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| 1 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 2 | China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design显示文摘 | Rachel P Dreyer Xi Li Xue Du Nicholas S Downing Li Li Hai-Bo Zhang Fang Feng Wen-Chi Guan Xiao Xu Shu-Xia Li Zhen-Qiu Lin Frederick A Masoudi John A Spertus Harlan M Krumholz Li-Xin Jiang | 2016 | Chinese Medical Journal2016，，1： | 13 |
| 3 | Admission Glucose and In-hospital Mortality after Acute Myocardial Infarction in Patients with or without Diabetes: A Cross-sectional Study显示文摘 | Shi Zhao Karthik Murugiah Na Li Xi Li Zi-Hui Xu Jing Li Chen Cheng Hong Mao Nicholas S Downing Harlan M Krumholz Li-Xin Jiang | 2017 | Chinese Medical Journal2017，，7： | 6 |
| 4 | Influence of birth order, birth weight, colostrum and serum immunoglobulin G on neonatal piglet survival显示文摘Background: Intake of colostrum after birth is essential to stimulate intestinal growth and function, and to provide systemic immunological protection via absorption of Immunoglobulin G (IgG). The birth order and weight of 745 piglets (from 75 litters) were recorded during a one-week period of farrowing. Only pigs weighing greater than 0.68 kg birth weight were chosen for the trial. Sow colostrum was collected during parturition, and piglets were bled between 48 and 72 hours post-birth. Piglet serum IgG and colostral IgG concentrations were determined by radial immunodiffusion. Results: Sow parity had a significant (P < 0.001) effect on sow colostral IgG concentration, being 5% higher in multiparous females. Sow colostral IgG concentration explained 6% and piglet birth order accounted for another 4% of the variation observed in piglet serum IgG concentration (P < 0.05); however, birth weight had no detectable effect. Piglet serum IgG concentration had both a linear (P < 0.05) and quadratic effect (P < 0.05) on % survival. Piglets with 1,000 mg/dl serum IgG or less (n=24) had a 67% survival; whereas, piglets with IgG concentrations between 2250 to 2500 mg/dl (n=247) had a 91% survival. Birth order had no detectable effect on survival, but birth weight had a positive linear effect (P < 0.05). Piglets weighing 0.9 kg (n = 107) at birth had a 68% survival rate, and those weighing 1.6 kg (n = 158) had an 89% survival. Conclusion: We found that the combination of sow colostrum IgG concentration and birth order can account for 10% of the variation of piglet serum IgG concentration and that piglets with less than 1,000 mg/dl IgG serum concentration and weight of 0.9 kg at birth had low survival rate when compared to their larger siblings. The effective management of colostrum uptake in neonatal piglets in the first 24 hrs post-birth may potentially improve survival from birth to weaning. | Rafael A Cabrera Xi Lin Joy M Campbell Adam J Moeser Jack Odle | 2013 | Journal of Animal Science and Biotechnology2013，4，2： | 2 |
| 5 | Desorption of copper and cadmium from soils enhanced by organic acids显示文摘 | Yuan S H Xi Z M Jiang Y | 2007 | Chemosphere2007，68，： | 1 |
| 6 | Desorption of copper and cadmium from soils enhanced by organic acids 显示文摘 | Yuan S H Xi Z M Jiang Y | 2007 | Chemosphere2007，，68： | 1 |
| 7 | Gene expression and tissue distribution of cytoglobin and myoglobin in the Amphibia and ReRtilia: Possible compensation of myoglobin with cytoglobin in skeletal muscle cells of anurans that lack the myoglobin gene 显示文摘 | Xi Y Obara M Ishida Y | 2007 | Gene2007，398，12： | 1 |
| 8 | Contributing to local policymaking on GHG emission reduction through inventoryingand attribution: A case study of Shenyang, China 显示文摘 | Xi F M Geng Y Chen X D | 2011 | Energy Policy2011，39，2011： | 1 |
| 9 | Biomimic superhydrophobic surface with high adhesive forces 显示文摘 | XI J M J1ANG L | 2008 | Industrial and Engineering Chemistry Research2008，47，17： | 1 |
| 10 | Insulin resistance,meta-bolic stress,and atherosclerosis显示文摘 | Pansuria M Xi H Li L | 2012 | Front Biosci(ScholEd)2012，4，： | 1 |
| 11 | Evidence that wakefulness and REM sleep are controlled by a GABAergic pontine mechanism 显示文摘 | XI M C MORALES F R CHASE M H | 1999 | J Neurophysiol1999，82，4： | 1 |
| 12 | Synthetic applications of photoredox catalysis with visible light显示文摘 | Xi Y M Yi H Lei A W | 2013 | Org Biomol Chem2013，11，： | 1 |
| 13 | Contralateral neuropathology in dorsal root ganglia in a rat model of noncompressive disc herniation显示文摘 | Li Y Xi C Niu M | 2011 | Neurosci lett2011，493，12： | 1 |
| 14 | Surface concentration and molecular interactions in binary mixtures of surfactants 显示文摘 | Rosen M J Xi Y H | 1982 | Jounral of Colloid and Interface Science1982，86，3： | 1 |
| 15 | Clinicopathological signif- icance and biological role of TCF21 mRNA in breast cancer显示文摘 | WANG J GAO XI WANG M etal | 2015 | Tumour Biol2015，36，11： | 1 |
| 16 | Adsorption of antimony( Ⅲ ) and antimony( V ) on bentonite : Kinetics, thermodynamics and anion competition显示文摘 | Xi J He M Lin C | 2011 | Micro- chemical Journal2011，97，1： | 1 |
| 17 | The condensin complexis essential for amitotic segregation of bulk chromosomes,but notnucleoli,in the ciliate Tetrahymena thermophila 显示文摘 | Cervantes M D Coyne R S Xi X | 2006 | Mol CellBiol2006，26，12： | 1 |
| 18 | 显示文摘 | CHENG L ZHANG X M XI X D | 1996 | J Electronanal Chem1996，407，： | 1 |
| 19 | Petal effect, a superhydrophobic state with high adhesive force 显示文摘 | Feng L Zhang Y A Xi J M | 2008 | Langmuir2008，24，8： | 1 |
| 20 | Fluorescence excitation- emission matrix spectroscopy with regional integration analysis for characterizing composition and transformation of dissolved organic matter in landfill leachates 显示文摘 | HE X S XI B D WEI Z M | 2011 | Journal of Hazardous Materials2011，190，123： | 1 |
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