|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | DNA Topoisomerase 1 Prevents R-loop Accumulation to Modulate Auxin-Regulated Root Development in Rice显示文摘R 环结构(RNA : DNA 混血儿) 在多样的有机体之中在许多生物进程,包括的 transcriptional 规定和染色体不稳定性有重要函数。DNA topoisomerase 1 (TOP1 ) , DNA 拓扑学的一个必要操纵者在 RNA 抄写和 DNA 复制期间处理,能由移开被 RNA 聚合酶在抄写期间做的积极、否定的 DNA supercoiling 阻止 R 环累积。TOP1 为植物开发被要求,但是很少在在植物在各种各样的生物进程阻止 co-transcriptional R 环累积对它的函数被知道。这里,我们显示出那击倒 OsTOP1 强烈影响米饭开发,在根建筑学和 gravitropism 引起缺点,它是植物生长素发信号和 transporter 基因的错误规定的后果。我们发现 R 环自然地在米饭被形成植物生长素相关的基因 loci,和 overaccumulate 当 OsTOP1 被击倒或 OsTOP1 蛋白质活动被禁止时。OsTOP1 因此将植物生长素相关的基因的精确表示层次放由阻止固有的 R 环的 overaccumulation。我们的数据表明在极的植物生长素的 R 环同样重要的因素搬运并且种 OsTOP1 作为一把钥匙工作与植物连接 transcriptional R 环的根开发,和热点荷尔蒙发信号,提供新卓见进荷尔蒙在植物发信号的 transcriptional 规定。 | Sarfraz Shafiq Chunli Chen Jing Yang Lingling Cheng Fei Ma Emilie Widemann Qianwen Sun | 2017 | Molecular Plant2017，10，6： | 2 |
| 2 | Human prothymosin alpha:amino acid sequence and immunologic properties显示文摘 | Pan LX Haritos AA Widemann J | 1986 | Arch Biochem Biophys1986，250，： | 1 |
| 3 | Allocating ecological footprints to final consumption categories with input-output analysis显示文摘 | Minx J Barrett J | 2006 | Ecological Economics2006，56，1： | 1 |
| 4 | Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifamib in children and adolescents with refractory leukemias:a report from the Children's Ontology Group 显示文摘 | Widemann BC Arceci RJ Jayaprakash N | 2011 | Pediatr Blood Cancer2011，56，2： | 1 |
| 5 | Phase 2 trial of sorafenib in children and young adults with refractory solid tumors: a report from the Children's Oncology Group 显示文摘 | Kim A Widemann BC Krailo M | 2015 | Pediatr Blood Cancer2015，62，9： | 1 |
| 6 | Phase 1 trial and pharmaco- kinetic study of arsenic trioxide in children and adolescents with refrac- tory or relapsed acute leukemia, including acute promyelocytic leukemia or lymphoma显示文摘 | Fox E Razzouk BI Widemann BC | 2008 | Blood2008，111，2： | 1 |
| 7 | Pharmaco-kinetics and metabolism of the methotrexate metabolite 2,4-diamino-N(10)-methylpteroic acid显示文摘 | Widemann BC Sung E Anderson L | 2000 | J Pharmacol Exp Ther2000，294，3： | 1 |
| 8 | PET‐guided biopsy with needle navigation facilitates diagnosis of angiosarcoma in neurofibromatosis type 1显示文摘 | Yilun Koethe Brigitte C. Widemann Fouad Hajjar Bradford J. Wood Aradhana M. Venkatesan | 2013 | Pediatr Blood Cancer2013，，12： | 1 |
| 9 | Understanding and man- aging methotrexate nephrotoxicity 显示文摘 | WIDEMANN B C ADAMSON P C | 2006 | Oncologist2006，11，6： | 1 |
| 10 | PET-guided biopsy with needle navigation facilitates diagnosis of angiosarcoma in neurofibromatosis type1显示文摘 | Koethe Y Widemann BC Hajjar F | 2013 | Pediatr Blood Cancer2013，60，12： | 1 |
| 11 | Glucarpidase, leucovorin, and thymidine for high-dose methotrexate- induced renal dysfunction: clinical and pharmacologic factors affecting outcome 显示文摘 | WIDEMANN B C BALIS F M KIM A | 2010 | J Clin Oncol2010，28，25： | 1 |
| 12 | Phase 1 trial and pharmacokinetic study of arsenic trioxide in children and adolescents with refractory or relapsed acute leukemia, including acute promyelocytic leukemia or lymphoma 显示文摘 | Fox E Razzouk BI Widemann BC | 2008 | Blood2008，111，2： | 1 |
| 13 | Phase 1 trial and pharmacokinetic study of arsenic trioxide in children and adolescents with refractory or relapsed acute leukemia, including acute promyelocytic leukemia or lymphoma显示文摘 | Fox E Razzouk BI Widemann BC | 2008 | Blood2008，111，2： | 1 |
| 14 | Understanding and managing methotrexate nephrotoxicity 显示文摘 | Widemann BC Adamson PC | 2006 | Oncologist2006，11，6： | 1 |
| 15 | Human prothymosin alpha: Amino acid sequence and immunologic properties显示文摘 | PAN Lu-xing HARITOS A A WIDEMANN J | 1986 | Arch Biochem Biophys1986，250，1： | 1 |
| 16 | Pharmacokinetics and metabolism of the methotrexate metabolite 2,4-diamino-N(10)-methylpteroic acid显示文摘 | Widemann BC Sung E Anderson L | 2000 | J Pharmacol Exp Ther2000，294，3： | 1 |
| 17 | Efficacy of glucarpidase(carboxypeptidase g2)in patients w ith acute kidney injury after high-dose methotrexate therapy显示文摘 | Widemann BC Schwartz S Jayaprakash N | 2014 | Pharmacotherapy2014，34，5： | 1 |
| 18 | Carboxypeptidase-G2,thymidine,and leucovorin rescue in cancer patients w ith methotrexate-induced renal dysfunction显示文摘 | Widemann BC Balis FM Murphy RF | 1997 | J Clin Oncol1997，15，5： | 1 |
| 19 | Glucarpidase,leucovorin,and thymidine for high-dose methotrexate-induced renal dysfunction:clinical and pharmacologic factors affecting outcome显示文摘 | Widemann BC Balis FM Kim A | 2010 | J Clin Oncol2010，28，25： | 1 |
| 20 | Using a lower dose of glucarpidase to reduce plasma levels of methotrexate显示文摘 | Widemann BC | 2013 | Clin Adv Hematol Oncol2013，11，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员