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| 1 | Construction and characterization of an experimental ISCOMS-based hepatitis B polypeptide vaccine显示文摘瞄准:描绘生物化学并且基于 HBsAg 的 T 房间 epitopes 从新奇治疗学的多肽准备的一支试验性的 ISCOMS 疫苗的免疫学的性质,和 heptatis B-ISCOMS 被准备并且调查。方法:刺激建筑群(ISCOMS ) 的免疫基于疫苗的包含新奇治疗学的肝炎 B 多肽被分离方法准备,并且它的形成被 SDS-polyacrylamide 胶化电气泳动化学上验证的电子显微镜学和简历设想。在 ISCOMS 以内的肽的数量被 Bradford 试金决定,并且特定的 CTL 反应被 ELISPOT 试金检测。结果:有大约 40nm 的一条直径的 submicroparticle 的典型像笼子的结构被电子显微镜学观察。从 Bradford 试金的结果证明肽加入的水平关于 0.33g .L (-1) 。在到分子的重量标记(3480kDa ) 的第六个乐队的 paralleled 位置结束,一个清楚的乐队在 SDS 页分析被给看,显示进 ISCOMS 的多肽的成功的加入。ISCOMS 交货系统能高效地改进多肽的 immunogenicity 并且由 ELISPOT 试金的结果在 vivo 得到特定的有免疫力的回答,这被建议,它证明生产房间(特定的 CTL 回答) 的 IFN-gamma 被增加(对待 ISCOMS 的组的点:47+/-5, n =3;控制组:5+/-2, n =3 ) 。结论:基于 ISCOMS 的肝炎 B 多肽疫苗成功地与在 vivo 疫苗的短多肽相比被构造,它导致更高的 CTL 回答。 | Xiao-Ju Guan Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 200031,China,previously worked as a postdoc in Institute of Immunology,Third Military Medical University,Chongqing 400038,China Xiao-Jun Guan,Department of Science & Research,Second Military Medical University,Shanghai 200433,China Yu-Zhang Wu Zheng-Cai Jia Tong-Dong Shi Yan Tan,Institute of Immunology,Third Military Medical University,Chongqing 400038,China | 2002 | World Journal of Gastroenterology2002，8，2： | 11 |
| 2 | 婚姻状况与心血管病风险的关系:系统评价和荟萃分析显示文摘虽然80%的未来心血管病风险可以从已知的心血管危险因素预测,如老年、男性、高血压、高血脂症、吸烟和糖尿病,但其余20%风险的决定因素仍不明确。婚姻对健康和死亡的益处已经在不同种族的两性中得到证实,并且与各种社会人口学特征无关。 | Wong CW Kwok CS Narain A Gulati M Mihalidou AS Wu P Alasnag M Myint PK Mamas MA 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 5 |
| 3 | Expression,purification and immunocharacteristics of recombination UreB protein of H.pylori显示文摘INTRODUCTIONHelicobacter pylori (H . pylori) is associated with the development of chronic gastritis ,peptic ulcer and gastric cancer and gastric MALT lymphoma[1-9],H .pylori has many antigens ,including urease ,heat shock protein and vacuolating cytotoxin and so on ,and urease is an important factor in the colinization of the gastric mucosa and suspected to cause damage to the gastric mucosa[10-14].At the same time ,urdase is also one of the important protective antigens . | Chao Wu~1 Quan Ming Zou~1 Hong Guo~2 Xiao Peng Yuan~1 Wei Jun Zhang~1 Dong Shui Lu~1 Xu Hu Mao~1 ~1Department of Clinical Microbiology,Third Military Medical University,Chongqing 400038,China ~2Department of Gastroenterology,Xinqiao Hospital,Third Military Medical University,Chongqing 40003?,ChinaDr.Chao Wu graduated from Third Military Medical University as a postgraduate in 2000,now a lecturer,specialized in diagnosis,prevention and therapy of Helicobacter pylori infection,having 6 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 5 |
| 4 | The incidence of intra-operative awareness during general anesthesia in china:a multi-center observational study显示文摘 | Xu L Wu AS Yue Y | | Acta Anaesthesiologica Scandinavica0，，： | 2 |
| 5 | Alpha 1-adrenergic stim- ulation inhibits 3,5,3 '-triiodothyronine-induced expression of the rat heart sarcoplasmic reticulum Ca^2 + adenosine triphosphatase gene显示文摘 | Wu PS Moriscot AS Knowlton KU | 1997 | Endocrinology1997，138，1： | 1 |
| 6 | Bladder cancer显示文摘 | Kaufman DS Shipley WU Feldman AS | | 0，，968： | 1 |
| 7 | Anti-HIV activity of medicinal herbs:usage and potential development显示文摘 | Wu JA Attele AS Zhang L | 2001 | Am J Chin Meal2001，29，1： | 1 |
| 8 | Spontaneous hepatitis B e antigen to antibody seroconversion and reversion in Chinese patients with chronic hepatitis B virus infection显示文摘 | Lok AS Lai CL Wu PC Leung EK Lam TS | 1987 | Gastroenterology1987，92，6： | 1 |
| 9 | Diffusion tensor eigenvector directional color imaging patterns in the evaluation of cerebral white matter tracts altered by tumor 显示文摘 | Field AS Alexander AL Wu YC | 2004 | J Magn Reson Imaging2004，20，4： | 1 |
| 10 | Anti - HIV activity of medicinal herbs :usage and potential development 显示文摘 | Wu JA Attele AS Zhang L | 2001 | An J Chin Med2001，29，1： | 1 |
| 11 | Anti-HIV activity of medicinal herbs: Usage and potential development 显示文摘 | Wu JA Attele AS Zhang L | 2001 | Am J Chin Med2001，29，1： | 1 |
| 12 | Anti-HIV activity of medicinal herbs:Usage and potential development 显示文摘 | Wu JA Attele AS Zhang L | 2001 | Am J ChinMed2001，29，1： | 1 |
| 13 | Ginseng Pharmacology: multiple constituents and multiple actions显示文摘 | Attele AS Wu JN Yuan CS | 1999 | Biochcm Pharma1999，58，11： | 1 |
| 14 | National Academy of Clinical Biochemistry laboratory medicine practice guidelines: use of cardiac troponin and B-type natriuretic peptide or N-terminal proB- type natriuretic peptide for etiologies other than acute coronary syn- dromes and heart failure 显示文摘 | NACB Writing Group Wu AH Jaffe AS | 2007 | J Clin Chem2007，53，12： | 1 |
| 15 | 显示文摘 | Wu AS Kiaei M Aguirre N | 2003 | J Neurochem2003，85，1： | 1 |
| 16 | Anti-HIV activity of medicinal herbs usage and development 显示文摘 | Wu JA Attele AS Zhang L | 2001 | Am J Chin Med2001，29，1： | 1 |
| 17 | Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies:evidence for a novel effect for an old antimalarial drug 显示文摘 | Rand JH Wu XX Quinn AS | 2010 | Blood2010，115，11： | 1 |
| 18 | Embryonic stem cells and their differentiated derivatives have a fragile immune privilege but still represent novel targets of immune attack 显示文摘 | Wu DC Boyd AS Wood KJ | 2008 | Stem Cells2008，26，8： | 1 |
| 19 | The incidence of intra-operative awareness during general anesthesia in China: a multi-center observational study 显示文摘 | Xu L Wu AS Yue Y | 2009 | Acta Anaesthesiol Seand2009，53，7： | 1 |
| 20 | European society of cardi ology and American college of cardiology guidelines for redefi nition of myocardial infarction:how to use existing assays din ieally and for clinical trials显示文摘 | Apple FS Wu AH Jaffe AS | 2002 | An Heart J2002，144，6： | 1 |
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