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| 1 | 骨锚式助听器对声源定位能力影响的系统回顾显示文摘声源定位(sound localization)是听者对声源空间位置的感知.声源定位能力是听觉功能的重要组成,是噪声环境下言语理解的关键[1].听觉中枢通过对外耳形成的波谱信号(spectral shape cues,SSC)、耳间时间差(interaural time difference,ITD)及耳间强度差(interaural level difference,ILD)信号的编码来实现声源的定位[2-3].由于水平方位角的判定主要依赖于ITD及ILD信号,因此当一耳出现听力下降时,会导致耳间信号差改变或消失,进而影响患者的言语理解及日常生活。 | 刘锦峰 王宁宇 | 2015 | 中华耳鼻咽喉头颈外科杂志2015，50，4： | 7 |
| 2 | 与中枢听觉处理障碍相关的下丘功能及机制探讨显示文摘下丘(inferior colliculus,IC)是听觉传导通路上的重要中继站,在声源定位、时域、频率和声音强度分析中均起着重要的作用,而这些功能障碍正是中枢听觉处理障碍(central auditory processing disorder,CAPD)的发病基础。本文将重点介绍下丘听觉处理功能及机制,特别是与CAPD~病机制相关的功能改变,探讨CPAD的发病机制。 | 刘鹏利 李晓璐 | 2017 | 国际耳鼻咽喉头颈外科杂志2017，41，6： | 3 |
| 3 | Responses from two firing patterns in inferior colliculus neurons to stimulation of the lateral lemniscus dorsal nucleus显示文摘The γ-aminobutyric acid neurons(GABAergic neurons) in the inferior colliculus are classified into various patterns based on their intrinsic electrical properties to a constant current injection. Although this classification is associated with physiological function, the exact role for neurons with various firing patterns in acoustic processing remains poorly understood. In the present study, we analyzed characteristics of inferior colliculus neurons in vitro, and recorded responses to stimulation of the dorsal nucleus of the lateral lemniscus using the wholecell patch clamp technique. Seven inferior colliculus neurons were tested and were classified into two firing patterns: sustained-regular(n = 4) and sustained-adapting firing patterns(n = 3). The majority of inferior colliculus neurons exhibited slight changes in response to stimulation and bicuculline. The responses of one neuron with a sustained-adapting firing pattern were suppressed after stimulation, but recovered to normal levels following application of the γ-aminobutyric acid receptor antagonist. One neuron with a sustained-regular pattern showed suppressed stimulation responses, which were not affected by bicuculline. Results suggest that GABAergic neurons in the inferior colliculus exhibit sustained-regular or sustained-adapting firing patterns. Additionally, GABAergic projections from the dorsal nucleus of the lateral lemniscus to the inferior colliculus are associated with sound localization. The different neuronal responses of various firing patterns suggest a role in sound localization. A better understanding of these mechanisms and functions will provide better clinical treatment paradigms for hearing deficiencies. | Xiao-ting Li Ning-yu Wang Yan-jun Wang Zhi-qing Xu Jin-feng Liu Yun-fei Bai Jin-sheng Dai Jing-yi Zhao | 2016 | Neural Regeneration Research2016，11，5： | 1 |
| 4 | 听觉优先效应在下丘的作用机制研究进展显示文摘良好的声源定位能力是识别言语、获得有意义声信号的重要前提,有利于我们在空间位置上区分目标信号和干扰信号,从而提高听觉系统的信噪比。听觉优先效应是声源定位的一种特殊机制,存在于我们日常生活中的各个场景中,可以帮助我们在复杂声学环境中排除干扰、准确定位目标声源。而对于听障患者来说,虽然通过各种辅听设备提高了听力,但是由于其不能在空间位置上很好的定位声源,无法在空间位置上区分目标信号与干扰信号,导致无法获得较高的言语识别率。因此,明确听觉优先效应的机制,有利于我们更好的理解复杂声环境中的声源定位以及改善辅听患者的言语识别率。听觉优先效应机制复杂,本文对其在下丘的作用机制及研究进展做一回顾。 | 葛鑫颖 周沫 王彦君 李晓婷 刘锦峰 戴金升 刘梦婷 张娟 王宁宇 | 2022 | 中华耳科学杂志2022，20，6： | 0 |
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