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| 1 | Comprehensive identification of lysine 2-hydroxyisobutyrylated proteins in Ustilaginoidea virens reveals the involvement of lysine 2-hydroxyisobutyrylation in fungal virulence显示文摘Lysine 2-hydroxyisobutyrylation(Khib) is a newly identified post-translational modification(PTM) that plays important roles in transcription and cell proliferation in eukaryotes. However, its function remains unknown in phytopathogenic fungi. Here,we performed a comprehensive assessment of Khibin the rice false smut fungus Ustilaginoidea virens, using Tandem Mass Tag(TMT)-based quantitative proteomics approach. A total of 3 426 Khibsites were identified in 977 proteins, sugg esting that Khibis a common and complex PTM in U. virens. Our data demonstrated that the2-hydroxyisobutyrylated proteins are involved in diverse biological processes. Network analysis of the modified proteins revealed a highly interconnected protein network that included many well-studied virulence factors. We confirmed that the Zn-binding reduced potassium dependency3-type histone deacetylase(UvRpd3) is a major enzyme that removes 2-hydroxyisobutyrylation and acetylation in U. virens. Notably, mutations of Khib sites in the mitogen-activated protein kinase(MAPK)UvSlt2 significantly reduced fungal virulence and decreased the enzymatic activity of UvSlt2. Molecular dynamics simulations demonstrated that 2-hydroxyisobutyrylation in UvSlt2 increased the hydrophobic solvent-accessible surface area and thereby affected binding between the UvSlt2 enzyme and its substrates. Our findings thus establish Khibas a major post-translational modification in U. virens and point to an important role for Khibin the virulence of this phytopathogenic fungus. | Xiaoyang Chen Xiabing Li Pingping Li Xiaolin Chen Hao Liu Junbin Huang Chaoxi Luo Tom Hsiang Lu Zheng | 2021 | Journal of Integrative Plant Biology2021，63，2： | 2 |
| 2 | Avian Influenza A(H7N9) Virus in a Wild Land Bird in Central China,Late 2015显示文摘Dear Editor,In early 2013,the first case of a human infection with avian influenza A(H7N9)virus was reported in the Yangtze River Delta region of China(Liu et al.2013).Since early2013,a total of 1533 laboratory-confirmed human infections with avian H7N9 viruses have been reported to | Yanfeng Yao Tao Zhang Wenhai Yang Zhiyong Shao Bin He Xiabing Chen Lijun Wu Erguang Jin Haizhou Liu Jianjun Chen Jie Chen | 2018 | Virologica Sinica2018，33，1： | 1 |
| 3 | Microstructures evolution and phase transformation behaviors of Ni-rich TiNi shape memory alloys after equal channel angular extrusion 显示文摘 | ZHANG X N SONG J HUANG C L XIAB Y CHEN B SUN X G Xie C Y | 2011 | Journal of Alloys and Compounds2011，509，6： | 1 |
| 4 | In- frared spectra of soluble polyaniline 显示文摘 | TANG Jinsong JING Xiabing WANG Baochen | 1988 | Synthetic Metals1988，24，： | 1 |
| 5 | CalciteSm-NdisochronageoftheShuiyindongCarlin-typegolddeposit,Guizhou,China显示文摘 | SuW C HuRZ XiaB etal | 2009 | ChemicalGeology2009，258，： | 1 |
| 6 | Visible gold in arsenian pyrite at the Shuiyindong Carlin-type gold deposit, Guizhou, China: Implications for the environment and proces- ses of ore formation显示文摘 | Su WC XiaB Zhang H T ZhangXC | 2008 | Ore Geology Reviews2008，33，： | 1 |
| 7 | Online coopetition between hotels and online travel agencies: From the perspective of cash back af- ter stay显示文摘 | Guo xiaolong Zheng xiabing Ling liuyi Yangchenchen | 2014 | Tourism Management Perspectives2014，12，： | 1 |
| 8 | Building brand loyalty through user engagement in online brand communities in social networking sites显示文摘 | Xiabing Zheng Christy M. K. Cheung Matthew K.O. Lee Liang Liang | 2015 | Information Technology & People2015，，： | 1 |
| 9 | Polyetheretherketone with citrate potentiated influx of copper boosts osteogenesis,angiogenesis,and bacteria-triggered antibacterial abilities显示文摘A well designed coating for polyetheretherketone(PEEK)implants can provide enough support to overcome crucial medical challenges,which are insufficient osseointegration and high rate of infection.Herein,we utilize the co-deposition of polydopamine(PDA)and copper-citrate nanoclusters to construct a p H-responsive coating on porous PEEK for synergistic bone regeneration,vascular formation and anti-infection.Specifically,this PDA coating released high dose of copper and citrate at lower p H value,which increased intracellular copper content,boosted production of reactive oxygen species and severe damage of protein,leading to killing of 93%planktonic bacterial and eradication of adherent bacteria.At p H of 7.4,the release of copper and citrate were in a slow and sustained behavior,synergistically enhanced vascular formation potential and osteodiffereration of Ad-MSC in vitro.After implanted in rabbit tibia for 6 and 12 weeks,the micro-CT evaluation and histological analysis consistently highlighted the ability of this PDA coating to increase new bone formation adjacent to coated PEEK implant and enhance bone-implant interfacial integration.These results were proven to be related to the synergistic effect that citrate facilitated a 2-fold influx of copper into cells,which not only enhanced the bacteria-killing ability but also encouraged bone regeneration of implants.This present work provides an effective method to control infections while promoting osseointegration simultaneously,which will show tremendous clinical application and can be a solution to current challenges facing orthopedics. | Jianglong Yan Dandan Xiab Pan Xionga Yangyang Li Wenhao Zhou Qiyao Li Pei Wang Yufeng Zheng Yan Cheng | 2021 | Journal of Materials Science & Technology2021，，12： | 1 |
| 10 | Ef- fects of binders and graphite on the sensitivity of ε-HNIW显示文摘 | Yu Lan Jiang Xiabing Guo Xueyong | 2013 | Journal of Thermal Analysis and Calorimetry2013，112，3： | 1 |
| 11 | LargebadloansheavilyinfluenceChina’Seconomicgrowth(巨额不良贷款严重影响经济增长)显示文摘 | XiaB(夏斌) | | 经济参考报0，，2003： | 1 |
| 12 | CalciteSm-Ndisochron age of the Shuiyindong Carlin-type gold deposit,Guizhou,China显示文摘 | SuWC HuRZ XiaB XiaY LiuYP | 2009 | Chemical Geology2009，258，： | 1 |
| 13 | An adaptive adjusting mechanism for agent distributed blackboard architecture 显示文摘 | Y C Jianga Z Y Xiab Y P Zhonga S Y Zhanga | 2005 | Microprocessors and Microsystems (S0141-9331)2005，29，8： | 1 |
| 14 | VisiblegoldinarsenianpyriteattheShuiyindongCarlintypegolddeposit, Guizhou,China:Implicationsforenvironmentandprocessesoforeformation显示文摘 | SUW C XIAB ZHANGHT etal | 2008 | OreGeologyReviews2008，33，： | 1 |
| 15 | Tailoring the magnetization behavior of Co - doped titanium dioxide nanobelts 显示文摘 | Chonga S V Xiab J Sureshc N | 2008 | 148 (7 -8 ) : 345 -3492008，148，78： | 1 |
| 16 | Rapid screening and quantification of sulfonate derivatives in white peony root by UHPLC-MS-MS显示文摘 | YAN ZHIXIANG CHEN CHEN XIE XIABING | 2012 | Analytical and Bioanalytical Chemistry2012，402，6： | 1 |
| 17 | HumanhealthriskfromsoilheavymetalcontaminationunderdifferentlandusesnearDabaoshanMine,SouthernChina显示文摘 | ZhaoH XiaB FanC etal | 2012 | ScienceoftheTotalEnvironment2012，，： | 1 |
| 18 | Autophagy-mediatedtumorpromotion显示文摘 | GuoJY XiaB WhiteE | 2013 | Cell2013，155，6： | 1 |
| 19 | Heat treatment on TiO2 nanoparticles prepared by vapor-phase hydrolysis 显示文摘 | XiaB HuangHZ Xie Y C | 1999 | Materials Science and Engineering B1999，57，2： | 1 |
| 20 | China and South Korea FTA Will Bring New Opportunities显示文摘On February 25,2015,China and South Korea have initialed their free trade agreement(FTA),the end of the FTA negotiations,according to a brief statement on the Ministry of Commerce(MOC)website.The China-South Korea FTA is a high-level and comprehensive one that also includes investment and services trade.What’s in the FTA?According to the information | Li Xiabing | 2015 | China's Foreign Trade2015，，2： | 0 |
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