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| 1 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 2 | A Single Nucleotide Deletion in J Encoding GmELF3 Confers Long Juvenility and Is Associated with Adaption of Tropic Soybean显示文摘 | Yanlei Yue Nianxi Liu Bingjun Jiang Mu Li Haijie Wang Ze Jiang Huanting Pan Qiuju Xia Qibin Ma Tianfu Han Hai Nian | 2017 | Molecular Plant2017，10，4： | 20 |
| 3 | Apogossypolone, a novel inhibitor of anfiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro显示文摘有限治疗选择为好攻击的前列腺癌症是可得到的。Gossypol 被报导了在癌症的许多类型举办一项有势力 anticancer 活动。它能增加癌症房间的敏感到 alkylating 代理人,减少 multidrug 抵抗和减少转移。它是否能在癌症房间导致 autophagy,还没是坚定的。这里,我们在 vitro 在人的前列腺癌症房间线 PC3 和 LNCaP 上调查了 apogossypolone (ApoG2 ) 和(?)-gossypol 的 antiproliferative 活动。到 ApoG2 的 PC-3 和 LNCaP 房间的暴露导致了 autophagy 的几个特定的特征特征,包括在酸的小囊的细胞器的细胞质和形成的膜的液泡的外观。联系 autophagy 的 LC3-II 和 beclin-1 的表示在治疗以后在两根房间线增加了。有 3-methyladenine 的 autophagy 的抑制支持了两种房间类型的 apoptosis。一起拿,这些数据证明 autophagy 的那正式就职能在人的前列腺癌症房间对 apoptosis 代表防卫机制。 | Xian-Qing Zhang Xiao-Feng Huang Xing-Bin Hu Yong-Hua Zhan Qun-Xing An Shi-Ming Yang Ai-Jun Xia Jing Yi Rui Chen Shi-Jie Mu Dao-Cheng Wu | 2010 | Asian Journal of Andrology2010，12，5： | 10 |
| 4 | One-pot synthesis and characterization of a new, branched polycarbosilane bearing allyl groups显示文摘A highly branched polycarbosilane bearing allyl groups has been prepared by a one-pot synthesis with chloromethyltrichlor-osilane, chloromethylmethyldichlorosilane and allyl chloride as the starting materials. The resultant polymer, with the approximate formula [SiH1.2(CH3)0.71(CH2CH=CH2)0.09CH2]n, has been characterized by 1H, 13C, and 29Si NMR, GPC, TG and elemental analysis. It could be cross-linked thermally at 170℃in the absence of oxygen. Pyrolysis of the polymer gave a ceramic with a yield of about 70%. | Tian Hua Huang Zhao Ju Yu Xu Min He Mu He Huang Li Fu Chen Hai Ping Xia Li Tong Zhang | 2007 | Chinese Chemical Letters2007，18，6： | 9 |
| 5 | CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells显示文摘 | Yongping Zhang Xingying Zhang Chen Cheng Wei Mu Xiaojuan Liu Na Li Xiaofei Wei Xiang Liu Changqing Xia Haoyi Wang | 2017 | Frontiers of Medicine2017，11，4： | 9 |
| 6 | A preliminary study of chronology for a newly-discovered ancient city and five archaeological sites in Lop Nor, China显示文摘In the past century, it has long been debated in the archeological, historical, geographical, and many other related communities where the capital of the Luolan and Shanshan states was in the Lop Nor region. This paper presents three AMS radiocarbon ages from a newly-discovered ancient city at about 6.3 km to the northwest of the Xiaohe Graveyard, and fifteen new radiocarbon ages from the Loulan (LA), LE, Qieerqiduke, Milan, and Tuyin sites in Lop Nor. The new investigation shows that the age of newly-discovered ancient city is at ca. 440–500 AD, belonging to the Northern Wei Dynasty (386–534 AD). This is about 100–300 years younger than Loulan (ca. 100–230 AD), LE (ca. 230–300 AD), Qieerqiduke (ca. 200 AD), and Tuyin (ca. 100 AD). A wooden beam from Milan fortress is dated to ca. 370 AD, while the age on north wall at west gate of the fortress is younger, around 770 AD, suggesting that its construction time might be at the Tang Dynasty. According to 14C ages, cultural relic style, and the geographical location, the newly-discovered ancient city is probably attributed to 'Zhubin City', as documented in the historical literature. Temporally, we name the city 'ancient Zhubin River City'. However, the characteristics and functions of this ancient city are largely unknown and need more detailed archaeological excavation and investigation in the future. Given its location near the ancient postal relay of Alagan on the crossroad, there is no doubt that the newly-discovered city was at an important geographical position on the Silk Road, no matter whether it was called 'Zhubin City', or 'Lielo City', or the capital of Loulan state–'Yuni City'. Our findings provide new evidence for the temporal and spatial distribution of ancient relic sites and the development of civilization in western China, thus contributing to our understanding of the relationship between human activities and environmental change in the Lop Nor region. | LU HouYuan XIA XunCheng LIU JiaQi QIN XiaoGuang WANG FuBao YIDILISI Abuduresule ZHOU Li Ping MU GuiJin JIAO YingXin LI JingZhi | 2010 | Chinese Science Bulletin2010，55，1： | 8 |
| 7 | Analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China: A Multicenter Retrospective Study显示文摘 | Chen-Hong Wang Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Xiao-Mei Tong Hong Liu Guo-Fang Ding Bin Yi Xin-Nian Pan Dan-Ni Zhong Ling Liu Mei Li Cui-Qing Li Shi-Wen Xia Hong-Yun Wang Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Ruo-Bing Shan De-Zhi Mu Xiao-Hong Liu Si-Qi Zhuang Jing Guo Li Liu Jia-Jun Zhu Hong Xiong | 2016 | Chinese Medical Journal2016，，22： | 8 |
| 8 | Overexpression of VCC-1 gene in human hepatocellular carcinoma cells promotes cell proliferation and invasion显示文摘脉管的 endothelial 生长相关因素的 chemokine 1 (VCC-1 ) ,新奇 chemokine,被假设与 carcinogenesis 被联系。VCC-1 在 hepatocellular 被表示癌(HCC ) 房间,而是它未知的功能遗体。在 HCC 房间上调查 VCC-1 的分子的效果, HCC 房间线 SMMC7721 是稳定地有 recombinant plasmid pcDNA3.1/VCC-1 的 transfected。我们的数据证明在 SMMC7721 房间的 VCC-1 的 overexpression 显著地提高了细胞的增长,侵略能力,和肿瘤生长,当时与两个空向量控制房间和父母房间相比。这些结果强烈建议 VCC-1 在 SMMC7721 侵略和肿瘤生长起一个重要作用,并且显示 VCC-1 可以为 anti-HCC 治疗用作潜在的 biomarker。 | Xia Mu Yao Chen Shuihai Wang Xiang Huang Huazhen Pan Ming Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，8： | 7 |
| 9 | Intensive phototherapy vs.exchange transfusion for the treatment of neonatal hyperbilirubinemia:a multicenter retrospective cohort study显示文摘Background:Intensive phototherapy(IPT)and exchange transfusion(ET)are the main treatments for extreme hyperbilirubinemia.However,there is no reliable evidence on determining the thresholds for these treatments.This multicenter study compared the effectiveness and complications of IPT and ET in the treatment of extreme hyperbilirubinemia.Methods:This retrospective cohort study was conducted in seven centers from January 2015 to January 2018.Patients with extreme hyperbilirubinemia that met the criteria of ET were included.Patients were divided into three subgroups(low-,medium-,and high-risk)according to gestational week and risk factors.Propensity score matching(PSM)was performed to balance the data before treatment.Study outcomes included the development of bilirubin encephalopathy,duration of hospitalization,expenses,and complications.Mortality,auditory complications,seizures,enamel dysplasia,ocular motility disorders,athetosis,motor,and language development were evaluated during follow-up at age of 3 years.Results:A total of 1164 patients were included in this study.After PSM,296 patients in the IPT only group and 296 patients in the IPT plus ET group were further divided into the low-,medium-,and high-risk subgroups with 188,364,and 40 matched patients,respectively.No significant differences were found between the IPT only and IPT plus ET groups in terms of morbidity,complications,and sequelae.Hospitalization duration and expenses were lower in the low-and medium-risk subgroups in the IPT only group.Conclusions:In this study,our results suggest that IPT is a safe and effective treatment for extreme hyperbilirubinemia.The indication of ET for patients with hyperbilirubinemia could be stricter.However,it is necessary to have a contingency plan for emergency ET as soon as IPT is commenced especially for infants with risk factors.If IPT can be guaranteed and proved to be therapeutic,ET should be avoided as much as possible. | Meng Zhang Yang He Jun Tang Wenbin Dong Yong Zhang Benjin Zhang Hong Wan Quanmin Deng Lirong Guan Bin Xia Zhong Chen Min Ge Jing Zhao Wenxing Li Jingjun Pei Yi Qu Dezhi Mu | 2022 | Chinese Medical Journal2022，，5： | 7 |
| 10 | The Relationship between Polymorphisms at 17 Gene Sites and Hypertension among the Aboriginal Tibetan People显示文摘Objective The incidence of hypertension in Tibet ranks highest among all Chinese provinces. This may be due to genetic changes caused by Tibet's unique natural environment and agrarian lifestyle, prompting us to investigated the relationship between gene polymorphisms and hypertension. Methods Blood samples were collected from 229 hypertensive participants and 372 healthy (control) participants from five Tibetan counties. Seventeen single nucleotide polymorphisms were investigated for their connection to hypertension. Results The C allele at rs2070744 of the NOS3 gene was shown to be significantly associated with hypertension (P=0.0443; OR=1.636). Additionally, the T allele of rs4961 of the ADD gene was correlated with hypertension in women (P=0.03124; OR=1.584). Conclusion In this study we found that the NOS3 and ADD genes were related to a high incidence of hypertension among Tibetans. NOS3 gene plays a role in regulating vascular tone and blood vessel diameter, which may be altered by the low-oxygen environment of Tibet. ADD is involved in water and salt metabolism, which is consistent with the high-salt diet of Tibetans. The correlations elucidated by our study were different from those of other ethnic groups, indicating that these findings may be specific to the Tibetan people. | LI Kui LIANG Yu SUN Yin ZHANG Ling Xia YI Xin CHEN Yong GU SANG LA MU WANG Jian | 2012 | Biomedical and Environmental Sciences2012，25，5： | 6 |
| 11 | High levels of circulating GM-CSF^(+) CD4^(+) T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study显示文摘Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients. | Huihuang Huang Siyu Wang Tianjun Jiang Rong Fan Zheng Zhang Jinsong Mu Ke Li Yonggang Wang Lei Jin Fang Lin Jie Xia Lijian Sun Biao Xu Chengcheng Ji Jing Chen Juan Chang Bo Tu Bing Song Chao Zhang Fu-Sheng Wang Ruonan Xu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 12 | A wireless secret key generation method based on Chinese remainder theorem in FDD systems显示文摘The wireless physical channel parameters are recently used to provide secret key.However,the key generation usually suffers from the quantization errors due to the noise,which decreases the key agreement ratio (KAR) between authorized users.Most existing approaches achieve high KAR by discarding some channel parameters which may lower the key generation efficiency and therefore lower the encryption strength.In the frequency-division duplex (FDD) systems,the number of reciprocal parameters,such as the multipath angle and delay,is limited.Therefore how to find a quantization method with high KAR and encryption strength is one of the major problems for secret key generation in FDD systems.In this paper,a robust quantization scheme based on grouping and shifting is proposed,in which all the available parameters are used for key generation.In addition,a key mapping method with error correction based on Chinese remainder theorem (CRT) is proposed to further improve the KAR performance.Simulations demonstrate the effectiveness of the proposed method. | WANG WenJie JIANG HongYan XIA XiangGen MU PengCheng YIN QinYe | 2012 | Science China(Information Sciences)2012，55，7： | 5 |
| 13 | Quality prediction of freshly-harvested wheat using Gluto Peak during postharvest maturation显示文摘Much recent researches have demonstrated that the quality of freshly-harvested wheat could be improved during postharvest maturation by determinating the rheological properties.However,this process is time-consuming and complex.This study aimed to provide a rapid and convenient method for predicting wheat quality during postharvest maturation by use of Gluto Peak device.Farinograph and Extensograph were used to determine the rheological properties of four wheat samples(WT1,WT2,WT3,WT4)stored under different conditions(WT1:15℃,50%RH;WT2:20℃65%RH;WT3:28℃75%RH;WT4:35℃85%RH)for a total of 10 weeks,and Gluto Peak test was used to determine the gluten aggregation properties of the four samples.Correlation analysis was also conducted between the rheological properties and the gluten aggregation properties.Results of rheological properties showed that all Extensographic properties(dough extensibility,resistance,maximum resistance and area)of the four samples increased along with the storage time,and the Farinographic properties(water absorption,dough development time,dough stability time,and farinograph quality number(FQN))had the same tendency,indicating that the rheological properties were improved considerably with storage time extending.The Gluto Peak curves revealed that Peak Maximum Time(PMT),Brabender Equivalents Maximum(BEM)and Energy to Maximum Torque(En MT)of wheat flour of the four samples varied greatly,particularly the PMT and En MT of the samples WT3 and WT4 increased remarkably.Results of correlation analysis showed that En MT had significant correlation with water absorption and area(P<0.05)for sample WT1,and also showed significant correlation with dough development time(P<0.05)for sample WT2.For sample WT3,PMT was significantly correlated with the dough development time,extensibility,area(P<0.05),and FQN(P<0.01);and En MT was in significant correction with water absorption(P<0.01),and dough stability time,FQN,extensibility,maximum resistance and area(P<0.05).For sample WT4,both PMT and En MT had significant correction with area(P<0.05).The study indicated that the Gluto Peak test is effective in quality prediction for the freshly-harvested wheat during postharvest maturation,making it possible to realize rapid wheat quality detection and evaluation in storage period. | Mengyu Mu Ruidie Geng Yuanyuan Yue Feng Jia Xia Zhang Jinshui Wang | 2021 | Grain & Oil Science and Technology2021，4，4： | 5 |
| 14 | Surface Amendments Can Ameliorate Subsoil Acidity in Tea Garden Soils of High-Rainfall Environments显示文摘强烈酸的土壤(pH < 5.0 ) 对茶(山茶 sinensis ) 有害生产和质量。很少信息都不在表面修正案的能力上存在改善在茶花园土壤的心土酸味。A 120-d 温室列沥滤实验用通常可得到的土壤改良物被进行。碱的炉渣(作为) 并且器官的残余,猪粪肥(下午) 和在灰碱度和 C/N 比率不同的油菜籽蛋糕(RC ) 独自并且在联合被合并到土壤列的表面(0-15 厘米)(10 厘米内部的直径 ×
50 厘米长) 从 Ultisol 的酸的土壤层(15-30 厘米) 与土壤收拾行李(起始的 pH = 4.4 ) 。在 120-d 实验期间,土壤列被浇(在 9 应用上的大约 127 公里) 根据长期的平均数,年度降雨(1 143 公里) 和 leachates 镇定、分析。在实验的结束,土壤列被划分成各种各样的深度,土壤的化学性质被测量。有更高的 C/N 比率的下午增加了心土 pH,而有更低的 C/N 比率的 RC 减少了心土 pH。然而,联合了有的修正案独自修正案比也减少心土酸味的一个极有能力。心土的 pH 的增加主要被归功于到减少的基础阳离子集中和在溶解的器官的碳(文档) 和从修改的层被沥滤在下面的硝酸盐的固定在场的器官的阴离子的分解。一重要(P < 0.05 ) 在碱度生产之间的关联(减少的可交换的酸味 -N 周期碱度) 并且碱度平衡(网碱度生产 -N 周期碱度) 在实验的结束被观察。另外,联合了显著地增加的修正案(P < 0.05 ) 心土阳离子集中和减少的心土艾尔浸透(P < 0.05 ) 。联合应用就象表面的器官的修正案,土壤在在高降雨的区域减少心土酸味是有效的。在地条件下面并且在更长的 timeframes 上的进一步的调查被需要充分在改善理解他们的实际有效性在自然地发生沥滤下面的更深的土壤层的酸味政体。 | WANG Lei Clayton R. BUTTERLY CHEN Qiuhui MU Zhibo WANG Xia XI Yunguan ZHANG Jibing XIAO Xingji | 2016 | Pedosphere2016，26，2： | 5 |
| 15 | An Efficient Synthetic Method of Nordihydroguaiaretic Acid (NDGA)显示文摘Nordihydroguaiaretic acid (NDGA) has been synthesized in nine steps from piperonal using Stobbe condensation as the key step with high yield. By this approach, five relative natural products were obtained. | Ya Mu XIA, Xiao Ping CAO, Kun PENG, Xin Feng REN, Xin Fu PAN* Department of Chemistry and National Laboratory of Applied Organic Chemistry Lanzhou University, Lanzhou 730000 | 2003 | Chinese Chemical Letters2003，14，4： | 5 |
| 16 | Analyzing the differences of brackish-water in the Badain Lake by geophysical exploration method显示文摘BadainJ aran Desert of Inner Mongolia is arid and rainless all the year around,with much more evaporation than rainfall.But the special groundwater recharge mechanism contributes to the generation of several lakes of different sizes that have never not dried up for years,among which there are many freshwater lakes.As the research object in this paper,East Badain Lake and West Badain Lake in the southeast of the desert,which are less than 50m away from each other,show the considerable difference in mineralization.In fact,one is a freshwater lake,but the other is a brackish-water lake.Considering the underground aquifer structure of BadainJ aran Desert and the special formation structure the particularity of the stratigraphic structure around Badain Lake,the author uses AMT(audio magneto telluric)method and ultra-high density resistivity method to analyze the difference in mineralization of East Badain Lake and West Badain Lake from the perspective of geophysical prospecting methods. | SONG Hong-wei MU Hai-dong XIA Fan | 2018 | Journal of Groundwater Science and Engineering2018，6，3： | 4 |
| 17 | Estimating global prevalence,incidence,and outcomes of nonalcoholic fatty liver disease from 2000 to 2021:systematic review and meta-analysis显示文摘Background:The increasing burden of non-alcoholic fatty liver disease(NAFLD)worldwide imposes an emerging public health issue.We perform the current study to estimate the global prevalence,incidence,disease progression,and clinical outcomes of NAFLD.Methods:A systematic search was conducted in Medline,Embase,Web of Science,Google Scholar,and Cochrane CENTRAL that screened articles in English language published from January 2000 to December 2021.NAFLD prevalence,incidence,rate of disease progression,and outcomes were calculated with the DerSimonian-Laird random effects model with arcsine transformation.Results:Our search identified 59,156 records,of which 578 studies fulfilled our inclusion criteria.The overall prevalence of NAFLD was 29.38%(95%confidence interval[CI]28.09-30.69)regardless of the diagnostic techniques.Looking at the group in which the diagnosis was made by ultrasound exclusively,the pooled prevalence was 30.49%(95%CI 29.55-31.43).NAFLD has become more prevalent during the year 2011-2021(31.63%,95%CI 30.23-33.04)compared with year 2000-2010(27.94%,95%CI 26.23-29.69).The pooled estimation of non-alcoholic steatohepatitis prevalence was 8.26%(95%CI 1.13-21.01),46.49%(95%CI 35.93-57.20),and 46.72%(95%CI 37.57-55.98)in general population,NAFLD patients,and severe/morbidly obese patients,respectively.Based on a total of 110,142 newly developed NAFLD patients,the pooled incident rate was estimated as 46.24 cases per 1000 person-years(95%CI 43.21-49.30).In patients with NAFLD,the incident rate of hepatocellular carcinoma was 1.46(95%CI 0.90-2.03)cases per 1000 person-years.The overall pooled estimate of NAFLD related mortality was 23.91(95%CI 13.55-37.18)death per 1000 person-years.Conclusions:The prevalence of NAFLD is increasing globally.It is contributing to poor clinical outcomes including hepatocellular carcinoma and death.Rising awareness and urgent actions are warranted to control the NAFLD pandemic across the globe.Registration:PROSPERO,No.CRD42020171104. | Jiaye Liu Ye Tian Xia Fu Chunyang Mu Menglin Yao Yinyun Ni Yong Liu Zhihui Li | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 18 | 左旋棉酚对前列腺癌PC-3细胞增殖的体内外抑制作用显示文摘本文研究左旋棉酚在体内外对前列腺癌PC-3细胞的抗增殖活性,并阐明其可能的分子机制。使用MTT法测定了细胞的生长与活性,用TUNEL与透射电镜检测了细胞的凋亡,用免疫组织化学技术检测了肿瘤组织中PCNA、Bcl-2、CD31、caspase-3与caspase-8的表达。结果表明左旋棉酚的IC。值为4.74mgmL-1。在体内实验中,给予荷瘤裸鼠左旋棉酚(〉5mgkg-1),每日一次,共7天,结果发现左旋棉酚以剂量依赖方式显著抑制肿瘤生长,免疫组化分析发现左旋棉酚增强caspase-3与caspase-8的表达,降低PCNA、Bcl-2、与CD31的表达。结果提示左旋棉酚可以通过诱导前列腺癌细胞凋亡和抑制血管生成而起到抗肿瘤作用。 | Xian-Qing Zhang Xiao-Feng Huang Shi-Jie Mu Qun-Xing An Ai-Jun Xia Rui Chen Dao-Cheng Wu | 2010 | Asian Journal of Andrology2010，12，3： | 4 |
| 19 | Genetic diagnosis strategy of hereditary non-polyposis colorectal cancer显示文摘AIM: To study the characteristics of mismatch repair gene mutation of Chinese hereditary non-polyposis colorectal cancer (HNPCC) and hMLH1 gene promoter methylation, and to improve the screening strategy and explore the pertinent test methods. METHODS: A systematic analysis of 30 probands from HNPCC families in the north of China was performed by immunohistochemistry, microsatellite instability (MSI), gene mutation and methylation detection. RESULTS: High frequency microsatellite instability occurred in 25 probands (83.3%) of HNPCC family. Loss of hMLH1 and hMSH2 protein expression accounted for 88% of all microsatellite instability. Pathogenic muta-tion occurred in 14 samples and 3 novel mutational sites were discovered. Deletion of exons 1-6, 1-7 and 8 of hMSH2 was detected in 3 samples and no large fragment deletion was found in hMLH1. Of the 30 probands, hMLH1 gene promoter methylation occurred in 3 probands. The rate of gene micromutation detection combined with large fragment deletion detection was 46.7%-56.7%. The rate of the two methods in combination with methylation detection was 63.3%. CONCLUSION: Scientific and rational detection strategy can improve the detection rate of HNPCC. Based on traditional molecular genetics and combined with epigenetics, multiple detection methods can accurately diagnose HNPCC. | Jian-Qiu Sheng Hong Zhang Min Ji Lei Fu Hong Mu Ming-Zhi Zhang Ji-Sheng Huang Min Han Ai-Qin Li Zhi Wei Zi-Qin Sun Zi-Tao Wu Chang-Hong Xia Shi-Rong Li | 2009 | World Journal of Gastroenterology2009，15，8： | 4 |
| 20 | Malnutrition Increases the Risk of Mortality in Hospitalized Lung Cancer Patients显示文摘Background The Global Leadership Initiative on Malnutrition(GLIM)recently developed a new set of diagnostic criteria for identifying patients with malnutrition.Because the GLIM criteria were only introduced a little over 3 years ago,additional validation and reliability testing are needed in a variety of populations.Methods We performed an observational,multicenter cohort study.From July 2013 to October 2018,lung cancer patients were recruited from the Daping Hospital of Army Medical University and the First Hospital of Jilin University as part of the INSCOC project.Previously-established cut-off values for the calf circumference(CC,male<30 cm,female<29.5 cm)were applied as the reduced muscal mass of phenotypic criteria to establish the GLIM diagnosis.Multivariate Cox regression analyses were performed to analyze the association between the GLIM criteria and survival.Results A total of 1219 patients with lung cancer were studied as subjects.Their age was 58.81±9.92 years old,and 820 were male and 399 were female.According to the GLIM diagnostic criteria using the CC as a muscle mass measurement,303 patients(24.9%)were categorized as malnourished,142 patients(23.1%)in the adult group(18≤age<60)and 161 patients(26.7%)in the older group(age≥60 years).The patients with malnutrition had a higher incidence of anemia than the nourished patients(P=0.012).The QLQ-C30 score and KPS score indicating that the malnourished patients had a consistently worse quality of life compared to the nourished group(all P<0.001).The median survival of the malnutrition group was 42(95%CI:34-50)months,which was much shorter than the 62(95%CI:57-66)months in the nourished group(P<0.001).In the adult group,the median survival decreased from 65(95%CI:55-72)months in nourished group to 34(95%CI:25-48)months in the patients with malnutrition(P<0.001).In the older group,it decreased from 61(95%CI:55-67)months to 48(95%CI:39-59)months(P=0.001).A Cox regression analysis showed that GLIM-diagnosed malnutrition was associated with an increased risk of death among adult group(HR=1.670,95%CI:1.29-2.16),older group(HR=1.332,95%CI:1.05-1.69)and overall(HR=1.453,95%CI:1.22-1.72).Conclusion All of these results demonstrate that GLIM-diagnosed malnutrition is associated with a poorer survival for all lung cancer patients,independent of age. | Fei Fei Chong Liang Yu Yin Jie Liu Na Li Jing Guo Yang Fan Meng Yuan Zhang Ling Zhang Xiu Mei He Hong Mei Zhang Mu Li Shi Wei Li Hong Xia Xu | 2022 | Journal of Nutritional Oncology2022，7，1： | 4 |
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