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| 1 | Effect of Ginkgo biloba leaf extract on cerebral cortex amino acid levels in cerebral ischemia model rats显示文摘OBJECTIVE: To investigate the effect of Ginkgo biloba leaf extract on amino acid levels in the cerebral cortex of cerebral ischemia model rats induced by middle cerebral artery occlusion(MCAO).METHODS: A rat model of cerebral ischemia was established by MCAO. Male rats were divided into a negative control group(Control), a sham-operated group(Sham), an ischemic group(MCAO), and an ischemic group treated with Ginkgo biloba leaf extract(MCAO_D). All groups were divided into two subgroups with occlusion times of 12 and 24 h, respectively. The levels of 18 endogenous amino acids in the cerebral cortex were quantified by triple quadrupole-liquid chromatography-mass spectrometry.RESULTS: Compared with the MCAO group, behavioral performance, neurological deficit score, and cerebral infarct volume were significantly improved in the MCAO_D group(P < 0.05, P < 0.01). Compared with the sham group, the levels of 17 amino acids in the cerebral cortex were markedly changed in the MCAO group. The levels of Alanine(Ala), Isoleucine(Ile), Glutamic acid(Glu), Serine(Ser), Valine(Val), Phenylalanine(Phe), Proline(Pro),Threonine(Thr), Lysine(Lys), Tyrosine(Tyr), Hydroxyproline(Hyp), Arginine(Arg), Leucine(Leu),Tryptophan(Trp), and Glycine(Gly) were increased(P < 0.001, P < 0.05), while levels of Gln and Tau were decreased(P < 0.001, P < 0.05). Compared with the MCAO group, Ginkgo biloba extract treatment in the MCAO_D group significantly down-regulated the levels of 11 amino acids, especially those of Arg, Thr, and Ser in 12 or 24 h.CONCLUSION: Injection of Ginkgo biloba leaf extract has a therapeutic effect on model rats with MCAO-induced cerebral ischemia by acting on amino acids in the cerebral cortex. This effect might be associated with the regulation of amino acid metabolism in the cerebral cortex. | Cui Yiran Wu Hongwei Liu Mengting Qin Haijiao Liu Xin Yang Hongjun | 2018 | Journal of Traditional Chinese Medicine2018，38，5： | 8 |
| 2 | In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model显示文摘The urokinase-type plasminogen activator(uPA)loaded hollow nanogels(nUK)were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly(ethylene oxide).The resultant formulation is sensitive to diagnostic ultrasound(US)of 2 MHz.Herein,we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery(MCA).Via intravenous(i.v.)administration,the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation,leading to enhanced thrombolysis efficiency of the nUK,evidenced from smaller infarct volume and better clinical scores when compared to the i.v.dose of free uPA no matter with or without US intervention.Meanwhile,the preservation ability of the nanogels not only prolonged the circulation duration of the protein,but also resulted in the better blood-brain barrier protection of the nUK formulation,showing no increased risk on the hemorrhagic transformation than the controls.This work suggests that the nUK is a safe sonothrombolytic formulation for the treatment of acute ischemic stroke. | Yuming Teng Haiqiang Jin Ding Nan Mengnan Li Chenghe Fan Yuanyuan Liu Pu Lv Wei Cui Yongan Sun Hongjun Hao Xiaozhong Qu Zhenzhong Yang Yining Huang | 2018 | Bioactive Materials2018，3，1： | 7 |
| 3 | Dual-band simultaneous lasing in MOFs single crystals with Fabry-Perot microcavities显示文摘Multi-band microlasers based on single microcrystalline materials with Fabry-Perot(F-P) cavities are critically and technologically essential. Here, we demonstrate simultaneous dual-band lasing output(615 and 685 nm) in metal-organic frameworks(MOFs) and organic dyes hybrid single crystals, which support F-P resonances. Through a two-step assembly strategy, two different types of cationic pyridinium hemicyanine dye molecules can be encapsulated into the channel pores of anionic bioMOF-1-2 Me successfully. In addition, the employment of the host-guest system significantly increases the dye loading, enhances luminescent efficiency, and diminishes the aggregation-caused quenching(ACQ) effect in the resultant MOFs/dye composites.This finding not only combines the characteristic of MOFs materials with excellent luminescent properties of organic dyes, but also points out a simple and promising strategy to design multi-band microlasers based on F-P mechanism, opening a low-cost avenue for the rational design of miniaturized lasers in the future. | Hongjun Li Huajun He Jiancan Yu Yuanjing Cui Yu Yang Guodong Qian | 2019 | Science China Chemistry2019，62，8： | 6 |
| 4 | Cloning of the full-length gene of activin receptor-interacting protein2a and characterization of its interaction with ActR Ⅱ A显示文摘为了调查细胞内部的信号 transduction 的机制,由 activin 受体调停了,编码新奇 activin 的全身的基因交往受体的 protein2a (ARIP2a ) 从一个老鼠大脑 cDNA 图书馆被识别。ARIP2a 和 ARIP2 和在导致 activin 的 RAW264 的 ARIP2 的序列。7 房间被比较,并且在 ARIP2a 和 ActRIIA 之间的相互作用被证实。序列分析表明除了 99 th 氨基酸。RT-PCR 试金证明 ARIP2a mRNA 高度在大脑,垂体和睾丸被表示,并且中等在胰和卵巢,但是在另外的纸巾无法发现。而, ARIP2 mRNA 广泛地在我们测试了的所有老鼠纸巾被散布。而且, ARIP2a mRNA 的表示显著地在刺激 activin 的 RAW264 被减少。7 个房间;然而, ARIP2 mRNA 的表示被增加。另外,在 ARIP2a 之间的相互作用和 activin 类型 IIA 受体(ActRIIA ) 被哺乳动物的二混血儿的试金和下拉试金进一步表明。总起来说,那些结果显示尽管 ARIP2a 对 ARIP2 相应,他们在到 activin 的织物分发和回答是不同的。ARIP2a 能也与 activin 类型 II 受体(ActRIIA ) 交往被哺乳动物的 two-hybird 试金和下拉试金进一步表明。总起来说,那些结果显示尽管 ARIP2a 对 ARIP2 相应,他们在到 activin 的织物分发和回答是不同的。ARIP2a 能也作为 ARIP 家庭的一篇小说与 activin 类型 II 受体交往。 | CUI Xueling TAI Guixiang ZHANG Hongjun FANG Lin LIU Zhonghui | 2007 | Progress in Natural Science:Materials International2007，17，2： | 5 |
| 5 | Genetic analysis of fertility restoring genes for AL-type male sterility in wheat显示文摘In order to screen molecular markers linked to fertility restoring genes and further improve the breeding efficiency of restorer lines,in this study,wheat varieties 18A,18B and 99AR144-1 were used as experimental materials to establish F2 fertility-segregating population. Plant quantitative trait'major gene + polygene mixed model'separation analysis method and simple sequence repeat(SSR) molecular markers were adopted for genetic analysis of four generations,including the parents(P1 and P2),and hybrid(Fl and F2) populations. The results show that AL-type fertility restoring gene is controlled by two pairs of additive-dominant-epistatic genes and additive-dominant polygene;two primers linked to fertility restoring genes were selected by SSR molecular markers, including Xgwm95 on chromosome 2A and Barc61 on chromosome 1B,with the linkage distance of 15.0 cM and 18.0 cM,respectively. Based on verification,these two markers are reliable for distinguishing AL-type wheat sterile lines and restorer lines. | Liu Xiaofang Tian Xiaoming Nie Yingbin Mu Peiyuan Han Xinnian Sang Wei Cui Fengjuan Xu Hongjun Xiang Jishan | 2013 | Engineering Sciences2013，11，5： | 4 |
| 6 | Identifying accident black spots based on the accident spacing distribution显示文摘The identification of accident black spots is of great significance for the prevention of traffic accidents.Commonly used accident black spot identification methods divide road sections for the analysis of accident data,the direct result of which is the splitting of accident black spots,which affects the results.This paper is based on three years of traffic accident data from the Beijing-Harbin Expressway,including the time and location of traffic accidents,form of the accident fatalities,severe injuries,slight injuries,and property damage only(PDO).To avoid road division effects,an identification method based on the accident spacing distribution is established by using quality control theory.The results show that the average number of accidents per kilometer by the method proposed in this paper is 42,which is much higher than 10,identified by other identification methods.The method proposed in this paper improves the accuracy of the identification results.This method avoids the problem of road segmentation found in other common methods and can more accurately reflect the spatial distribution of traffic accidents.Thus making the identification of accidents more scientific and accurate. | Hongjun Cui Jianguo Dong Minqing Zhu Xia Li Qingzhou Wang | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，6： | 2 |
| 7 | Controllable broadband multicolour single-mode polarized laser in a dye-assembled homoepitaxial MOF microcrystal显示文摘Multicolour single-mode polarized microlasers with visible to near-infrared output have very important applications in photonic integration and multimodal biochemical sensing/imaging but are very difficult to realize.Here,we demonstrate a single crystal with multiple segments based on the host-guest metal-organic framework ZJU-68 hierarchically hybridized with different dye molecules generating controllable single-mode green,red,and nearinfrared lasing,with the lasing mode mechanism revealed by computational simulation.The segmented and oriented assembly of different dye molecules within the ZJU-68 microcrystal causes it to act as a shortened resonator,enabling us to achieve dynamically controllable multicolour single-mode lasing with a low three-colour-lasing threshold of ~1.72 mJ/cm^(2)(approximately seven times lower than that of state-of-the-art designed heterostructure alloys,as reported by Fan F et al.(Nat.Nanotechnol.10:796-803,2015)considering the single pulse energy density)and degree of polarization>99.9%.Furthermore,the resulting three-colour single-mode lasing possesses the largest wavelength coverage of ~186 nm(ranging from ~534 to ~720 nm)ever reported.These findings may open a new route to the exploitation of multicolour single-mode micro/nanolasers constructed by MOF engineering for photonic and biochemical applications. | Huajun He Yuanjing Cui Hongjun Li Kai Shao Banglin Chen Guodong Qian | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 8 | Confirmation of flixweed (Descurainia sophia) resistance to tribenuron in China显示文摘 | Cui Hailan Zhang Chaoxian Zhang Hongjun | 2008 | Weed Science2008，56，： | 1 |
| 9 | Based on the cost line toll lanes open operating costs and the number of driver optimization显示文摘 | CUI Hongjun LI Yaping | 2013 | Highway2013，，4： | 1 |
| 10 | The Control System of the Boiler Based on Kingview and IC Block 显示文摘 | Jing Qing Guo Zhi Hongjun C Cui Y | 2009 | The Journal of Shenyang jianzhu University ( Natural Science )2009，，7： | 1 |
| 11 | Membranes for extracorporeal membrane oxygenator(ECMO): History,preparation, modification and mass transfer显示文摘Extracorporeal membrane oxygenator(ECMO) has been in development for nearly 70 years, and the oxygenator has gone through several generations of optimizations, with advances from bubble oxygenators to membrane oxygenators leading to more and more widespread use of ECMO. Membrane is the core of a ECMO system and the working mechanism of membrane oxygenator depends on the membrane material,from PDMS flat membrane to PMP hollow fiber membrane, which have experienced three generations.Blood compatibility on the surface of the membrane material is very vital, which directly determines the use duration of the oxygenator and can reduce the occurrence of complications. The mechanism of mass transfer is the basis of oxygenator operation and optimization. This review summarizes the membrane development history and preparation technology, modification approaches and mass transfer theory in the process of oxygen and blood exchange. We hoped that this review will provide more ideas for the study of gas blood exchange membrane. | Ting He Songhong Yu Jinhui He Dejian Chen Jie Li Hongjun Hu Xingrui Zhong Yawei Wang Zhaohui Wang Zhaoliang Cui | 2022 | Chinese Journal of Chemical Engineering2022，35，9： | 0 |
| 12 | Identification of Resistance of Powdery Mildew and Stripe Rust of Winter Wheat Strains in Xinjiang显示文摘Wheat powdery mildew and stripe rust are the major diseases in wheat producing area in Xinjiang.To obtain wheat germplasm resources and varieties resistant to powdery mildew and rust,36 high-generation stable strains of Xinjiang winter wheat were evaluated using the method of natural inducement from 2018 to 2020.A total of 5 strains with high resistance to powdery mildew,4 strains with slow stripe rust and 1 strain with resistance to powdery mildew and adult plant slow stripe rust were obtained.And the parental combination of disease-resistant varieties was analyzed.These studies will provide theoretical basis for the breeding of resistant wheat varieties in Xinjiang. | Wei SANG Pengpeng LIU Yingbin NIE Dezheng KONG Fengjuan CUI Xinnian HAN Hongjun XU Peiyuan MU | 2022 | Plant Diseases and Pests2022，13，2： | 0 |
| 13 | Crystal plane engineering of MAPbI_(3) in epoxy-based materials for superior gamma-ray shielding performance显示文摘The rapid development of the aerospace and nuclear industries is accompanied by increased exposure to high-energy ionising radiation.Thus,the performance of radiation shielding materials needs to be improved to extend the service life of detectors and ensure the safety of personnel.The development of novel lightweight materials with high electron density has therefore become urgent to alleviate radiation risks.In this work,new MAPbI_(3)/epoxy(CH 3NH 3PbI 3/epoxy)composites were prepared via a crystal plane engineering strategy.These composites delivered excellent radiation shielding performance against 59.5 keV gamma rays.A high linear attenuation coefficient(1.887 cm−1)and mass attenuation coefficient(1.352 cm2 g−1)were achieved for a representative MAPbI_(3)/epoxy composite,which was 10 times higher than that of the epoxy.Theoretical calculations indicate that the electron density of MAPbI_(3)/epoxy composites significantly increases when the content ratio of the(110)plane in MAPbI_(3) increases.As a result,the chances of collision between the incident gamma rays and electrons in the MAPbI_(3)/epoxy composites were enhanced.The present work provides a novel strategy for designing and developing high-efficiency radiation shielding materials. | Kai Cui Yang Li Wenjing Wei Qianqian Teng Tianyu Zhang Jinzhu Wu Hongjun Kang Wei Qin Xiaohong Wu | 2022 | Light(Advanced Manufacturing)2022，3，4： | 0 |
| 14 | Simulation of transport mechanism of radium isotopes in aquifer on the southern coast of Laizhou Bay显示文摘Naturally occurring radium(^(223)Ra,^(224)Ra,^(226)Ra,and^(228)Ra)isotopes have been widely applied as geochemical tracers in marine environments,especially when estimating the submarine groundwater discharge(SGD).In this sense,the influencing factors and transport mechanism of radium isotope activity in aquifers can be key information for SGD estimation.This work evaluates the adsorption/desorption behavior of^(224)Ra and^(226)Ra in the solid-liquid phase through a leaching experiment and analysis of field data.The results suggested that radium isotope activity was positively correlated with salinity and grain size,in the case of abundant sediments.Through ion analysis,we found that the ions(Na^(+),Ca^(2+),Mg^(2+),and Ba^(2+))exchanged with radium isotopes in the process of transport.A 1-D reactive transport model was established to simulate the transport process of radium isotope in aquifers.The model successfully simulated the variation of radium isotope desorption activity with salinity and was subsequently verified in the field.This study contributes to the understanding of the geochemical behavior of radium isotopes in aquifers and provides guidance for selecting a suitable groundwater endmember in SGD estimation. | Yancheng Wang Guangquan Chen Hongjun Yu Xingyong Xu Yinqiao Zou Wenqing Zhao Weitao Han Wenzhe Lyu Zhen Cui Runtian Ding | 2023 | Acta Oceanologica Sinica2023，42，8： | 0 |
| 15 | Effects of angiotensin-Ⅱ receptor blockers on β-catenin expression in a rat model of experimental streptozotocin-induced early-stage of diabetic nephropathy显示文摘Objective: Diabetic nephropathy (DN) is one of the most common causes of end-stage renal failure. The pathogenesis of progressive renal injury is multifactorial and the mechanism by which hyperglycemia causes microangiopathy is still poorly understood. The WNT pathway is activated in DN and regulating β-catenin protein levels is referred to as the canonical Wnt/β-catenin pathway. Because the renin angiotensin system has been reported to be an important contributory factor in the pathophysiology of DN, exogenous administration of angiotensin II receptor antagonist may be beneficial in counteracting some biochemical or functional changes of DN. The aim of the study was to determine the β-catenin expression and the possible protective effects of irbesartan, an angiotensin II type 1 receptor blocker (ARB) in a rat model of streptozotocin(STZ)-induced diabetic nephropathy. Methods: STZ-induced DN in rats was assessed biochemically by measuring urine volume, protein and creatinine clearance as well as Kidney weight/body weight (KW/BW) and the index of mesangial expansion. Three groups of male Sprague-dawley rats were used. The ?rst group consisted of non-diabetic control rats (control). The second group was the untreated diabetic rats(STZ+vehicle). The third group consisted of diabeti rats treated with irbesartan, 50 mg/kg for 12 weeks (STZ+irbesartan). Immunohistochemical stainings and real time PCR for β-catenin were performed in renal cortex of rat modals. Results: Marked hyperglycemia, polyuria, proteinuria, renal hypertrophy, mesangial matrix expansion and glomerular hyper?ltration were observed in STZ diabetic rats. The levels of microalbuminuria and KW/BW in the STZ+irbesartan group were lower than those in the STZ+vehicle group (P<0.05). The up-regulated immunostaining and mRNA expression of β-catenin were decreased in renal cortic of the Irbesartan-treated diabetic group, but there was no significant difference compared to the untreated diabetic group. Conclusion: The data suggest that irbesartan ameliorates proteinuria and renal hypertrophy, charactered damages of STZ-induced early-stage DN in rats, but its effective drug target is not to inhibit the up-regulated expressions of β-catenin. | Zhou Shuhong Shi blngyin Lu Hongjun Cui bo Xu li | 2012 | Journal of Medical Colleges of PLA(China)2012，27，5： | 0 |
| 16 | Situation and hotspot analysis on rural transport infrastructure from the perspective of bibliometric analysis显示文摘The construction of rural transportation infrastructure is of great significance to promote the organic integration of transportation construction with resource exploitation and industrial development in rural areas,and realize poverty alleviation and poverty reduction driven by convenient transportation.In order to understand the research status of rural transport infrastructure at home and abroad,this paper adopts CiteSpace,VOSviewer,Pajek,SPSS and other software and makes quantitative analysis and knowledge map drawing of the literature on rural transportation infrastructure collected in Web of Science database.The results show that the emphasis of this field is different in different periods,Chinese scholars'attention to this field increased significantly after the rural revitalization strategy was put forward.Based on the classification results of keyword clustering,the following conclusions are drawn:The planning mode of rural transportation infrastructure under rural revitalization is relatively backward and the lack of theoretical analysis of the root causes has achieved the purpose of rational allocation of transportation resources.Moreover,there are few studies on the mechanism and empirical analysis of transport infrastructure's effect on rural poverty reduction.From the analysis of research hotspots,the integration of urban and rural areas and rural road safety will be the main research direction in the future,and rural road accidents and other topics have research potential. | Minqing Zhu Zi Wang Hongjun Cui Yizhe Yang Peiqi Qie | 2023 | Journal of Traffic and Transportation Engineering(English Edition)2023，10，6： | 0 |
| 17 | Magnetic properties indicate the sources of hadal sediments in the Yap Trench,northwest Pacific Ocean显示文摘Magnetic minerals in marine sediments are often masked by the primary natural remanent magnetization and material source signals.In order to understand sedimentary environment and sources of sediments in the abyss,we studied 126 samples of five bottom surface cores collected by the Jiaolong Submersible at 4000-7000 m in depth during the third stage of the China's 38th Ocean Voyage.The magnetic properties of the sediments were analyzed using Thermosusceptibility(k-T)curves and Day plot.The results show that the magnetic minerals in the sediments of the Yap Trench are mainly maghemite,and the overall magnetic and soft magnetic properties were strong.The magnetic particles of sediments are dominated by pseudo single domains(PSD)grains.The main source of sediment is locally-derived basalt debris and volcanic debris,and the process of sedimentation is gravity-like flow deposition. | CHEN Yu YANG Jichao DADA Olusegun A YANG Yaomin LIN Zhen CUI Zhen XU Yue YU Hongjun LIU Baohua | 2020 | Journal of Oceanology and Limnology2020，38，3： | 0 |
| 18 | Benthic bacterial communities indicate anthropogenic activity footprints in coastal area under long-term marine spatial planning practice显示文摘Marine spatial planning(MSP)is designed to divide the sea area into different types of functional zones,to implement corresponding development activities.However,the long-term impacts of anthropogenic activities associated with MSP practice on the marine microbial biosphere are still unclear.Yalu River Estuary,a coastal region in northeast of China,has been divided into fishery&agricultural(F&A)zone,shipping&port(S&P)zone and marine protected area(MPA)zone by a local MSP guideline that has been run for decades.To examine the effects of long-term executed MSP,benthic bacterial communities from different MSP zones were obtained and compared in this study.The results revealed significant differences in the bacterial community structure and predict functions among different zones.Bacterial genera enriched in different zones were identified,including SBR1031 in MPA,Woeseia and Sva0996 in S&P,and Halioglobus in F&A.In addition,correlations between some bacterial genera and sediment pollutants were uncovered.Furthermore,bacteria related to sulphide production were more abundant in the F&A zone,which was according to the accumulation of sulphides in this area.Moreover,bacteria associated with chemoheterotrophy and fermentation were more predominant in the S&P zone,consistent with high levels of organic matter and petroleum caused by shipping.Our findings indicated benthic bacterial communities could bring to light the anthropogenic activity footprints by different activities induced by long-term MSP practice. | Yi Sun Hongjun Li Daixi Liu Xiaocheng Wang Quanming Wang Xiaoyu Cui Jingfeng Fan | 2023 | Acta Oceanologica Sinica2023，42，11： | 0 |
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