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| 1 | A Highly Pathogenic Strain of Porcine Deltacoronavirus Caused Watery Diarrhea in Newborn Piglets显示文摘Porcine deltacoronavirus(PDCoV) is a newly identified virus that causes watery diarrhea in newborn piglets and results in significant economic losses to the pig industry. Since first reported in Hong Kong in 2012, PDCoV has been subsequently detected in USA, South Korea, Thailand, and China's Mainland. Here we isolated a strain of PDCoV, named CHN-GD-2016,from the intestinal content of a diseased newborn piglet with severe diarrhea in a pig farm in Guangdong, China. PDCoV CHN-GD-2016 could be identified by immunofluorescence with PDCoV specific rabbit antisera, and typical crown-shaped particles with spiky surface projections of this PDCoV were observed with electron microscopy. Genomic analysis showed that the PDCoV CHN-GD-2016 was closely related to other Chinese PDCoV strains, with the highest sequence similarity with the strain CHN/Tianjin/2016. Importantly, inoculation of newborn piglets with 1×10~5 TCID_(50) of CHN-GD-2016 by oral feeding successfully reproduced clear clinical symptoms, including vomiting, dehydration, and severe diarrhea in piglets. In addition, the virus RNA in rectal swabs from 1 to 7 days post inoculation was detected, macroscopic and microscopic lesions in small intestine were observed, and viral antigen was also detected in the small intestines with immunohistochemical staining. Collectively, the data show in this study confirms that PDCoV is present in Guangdong,China and is highly pathogenic in newborn piglets. | Zhichao Xu Huiling Zhong Qingfeng Zhou Yunping Du Li Chen Yun Zhang Chunyi Xue Yongchang Cao | 2018 | Virologica Sinica2018，33，2： | 16 |
| 2 | An experimental and numerical study on the charring rate of timber beams exposed to three-side fire显示文摘To investigate the charring rate of timber beams exposed to three-side fire, a total of fifteen new and used Douglas-Fir timber beams in four groups exposed to three-side fire were experimentally studied, together with the finite element analyses of the temperature distribution in the beam section. The durations of fire exposure were 0 (on a test piece), 10, 15, 20 and 30 min, according to the ISO 834 standard fire curve. The charring depth of each timber beam was calculated by averaging the values at one-third and two-thirds along each cross section to give the charring rate of timber beams. It was found that the timber beam's charring rate reduces as the duration of fire exposure increases and the vertical charring rate is slightly higher than the horizontal one. The areas of beam sections reduce due to charring and the strength and stiffness of the pyrolysis layer near the charring edge decrease owing to the high-temperature. The average horizontal and vertical charring rates are 0.98 and 1.08 mm/min, respectively. To take into account the difference between the test furnace temperature curve and the ISO 834 stand- ard fire curve, some corrections were made for these data to yield the solution for charring rate. With the help of the finite element software ANSYS, the temperature distribution of the wood's cross-section was analyzed. The longer the exposure time is, the greater the effect of density will impose on the distribution of temperature, but the moisture content has no effect. | ZHANG Jin LIU ZengHui XU YiXiang MA ShuWei XU QingFeng | 2012 | Science China(Technological Sciences)2012，55，12： | 8 |
| 3 | Hierarchical Ni-Co-S@Ni-W-O core-shell nanosheet arrays on nickel foam for high-performance asymmetric supercapacitors显示文摘镍钴硫化物(Ni-Co-S ) 由于他们的优秀传导性和高电气化学的电容在电子设备为申请吸引了广泛的注意。为了便于 Ni-Co-S,优秀的率能力和这些的周期的稳定性的大规模实际申请,混合物必须充分被利用。因此,镍泡沫上的层次 Ni-Co-S@Ni-W-O (Ni-Co-S-W ) 核心 / 壳混血儿 nanosheet 数组经由一个灵巧的三步的热水的方法此处被设计并且综合,由在氩空气下面在一个管状的炉子退火列在后面。混合结构直接作为一个自立的电极被装配,它展出了 1,988 F | Weidong He Zhifu Liang Keyu ji Qingfeng Sun Tianyou Zhai Xijin Xu | 2018 | Nano Research2018，11，3： | 7 |
| 4 | A naturally occurring CD8^+CD122^+ T-cell subset as a memory-like Treg family显示文摘尽管有 CD4 + CD25 + 规章的 T 房间(Tregs ) 在过去的十年期间,在他们的临床的翻译以后的进步仍然保持停滞。增长证据建议那自然地发生的 CD8 + CD122 + T 房间也是有能力的 Tregs 禁止 T 房间回答并且象 alloimmunity 一样压制 autoimmunity。事实上,他们是像记忆的 Tregs 类似于一个中央记忆 T 房间(T 厘米 ) 显型。位于他们的抑制下面的机制仍然不好被理解,尽管他们可以包括 IL-10 生产。我们最近证明了那个规划 death-1 (PD-1 ) 表达式区分在之间规章并且存储器 CD8 + CD122 + T 房间和那 CD8 + CD122 + Tregs 经历更快的 homeostatic 增长并且比常规 CD4 + CD25 + Tregs。这些调查结果可以为在诊所加速有效 Treg 治疗打开调查的一根新线。在这评论,我们在 CD8 + CD122 + Treg 在诊所研究并且讨论他们的显型,在 autoimmunity 和 alloimmunity 的镇压角色,功能的要求,行动的机制和潜在的应用。 | Shanshan Li Qingfeng Xie Yuqun Zeng Chuan Zou Xusheng Liu Shouhai Wu Haixia Deng Yang Xu Xian C Li Zhenhua Dai | 2014 | Cellular & Molecular Immunology2014，11，4： | 6 |
| 5 | Zeolitic Imidazolate Framework 8-Derived Au@ZnO for Efficient and Robust Photocatalytic Degradation of Tetracycline显示文摘Summary of main observation and conclusion Tetracycline (TC) and other antibiotics accumulated in groundwater and soil pollute ecological environment and threaten human health. Gold nan oparticles doped on photocatalysts are able to enhance the photodegradation efficiency during removing these antibiotics, but preparation of Au nanoparticles of well-dispersion on photocatalysts remains challenging. In this work, zeolite imidazolate (ZIF-8) was employed as the precursor to prepare Au@ZnO photocatalyst via impregnation and in-situ reduction method to efficiently degrade the tetracycline in the aqueous solution. Au nanoparticles are of 10 nm in size and uniformly dispersed on the surfaces of ZnO microstructures. The as-prepared Au@ZnO is able to remove 85.5% of TC of 0.010 mg/mL within 2h, presenting higher photocatalytic activity than pure ZnO catalyst. Most importantly, the catalyst shows its superior stability after five cycles without structure and activity changing. The mechanism of the photocatalytic degradation was discussed in detail. | Bijun Gao Jin Zhou Hongliang Wang Guping Zhang Jinghui He Qingfeng Xu Najun Li Dongyun Chen Hua Li Jianmei Lu | 2019 | Chinese Journal of Chemistry2019，37，2： | 6 |
| 6 | The chimeric genes in the hybrid lineage of Carassius auratus cuvieri(♀)×Carassius auratus red var.(♂)显示文摘Hybridization can combine the genomes of different strains or species, which leads to changes of genotype and phenotype in the hybrids. In this study, we aimed to investigate the genetic variations of hybrids(WR-F1 and WR-F2) derived from the intraspecific hybridization of white crucian carp(Carassius auratus cuvieri, WCC, ♀) and red crucian carp(Carassius auratus red var., RCC, ♂). Here, we compared the orthologous genes in the liver transcriptomes of hybrids with those of WCC and RCC, and classified the orthologous genes into eight gene patterns within three categories(chimera, mutant, and biparental origin genes).The results revealed 19.04%, 4.17% chimeric genes and 6.90%, 5.05% mutations of orthologous genes in WR-F1 and WR-F2 respectively. Seventeen of twenty-three characterized genes(77%) were confirmed to be the chimeras at the genomic DNA level.The GO classification discovered that some chimeric and mutant genes were related to metabolic process, immune system and developmental process in WR-F1. Our results provide the new evidence that hybridization can combine the parental genomes,leading to changes in the genotype of the resultant hybrids. This is the first report on the formation of chimeric genes from fish intraspecific hybridization, which is potentially interesting from the context of both evolution and the genetic breeding of fish. | Qingfeng Liu Yanhua Qi Qiuli Liang Xiujuan Xu Fangzhou Hu Jing Wang Jun Xiao Shi Wang Wuhui Li Min Tao Qinbo Qin Rurong Zhao Zhanzhou Yao Shaojun Liu | 2018 | Science China(Life Sciences)2018，61，9： | 6 |
| 7 | A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling显示文摘Long noncoding RNAs(lncRNAs)are emerging as a new class of important regulators of signal transduction in tissue homeostasis and cancer development.Liquid–liquid phase separation(LLPS)occurs in a wide range of biological processes,while its role in signal transduction remains largely undeciphered.In this study,we uncovered a lipid-associated lncRNA,small nucleolar RNA host gene 9(SNHG9)as a tumor-promoting lncRNA driving liquid droplet formation of Large Tumor Suppressor Kinase 1(LATS1)and inhibiting the Hippo pathway.Mechanistically,SNHG9 and its associated phosphatidic acids(PA)interact with the C-terminal domain of LATS1,promoting LATS1 phase separation and inhibiting LATS1-mediated YAP phosphorylation.Loss of SNHG9 suppresses xenograft breast tumor growth.Clinically,expression of SNHG9 positively correlates with YAP activity and breast cancer progression.Taken together,our results uncover a novel regulatory role of a tumor-promoting lncRNA(i.e.,SNHG9)in signal transduction and cancer development by facilitating the LLPS of a signaling kinase(i.e.,LATS1). | Rui-Hua Li Tian Tian Qi-Wei Ge Xin-Yu He Cheng-Yu Shi Jun-Hong Li Zhen Zhang Fang-Zhou Liu Ling-Jie Sang Zuo-Zhen Yang Ya-Zhuo Liu Yan Xiong Qingfeng Yan Xu Li Huai-Qiang Ju Jian Liu Liang-Jing Wang Jian-Zhong Shao Wenqi Wang Tianhua Zhou Aifu Lin | 2021 | Cell Research2021，31，10： | 6 |
| 8 | Multimetallic AuPd@Pd@Pt core-interlayer-shell icosahedral electrocatalysts for highly efficient oxygen reduction reaction显示文摘Incorporating Pt with core metals into Pt-based core-shell catalysts is regarded as a promising strategy to substantially enhance the catalytic properties towards oxygen reduction reaction(ORR) in fuel cells due to the synergetic effect between distinct metals. In this wok, ultrathin Pt skins with two atomic layers were epitaxially coated on as-prepared icosahedral Au_50Pd_50, Au_60Pd_40 and Au_66Pd_34 nanocrystal seeds,which are constructed with alloyed cores and Pd shells with different thickness. Through electron microscopic characterizations, Pd interlayers with tunable thickness of 3, 6, and 12 atomic layers can be found in the Au_66Pd_34@Pt, Au_60 Pd_40@Pt and Au_50Pd_50@Pt icosahedra, respectively. These icosahedral Au Pd@Pd@Pt nanocrystals show substantially enhanced activities and durabilities in electrocatalytic measurements towards ORR compared to Au_75Pd_25@Pt icosahedra without Pd interlayer and commercial Pt/C catalysts. Specifically, Au_60Pd_40@Pt icosahedra with 6 atomically thick Pd interlayer display the best electrocatalytic performances, whose mass activities before and after durability tests of 50,000 cycles are11.6 and 30.2 times, respectively, as high as that of the commercial Pt/C. | Qingfeng Xu Wenlong Chen Yucong Yan Zhemin Wu Yi Jiang Junjie Li Ting Bian Hui Zhang Jianbo Wu Deren Yang | 2018 | Science Bulletin2018，63，8： | 5 |
| 9 | Microstructure and composition engineering Yb single-filled CoSb_(3) for high thermoelectric and mechanical performances显示文摘A broad tunability of the thermoelectric and mechanical properties of CoSb_(3) has been demonstrated by adjusting the composition with the addition of an increasing number of elements.However,such a strategy may negatively impact processing repeatability and composition control.In this work,singleelement-filled skutterudite is engineered to have high thermoelectric and mechanical performances.Increased Yb filling fraction is found to increase phonon scattering,whereas cryogenic grinding contributes additional microstructural scattering.A peak zT of 1.55 and an average zT of about 1.09,which is comparable to the reported results of multiple-filled SKDs,are realized by the combination of simple composition and microstructure engineering.Furthermore,the mechanical properties of Yb single-filled CoSb_(3) skutterudite are improved by manipulation of the microstructure through cryogenic grinding.These findings highlight the realistic prospect of producing high-performance thermoelectric materials with reduced compositional complexity. | Zhenxing Zhou Matthias T.Agne Qihao Zhang Shun Wan Qingfeng Song Qing Xu Xiaofang Lu Shijia Gu Yuchi Fan Wan Jiang Gerald Jeffrey Snyder Lianjun Wang | 2019 | Journal of Materiomics2019，5，4： | 4 |
| 10 | Roles of intracellular fibroblast growth factors in neural development and functions显示文摘Fibroblast growth factors (FGFs) can be classified as secretory (FGF1-10 and FGF15-23) or intracellular non-secretory forms (FGF11-14). Secretory forms of FGF and their receptors are best known for their regulatory roles in cell growth, differentiation and morphogenesis in the early stages of neural development. However, the functions of intracellular FGFs remain to be explored. FGF12 and FGF14 are found to interact with voltage-gated sodium channels, and regulate the channel activity in neurons. FGF13 is expressed in primary sensory neurons, and is colocalized with sodium channels at the nodes of Ranvier along the myelinated afferent fibers. FGF13 is also expressed in cerebral cortical neurons during the late developmental stage. A recent study showed that FGF13 is a microtubule-stabilizing protein required for regulating the neuronal development in the cerebral cortex. Thus, non-secretory forms of FGF appear to have important roles in the brain, and it would be interesting to further investigate the functions of intracellular FGFs in the nervous system and in neural diseases. | ZHANG Xu BAO Lan YANG Liu WU QingFeng LI Shuai | 2012 | Science China(Life Sciences)2012，55，12： | 4 |
| 11 | Obacunone activates the Nrf2-dependent antioxidant responses显示文摘 | Xu, Shengmei Chen, Weimin Xie, Qingfeng Xu, Yang | 2016 | Protein & Cell2016，7，9： | 4 |
| 12 | Study of brain morphology change in Alzheimer’s disease and amnestic mild cognitive impairment compared with normal controls显示文摘Background With an aggravated social ageing level, the number of patients with Alzheimer's disease (AD) is gradually increasing, and mild cognitive impairment (MCI) is considered to be an early form of Alzheimer's disease. How to distinguish diseases in the early stage for the purposes of early diagnosis and treatment is an important topic. Aims The purpose of our study was to investigate the differences in brain cortical thickness and surface area among elderly patients with AD, elderly patients with amnestic MCI (aMCI) and normal controls (NC). Methods 20 AD patients, 21 aMCIs and 25 NC were recruited in the study. FreeSurfer software was used to calculate cortical thickness and surface area among groups. Results The patients with AD had less cortical thickness both in the left and right hemisphere in 17 of the 36 brain regions examined than the patients with aMCI or NC. The patients with AD also had smaller cerebral surface area both in the left and right hemisphere in 3 of the 36 brain regions examined than the patients with aMCI or NC. Compared with the NC, the patients with aMCI only had slight atrophy in the inferior parietal lobe of the left hemisphere, and no significant difference was found. Conclusion AD, as well as aMCI (to a lesser extent), is associated with reduced cortical thickness and surface area in a few brain regions associated with cognitive impairment. These results suggest that cortical thickness and surface area could be used for early detection of AD. | Huanqing Yang Hua Xu Qingfeng Li Yan Jin Weixiong Jiang Jinghua Wang Yina Wu Wei Li Cece Yang Xia Li Shifu Xiao Feng Shi Tao Wang | 2019 | General Psychiatry2019，32，2： | 3 |
| 13 | Role of CD8^(+) regulatory T cells in organ transplantation显示文摘CD8^(+)T cells are regulatory T cells(Tregs)that suppress both alloimmunity and autoimmunity in many animal models.This class of regulatory cells includes the CD8^(+)CD28^(-),CD8^(+)CD103^(+),CD8^(+)FoxP3^(+)and CD8^(+)CD122^(+)subsets.The mechanisms of action of these regulatory cells are not fully understood;however,the secretion of immunosuppressive cytokines,such as interleukin(IL)-4,IL-10 and transforming growth factor beta(TGF-β)as well as the direct killing of target cells via Fas L/Fas and the perforin/granzyme B pathways have been demonstrated in various models.Further studies are necessary to fully understand the mechanisms underlying the suppressive effects of Tregs and to provide experimental support for potential clinical trials.We recently observed that CD8^(+)CD122^(+)Tregs more potently suppressed allograft rejection compared to their CD4^(+)CD25^(+)counterparts,supporting the hypothesis that CD8^(+)Tregs may represent a new and promising Treg family that can be targeted to prevent allograft rejection in the clinic.In this review,we summarize the progress in the field during the past 7-10 years and discuss CD8^(+)Treg phenotypes,mechanisms of action,and their potential clinical applications;particularly in composite tissue transplants in burn and trauma patients. | Jiyan Su Qingfeng Xie Yang Xu Xian C.Li Zhenhua Dai | 2014 | Burns & Trauma2014，2，1： | 3 |
| 14 | A mini-review on ZnIn_(2)S_(4)-Based photocatalysts for energy and environmental application显示文摘As one of the most attractive and eco-friendly technologies,semiconductor photocatalysis is demonstrated as a potential strategy to solve global energy shortage environmental pollution problems.Regarding semiconductor-based photocatalysts,Zinc indium sulfide(ZnIn_(2)S_(4)) with various morphological structures has become research hotspots owing to its superior visible light absorption,high chemical durability and low cost.Nevertheless,the photocatalytic activity of pristine ZnIn_(2)S_(4) is unsatisfactory due to limited range of visible light absorption and fast recombination rate of light-induced electrons and holes.Different modification strategies,such as metal deposition,element doping,vacancy engineering and semiconductor combination,have been systematically developed for enhancing the photocatalytic performance of ZnIn_(2)S_(4) materials.In order to promote further developments of ZnIn_(2)S_(4) in photocatalytic applications,this mini-review summarizes the progress of recent research works for the construction of highly activity ZnIn_(2)S_(4)-based photocatalysts for the first time.In addition,the typical applications of ZnIn_(2)S_(4)-based photocatalytic materials have been critically reviewed and described such as in hydrogen evolution from photocatalytic water splitting,carbon dioxide photoreduction,and treatment of water pollution.The current challenges and further prospects for the development of ZnIn_(2)S_(4) semiconductor photocatalysts are finally pointed out. | Guping Zhang Hao Wu Dongyun Chen Najun Li Qingfeng Xu Hua Li Jinghui He Jianmei Lu | 2022 | Green Energy & Environment2022，7，2： | 2 |
| 15 | PRESSURE COMPENSATION METHOD OF UNDERWATER HYDRAULIC SYSTEM WITH HYDRAULIC POWER UNIT BEING UNDER ATMOSPHERIC CIRCUMSTANCE AND PRESSURE COMPENSATED VALVE显示文摘Based on the analysis of the-state-of-the-art of pressure compensation of underwater hy-draulic systems (UHSs), a new method of pressure compensation of UHSs, whose hydraulic powerunit is in the atmospheric circumstance, is proposed. And a pilot-operated relief valve with pressurecompensation is realized. The pressure compensation precision is guaranteed by direct detection. Itsdynamic performance and stability are improved by a dynamic feedback. Theoretical study,simulation and experiment show that the pilot-operated relief valve with pressure compensation has afine property of tracking underwater ambient pressure and meet the requirement of underwaterambient pressure compensation. | Wang Qingfeng Li Yanmin Zhong Tianyu Xu Guohua | 2005 | Chinese Journal of Mechanical Engineering2005，18，3： | 2 |
| 16 | Material Properties of Marine Hydrogenous Ferromanganese Crust and Its Performance in Desulfurization显示文摘海洋的氢的铁锰合金外壳,一个重要金属资源以后,作为自然 nano-structuredmaterial 的一种类型在各种各样的应用有重要潜力。由采用扫描电子显微镜学,氮吸附解吸附作用等温线测量, X 光检查荧光分光计和 X 光检查衍射方法,微观结构,表面性质和几个像板的铁锰合金外壳的化学成分从西北的太平洋取样了包括地被调查。尽管明显的差别从不同的层被观察,外壳是有高比面积区域,唯一的毛孔结构和丰富的过渡元素的典型多孔的材料。而且,在 desulfurization 过程的自然外壳的性能 preliminarily 在实验室实验被测试。外壳的 Thesulfur 能力分别地在房间温度和 350 deg C 是 13.1% 和 18.1% 。外壳能一个金属资源被用作不仅,而且作为环境材料。 | LU Xiancai HOU Qingfeng LIU Xiandong YANG Kan WANG Rucheng LING Hongfei XU Shijin | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 2 |
| 17 | Titanium-supported nanoporous bimetallic Pt Ir electrocatalysts for formic acid oxidation显示文摘 | Qingfeng Yi Aicheng Chen Wu Huang Jingiing Zhang Xiaoping Liu Guorong Xu Zhihua Zhou | 2007 | Electrochemistry Communications2007，，9： | 1 |
| 18 | The clinical feasibility and effect of online cone beam computer tomography-guided intensity-modulated radiotherapy for nasopharyngeal cancer显示文摘 | Jin Wang Sen Bai Nianyong Chen Feng Xu Xiaoqin Jiang Yan Li Qingfeng Xu Yali Shen Hong Zhang Youling Gong Renming Zhong Qingfeng Jiang | 2008 | Radiotherapy and Oncology2008，，： | 1 |
| 19 | Detection of intrafractional tumour position error in radiotherapy utilizing cone beam computed tomography显示文摘 | Feng Xu Jin Wang Sen Bai Yan Li Yali Shen Renming Zhong Xiaoqin Jiang Qingfeng Xu | 2008 | Radiotherapy and Oncology2008，，： | 1 |
| 20 | Author Correction:Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfs5w5ucq5q0vq96ckq.ffgz.tsg.suse.edu.cn/10.1038/s41422-022-00635-9,published online 10 March 2022 We found that the information in the original Supplementary Figs.S2–S4 was not fully displayed due to an error in the image upload.The correct images are shown below for better display.These corrections do not affect the description of the results or the conclusion of this work.No change of the original figure legends is needed.We apologize for the mistake.The original article has been corrected. | Ziqi Zhao Dan Zhang Fuqiang Yang Mingrui Xu Shaoli Zhao Taotao Pan Chuanyu Liu Yongjie Liu Qingfeng Wu Qiang Tu Ping Zhou Rong Li Jia Kang Lan Zhu Fei Gao Yaqing Wang Zhiheng Xu | 2023 | Cell Research2023，33，7： | 1 |
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