|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Modeling Shear Behavior of Hybrid RCS Beam-Column Connections显示文摘 | Gustavo Parra-Montesinos James K. Wight | 2001 | Journal of Structural Engineering2001，，1： | 3 |
| 3 | Intracellular localization of hyaluronan in proliferating cells显示文摘 | Evanko S P Wight T N | 1999 | J Histochem Cytochem1999，47，10： | 2 |
| 4 | A systematic review of the clinical effectiveness of pioglitazone in the treatment of type 2 diabetes mellitus显示文摘 | Jim Chilcott Paul Tappenden Myfanwy Lloyd Jones Jeremy P. Wight | 2001 | Clinical Therapeutics2001，，11： | 2 |
| 5 | Model-free and model-fitting approaches to kinetic analysis of isothermal and nonisothermal data显示文摘 | Sergey Vyazovkin Charles A Wight | 1999 | Thermochimica Acta1999，，： | 2 |
| 6 | Prestressed fiber-reinforced polymer laminates for strengthening structures 显示文摘 | EI-Hacha R Wight R G Green M F | 2001 | Prog Struct Engng Master2001，，3： | 1 |
| 7 | Prestressed FRP sheets for poststrengthening reinforced concrete beams 显示文摘 | Wight R G Green M F Erki M A | 2001 | Journal of Composites for Construction2001，5，4： | 1 |
| 8 | Prestressed FRP sheets for poststrengthening reinforced concrete beams 显示文摘 | Wight R G Green M F Erki M A | 2001 | Journal of Composites for Construction2001，5，4： | 1 |
| 9 | Prestressed and nonprestressed CFRP sheet strengthening: damaged continu- ous reinforced concrete beams 显示文摘 | Wight R G El-Hacha R Erki M A | 2003 | International Journal of Materials and Product Technology2003，19，12： | 1 |
| 10 | Prestressed FRP Sheets for Post Strengthening Reinforced Concrete Beams显示文摘 | Wight R G Green M F Erki M A | 2001 | Journal of Composites for Construction2001，5，4： | 1 |
| 11 | Experimental study of reinforced concrete interior wide beam - column connections subjected to lateral loading显示文摘 | Carlos G Quintero - Febres James K Wight | 2001 | ACI Structural Journal2001，98，4： | 1 |
| 12 | Model-free and model-fitting approaches to kinetic analysis of isothermal and nonisothermal data显示文摘 | Vyazovkin S Wight Charles A | 1999 | Thermochimica Acta1999，34，14： | 1 |
| 13 | Prestressed FRP Sheets for Poststrengthening Reinforced Concrete Beams 显示文摘 | WIGHT R G GREEN M F | 2001 | Journal of Composites for Construction2001，，： | 1 |
| 14 | Prestressed FRP Sheets for Poststrengthening Reinforced Concrete Beams显示文摘 | Wight R G Green M F Erki M A | 2001 | Journal of Composites for Construction2001，5，4： | 1 |
| 15 | Introduction of the foot placement estimator: A dynamic measure ot' balance tbr bipedal robotics显示文摘 | Wight D L Kubica E G Wang D W L | 2008 | Journal of Computational and Nonlinear Dynamics2008，3，1： | 1 |
| 16 | Behavior of HPFRC connections for precast concrete frames under reversed cyclic loading显示文摘 | VASCONEZ M V NAAMAN A E WIGHT J K | 1998 | PCI Journal1998，43，6： | 1 |
| 17 | Kinetics of the thermal and thermo-oxidative degradation of polystyrene, polyethylene and poly (propylene) 显示文摘 | PETERSON J D VYAZOVKIN S WIGHT C A | 2001 | Macromol Chem Phys2001，202，6： | 1 |
| 18 | Strength of struts in deep concrete members designed using strut-and-tie method显示文摘 | Quintero-Febres C G Parra-Montesions G Wight J K | 2006 | ACI Journal2006，103，4： | 1 |
| 19 | North American Ecotourists:Market Profile and Trip Characteristics显示文摘 | Wight P | 1996 | Journal of Travel Research1996，，： | 1 |
| 20 | Modeling shear behavior of hybrid RCS beam-column connections 显示文摘 | Parra-Montesinos G Wight J K | 2001 | Journal of Structural Engineering ASCE2001，127，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员