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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | Computer Aided Simulation on Precision Cold Forging of Universal Joint Cross显示文摘The 3D FEM numerical simulation on multi-action precision cold forging technology of universal joint cross and differential spider is done in this article using DEFORM Software, a commercial computer aided engineering software specializing in forming and heat treatment simulation technology, and suitable for cold, warm and hot forging process. The material flow properties, the dynamic variation of stress and strain in the process of deformation and the load-stroke curve have also been achieved. A good consistency is exhibited between simulation results and practical data. Based on the DEFORM simulation results, the optimized procedure has been found for forging a universal joint cross. What should be emphasized here is that a better understanding of practical forging characters and the environmental factors can greatly improve the simulation accuracy thus make the simulation results more reliable. | H. Liu, G.N Liu, K J Huo ,T Liu, X H Zhang, K Liu, K Tao, Y. J. Liu 1. Mechanical Engineering School, Xi’an Jiaotong University, Xi’an, 710049, China 2.Strength Centre, Zhengzhou Research Institute of Mechanical Engineering, Zhengzhou 450052, China 3.Fo | 2000 | Journal of Shanghai Jiaotong university(Science)2000，5，1： | 7 |
| 3 | Mechanisms of brain injury after intracerebral haemorrhage显示文摘 | Guohua Xi Richard F Keep Julian T Hoff | 2006 | Lancet Neurology2006，，1： | 4 |
| 4 | Enhanced high-potential and elevated-temperature cycling stability of LiMn2O4 cathode by TiO2 modification for Li-ion battery 显示文摘 | Yu L Qiu x xi J Zhu W T Chen L Q | 2006 | Eleetrochimica Acta2006，51，： | 1 |
| 5 | Self-evolution Neural Model 显示文摘 | Shuai J W Chen Z XI Liu R T | 1996 | Physics Letters-A1996，221，5： | 1 |
| 6 | Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexprssion of interleukin-1 receptor antagonist显示文摘 | Masada T Hua Y Xi G | 2001 | J Neurosurg2001，95，： | 1 |
| 7 | Effect of delayed argatroban treatment on intracerebral hemorrhage-induced edema in the rat显示文摘 | Kitaoka T Hua Y Xi G | 2003 | Acta Neurochir2003，，： | 1 |
| 8 | Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression显示文摘 | XI H J ZHANG T H TAO T | 2011 | Brain Res2011，1410，23： | 1 |
| 9 | Microstructureevolution and mechanical properties of Ni3AI/A1203 composite during self-propagation high-temperature synthesis and hot extrusion显示文摘 | SHENG L Y YANG F XI T F | 2012 | Materials Science En- gineering : A2012，555，： | 1 |
| 10 | Hepatocellular carcinoma expressing cholangiocyte phenotype is a novel subtype with highly aggressive behavior显示文摘 | Lu XY Xi T Lau W Y | | 0，，08： | 1 |
| 11 | Interaction of light filaments generated by femtosecond laser pulses in air显示文摘 | Xi T T Lu X Zhang J | 2006 | PhysRev Lett2006，96，02： | 1 |
| 12 | Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist 显示文摘 | Masada T Hua Y Xi GH | 2001 | J Neurosurg2001，95，： | 1 |
| 13 | On the finite volume element method for general self-adjoint elliptic problems显示文摘 | Xi S T | 1998 | SIAM J Numeri Anal1998，35，： | 1 |
| 14 | Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats显示文摘 | Keep RF Hoff J T | 1998 | J Neurosurg1998，89，： | 1 |
| 15 | The effects of thrombin preconditioning on focal cerebral ischemia in rats 显示文摘 | Masada T Xi G Hua Y | 2000 | Brain Res2000，867，12： | 1 |
| 16 | On the finite volume element method for general self-adjoint elliptic problems显示文摘 | Huang J G Xi S T | 1998 | SIAM J Numer Anal1998，35，5： | 1 |
| 17 | Synthesis and proper- ties of self - crosslinkable polyurethane - urea with sils- esquioxane formation 显示文摘 | ZHANG T XI K CHEN H | 2004 | J Appl Polymr Sci2004，91，1： | 1 |
| 18 | Spatiotemporal Moving Focus of Long Femtosecond-laser Filaments in Air显示文摘 | Xi T T Lu X Zhang J | 2008 | Physical Review E2008，78，05： | 1 |
| 19 | Hepatocellular carcinoma ex- pressing cholangiocyte phenotype is a novel subtype with highly aggressive behavior 显示文摘 | LU X Y XI T LAU W Y | 2011 | Ann Surg Oncol2011，18，8： | 1 |
| 20 | Stability analysis of non-time referenced Internetbased telerobotic systems 显示文摘 | Tam T J | 2000 | Robotics and Autonomous System2000，32，2： | 1 |
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