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| 1 | Systems metabolic engineering strategies for the production of amino acids显示文摘Systems metabolic engineering is a multidisciplinary area that integrates systems biology,synthetic biology and evolutionary engineering.It is an efficient approach for strain improvement and process optimization,and has been successfully applied in the microbial production of various chemicals including amino acids.In this review,systems metabolic engineering strategies including pathwayfocused approaches,systems biology-based approaches,evolutionary approaches and their applications in two major amino acid producing microorganisms:Corynebacterium glutamicum and Escherichia coli,are summarized. | Qian Ma Quanwei Zhang Qingyang Xu Chenglin Zhang Yanjun Li Xiaoguang Fan Xixian Xie Ning Chen | 2017 | Synthetic and Systems Biotechnology2017，2，2： | 10 |
| 2 | Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis显示文摘 | Yi Lu Shanshan Xie Wen Zhang Cheng Zhang Cheng Gao Qiang Sun Yuqi Cai Zhangqi Xu Min Xiao Yanjun Xu Xiao Huang Ximei Wu Wei Liu Fudi Wang Yibin Kang Tianhua Zhou | 2017 | Cell Research2017，27，12： | 9 |
| 3 | Warm temperature compromises JA-regulated basal resistance to enhance Magnaporthe oryzae infection in rice显示文摘Changes in global temperatures profoundly affect the occurrence of plant diseases.It is well known that rice blast can easily become epidemic in relatively warm weather.However,the molecular mechanism remains unclear.In this study,we show that enhanced blast development at a warm temperature(22C)compared with the normal growth temperature(28C)is rice plant-determined.Comparative transcriptome analysis revealed that jasmonic acid(JA)biosynthesis and signaling genes in rice could be effectively induced by Magnaporthe oryzae at 28C but not at 22C.Phenotypic analyses of the osaoc1 and osmyc2 mutants,OsCOI1 RNAi lines,and OsMYC2-OE plants further demonstrated that compromised M.oryzaeinduced JA biosynthesis and signaling lead to enhanced blast susceptibility at the warm temperature.Consistent with these results,we found that exogenous application of methyl jasmonate served as an effective strategy for improving blast resistance under the warm environmental conditions.Furthermore,decreased activation of JA signaling resulted in the downregulated expression of some key basal resistance genes at 22C when compared with 28C.Among these affected genes,OsCEBiP(chitin elicitorbinding protein precursor)was found to be directly regulated by OsMYB22 and its interacting protein OsMYC2,a key component of JA signaling,and this contributed to temperature-modulated blast resistance.Taken together,these results suggest that warm temperature compromises basal resistance in rice and enhances M.oryzae infection by reducing JA biosynthesis and signaling,providing potential new strategies for managing rice blast disease under warm climate conditions. | Jiehua Qiu Junhui Xie Ya Chen Zhenan Shen Huanbin Shi Naweed I.Naqvi Qian Qian Yan Liang Yanjun Kou | 2022 | Molecular Plant2022，15，4： | 5 |
| 4 | Nonfatal Child Pedestrian Injury in Two Urban Cities of Guangdong Province,China:Results from a Cross-sectional Survey显示文摘Objective To describe the epidemiological characteristics of nonfatal child pedestrian injuries and provide information to help understand an important public-health problem.Methods This was a school-based,cross-sectional questionnaire survey.The sample (42 750 children) was obtained from two urban cities of Guangdong Province,China,using multi-stage randomized sampling.Information was collected by the respondents self-reporting in the classroom.Results The incidence rate of nonfatal child pedestrian injuries in the cities was 2.0%.Boys had a higher incidence rate (2.6%) than girls (1.4%).Compared to other children,those aged 10 years are at the highest risk.The primary places of occurrence were sidewalks,residential roads,and crosswalks.High-risk behavior of the children immediately prior to injury included mid-block crossings,playing on roads,and crossing on red lights.The major vehicles that caused pedestrian injuries were bicycles,car or vans,and motorcycles.Bruises,fractures,and injuries to the internal organs were the top three types of injuries.Almost 40% of victims were hospitalized,and nearly 30% of the victims suffered long-term disabilities.Conclusion This study shows that nonfatal child pedestrian injuries are a very serious public-health problem in the urban cities of Guangdong.Based on the epidemiological characteristics,prevention strategies and further research should be carried out to reduce the occurrence of injuries. | MA WenJun NIE ShaoPing XU HaoFeng XU YanJun XIE HuiYan ZHANG YuRun | 2011 | Biomedical and Environmental Sciences2011，24，4： | 4 |
| 5 | Current landscape in motoneuron regeneration and reconstruction for motor cranial nerve injuries显示文摘The intricate anatomy and physiology of cranial nerves have inspired clinicians and scientists to study their roles in the nervous system. Damage to motor cranial nerves may result from a variety of organic or iatrogenic insults and causes devastating functional impairment and disfigurement. Surgical innovations directed towards restoring function to injured motor cranial nerves and their associated organs have evolved to include nerve repair, grafting, substitution, and muscle transposition. In parallel with this progress, research on tissue-engineered constructs, development of bioelectrical interfaces, and modulation of the regenerative milieu through cellular, immunomodulatory, or neurotrophic mechanisms has proliferated to enhance the available repertoire of clinically applicable reconstructive options. Despite these advances, patients continue to suffer from functional limitations relating to inadequate cranial nerve regeneration, aberrant reinnervation, or incomplete recovery of neuromuscular function. These shortfalls have profound quality of life ramifications and provide an impetus to further elucidate mechanisms underlying cranial nerve denervation and to improve repair. In this review, we summarize the literature on reconstruction and regeneration of motor cranial nerves following various injury patterns. We focus on seven cranial nerves with predominantly efferent functions and highlight shared patterns of injuries and clinical manifestations. We also present an overview of the existing reconstructive approaches, from facial reanimation, laryngeal reinnervation, to variations of interposition nerve grafts for reconstruction. We discuss ongoing endeavors to promote nerve regeneration and to suppress aberrant reinnervation and the development of synkinesis. Insights from these studies will shed light on recent progress and new horizons in understanding the biomechanics of peripheral nerve neurobiology, with emphasis on promising strategies for optimizing neural regeneration and identifying future directions in the field of motor cranial neuron research. | Yanjun Xie Kevin J.Schneider Syed A.Ali Norman D.Hogikyan Eva L.Feldman Michael J.Brenner | 2020 | Neural Regeneration Research2020，15，9： | 4 |
| 6 | Local inhibition of GABA affects precedence effect in the inferior colliculus显示文摘The precedence effect is a prerequisite for faithful sound localization in a complex auditory environment,and is a physiological phenomenon in which the auditory system selectively suppresses the directional information from echoes.Here we investigated how neurons in the inferior colliculus respond to the paired sounds that produce precedence-effect illusions,and whether their firing behavior can be modulated through inhibition with gamma-aminobutyric acid(GABA).We recorded extracellularly from 36 neurons in rat inferior colliculus under three conditions: no injection,injection with saline,and injection with gamma-aminobutyric acid.The paired sounds that produced precedence effects were two identical 4-ms noise bursts,which were delivered contralaterally or ipsilaterally to the recording site.The normalized neural responses were measured as a function of different inter-stimulus delays and half-maximal interstimulus delays were acquired.Neuronal responses to the lagging sounds were weak when the inter-stimulus delay was short,but increased gradually as the delay was lengthened.Saline injection produced no changes in neural responses,but after local gamma-aminobutyric acid application,responses to the lagging stimulus were suppressed.Application of gamma-aminobutyric acid affected the normalized response to lagging sounds,independently of whether they or the paired sounds were contralateral or ipsilateral to the recording site.These observations suggest that local inhibition by gamma-aminobutyric acid in the rat inferior colliculus shapes the neural responses to lagging sounds,and modulates the precedence effect. | Yanjun Wang Ningyu Wang Dan Wang Jun Jia Jinfeng Liu Yan Xie Xiaohui Wen Xiaoting Li | 2014 | Neural Regeneration Research2014，9，4： | 4 |
| 7 | Establishment of an Objective Standard for the Definition of Binary Tropical Cyclones in the Western North Pacific显示文摘To develop an objective standard for defining binary tropical cyclones(BTCs)in the western North Pacific(WNP),two best-track datasets,from the China Meteorological Administration and the Joint Typhoon Warning Center,were adopted for statistical analyses on two important characteristics of BTCs-two TCs approaching each other,and counterclockwise spinning.Based on the high consistency between the two datasets,we established an objective standard,which includes a main standard for defining BTCs and a secondary standard for identifying typical/atypical BTCs.The main standard includes two requirements:two coexisting TCs are a pair of BTCs if(i)the separation distance is≤1800 km,and(ii)this separation maintains for at least 12 h.Meanwhile,the secondary standard defines a typical BTC as one for which there is at least one observation when the two TCs approach each other and spin counterclockwise simultaneously.Under the standard,the ratio of typical BTCs increases as the BTC duration increases or the minimum distance between the two TCs decreases.Then,using the JTWC dataset,it was found that there are 505 pairs of BTCs during the period 1951−2014,including 328 typical BTCs and 177 atypical BTCs,accounting for 65.0%and 35.0%of the total,respectively.In addition,a study of two extreme phenomena-the maximum approaching speed and the maximum counterclockwise angular velocity in typical BTCs-shows that the configuration of the circulation conditions and the distribution of the BTCs favor the formation of these extreme phenomena. | Fumin REN Yanjun XIE Biwen YIN Mingyang WANG Guoping LI | 2020 | Advances in Atmospheric Sciences2020，37，11： | 3 |
| 8 | Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery显示文摘The incidence rate of diabetes has been increasing every year in nearly all nations and regions.The traditional control of diabetes using transdermal insulin delivery by metal needles is generally associated with pain and potential infections.While microneedle arrays(MAs)have emerged as painless delivery techniques,the integration of MA systems with electronic devices to precisely control drug delivery has rarely been realized.In this study,we developed an iontophoresis-microneedle array patch(IMAP)powered by a portable smartphone for the active and controllable transdermal delivery of insulin.The IMAP in situ integrates iontophoresis and charged nanovesicles into one patch,achieving a one-step drug administration strategy of“penetration,diffusion and iontophoresis”.The MA of the IMAP is first pressed on the skin to create microholes and then is retracted,followed by the iontophoresis delivery of insulin-loaded nanovesicles through these microholes in an electrically controlled manner.This method has synergistically and remarkably enhanced controlled insulin delivery.The amount of insulin can be effectively regulated by the IMAP by applying different current intensities.This in vivo study has demonstrated that the IMAP effectively delivers insulin and produces robust hypoglycemic effects in a type-1 diabetic rat model,with more advanced controllability and efficiency than delivery by a pristine microneedle or iontophoresis.The IMAP system shows high potential for diabetes therapy and the capacity to provide active as well as long-term glycemic regulation without medical staff care. | Jingbo Yang Yanjun Li Rui Ye Ying Zheng Xiangling Li Yuzhen Chen Xi Xie Lelun Jiang | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 9 | Coating performance on glutaraldehyde-modified wood显示文摘Scots pine(Pinus sylvestris L.) panels were modified with glutaraldehyde(GA) to various weight percent gains and subsequently coated with several commercial coatings. The drying rate and adhesion of the coatings on the modified wood were measured; the coated/modified woods were exposed outdoors to analyze how the wood modifications influence the coating deterioration. The results showed that GA modification caused an increase in the drying rate of the waterborne coatings, but had no influence on drying of tested solvent-borne coatings. GAmodification did not change the dry adhesion but reduced the wood strength in a pull-off test. Wet adhesion of waterborne coatings was improved, while that of the solvent-borne coatings tended to be somewhat reduced. During 22 months of outdoor weathering, the coated/modified samples exhibited lower moisture content than the coated/unmodified samples, but GA modification didn't contribute a substantially synergistic effect with surface coatings on resistance to weathering. | Zefang Xiao Haiou Chen Carsten Mai Holger Militz Yanjun Xie | 2019 | Journal of Forestry Research2019，30，1： | 2 |
| 10 | Experimental study of seepage characteristics of single rock fracture based on stress states and stress history显示文摘Through seepage tests under different loading and unloading confining pressures and different hydraulic gradients,the authors studied the effects of stress states and stress history on fracture permeability evolution for single granite fracture and sandstone fracture. The results show that there exists a linear relationship between the seepage discharge and osmotic pressure in sandstone fissure under each level of confining pressure. With the increasing in the confining pressure,the permeability of the fracture decreases,but the decreasing rate is changeing. During the unloading process,the fracture seepage velocity cannot be fully recovered to the size of the loading process. Therefore,in the unloading process of the confining pressure,the recovery of fracture permeability shows obvious hysteresis effects. The flow rate of the fracture remains unchanged during five cycles of loading and unloading processes of the confining pressure. In each cycle,the evolution character of the flow rate with the confining pressure remains unchanged. These experiments show that the seepage characteristics of sandstone and granite fractures are not the same under the same stress state. | ZHANG Chi ZHANG Yanjun LI Zhengwei ZHANG Tong LIU Tong XIE Yangyang | 2016 | Global Geology2016，19，3： | 2 |
| 11 | Two Ultraviolet Radiation Datasets that Cover China显示文摘Ultraviolet(UV) radiation has significant effects on ecosystems, environments, and human health, as well as atmospheric processes and climate change. Two ultraviolet radiation datasets are described in this paper. One contains hourly observations of UV radiation measured at 40 Chinese Ecosystem Research Network stations from 2005 to 2015. CUV3 broadband radiometers were used to observe the UV radiation, with an accuracy of 5%, which meets the World Meteorology Organization's measurement standards. The extremum method was used to control the quality of the measured datasets. The other dataset contains daily cumulative UV radiation estimates that were calculated using an all-sky estimation model combined with a hybrid model. The reconstructed daily UV radiation data span from 1961 to 2014. The mean absolute bias error and root-mean-square error are smaller than 30% at most stations, and most of the mean bias error values are negative, which indicates underestimation of the UV radiation intensity. These datasets can improve our basic knowledge of the spatial and temporal variations in UV radiation. Additionally, these datasets can be used in studies of potential ozone formation and atmospheric oxidation, as well as simulations of ecological processes. | Hui LIU Bo HU Yuesi WANG Guangren LIU Liqin TANG Dongsheng JI Yongfei BAI Weikai BAO Xin CHEN Yunming CHEN Weixin DING Xiaozeng HAN Fei HE Hui HUANG Zhenying HUANG Xinrong LI Yan LI Wenzhao LIU Luxiang LIN Zhu OUYANG Boqiang QIN Weijun SHEN Yanjun SHEN Hongxin SU Changchun SONG Bo SUN Song SUN Anzhi WANG Genxu WANG Huimin WANG Silong WANG Youshao WANG Wenxue WEI Ping XIE Zongqiang XIE Xiaoyuan YAN Fanjiang ZENG Fawei ZHANG Yangjian ZHANG Yiping ZHANG Chengyi ZHAO Wenzhi ZHAO Xueyong ZHAO Guoyi ZHOU Bo ZHU | 2017 | Advances in Atmospheric Sciences2017，34，7： | 2 |
| 12 | The behaviors of ultra-low-gold-loaded catalysts (Au/ Ce02) for CO oxidation in the presence of water on the catalysts显示文摘The catalytic behavior of ultra-low-gold-loaded Au/CeO2 during CO oxidation was studied using HRTEM, TGA, in-situ FTIR, CO--TPD, O2-TPD, and O2-TPO. Herein, water, which facilitates CO oxidation, is present on the catalyst rather than obtained from the reactant gas. The experimental results show that the presence of water on the catalyst enhances the adsorption and activation of 02 to produce Oact on the catalyst surface, resulting in excellent catalytic activity. Different reaction pathways for CO oxidation over Au/CeO2 may be present; however, the dominant pathway is influenced by the species on the catalyst surface. | Qiaoling Li Wei Xie Guoqin Chen Yuefeng Li Yanjun Huang Xiaodong Chen | 2015 | Nano Research2015，8，9： | 2 |
| 13 | Endogenous auxin and its manipulation influence in vitro shoot organogenesis of citrus epicotyl explants显示文摘Endogenous auxin is an important regulator of in vivo organ development,but its role in in vitro organogenesis is unclear.It has been observed that the basal end of epicotyl cuttings of juvenile citrus seedlings produces fewer shoots than the apical end.Here,we report that elevated endogenous auxin levels in the basal end of citrus epicotyl cuttings are inhibitory for in vitro shoot organogenesis.Using transgenic citrus plants expressing an auxin-inducible GUS reporter gene,we have observed elevated levels of auxin at the basal end of stem cuttings that are mediated by polar auxin transport.Depleting endogenous auxin or blocking polar auxin transport enhances shoot organogenesis.An auxin transport inhibitor,N-1-naphthylphthalamic acid(NPA),can also enhance shoot organogenesis independent of its action on polar auxin transport.Finally,we demonstrate that the promotional effects of depleting endogenous auxin or blocking polar auxin transport on shoot organogenesis are cytokinin-dependent.Our study thus provides meaningful insights into possible roles of endogenous auxin and polar auxin transport,as well as auxin–cytokinin interactions,in in vitro shoot organogenesis.Meanwhile,our results may also provide practical strategies for improving in vitro shoot organogenesis for citrus and many other plant species. | Wei Hu Sabrina Fagundez Lorenzo Katin-Grazzini Yanjun Li Wei Li Yingnan Chen Xiaomin Wang Ziniu Deng Shenxi Xie Richard J McAvoy Yi Li | 2017 | Horticulture Research2017，4，1： | 1 |
| 14 | Lipid distribution in a subtropical southern China stalagmite as a record of soil ecosystem response to palaeoclimate change 显示文摘 | Xie Shucheng Yi Yi Huang Junhua Hu Chaoyong Cai Yanjun Matthew Collins Andy Baker | 2003 | Quaternary Research2003，，60： | 1 |
| 15 | The UK market for tourism in China显示文摘 | Douglas Jeffrey Yanjun Xie | 1995 | Annals of Tourism Research1995，，4： | 1 |
| 16 | Silane coupling agents used for natural fiber/polymer composites: A review 显示文摘 | XIE Yanjun HILL C A S XIAO Zefang | 2010 | Composites Part A2010，41，： | 1 |
| 17 | Carbon dioxide/calcium oxide responsive behavior and application potential of amine emulsion显示文摘Green and low cost CO_(2) and CaO were used to stimulate amine emulsions to reveal the responsive behavior of amine emulsions.On this basis,oil-based drilling fluids responsive to CO_(2) and CaO were formulated and their properties were evaluated.The results showed that the amine emulsions inversed from water-in-oil state to oil-in-water state readily and their rheological behavior underwent transitions of decreasing,rising again and decreasing again via induction by CO_(2).These CO_(2) responsive behaviors could be reversed by CaO.Oil-based drilling fluids prepared based on the amine emulsions with oil-water volume ratios of 50:50 to 70:30,densities of 1.4-2.0 g/cm^(3) had good rheological and filtration properties at 160℃;and be readily cleaned up using CO_(2) bubbling.The useless solid phase with low density could be removed efficiently via reducing the viscosity of emulsion by CO_(2) and the residual liquid phase could be restored to the original state by CaO and reused to prepare drilling fluid.The mechanisms analysis indicated that CO_(2)/CaO induced the reversible conversion between amine emulsifiers and their salts,which enabled the reversible regulation of both the hydrophilic-lipophilic balance of amine emulsifiers and the emulsion particles’size and finally caused the controllable-reversion of the form and rheology of amine emulsion. | REN Yanjun LU Yanyan JIANG Guancheng ZHOU Wenjing WU Liansong YAO Rugang XIE Shuixiang | 2021 | Petroleum Exploration and Development2021，48，5： | 1 |
| 18 | Numerical and experimental analysis of a point focus solar collector using high concentration imaging PMMA Fresnel lens 显示文摘 | Xie Wentao Dai Yanjun Wang Ruzhu | 2011 | Energy Conversion and Management2011，52，6： | 1 |
| 19 | Concentrated solar energy applications using Fresnel lenses: A review显示文摘 | Xie Wentao Dai Yanjun Wang Ruzhu | 2011 | Renewable and Sustainable Energy Reviews2011，15，6： | 1 |
| 20 | Silane couplingagents used for natural fiber/polymer composites : A review显示文摘 | XIE Yanjun HILLB CAS XIAO Zefang | 2010 | Composites: Part A2010，41，： | 1 |
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