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1Pre-operative hypoalbuminemia is a major risk factor for postoperative complications following rectal cancer surgery显示文摘AIM:To determine the relationship between pre-operative hypoalbuminemia and the development of complications following rectal cancer surgery, as well as postoperative bowel function and hospital stay. METHODS:The medical records of 244 patients undergoing elective oncological resection for rectal adenocarcinoma at Siriraj Hospital during 2003 and 2006 were reviewed. The patients had pre-operative serum albumin assessment. Albumin less than 35 g/L was recognized as hypoalbuminemia. Postoperative outcomes, including mortality, complications, time to first bowel movement, time to first defecation, time to resumption of normal diet and length of hospital stay, were analyzed. RESULTS:The patients were 139 males (57%) and 105 females (43%) with mean age of 62 years. Fifty-six patients (23%) had hypoalbuminemia. Hypoalbuminemic patients had a significantly larger tumor size and lower body mass index compared with non-hypoalbuminemic patients (5.5 vs 4.3 cm;P < 0.001 and 21.9 vs 23.2 kg/m2;P = 0.02, respectively). Thirty day postoperative mortality was 1.2%. Overall complication rate was 25%. Hypoalbuminemic patients had a significantly higher rate of postoperative complications (37.5% vs 21.3%;P = 0.014). In univariate analysis, hypoalbuminemia and ASA status were two risk factors for postoperative complications. In multivariate analysis, hypoalbuminemia was the only significant risk factor (odds ratio 2.22,95% CI 1.17-4.23;P < 0.015). Hospitalization in hypoalbuminemic patients was significantly longer than that in non-hypoalbuminemic patients (13 vs 10 d, P = 0.034), but the parameters of postoperative bowel function were not significantly different between the two groups. CONCLUSION:Pre-operative hypoalbuminemia is an independent risk factor for postoperative complications following rectal cancer surgery.Varut Lohsiriwat Darin Lohsiriwat Wiroon Boonnuch Vitoon Chinswangwatanakul Thawatchai Akaraviputh Narong Lert-akayamanee 2008World Journal of Gastroenterology2008,14,8:24
2Surgical Outcomes of Lichtenstein Tension-Free Hernioplasty for Acutely Incarcerated Inguinal Hernia显示文摘Varut Lohsiriwat Wasupong Sridermma Thawatchai Akaraviputh Wiroon Boonnuch Vitoon Chinsawangwatthanakol Asada Methasate Narong Lert-akyamanee Darin Lohsiriwat 2007Surgery Today2007,,3:1
3Effects of Zingiber cassumunar(Plai cream) in the treatment of delayed onset muscle soreness显示文摘OBJECTIVE: To evaluate the effects of Zingiber cassumunar(Plai cream) in either 7% or 14% concentration on delayed onset muscle soreness(DOMS).METHODS: Seventy-five untrained healthy volunteers(28 males and 47 females), performed 4 sets of 25 eccentric repetitions of the dominant quadriceps muscle on an isokinetic dynamometry machine. Participants were then randomized into 3 groups: 14% Plai cream, 7% Plai cream and placebo cream. Two grams of the cream(strips of 5-cm long) were gently rubbed into the quadriceps muscles for 5 min immediately following the exercise and every 8 h thereafter for 7 d in all groups. Muscle soreness, muscle strength, jump height, thigh circumference and creatine kinase were measured before and after eccentric exercise.RESULTS: Compared to the placebo cream the 14% Plai cream substantially reduced muscle soreness over the 7 d by –82%(95% CI = –155% to –6%, P = 0.03), but had similar muscle soreness effects to 7% Plai cream(–34%, –96% to 27%, P = 0.2). Compared to the placebo cream the 7% Plai cream resulted in a small non-significant reduction in muscle soreness levels over the following 7 d(–40%, –116% to 36%, P = 0.3). Compared to placebo cream there was little effect of Plai cream(7% or 14%) on muscle strength, jump height, thigh circumference or creatine kinase concentration. CONCLUSION: Using 14% Plai cream over a 7-day period substantially reduced muscle soreness symptoms compared to 7% Plai cream or a placebo cream. The authors suggest that the administration of 14% Plai cream is a useful alternative in the management of DOMS.TRIAL REGISTRATION: Thai Clinical Trial Registry TCTR20140215001.Nuttaset Manimmanakorn Apiwan Manimmanakorn Disaphon Boobphachart Worrawut Thuwakum Wiroon Laupattarakasem Michael J Hamlin 2016Journal of Integrative Medicine2016,14,2:1
4Successful treatment of esophageal metastasis from hepatocellular carcinoma using the da Vinci robotic surgical system显示文摘A 59-year-old man with metastatic an esophageal tumor from hepatocellular carcinoma(HCC) presented with progressive dysphagia.He had undergone liver transplantation for HCC three and a half years prevously.At presentation,his radiological and endoscopic examinations suggested a submucosal tumor in the lower esophagus,causing a luminal stricture.We performed complete resection of the esophageal metastases and esophagogastrostomy reconstruction using the da Vinci robotic system.Recovery was uneventful and he was been doing well 2 mo after surgery.α-fetoprotein level decreased from 510 ng/mL to 30 ng/mL postoperatively.During the follow-up period,he developed a recurrent esophageal stricture at the anastomosis site and this was successfully treated by endoscopic esophageal dilatation.Wiroon Boonnuch Thawatchai Akaraviputh Carnivale Nino Anusak Yiengpruksawan Arthur Andrew Christiano 2011World Journal of Gastrointestinal Surgery2011,3,6:1
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