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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Intracellular localization of hyaluronan in proliferating cells显示文摘 | Evanko S P Wight T N | 1999 | J Histochem Cytochem1999，47，10： | 2 |
| 3 | North American Ecotourists:Market Profile and Trip Characteristics显示文摘 | Wight P | 1996 | Journal of Travel Research1996，，： | 1 |
| 4 | Hyaluronan-cell in- teractions in cancer and vau|ar disea 显示文摘 | TOOLE B P WIGHT T N TAMMI M I | 2002 | J Biol Chem2002，277，7： | 1 |
| 5 | North American Ecotourists Market: Market profile and trip characteristics 显示文摘 | Wight A P | 1996 | Journal of Travel Research1996，，3： | 1 |
| 6 | Ecotoufism accommodation spectrum:does supply match the demand显示文摘 | Wight P A | 1997 | Tourism Management1997，18，4： | 1 |
| 7 | North American Ecotourists: Market Profile and Trip Characteristics显示文摘 | Wight P | 1996 | Journal of Travel Research1996，34，： | 1 |
| 8 | North American Eeotourism Markets: Motivations, Preferences, and Destinations显示文摘 | Wight P | 1996 | Journal Of Travel Research1996，35，： | 1 |
| 9 | Locatization of stem rust resistance genes and associated molecular marker in cultivated oat 显示文摘 | DONOUGHUE O CHONG J WIGHT C P | 1996 | Phytopathology1996，86，： | 1 |
| 10 | North American Ecotourists: Market Profile and Trip Characteristics 显示文摘 | Wight P A | 1996 | Journal of Travel Research1996，34，4： | 1 |
| 11 | Ecotourism accommodation spectrum:does supply match the demand显示文摘 | WIGHT P A | 1997 | Tourism Management1997，18，4： | 1 |
| 12 | Eco Tourism : Ethics or Eco - Sell显示文摘 | Wight P | 1993 | Journal of Travel Research1993，16，2： | 1 |
| 13 | Identification of a RAPD marker for the crown rust resistance gene Pc68 in oats显示文摘 | PENNERGA CHONG J WIGHT C P | 1993 | Genome1993，36，： | 1 |
| 14 | Ecotourism: Ethics or ecocell 显示文摘 | Wight P | 1993 | Journal of Travel Research1993，131，3： | 1 |
| 15 | Design and preparation of organic-inorganic hybrid catalysts显示文摘 | Wight A P Davis M E | 2002 | Chem Rev2002，102，： | 1 |
| 16 | Design and preparation of organic-inorganic hybrid catalyts显示文摘 | Wight A P Davis M E | 2002 | Chem Rev2002，102，： | 1 |
| 17 | Monocytosis in experimental zinc deficiency of domestic birds显示文摘 | Wight P A Dewar W A Mackenzie G M | 1981 | Avian Pathol1981，9，1： | 1 |
| 18 | The significance of the lymphoid nodule 显示文摘 | Wight P Burns R Rothwell B | 1971 | J Anat1971，110，： | 1 |
| 19 | Hyaluronan-cell interac-tions in cancer and vascular disease显示文摘 | Toole B P Wight T N Tammi M I | 2002 | J Biol Chem2002，277，7： | 1 |
| 20 | Ecotourism:ethics of eco-sell? 显示文摘 | Wight P | 1993 | Journal of Travel Research1993，37，： | 1 |
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