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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 3 | Active DNA or active histone triggering the production of antinuclear antibodies: inducing the generation of kidney iniury in mice显示文摘 | Wu H S Ma A N Guo L | 2000 | J Allergy Clin Immunol2000，105，1： | 2 |
| 4 | A major outbreak of severe acute respiratory syndrome in Hong Kong显示文摘 | LEE N HUI D WU A | 2003 | N Engl J Med2003，348，20： | 2 |
| 5 | Combining bioinformatics and phylogenetics to identify large sets of single-copy orthologous genes (COSⅡ) for comparative, evolutionary and systematic studies: a test case in the euasterid plant clade显示文摘 | Wu F N Mueller L A Crouzillat D Petiard V Tanksley S D | 2006 | Genetics2006，174，： | 1 |
| 6 | A major outbreak of severe acute respiratory syndrome in Hong Kong显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，348，： | 1 |
| 7 | Arginine degradation in developing porcine enterocytes显示文摘 | Wu G Knabe D A Flynn N E | 1996 | American Journal of Physiology-Gastrointestinal and Liver Physiology1996，271，5： | 1 |
| 8 | Sliding mode control for nonlinear and hysteretic structures显示文摘 | Yang J N Wu J C Agrawal A K | 1995 | Journal of Engineering Mechanics1995，12，： | 1 |
| 9 | Stable conservative multidomain treat ments for implicit Euler Solvers显示文摘 | Lerat A Wu Z N | 1996 | Journal of Computational Physics1996，123，1： | 1 |
| 10 | Macrophage prostaglandin pro- duction contributes to the age associated decrease in T - cekk function which is reversed by the dietary antiox- idant vitamin E显示文摘 | Beharka A A Wu S N | 1997 | Mech Ageing Dev1997，93，13： | 1 |
| 11 | Purification and enzymatic characteristics of cysteine desulfurase, IscS, in Acidithiobacillus ferrooxidaus ATCC23270显示文摘 | Wu A N Zhang Y F Zheng C L | 2008 | Trans Nonferrous Met Soc China2008，18，6： | 1 |
| 12 | A major outbreak of severe acute respiratory syndrome in Hong Kong 显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，7，： | 1 |
| 13 | Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，14，： | 1 |
| 14 | A major outbreak of severe acute respiratory syndrome in Hong Kong显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，348，20： | 1 |
| 15 | Immunological study of hal domain of he- magglutinin of influenza hSnl virus 显示文摘 | Chiu F F Venkatesan N Wu C R Chou A H Chen H W Lian S P Liu SJ Huang C C Lian W C Chong P Leng C H | 2009 | Biochemical Biophys ResCommun2009，383，1： | 1 |
| 16 | Multistability and stable asynchronous periodic oscillations in a multiple-Delayod neural system显示文摘 | CAMPBELL S A N CUBE l WU J | 2006 | Physica D Nonlinear Phenom2006，214，2： | 1 |
| 17 | Optimizing production of ethyl esters of grease using 95% ethanol by response surface methodology显示文摘 | WU W H FOGLIA T A MARMER W N | 1999 | J Am Oil Chem Soe1999，76，4： | 1 |
| 18 | Inhibition of crys- tallite growth in the sol-gel synthesis of nanocrystalline metal oxides 显示文摘 | Wu N L Wang S Y Rusakova I A | | Science0，285，： | 1 |
| 19 | A Major Outbreak of Severe Acute Respiratory Syndrome in Hong Kong 显示文摘 | Lee N Hui D Wu A | 2003 | N Engl J Med2003，348，： | 1 |
| 20 | A deficiency of CD4^+ CD25^+ T cells permits the development of spontaneous lupus - like disease in mice,and can be revensed by induction of mucosal tolerance to histone peptide autoantigen显示文摘 | WU H Y STA1NES N A | 2004 | Lupus2004，13，： | 1 |
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