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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong显示文摘瞄准:用香港汉语调查流行和胃肠的基质肿瘤(大意) 的临床的模式,并且估计发病率的 CD117 的介绍的影响。方法:从 Yan Chai 医院的病理的部门的数据库, 47 个病人,在这研究与到 2003 年 12 月的从 1995 年 9 月的大意被包括。十大意在 CD117 的介绍前被诊断。临床的特征,肿瘤特征,和治疗被分析。预言肿瘤的因素联系了死亡或复发与比例的危险建模的考克斯一起被学习。结果:病人包括了 26 男性和 21 女性,与 66.6 年的吝啬的年龄(SD 13.1,范围 29-87 年) 。大意的估计的流行每 100,000 个人是 13.4-15.6,与每 100,000 个人的 1.68-1.96 的年度发生。在 CD117 的介绍前后的大意的年度发生每 100,000 个人是 1.1 并且 2.1 每 100,000 个人分别地。胃(34 个病人, 72.3%) 是为肿瘤的最普通的地点,由小肠列在后面(8 个病人, 17.0%) ,食管(2 个病人, 4.3%) ,网膜(2 个病人, 4.3%) 并且冒号(1 个病人, 2.1%) 。31 个病人(66%) 有完全的肿瘤切除术。十一从 16 死亡(23%) 是肿瘤相关的。中部的生存时间是 26 瞬间。五年的幸存率是 61.3% 。与肿瘤相关的死亡或复发联系的重要因素是不完全的切除术,肿瘤尺寸 5 厘米以上,侵略到转移的邻近的机关或存在。结论:在香港的大意的发生在美国比得上那,但是在芬兰比那降低。大意的真发生能在 CD117 的介绍前被低估。不完全的切除术,肿瘤尺寸 5 厘米以上,到转移的邻近的机关或存在的侵略是预言肿瘤相关的死亡或复发的因素。 | Kam Hoi Chan Chun Wing Chan Wai Hung Chow Wai Keung Kwan Chi Kwan Kong Ka Fung Mak Miu Yi Leung Lin Kiu Lau | 2006 | World Journal of Gastroenterology2006，12，14： | 12 |
| 3 | Percutaneous transgastric computed tomography-guided biopsy of the pancreas using large needles显示文摘AIM:To assess the safety,yield and clinical utility of percutaneous transgastric computed tomography(CT)-guided biopsy of pancreatic tumor using large needles, in selected patients. METHODS:We reviewed 34 CT-guided biopsies in patients with pancreas mass,of whom 24(71%)had a direct path to the mass without passing through a major organ.The needle passed through the liver in one case(3%).Nine passes(26%)were made through the stomach.These nine transgastric biopsies which used a coaxial technique(i.e.a 17-gauge coaxial introducer needle and an 18-gauge biopsy needle)were the basis of this study.Immediate and late follow-up CT images to detect complications were obtained. RESULTS:Tumor tissues were obtained in nine pancreatic biopsies,and histologic specimens for diagnosis were obtained in all cases.One patient,who had a rare sarco-matoid carcinoma,received a second biopsy.One patient had a complication of transient pneumoperitoneum but no subjective complaints.An immediate imaging study and clinical follow-up detected neither hemorrhage nor peritonitis.No delayed procedure-related complication was seen during the survival period of our patients.CONCLUSION:Pancreatic biopsy can be obtained by a transgastric route using a large needle as an alternative method,without complications of peritonitis or bleeding. | Hsiuo-Shan Tseng Chia-Yuen Chen Wing P Chan Jen-Huey Chiang | 2009 | World Journal of Gastroenterology2009，15，47： | 11 |
| 4 | 7075铝合金在复杂触变挤压过程中的显微组织和力学性能显示文摘采用复杂触变挤压技术制备7075铝合金弯头零件,随后采用SEM、TEM等分析方法研究材料在复杂触变挤压过程中显微组织和力学性能的变化。研究结果表明:7075铝合金弯头各部分的显微组织存在较大差异。反向挤压形成的薄壁部位的显微组织出现分层现象,而角挤压形成的零件底部表现为明显的变形组织,且剪切力可以促进晶粒和粗大第二相的破碎。材料中主要的强化相为η相和E相。在坯料加热至半固态和触变挤压的过程中,η相和E相会大量减少。经过热处理后η相和E相均匀析出,可提高材料的力学性能。经过触变挤压和热处理后,弯头零件的平均抗拉强度为485.49 MPa,平均伸长率为5.49%。 | 刘健 程远胜 Sin Wing Norman CHAN Daniel SUNG | 2020 | Transactions of Nonferrous Metals Society of China2020，30，12： | 9 |
| 5 | Pancreaticoduodenectomy with vascular reconstruction for adenocarcinoma of the pancreas with borderline resectability显示文摘AIM:To analyze whether pancreaticoduodenectomy with simultaneous resection of tumor-involved vessels is a safe approach with acceptable patient survival.METHODS:Between January 2001 and March 2012,136 patients received pancreaticoduodenectomy for adenocarcinoma at our hospital.Seventy-eight patients diagnosed with pancreatic head carcinoma were included in this study.Among them,46 patients received standard pancreaticoduodenectomy(group 1)and32 patients received pancreaticoduodenectomy with simultaneous resection of the portal vein or the superior mesenteric vein or artery(group 2)followed by reconstruction.The immediate surgical outcomes and survivals were compared between the groups.Fifty-five patients with unresectable adenocarcinoma of the pancreas without liver metastasis who received only bypassoperations(group 3)were selected for additional survival comparison.RESULTS:The median ages of patients were 67 years(range:37-82 years)in group 1,and 63 years(range:35-86 years)in group 2.All group 2 patients had resection of the portal vein or the superior mesenteric vein and three patients had resection of the superior mesenteric artery.The pancreatic fistula formation rate was21.7%(10/46)in group 1 and 15.6%(5/32)in group2(P=0.662).Two hospital deaths(4.3%)occurred in group 1 and one hospital death(3.1%)occurred in group 2(P=0.641).The one-year,three-year and five-year overall survival rates in group 1 were 71.1%,23.6%and 13.5%,respectively.The corresponding rates in group 2 were 70.6%,33.3%and 22.2%(P=0.815).The one-year survival rate in group 3 was13.8%.Pancreaticoduodenectomy with simultaneous vascular resection was safe for pancreatic head adenocarcinoma.CONCLUSION:The short-term and survival outcomes with simultaneous resection were not compromised when compared with that of standard pancreaticoduodenectomy. | Tan To Cheung Ronnie TP Poon Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai See Ching Chan Sheung Tat Fan Chung Mau Lo | 2014 | World Journal of Gastroenterology2014，20，46： | 8 |
| 6 | Profiles and removal efficiency of polycyclic aromatic hydrocarbons by two different types of sewage treatment plants in Hong Kong显示文摘Sewage discharge could be a major source of polycyclic aromatic hydrocarbons(PAHs) in the coastal waters. Stonecutters Island and Shatin Sewage Treatment Works(SCISTW and STSTW)in Hong Kong, adopted chemically enhanced primary treatment and biological treatment,respectively. This study aimed at(1) determining the removal efficiencies of PAHs,(2) comparing the capabilities in removing PAHs, and(3) characterizing the profile of each individual PAHs, in the two sewage treatment plants(STPs). Quantification of 16 PAHs was conducted by a Gas Chromatography. The concentrations of total PAHs decreased gradually along the treatment processes(from 301 ± 255 and 307 ± 217 ng/L to 14.9 ± 12.1 and 63.3 ± 54.1 ng/L in STSTW and SCISTW, respectively). It was noted that STSTW was more capable in removing total PAHs than SCISTW with average total removal efficiency 94.4% ± 4.12% vs. 79.2% ± 7.48%(p < 0.05). The removal of PAHs was probably due to sorption in particular matter, confirmed by the higher distribution coefficient of individual and total PAHs in solid samples(dewatered sludge contained92.5% and 74.7% of total PAHs in SCISTW and STSTW, respectively) than liquid samples(final effluent-total contained 7.53% and 25.3% of total PAHs in STSTW and SCISTW, respectively).Despite the impressive capability of STSTW and SCISTW in removing PAHs, there was still a considerable amount of total PAHs(1.85 and 39.3 kg/year, respectively for the two STPs) being discharged into Hong Kong coastal waters, which would be an environmental concern. | Yu Bon Man Ka Lai Chow Zhang Cheng Wing Yin Mo Yung Hau Chan James Chung Wah Lam Frankie Tat Kwong Lau Wing Cheong Fung Ming Hung Wong | 2017 | Journal of Environmental Sciences2017，29，3： | 5 |
| 7 | Social network, social trust and shared goals in organizational knowledge sharing显示文摘 | Wing S. Chow Lai Sheung Chan | 2008 | Information & Management2008，，7： | 4 |
| 8 | Entecavir Monotherapy Is Effective in Suppressing Hepatitis B Virus After Liver Transplantation显示文摘 | James Fung Cindy Cheung See–Ching Chan Man–Fung Yuen Kenneth S.H. Chok William Sharr Wing–Chiu Dai Albert C.Y. Chan Tan–To Cheung Simon Tsang Banny Lam Ching–Lung Lai Chung–Mau Lo | 2011 | Gastroenterology2011，，4： | 3 |
| 9 | Outcome analysis of management of liver trauma: A 10-year experience at a trauma center显示文摘AIM: To review the outcomes of liver trauma in patients with hepatic injuries only and in patients with associated injuries outside the liver.METHODS: Data of liver trauma patients presented to our center from January 2003 to October 2013 were reviewed. The patients were divided into two groups. Group 1 consisted of patients who had hepatic injuries only. Group 2 consisted of patients who also had associated injuries outside the liver.RESULTS: Seven(30.4%) patients in group 1 and 10(28.6%) patients in group 2 received non-operative management; the rest underwent operation. Blunt trauma occurred in 82.8%(48/58) of the patients and penetrative trauma in 17.2%(10/58). A higher injury severity score(ISS) was observed in group 2(median 45 vs 25, P < 0.0001). More patients in group 1 were hemodynamically stable(65.2% vs 37.1%, P = 0.036). Other parameters were comparable between groups. Group 1 had better 30-d survival(91.3% vs 71.4%, P = 0.045). On multivariate analysis using the logistic regression model, ISS was found to be associated with mortality(P = 0.004, hazard ratio = 1.035, 95%CI:CONCLUSION: Liver trauma patients with multiple injuries are relatively unstable on presentation. Despite a higher ISS in group 2, non-operative management was possible for selected patients. Associated injuries outside the liver usually account for morbidity and mortality. | Wong Hoi She Tan To Cheung Wing Chiu Dai Simon HY Tsang Albert CY Chan Daniel KH Tong Gilberto KK Leung Chung Mau Lo | 2016 | World Journal of Hepatology2016，8，15： | 3 |
| 10 | Survival analysis of breast cancer liver metastasis treated by hepatectomy: A propensity score analysis for Chinese women in Hong Kong显示文摘Background: Survival of patients with breast cancer liver metastasis is very poor. This study aimed to analyze the survival outcome of hepatectomy for this patient population. Methods: From January 1995 to December 2014, 2522 patients with liver cancer received hepatectomy at our hospital. Twenty-one of them, all female, received the operation for breast cancer liver metastasis. Performance was compared with patients with colorectal liver metastasis treated with hepatectomy after propensity score analysis in a ratio of 1:3. Results: Twenty-one patients received hepatectomy for breast cancer. After propensity score matching, 63 patients who had hepatectomy for colorectal cancer were selected for comparison. There was no significant difference in immediate or short-term outcomes between the two groups of patients in terms of operative time, blood loss and surgical morbidities. All patients with breast cancer had R0 resection. No hospital death occurred. After hepatectomy, the 1-, 3- and 5-year overall survival rates were 100.0%, 58.9% and 58.9% respectively in patients with breast cancer. The 1-, 3- and 5-year overall survival rates were 95.0%, 57.2% and 39.7% respectively in patients with colorectal cancer (P = 0.572). On multivariate analysis, triple negative status was the only independent poor prognostic factor in breast cancer liver metastasis (OR = 6.411;95% CI: 1.351–30.435;P = 0.019). Conclusions: Hepatectomy is a safe and effective way of treating breast cancer liver metastasis at experienced centers where multidisciplinary adjuvant treatments are available. It can be considered more frequently as part of the multidisciplinary care for this patient population. | Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai Thomas CC Yau Ava Kwong Chung Mau Lo | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 3 |
| 11 | Magnetoelectric and converse magnetoelectric responses in Tb_xDy_(1-x)Fe_(2-y) alloy & Pb(Mg_(1/3)Nb_(2/3))_(1-x)Ti_xO_3 crystal laminated composites显示文摘Measured results of magnetoelectric (ME) and converse magnetoelectric (CME) effects of TbxDy1-xFe2-y/ Pb(Mg1/3Nb2/3)(1-x)TixO3/TbxDy1-xFe2-y (TD/PMNT/TD) and PMNT/TD/PMNT laminated composites are pre- sented. ME effect was determined by measuring laminate voltage output under a Helmholtz-gener- ated AC field biased by a DC field (0―1 kOe) (1 Oe = 79.58 A/m). The CME effect was measured by re- cording the voltage induced in a solenoid encompassing the ME sample while exposed to a DC bias field and PMNT layer driven by a 10 V AC source. The ME and CME responses in the two laminated structure are linear. The highest values of ME coefficients in TD/PMNT/TD and PMNT/TD/PMNT com- posites are 384 mV/Oe and 158 mV/Oe, respectively, while the highest values of CME coefficients in the two composites are 118 mG/V and 162 mG/V (1 G=10-4 T), respectively. | JIA YanMin LUO HaoSu OR Siu Wing WANG YaoJin CHAN Helen L W | 2008 | Chinese Science Bulletin2008，53，14： | 3 |
| 12 | Intravenous fluid selection rationales in acute clinical management显示文摘BACKGROUND: Intravenous fluid(IVF) is commonly used in acute clinical management. This study aimed to review the choice and primary considerations in IVF prescriptions and to evaluate the adequacy of guidelines and trainings on it in the New Territories West Cluster(NTWC) of Hong Kong.METHODS: This is a descriptive study based on data collected from an online survey. Data were processed by SPSS for statistical analysis. This study focused on a general description and doctor-nurse between group comparison. Participants were asked the choice of IVF for nine acute clinical scenarios and provide reason. A 1–10 scale was used to assess the sufficiency of guideline, training and information, and time for revision on IVF prescription.RESULTS: 0.9% sodium chloride was the most familiar IVF(36%), followed by 5% Dextrose solution(26%). In the nine scenarios, the most chosen IVF was 0.9% sodium chloride(37%–61%). There was significant difference in the choice of IVF between doctors and nurses in 7 cases. The second most chosen IVF for doctors was Plasma-Lyte A while that for nurses was Gelofusine. Departmental practice was the most chosen reason to account for the prescription. The adequacy of guideline, information and training, and time for revision was rated 5. Doctors had significantly more time at work than nurses to update knowledge in IVF prescription(5.41 versus 4.57).CONCLUSION: 0.9% sodium chloride was mostly chosen. The choice of IVF was mainly based on departmental practice. Adequacy of guideline, information and training, and time for revision on IVF prescription were average, indicating significant training deficit. | Wing Yan Shirley Cheung Wai Kwan Cheung Chun Ho Lam Yeuk Wai Chan Hau Ching Chow Ka Lok Cheng Yau Hang Wong Chak Wah Kam | 2018 | World Journal of Emergency Medicine2018，9，1： | 3 |
| 13 | 复合材料Terfenol-D/PMNT的磁电和逆磁电响应显示文摘给出了Terfenol-D/PMN-PT/Terfenol-D(TD/PMNT/TD)和PMNT/TD/PMNT两种层状复合材料的磁电和逆磁电响应的测试方法和测试结果.这两种复合结构的优化直流偏置磁场大小均为350Oe(1Oe=79.58A/m).在1kHz频率下,这两种复合材料的最大磁电电压系数分别为384mV/Oe和158mV/Oe,最大逆磁电系数分别为118mG/V和162mG/V(1G=10-4T).另外研究了这两种复合材料在谐振频率下的磁电响应.通过对两种复合结构的比较得知,磁致/压电/磁致复合结构具有好的磁电响应;而压电/磁致/压电复合结构具有好的逆磁电响应.这一结果有助于优化设计高性能压电/磁致复合磁电材料. | 贾艳敏 罗豪甦 Or Siu Wing 汪尧进 Chan Helen L W | 2008 | 科学通报2008，53，10： | 3 |
| 14 | Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis显示文摘BACKGROUND Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM To evaluate the impact of small-for-size liver grafts on medium-term and longterm graft survival in adult to adult LDLT. METHODS A systematic review and meta-analysis were performed by searching eligible studies published before January 24, 2019 on PubMed, EMBASE, and Web of Science databases. The primary outcomes were 3-year and 5-year graft survival. Incidence of small-for-size syndrome and short term mortality were also extracted. RESULTS This meta-analysis is reported according to the guidelines of the PRISMA 2009 Statement. Seven retrospective observational studies with a total of 1821 LDLT recipients were included in the meta-analysis. SFSG is associated with significantly poorer medium-term graft survival. The pooled odds ratio for 3-year graft survival was 1.58 [95% confidence interval 1.10-2.29, P = 0.014]. On the other hand, pooled results of the studies showed that SFSG had no significant discriminatory effect on 5-year graft survival with an odds ratio of 1.31 (95% confidence interval 0.87-1.97, P = 0.199). Furthermore, incidence of small-for-size syndrome detected in recipients of SFSG ranged from 0-11.4% in the included studies. CONCLUSION SFSG is associated with inferior medium-term but not long-term graft survival. Comparable long-term graft survival based on liver graft size shows that smaller grafts could be accepted for LDLT with appropriate flow modulatory measures. Close follow-up for graft function is warranted within 3 years after liver transplantation. | Ka Wing Ma Kelly Hiu Ching Wong Albert Chi Yan Chan Tan To Cheung Wing Chiu Dai James Yan Yue Fung Wong Hoi She Chung Mau Lo Kenneth Siu Ho Chok | 2019 | World Journal of Gastroenterology2019，25，36： | 3 |
| 15 | 中国农村剩余劳动力转移的趋向和措施显示文摘在对中国农村剩余劳动力现状描述的基础上 ,对剩余劳动力形成的原因进行了分析与阐述 ;结合目前形势 ,指出未来农村剩余劳动力的转移前景不容乐观 ; | 范宇 姚士谋 Kam Wing Chan | 2002 | 热带地理2002，22，1： | 3 |
| 16 | Accuracy of Risk Scores for Patients With Chronic Hepatitis B Receiving Entecavir Treatment显示文摘 | Grace Lai–Hung Wong Henry Lik–Yuen Chan Hoi–Yun Chan Pete Chi–Hang Tse Yee–Kit Tse Christy Wing–Hin Mak Stanley King–Yeung Lee Zoe Man–Yi Ip Andrew Ting–Ho Lam Henry Wing–Hang Iu Joyce May–Sum Leung Vincent Wai–Sun Wong | 2013 | Gastroenterology2013，，5： | 2 |
| 17 | A MULTIPLE INTELLIGENT AGENT SYSTEM FOR CREDIT RISK PREDICTION VIA AN OPTIMIZATION OF LOCALIZED GENERALIZATION ERROR WITH DIVERSITY显示文摘公司破产每年在损失花费了十亿美元到银行。因此承认风险预言是一个银行的贷款赞同决定过程的关键部分。为信用风险预言的传统的金融模型为 describingtoday 在金融健康和一个公司的潜在的破产之间的复杂关系不再是足够的。Inthis 工作,一个多重分类器系统(在一个多重聪明的代理人系统嵌入) 被建议预言一个公司的金融健康。在我们的模型,每个单个代理人(分类器) 基于公司的仅仅偏爱的信息在信用风险的可能性上做预言。每代理人是一位专家,但是限制了知识(由特征代表了) 关于公司。所有代理人的决定一起被联合形成最后的信用风险预言。实验证明我们的模型用 benchmarking Compustat 美国公司数据集超过另外的存在方法。 | Daniel S. YEUNG Wing W. Y. NG Aki P. F. CHAN Patrick P. K. CHAN Michael FIRTH Eric C. C. TSANG | 2007 | Journal of Systems Science and Systems Engineering2007，16，2： | 2 |
| 18 | Liver transplantation:would it be the best and last chance of cure for hepatocellular carcinoma with major venous invasion?显示文摘Background:Hepatocellular carcinoma(HCC)with portal vein tumour thrombus(PVTT)signifies advanced disease,whether LT confers any survival superiority over resection remains uncertain.Methods:A propensity score matched(PSM)analysis of liver transplantation(LT)and liver resection(LR)for HCC with PVTT was performed.Results:A consecutive series of 88 patients who received either LT(10 DDLTs and 3 LDLTs)or LR(n=75)respectively were recruited.Before PSM,the LT group has a higher MELD score(17.3 vs.7.8,P<0.001),lower serum AFP levels(96 vs.2,164 ng/mL,P=0.017)and smaller tumour size(4 vs.10 cm,P<0.001).The 5-year overall survival for LT and LR were 55.4%and 15.9%respectively(P=0.007).After matching for serum AFP levels and tumour size,1-,3-and 5-year overall survival for LT were 81 ng/mL,3.9 cm,80%,70%and 70%and the corresponding rates for LR were 1,417 ng/mL,5.3 cm,51.8%,19,6%and 9.8%(P value=0.12,0.27 and 0.009 respectively).Conclusions:LT is associated with significantly better oncological outcomes in HCC patients with PVTT involving the lobar or segmental level.A modest expansion of selection criteria to include small HCC with segmental PVTT should be considered. | Ka Wing Ma Albert Chi Yan Chan Kenneth Siu Ho Chok Wong Hoi She Tan To Cheung Wing Chiu Dai James Yan Yue Fung Chung Mau Lo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，3： | 2 |
| 19 | 伴有特殊表型的Wiskott-Aldrich综合征3例显示文摘病例1 患儿,男,4个月。因发现血小板减少4月余,咳嗽50 d,发热4 d入院。患儿4个月前(生后2 d)发现血小板减少(PLT 22×10^9/L),外院经骨髓细胞学检查诊断为血小板减少性紫癜,口服泼尼松及静脉丙种球蛋白治疗,血小板正常后出院。出院后不规律口服泼尼松,2个月前停用,血小板波动于50~60×10^9/L。 | 贺建新 Chan Koon Wing 徐保平 刘秀云 桂晋刚 申昆玲 江载芳 Lau Yu Lung | 2017 | 中国当代儿科杂志2017，19，2： | 2 |
| 20 | The impact of family history of hepatocellular carcinoma on its patients' survival显示文摘BACKGROUND:Family history of hepatocellular carcinoma(HCC) has been identified as a risk factor for the development of the disease.The aim of this study is to evaluate the impact of such a history on HCC patients' survival.METHODS:Data of all HCC patients(n=4532) managed at our center from 1989 to 2008 were prospectively collected.The patients were quizzed on their various characteristics including family HCC history.RESULTS:Totally 475(10.48%) patients had a family history of HCC.They presented the disease at a significantly earlier age(median 53 vs 59 years,P<0.0001) and at an earlier stage(the United Network for Organ Sharing staging system).They had significantly better liver function in terms of ChildPugh classification and serum albumin and bilirubin levels.Significantly more of them presented the disease without symptoms(44.0% vs 29.4%,P<0.0001).They also had significantly better overall survival under these specifications:patients in the whole study cohort,patients who had minor hepatectomy,patients with stage I disease,patients with stage II disease,and patients with stage III disease.CONCLUSIONS:Contrary to what is generally believed,we found in this study cohort that patients with a family history of HCC had better overall survival than those without such a history.We believe this was in part due to earlier diagnosis of the disease and better liver function in this group of patients.However,the effects of genetic factors on the risk of HCC cannot be overlooked and are yet to be identified. | Wing Chiu Dai Sheung Tat Fan Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Ronnie TP Poon Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 2 |
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