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| 1 | Expression and Function of Zinc-α2-Glycoprotein显示文摘Zinc-α2-glycoprotein(ZAG), encoded by the AZGP1 gene, is a major histocompatibility complex I molecule and a lipid-mobilizing factor. ZAG has been demonstrated to promote lipid metabolism and glucose utilization, and to regulate insulin sensitivity. Apart from adipose tissue, skeletal muscle, liver, and kidney, ZAG also occurs in brain tissue, but its distribution in brain is debatable. Only a few studies have investigated ZAG in the brain. It has been found in the brains of patients with Krabbe disease and epilepsy, and in the cerebrospinal fluid of patients with Alzheimer disease, frontotemporal lobe dementia, and amyotrophic lateral sclerosis. Both ZAG protein and AZGP1 m RNA are decreased in epilepsy patients and animal models, while overexpression of ZAG suppresses seizure and epileptic discharges in animal models of epilepsy, but knowledge of the specific mechanism of ZAG in epilepsy is limited. In this review, we summarize the known roles and molecular mechanisms of ZAG in lipid metabolism and glucose metabolism, and in the regulation of insulin sensitivity, and discuss the possible mechanisms by which it suppresses epilepsy. | Xin Wei Xi Liu Changhong Tan Lijuan Mo Hui Wang Xi Peng Fen Deng Lifen Chen | 2019 | Neuroscience Bulletin2019，35，3： | 14 |
| 2 | An advanced carbon dioxide retrieval algorithm for satellite measurements and its application to GOSAT observations显示文摘An advanced carbon dioxide retrieval algorithm for satellite observations has been developed at the Institute of Atmospheric Physics, Chinese Academy of Sciences. The algorithm is tested using Greenhouse gases Observing SATellite(GOSAT) L1 B data and validated using the Total Column Carbon Observing Network(TCCON) measurements. The retrieved XCO2 agrees well with TCCON measurements in a low bias of 0.15 ppmv and RMSE of 1.48 ppmv, and captured the seasonal variation and increasing of XCO2 in Northern and Southern Hemisphere, respectively, as other measurements. | Dongxu Yang Yi Liu Zhaonan Cai Jianbo Deng Jing Wang Xi Chen | 2015 | Science Bulletin2015，60，23： | 12 |
| 3 | The Photomorphogenic Central Repressor COP1: Conservation and Functional Diversification during Evolution显示文摘Green plants on the earth have evolved intricate mechanisms to acclimatize to and utilize sunlight.In Arabidopsis,light signals are perceived by photoreceptors and transmitted through divergent but overlapping signaling networks to modulate plant photomorphogenic development.COP1(CONSTITUTIVE PHOTOMORPHOGENIC 1)was first cloned as a central repressor of photomorphogenesis in higher plants and has been extensively studied for over 30 years.It acts as a RING E3 ubiquitin ligase downstream of multiple photoreceptors to target key light-signaling regulators for degradation,primarily as part of large protein complexes.The mammalian counterpart of COP1 is a pluripotent regulator of tumorigenesis and metabolism.A great deal of information on COP1 has been derived from whole-genome sequencing and functional studies in lower green plants,which enables us to illustrate its evolutionary history.Here,we reviewthe current understanding about COP1,with a focus on the conservation and functional diversification of COP1 and its signaling partners in different taxonomic clades. | Xue Han Xi Huang Xing Wang Deng | 2020 | Plant Communications2020，1，3： | 12 |
| 4 | Heavy metal accumulation by panicled goldenrain tree(Koelreuteria paniculata) and common elaeocarpus(Elaeocarpus decipens) in abandoned mine soils in southern China显示文摘Phytoremediation can be used as a sustainable technology for mine spoil remediation to remove heavy metals.This study investigated the concentration of 7 heavy metal contamination in soil and plant samples at an abandoned mine site.We found that,after vegetation remediation at the abandoned mine site,the reduction rates for 7 heavy metals were in the range of 4.2%-86%,where reduction rates over 50% were achieved for four heavy metals(Zn,Mn,Cd,Ni).Transfer coeffcients of the panicled goldenrain tree(Koelreuteria paniculata Laxm) and the common elaeocarpus(Elaeocarpus decipens) for Zn,Mn,Ni,and Co were more than 1.Enrichment coeffcients of both trees for Mn were higher than 1.Our results suggest that the panicled goldenrain tree and the common elaeocarpus tree may act as accumulators in remediation.Moreover,the woody vegetation remediation in abandoned mining areas play an important role in improving scenery besides removing heavy metal from contaminated soil. | TIAN Dalun ZHU Fan YAN Wende Fang Xi XIANG Wenhua DENG Xiangwen WANG Guangjun PENG Changhui | 2009 | Journal of Environmental Sciences2009，21，3： | 11 |
| 5 | Thermoelastic properties of sandwich materials with pin-reinforced foam cores显示文摘Pin-reinforced foam is a novel type of sandwich core materials formed by inserting pins(trusses) into a foam matrix to create a truss-like network reinforced foam core.Upon loading,the pins deform predominantly by local stretching whilst the deformation of foam is governed by local bending.This paper presents a theoretical study on the thermoelasticity of pin-reinforced foam sandwich cores.To calculate the effective thermoelastic properties of pin-reinforced foam cores,the energy-based homogenization approach is employed to develop a micromechanics-based model,calibrated by the existing experimental data.It is found that the stiffness of the sandwich core is mainly governed by pin reinforcements:the foam matrix contributes little to sandwich stiffness.Compared with traditional foam cores without pin reinforcements,the changes in inplane thermal expansion coefficients are not vigorous as a result of pin reinforcements,while the through-thickness thermal expansion coefficient changes significantly.It is also demonstrated that it is possible to design materials with zero or negative thermal expansion coefficients under such a context. | LU TianJian1,LIU Tao2,3 & DENG ZiChen2,4 1 MOE Key Laboratory of Strength and Vibration,School of Aerospace,Xi’an Jiaotong University,Xi’an 710049,China 2 Department of Engineering Mechanics,Northwestern Polytechnical University,Xi’an 710072,China 3 Department of Engineering,University of Cambridge,Cambridge CB2 1PZ,UK 4 State Key Laboratory of Structural Analysis of Industrial Equipment,Dalian University of Technology,Dalian 116024,China | 2008 | Science China(Technological Sciences)2008，51，12： | 10 |
| 6 | Efficacy Observation on Acupuncture Combined with Auricular Point Sticking Treatment for Primary Dysmenorrhea显示文摘Objective:To observe the clinical efficacy of acupuncture combined with auricular point sticking treatment for primary dysmenorrhea. Methods:Sixty-eight patients with primary dysmenorrhea were randomly divided into two groups, and 35 cases in the treatment group were treated by acupuncture combined with auricular point sticking, while 33 cases in the control group were only treated by acupuncture. The treatments for the patients in both groups began from one week before their menstruation and continued till the menstruation came. And the efficacy was observed after treatments of three consecutive menstrual cycles. Results:The total effective rate was 94.2% in the treatment group, versus 84.8% in the control group, and the difference was statistically significant (P<0.05). Conclusion:Acupuncture combined with auricular point sticking treatment for primary dysmenorrhea is more effective than simple acupuncture. | Liu Xiao-xia Wang Xi Deng Ying | 2013 | Journal of Acupuncture and Tuina Science2013，11，4： | 10 |
| 7 | Extraction, identification, and antioxidant property evaluation of limonin from pummelo seeds显示文摘Limonin, the main bioactive phytochemical constituent of limonoids with multi-functions, is enriched in citrus fruits and often found at a high concentration in citrus seeds. The present study was attempted to introduce a new and efficient extraction method to isolate limonoids from pummelo seeds, and to evaluate the antioxidant property of the main constituent limonin in Hep G2 cells. Three key single factors were identified for the extraction of limonoids from pummelo seeds using the Box-Behnken experiment design of response surface methodology(RSM), and the optimized extraction parameters were treatment with 89.68 m L of anhydrous acetone for 4.62 h at 78.94C, while the yield of limonoids was 11.52 mg/g. The structure of isolated main constituent of the limonoids was further identified as limonin by Fourier transform infrared(FT-IR) spectrometer and nuclear magnetic resonance(NMR)spectrum. Moreover, the molecular data in Hep G2 cells revealed that limonin exerted its anti-oxidant property mainly by the activation of nuclear factor(erythroid-2)-like 2(Nrf2)/kelch-like ECHassociated protein 1(Keap1)-antioxidant response element(ARE) pathway in the form of transcriptional regulation of Nrf2 m RNA and posttranscriptional regulation of Nrf2/Keap1 system. These results demonstrate that pummelo seeds are an ideal source of limonoids, and limonin is proved to exert its anti-oxidant property by the activation of Nrf2/Keap1 pathway. | Si Qin Chenghao Lv Qingshan Wang Zhibing Zheng Xi Sun Minyi Tang Fangming Deng | 2018 | Animal Nutrition2018，，3： | 10 |
| 8 | Highly expressed BMP9/GDF2 in postnatal mouse liver and lungs may account for its pleiotropic effects on stem cell differentiation,angiogenesis,tumor growth and metabolism显示文摘Bone morphogenetic protein 9(BMP9)(or GDF2)was originally identified from fetal mouse liver cDNA libraries.Emerging evidence indicates BMP9 exerts diverse and pleiotropic functions during postnatal development and in maintaining tissue homeostasis.However,the expression landscape of BMP9 signaling during development and/or in adult tissues remains to be analyzed.Here,we conducted a comprehensive analysis of the expression landscape of BMP9 and its signaling mediators in postnatal mice.By analyzing mouse ENCODE transcriptome datasets we found Bmp9 was highly expressed in the liver and detectable in embryonic brain,adult lungs and adult placenta.We next conducted a comprehensive qPCR analysis of RNAs isolated from major mouse tissues/organs at various ages.We found that Bmp9 was highly expressed in the liver and lung tissues of young adult mice,but decreased in older mice.Interestingly,Bmp9 was only expressed at low to modest levels in developing bones.BMP9-associated TGFβ/BMPR type I receptor Alk1 was highly expressed in the adult lungs.Furthermore,the feedback inhibitor Smads Smad6 and Smad7 were widely expressed in mouse postnatal tissues.However,the BMP signaling antagonist noggin was highly expressed in fat and heart in the older age groups,as well as in kidney,liver and lungs in a biphasic fashion.Thus,our findings indicate that the circulating BMP9 produced in liver and lungs may account for its pleiotropic effects on postnatal tissues/organs although possible roles of BMP9 signaling in liver and lungs remain to be fully understood. | Wei Liu Zhongliang Deng Zongyue Zeng Jiaming Fan Yixiao Feng Xi Wang Daigui Cao Bo Zhang Lijuan Yang Bin Liu Mikhail Pakvasa William Wagstaff Xiaoxing Wu Huaxiu Luo Jing Zhang Meng Zhang Fang He Yukun Mao Huiming Ding Yongtao Zhang Changchun Niu Rex C.Haydon Hue H.Luu Jennifer Moriatis Wolf Michael J.Lee Wei Huang Tong-Chuan He Yulong Zou | 2020 | Genes & Diseases2020，7，2： | 9 |
| 9 | Indicators for prediction of Mycobacterium tuberculosis positivity detected with bronchoalveolar lavage fluid显示文摘Background:The diagnosis of active pulmonary tuberculosis(TB)remains a challenge in clinic,especially for sputum negative pulmonary TB.Bronchoalveolar lavage fluid(BALF)has higher sensitivity than sputum for detection of Mycobacterium tuberculosis(Mtb).However,bronchoscopy is invasive and costly,and not suitable for all patients.In order to make TB patients get more benefit from BALF for diagnosis,we explore which indicator might be used to optimize the choice of bronchoscopy.Methods:A total of 1539 sputum-smear-negative pulmonary TB suspects who underwent bronchoscopy were recruited for evaluation.The sensitivity,specificity and accuracy of Mtb detection in sputum and BALF were compared.Odds ratios and 95%confidence intervals were used to assess variables that associated with positive acid-fast bacilli(AFB)smear,Mtb culture and nucleic acid amplification test(NAAT)of BALF in sputum-negative and non-sputum-producing pulmonary TB suspects.Results:BALF has significantly higher sensitivity(63.4%)than sputum(43.5%)for Mtb detection by culture and NAAT.19.7%(122/620)sputum-negative and 40.0%(163/408)non-sputum-producing suspects had positive bacteriological results in BALF.Among sputum-negative and non-sputum-producing pulmonary TB suspects,the positivity of Mtb detection in BALF is associated with a younger age,the presence of pulmonary cavities and a positive result of interferon-gamma release assay(IGRA).Sputum-negative patients under 35 years old with positive IGRA and pulmonary cavity had 84.8%positivity of Mtb in BALF.Conclusions:Our study indicated that combination of age,the presence of pulmonary cavity,and the result of IGRA is useful to predict the positivity of Mtb detection in BALF among sputum-negative and non-sputum producing pulmonary TB suspects.Those who are under 35 years old,positive for the presence of pulmonary cavity and IGRA,should undergo bronchoscopy to collect BAFL for Mtb tests,as they have the highest possibility to get bacteriologically confirmation of TB. | Xi Liu Xing-Fang Hou Lei Gao Guo-Fang Deng Ming-Xia Zhang Qun-Yi Deng Tao-Sheng Ye Qian-Ting Yang Bo-Ping Zhou Zhi-Hua Wen Hai-Ying Liu Hardy Kornfeld Xin-Chun Chen | 2018 | Infectious Diseases of Poverty2018，7，1： | 9 |
| 10 | Prevalence and molecular characteristics of Listeria monocytogenes in cooked products and its comparison with isolates from listeriosis cases显示文摘这研究试图在 Zigong 城市里在煮的产品调查流行和 Listeria monocytogenes 的分子的特征,中国。L 的全面出现。在商店和羊肉餐馆调查了的 ready-to-eat (RTE ) 的 monocytogenes 是 16.2%(141/873 ) 。13.5% 的出现在 RTE 猪肉被观察, 6.5% 在 RTE 蔬菜,并且非常, 24.0% 在也煮了羊肉或煮了将羊杂切碎加麦片纳入羊胃中煮成的食物。Serotype 1/2b (45.4%) , 1/2a (33.3%) ,和 1/2c (14.2%) 是占优势的类型。由基于 L 的打字的 multilocus 顺序(MLST ) 比较同种细胞的建筑群(CC ) 。从从中国, CC87, CC9, CC8,和 CC3 的不同区域的 Zigong 城市和 33 个 listeriosis 案例里的煮的食物的 monocytogenes 被显示在煮的产品和 CC87 流行, CC3 是在 33 诊所来源紧张的开始的二种经常的类型。所有 CC87 污点怀有最新报导的 Listeria 致病力岛 4 (LIPI-4 ) 基因碎片 ptsA,和所有 CC3 紧张拥有了 Listeria 致病力岛 3 (LIPI-3 ) 基因碎片 llsX。这些可以增加在中国在 listeriosis 情况中属于 CC87 和 CC3 的紧张的出现并且也从 Zigong 由于煮的产品的消费加重感染的风险。ST619 (serotype 1/2b ) 怀有 llsX 和 ptsA,显示在 Zigong 的一种潜在的 hypervirulent 顺序类型。 | Hong Wang Lijuan Luo Zhengdong Zhang Jianping Deng Yan Wang Yimao Miao Ling Zhang Xi Chen Xiang Liu Songsong Sun Bo Xiao Qun Li Changyun Ye | 2018 | Frontiers of Medicine2018，12，1： | 9 |
| 11 | Ursolic acid induces U937 cells differentiation by PI3K/Akt pathway activation显示文摘AIM: Ursolic acid(UA), a pentacyclic triterpenoid, is used as an anti-inflammatory and anti-cancer agent. There were few studies on the effects of UA on differentiation, and this is the first time to elucidate the potential effect and molecular mechanism of UA on inducing differentiation in the human leukemia cell line U937. METHODS: Wright-Giemsa staining, nitroblue tetrazolium reduction assay and flow cytometric analysis were utilized to demonstrate the differentiation of U937 cells induced by UA. Western blotting and immunofluorescence assay were used to investigate the possible mechanism. RESULTS: It was found that UA could induce the differentiation of U937cells and Akt-activity was significantly increased during differentiation. Additionally, LY294002, a PI3K-Akt inhibitor, could block the differentiation of U937 cells induced by UA. CONCLUSION: UA could induce the differentiation of U937 cells by activating the PI3K/Akt pathway, and it could be a potential candidate as a differentiation-inducing agent for the therapy of leukemia. | DENG Lin ZHANG Rui TANG Feng LI Chen XING Ying-Ying XI Tao | 2014 | Chinese Journal of Natural Medicines2014，12，1： | 8 |
| 12 | The Use of Lipoprotein-Associated Phospholipase A2 in a Chinese Population to Predict Cardiovascular Events显示文摘Objective To explore associations between lipoprotein-associated phospholipase A2(Lp-PLA2)and the risk of cardiovascular events in a Chinese population,with a long-term follow-up.Methods A random sample of 2,031 participants(73.6%males,mean age=60.4 years)was derived from the Asymptomatic Polyvascular Abnormalities Community study(APAC)from 2010 to 2011.Serum Lp-PLA2 levels were determined by enzyme-linked immunosorbent assay(ELISA).The composite endpoint was a combination of first-ever stroke,myocardial infarction(MI)or all-cause death.Lp-PLA2 associations with outcomes were assessed using Cox models.Results The median Lp-PLA2 level was 141.0 ng/m L.Over a median follow-up of 9.1 years,we identified 389 events(19.2%),including 137 stroke incidents,43 MIs,and 244 all-cause deaths.Using multivariate Cox regression,when compared with the lowest Lp-PLA2 quartile,the hazard ratios with95%confidence intervals for developing composite endpoints,stroke,major adverse cardiovascular events,and all-cause death were 1.77(1.24–2.54),1.92(1.03–3.60),1.69(1.003–2.84),and 1.94(1.18–3.18)in the highest quartile,respectively.Composite endpoints in 145(28.6%)patients occurred in the highest quartile where Lp-PLA2(159.0 ng/m L)was much lower than the American Association of Clinical Endocrinologists recommended cut-off point,200 ng/m L.Conclusion Higher Lp-PLA2 levels were associated with an increased risk of cardiovascular event/death in a middle-aged Chinese population.The Lp-PLA2 cut-off point may be lower in the Chinese population when predicting cardiovascular events. | XI Hui CHENG Guan Liang HU Fei Fei LI Song Nan DENG Xuan ZHOU Yong | 2022 | Biomedical and Environmental Sciences2022，35，3： | 8 |
| 13 | Diagnostic value of Epstein-Barr virus capsid antigen-IgA in nasopharyngeal carcinoma: a meta-analysis显示文摘屏蔽的背景非侵略的鼻咽的癌(NPC ) 通常包含到 Epstein-Barr 的为 IgA 抗体的存在的血清学的测试病毒(EBV ) 衣壳抗原(VCA ) 。现在的元分析在 NPC.Methods 的诊断决定了 VCA-lgA 的精确性研究的系统的评论被进行,在 NPC 的诊断的 VCA-lgA 集中的精确性上的数据用随机的效果模型被分享。操作典型曲线的接收装置被用来总结全面测试表演。二十研究遇见了的结果为元分析的包括标准。为在 NPC 的诊断的 VCA-lgA 的概括估计是:敏感 0.91 (95% 信心间隔(Cl ) :0.90-0.92 ) ,特性 0.92 (95% Cl:0.92-0.93 ) ,积极可能性的比率 31.65 (95% Cl:10.99-91.15 ) ,否定可能性的比率 0.10 (95% Cl:0.07-0.13 ) 并且诊断机会比率 414.59 (95% Cl:174.96-982.42 ) 。在操作典型曲线的概括接收装置下面的区域是 0.98 .Conclusion 很高,敏感和浆液 VCA-lgA 的特性正在建议在外部血的 VCA-lgA 的存在是为 NPC 的一个珍贵预言者。 | LI Shan DENG Yan LI Xi CHEN Qiao-pei LIAO Xiang-cheng QIN Xue | 2010 | Chinese Medical Journal2010，，9： | 8 |
| 14 | Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020). | Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen | 2020 | Protein & Cell2020，11，9： | 7 |
| 15 | The Association of Socioeconomic Status with the Burden of Cataract-related Blindness and the Effect of Ultraviolet Radiation Exposure: An Ecological Study显示文摘Objective To assess the association of socioeconomic status with the burden of cataract blindness in terms of year lived with disability(YLD) rates and to determine whether ultraviolet radiation(UVR) levels modify the effect of socioeconomic status on this health burden.Methods National and subnational age-standardized YLD rates associated with cataract-related blindness were derived from the Global Burden of Disease(GBD) study 2017. The human development index(HDI) from the Human Development Report was used as a measure of socioeconomic status.Estimated ground-level UVR exposure was obtained from the Ozone Monitoring Instrument(OMI)dataset of the National Aeronautics and Space Administration(NASA).Results Across 185 countries, socioeconomic status was inversely associated with the burden of cataract blindness. Countries with a very high HDI had an 84% lower age-standardized YLD rate [95%confidence interval(CI): 60%–93%, P < 0.001] than countries with a low HDI;for high-HDI countries, the proportion was 76%(95% CI: 53%–88%, P < 0.001), and for medium-HDI countries, the proportion was48%(95% CI: 15%–68%, P = 0.010;P for trend < 0.001). The interaction analysis showed that UVR exposure played an interactive role in the association between socioeconomic status and cataract blindness burden(P value for interaction = 0.047).Conclusion Long-term high-UVR exposure amplifies the association of poor socioeconomic status with the burden of cataract-related blindness. The findings emphasize the need for strengthening UVR exposure protection interventions in developing countries with high-UVR exposure. | DENG Yan YANG Dan YU Jia Ming XU Jing Xian HUA Hui CHEN Ren Tong WANG Nan OU Feng Rong LIU Ru Xi WU Bo LIU Yang | 2021 | Biomedical and Environmental Sciences2021，34，2： | 6 |
| 16 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 17 | Slope Seismic Response Monitoring on the Aftershocks of the Wenchuan Earthquake in the Mianzhu Section显示文摘Previous investigations have shown that the seismic response of slopes during the Wenchuan earthquake was highly variable.The present study tries to give an answer to the question:Which are the main factors affecting the seismic response degree of slopes? With the support of the China Geological Survey Bureau,we set 3 monitoring sections in Jiulong slope,Mianzhu city,China with the aim to record the site response of the slope during the aftershocks of the Wenchuan earthquake.After the Wenchuan earthquake,which happened on 12 May 2008,30 aftershocks have been recorded in these monitoring points.We analyzed 11 records,with magnitudes ranging from ML = 4.6 to ML = 3.1.The amplification factors of the horizontal compound PGA and 3D compound PGA have been determined for the 3 points at different elevations on the slope.Results showed that the dynamic response of the slope on the earthquake was controlled by factors such as topography and the thickness of the Quaternary overburden. | WANG Yunsheng LUO Yonghong WANG Fuhai WANG Dong MA Xiao LI Shun DENG Xi | 2012 | Journal of Mountain Science2012，9，4： | 6 |
| 18 | Chromatography studies on bio-affinity of nine ligands of a1-adrenoceptor to a1D subtypes overexpressed in cell membrane显示文摘To improve selectivity and specificity of cell membrane chromatography (CMC), the chromatography affinities of nine ligands of a1-adrenergic receptor(AR)to a1D-AR subtype were investigated. The human embryonic kidney (HEK) 293 cells expressed by cDNA of a1D-AR subtypes were cultured and cell membrane stationary phase (CMSP) was prepared. Then the interactions between ligands and a1D-AR in CMSP were investigated using CMC. The affinity rank order to a1D-AR subtype obtained from CMC for the nine a1-adrenoceceptor ligands is: prazosin, BMY7378, phentolamine, oxymetazoline, 5-methylurapidil, norepinephrine, phenyle- phrine, methoxamine, RS-17053. The affinity rank order is similar and correlates well with that obtained from others radioligand binding assays (RBA). CMSP prepared by transfected HEK293 cells with 1D-adrenoceptor cDNA and CMC method could be used to evaluate affinities of drug-receptor and drug-receptor subtypes and to screen drugs selective to a1D-AR. | ZHANG Dian1, YUAN Bingxiang1, DENG Xiuling1, YANG Guangde2, HE Langchong2, ZHANG Youyi3 & HAN Qide3 1. School of Medicine, Xi’an Jiaotong University, Xi’an 710061, China 2. College of pharmacy, Xi’an Jiaotong University, Xi’an 710061, China 3. Third Hospital, Beijing University, Beijing 100083, China | 2004 | Science China(Life Sciences)2004，47，4： | 6 |
| 19 | Source Contributions to PM2.5 under Unfavorable Weather Conditions in Guangzhou City,China显示文摘Historical haze episodes(2013–16) in Guangzhou were examined and classified according to synoptic weather systems.Four types of weather systems were found to be unfavorable, among which 'foreside of a cold front'(FC) and 'sea high pressure'(SP) were the most frequent(> 75% of the total). Targeted case studies were conducted based on an FC-affected event and an SP-affected event with the aim of understanding the characteristics of the contributions of source regions to fine particulate matter(PM_(2.5)) in Guangzhou. Four kinds of contributions—namely, emissions outside Guangdong Province(super-region), emissions from the Pearl River Delta region(PRD region), emissions from Guangzhou–Foshan–Shenzhen(GFS region), and emissions from Guangzhou(local)—were investigated using the Weather Research and Forecasting–Community Multiscale Air Quality model. The results showed that the source region contribution differed with different weather systems. SP was a stagnant weather condition, and the source region contribution ratio showed that the local region was a major contributor(37%), while the PRD region, GFS region and the super-region only contributed 8%, 2.8% and 7%, respectively, to PM_(2.5) concentrations. By contrast, FC favored regional transport. The super-region became noticeable,contributing 34.8%, while the local region decreased to 12%. A simple method was proposed to quantify the relative impact of meteorology and emissions. Meteorology had a 35% impact, compared with an impact of-18% for emissions, when comparing the FC-affected event with that of the SP. The results from this study can provide guidance to policymakers for the implementation of effective control strategies. | Nan WANG Zhenhao LING Xuejiao DENG Tao DENG Xiaopu LYU Tingyuan LI Xiaorong GAO Xi CHEN | 2018 | Advances in Atmospheric Sciences2018，35，9： | 5 |
| 20 | Natural Climate Solutions for China:The Last Mile to Carbon Neutrality显示文摘“I call on all leaders worldwide to declare a State of Climate Emergency in their own countries until carbon neutrality is reached.”–António GUTERRES(United Nations Secretary General),12 December,2020 There is no shortcut to a carbon neutral society;solutions are urgently required from both energy&industrial sectors and global ecosystems.While the former is often held accountable and emphasized in terms of its emissions reduction capability,the latter(recently termed natural climate solutions)should also be assessed for potential and limitations by the scientific community,the public,and policy makers. | Zhangcai QIN Xi DENG Bronson GRISCOM Yao HUANG Tingting LI Pete SMITH Wenping YUAN Wen ZHANG | 2021 | Advances in Atmospheric Sciences2021，38，6： | 5 |
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