mmHg)were obtained by NE titration,and the corresponding global hemodynamic parameters and PI were recorded.The general linear model with repeated measures was used for analysis of variance of related parameters at three MAP levels.Results:With increasing NE infusion,significant changes were found in MAP(F=502.46,P<0.001)and central venous pressure(F=27.45,P<0.001)during NE titration.However,there was not a significant and consistent change in continuous cardiac output(CO)(F=0.41,P=0.720)and PI(F=0.73,P=0.482)at different MAP levels.Of the 20 patients enrolled,seven reached the maximum PI value at usual MAP-10 mmHg,three reached the maximum PI value at usual MAP,and ten reached the maximum PI value at usual MAP+10 mmHg.The change in PI was not significantly correlated with the change in CO(r=0.260,P=0.269)from usual MAP-10 mmHg to usual MAP.There was also no significant correlation between the change in PI and change in CO(r=0.084,P=0.726)from usual MAP to usual MAP+10 mmHg.Conclusions:Differing MAP levels by NE infusion induced diverse PI responses in septic shock patients,and these PI responses may be independent of the change in CO.PI may have potential applications for MAP optimization based on changes in peripheral tissue perfusion. | Huai-Wu He Wang-Lin Liu Xiang Zhou Yun Long Da-Wei Liu | 2020 | Chinese Medical Journal2020，，18： | 6 |
| 17 | Factors that determine catastrophic expenditure for tuberculosis care: a patient survey in China显示文摘Background:Tuberculosis(TB)often causes catastrophic economic effects on both the individual suffering the disease and their households.A number of studies have analyzed patient and household expenditure on TB care,but there does not appear to be any that have assessed the incidence,intensity and determinants of catastrophic health expenditure(CHE)relating to TB care in China.That will be the objective of this paper.Methods:The data used for this study were derived from the baseline survey of the China Government–Gates Foundation TB Phase Ⅱ program.Our analysis included 747 TB cases.Catastrophic health expenditure for TB care was estimated using two approaches,with households defined as experiencing CHE if their annual expenditure on TB care:(a)exceeded 10%of total household income;and(b)exceeded 40%of their non-food expenditure(capacity to pay).Chi-square tests were used to identify associated factors and logistic regression analysis to identify the determinants of CHE.Results:The incidence of CHE was 66.8%using the household income measure and 54.7%using non-food expenditure(capacity to pay).An inverse association was observed between CHE rates and household income level.Significant determinants of CHE were:age,household size,employment status,health insurance status,patient income as a percentage of total household income,hospitalization and status as a minimum living security household.Factors including gender,marital status and type of TB case had no significant associations with CHE.Conclusions:Catastrophic health expenditure incidence from TB care is high in China.An integrated policy expanding the free treatment package and ensuring universal coverage,especially the height of UHC for TB patients,is needed.Financial and social protection interventions are essential for identified at-risk groups. | Chengchao Zhou Qian Long Jiaying Chen Li Xiang Qiang Li Shenglan Tang Fei Huang Qiang Sun Henry Lucas | 2016 | Infectious Diseases of Poverty2016，5，1： | 6 |
| 18 | Rules of anti-infection therapy for sepsis and septic shock显示文摘Objective: Sepsis is a deadly infection that causes injury to tissues and organs. Infection and anti-infective treatment are the eternal themes of sepsis. The successful control of infection is a key factor of resuscitation for sepsis and septic shock. This review examines evidence for the treatment of sepsis. This evidence is combined with clinical experiments to reveal the rules and a standard flowchart of anti-infection therapy for sepsis. Data Sources: We retrieved information from the PubMed database up to October 2018 using various search terms and their combinations, including sepsis, septic shock, infection, antibiotics, and anti-infection. Study Selection: We included data from peer-reviewed journals printed in English on the relationships between infections and antibiotics. Results: By combining the literature review and clinical experience, we propose a 6Rs rule for sepsis and septic shock management: right patients, right time, right target, right antibiotics, right dose, and right source control. This rule encompasses rational decisions regarding the timing of treatment, the identification of the correct pathogen, the selection of appropriate antibiotics, the formulation of a scientifically based antibiotic dosage regimen, and the adequate control of infectious foci. Conclusions: This review highlights how to recognize and treat sepsis and septic shock and provides rules and a standard flowchart for anti-infection therapy for sepsis and septic shock for use in the clinical setting. | Xiang Zhou Long-Xiang Su Jia-Hui Zhang Da-Wei Liu Yun Long | 2019 | Chinese Medical Journal2019，，5： | 6 |
| 19 | A fast decoupled ISAR high-resolution imaging method using structural sparse information under low SNR显示文摘Inverse synthetic aperture radar (ISAR) image can be represented and reconstructed by sparse recovery (SR) approaches. However, the existing SR algorithms, which are used for ISAR imaging, have suffered from high computational cost and poor imaging quality under a low signal to noise ratio (SNR) condition. This paper proposes a fast decoupled ISAR imaging method by exploiting the inherent structural sparse information of the targets. Firstly, the ISAR imaging problem is decoupled into two sub-problems. One is range direction imaging and the other is azimuth direction focusing. Secondly, an efficient two-stage SR method is proposed to obtain higher resolution range profiles by using jointly sparse information. Finally, the residual linear Bregman iteration via fast Fourier transforms (RLBI-FFT) is proposed to perform the azimuth focusing on low SNR efficiently. Theoretical analysis and simulation results show that the proposed method has better performence to efficiently implement higher-resolution ISAR imaging under the low SNR condition. | XIANG Long LI Shaodong YANG Jun CHEN Wenfeng XIANG Hu | 2019 | Journal of Systems Engineering and Electronics2019，30，3： | 6 |
| 20 | Clinical evaluation of the quantitative locator for conjunctiva resection used as an instrument for the treatment of conjunctivochalasis显示文摘背景劣等的球根的结膜的新月状的切除在对医疗倔强的 conjunctivochalasis 的管理作为一个外科的过程被劝告了。然而,这个过程设计织物多少结膜应该被切除是困难的。这研究试图为结膜切除术介绍一个量的定位器并且在 conjunctivochalasis (CCh ) 的治疗上评估它的效果。方法 Poly P-hydroxyethyl methacrylate resin/|3-hydroxyethyl methacrylate (HEMA,水胶化) 被用作材料做被设计适合特定的病人的量的定位器。有双边的征兆的 CCh 的 46 个病人在这未来的研究被包括。病人,当右眼睛经历了流行地使用的新月形的结膜切除术(组) 时,左眼睛被对待,结膜切除术由量的定位器(组) 帮助了。国际眼睛的表面疾病索引(OSDI ) ,残余结膜褶层的分数,复杂并发症和结膜切了愈合,眼泪新月的高度,眼泪分散时间(,但是) ,并且外科的时间被评估。品尝的氯霉素测试(TCT ) 被用来评估怎么在组 II 的眼泪的管 worked.Results OSDI (8.82 浵摩瑩 ? 愠 ? 敷汬愠 ? 数獲湯敮 ? 慷 ? | LI Qing-song ZHANG Xing-ru XIANG Min-hong ZHENG Yi-ren ZHOU Huan-ming ZHANG Zhen-yong ZHANG Long | 2011 | Chinese Medical Journal2011，，13： | 6 |
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