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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Tempora- ry closure of the open abdomen:A systematic review on delayed primary fascial closure in patients with an openabdomen显示文摘 | van Hensbroek P Wind J Dijkgraaf MG | 2009 | Worm J Surg2009，，： | 1 |
| 3 | Anal implantation of exfoliated tumour cells from a rectal adenocarcinoma after colorectal stapled anastomosis显示文摘 | Wind P Douard R Poupardin E | 1999 | Eur J Surg1999，165，9： | 1 |
| 4 | Esophagectomy for squamous cell carcinoma of the esophagus isolated or associated with head and neck cancer:long-term survival显示文摘 | Roullet MH Wind P Zinzindohoue F | 2001 | Ann Chir2001，126，6： | 1 |
| 5 | Systematic review of enhanced recovery programmes in colonic surgery显示文摘 | WIND J POLLE S W FUNG KONJIN P H | 2006 | Br J Surg2006，93，7： | 1 |
| 6 | Contribution of endoscopic retrograde pancreatography in management of complications following distal pancreatic trauma显示文摘 | Wind P Tiret E Cunningham C | 1999 | Am Surg1999，65，8： | 1 |
| 7 | International perspectives on transnational migration: An introduction显示文摘 | Levitt P De Wind J Vertovec S | 2003 | International Migration Review2003，37，3： | 1 |
| 8 | DataWare: sea clutter and small boat radar reflectivity databases 显示文摘 | WIND H J CILLIERS J E HERSEI34AN P L | 2010 | IEEE Signal Processing Magazine2010，，： | 1 |
| 9 | Experience in the treatment of synchronous and metachronous carcinoma of the oesophagus and the head and neck显示文摘 | Wind P Roullet MH Douard R | 2000 | J Surg Oncol2000，73，3： | 1 |
| 10 | Systematic review of enhanced recovery programmes in colonic surgery 显示文摘 | Wind J Polle S W Fung Kon Jin P H | 2006 | Br J Surg2006，93，7： | 1 |
| 11 | The chicken B cell line DT40:a novel tool for gene disruption experiments显示文摘 | Winding P Berchtold M W | 2001 | J Immunol Methods2001，249，： | 1 |
| 12 | Esoohagectomy for squamous cell carcinoma of the esophagus isolated or associated with head and neck cancer:long-term survival显示文摘 | Roullet MH Wind P Zinzindohoue F | 2001 | Ann Chir2001，126，6： | 1 |
| 13 | Systematic review of enhanced recovery programmes in colonic surgery 显示文摘 | Wind J Polle S W Fung Kon Jin P H | 2006 | Br J Surg2006，93，7： | 1 |
| 14 | Contribution of endoscopic retro- grade pancreatography in management of complications following distal pancreatic trauma显示文摘 | Wind P Tiret E Cunningham C | 1999 | Am Surg1999，65，8： | 1 |
| 15 | Establishment of oxidative D-xylose metabolism in Pseudomonas putida S12显示文摘 | Meijnen J P Winde J H Ruijssenaars H J | 2009 | Applied and Environment Microbiology2009，75，9： | 1 |
| 16 | The chicken B cell line DT40: a novel tool for gene disruption experiments 显示文摘 | WINDING P BERCHTOLD M W | 2001 | J Immunol Methods2001，249，： | 1 |
| 17 | Identification of a functional EGF-R/p60c-src/STAT3 pathway in colorectal eareianma:analysis of its long-term prognostic value显示文摘 | Hbibi AT Lngorce C Wind P | 2008 | Cancer Biomark2008，4，2： | 1 |
| 18 | The Long Term Stability of Mercury Based Ferromagnetic Liquids 显示文摘 | | 1975 | IEEE Trans on Mag1975，11，5： | 1 |
| 19 | Intraoperative enteroscopy for diagnosis and management of unexplained gastrointestinal bleeding显示文摘 | Douard R Wind P Panis Y | 2000 | Am J Surg2000，180，3： | 1 |
| 20 | Systematic review of enhanced recovery programmes in colonic surgery显示文摘 | WIND J POLLE S W FUNG KON JIN P H | 2006 | Br J Surg2006，93，7： | 1 |
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