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| 1 | WJBC 5^(th) Anniversary Special Issues(2): Proteomics In 2014, can we do better than CA125 in the early detection of ovarian cancer?显示文摘Ovarian cancer is a lethal gynecologic malignancy with greater than 70% of women presenting with advanced stage disease. Despite new treatments, long term outcomes have not significantly changed in the past 30 years with the five-year overall survival remaining between 20% and 40% for stage Ⅲ and Ⅳ disease. In contrast patients with stage Ⅰ disease have a greater than 90% five-year overall survival. Detection of ovarian cancer at an early stage would likely have significant impact on mortality rate. Screening biomarkers discovered at the bench have not translated to success in clinical trials. Existing screening modalities have not demonstrated survival benefit in completed prospective trials. Advances in high throughput screening are making it possible to evaluate the development of ovarian cancer in ways never before imagined. Data in the form of human '-omes' including the proteome, genome, metabolome, and transcriptome are now available in various packaged forms. With the correct pooling of resources including prospective collection of patient specimens, integration of high throughput screening, and use of molecular heterogeneity in biomarker discovery, we are poised to make progress in ovarian cancer screening. This review will summarize current biomarkers, imaging, and multimodality screening strategies in the context of emerging technologies. | Joshua G Cohen Matthew White Ana Cruz Robin Farias-Eisner | 2014 | World Journal of Biological Chemistry2014，5，3： | 18 |
| 2 | 甜樱桃高密栽培适用的直立主枝树形显示文摘美国Matthew Whiting教授研究的甜樱桃矮砧密植整形修剪模式—直立主枝树形,系顺行向倾斜45~60°栽植2年生无分枝嫁接苗,于苗干高度50~55cm处水平拉平,并支架绑缚固定,在水平干段上培养5~6个直立主枝,间距15~20cm,树高保持在2.8~3.0m。苗木栽植当年成花,第2年结果,3~4年进入盛果期,第5年666.7m2产量1000kg。该树形修剪简单,树体营养消耗少,早果性强,易于生产操作和机械化作业。 | 魏国芹 苏胜茂 孙玉刚 Matthew Whiting 焦其庆 | 2012 | 落叶果树2012，44，1： | 3 |
| 3 | Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions显示文摘Osmotic conditions play an important role in the cell properties of human red blood cells(RBCs),which are crucial for the pathological analysis of some blood diseases such as malaria.Over the past decades,numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes.Here,we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions.Specifically,we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions,where the strength of the optical nonlinearity increases with osmotic pressure on the cells.This tunable nonlinearity is attributed to optical forces,particularly the forward-scattering and gradient forces.Interestingly,in aged blood samples(with lysed cells),a notably different nonlinear behavior is observed due to the presence of free hemoglobin.We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations.Our work on light self-guiding through scattering biosoft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis. | Rekha Gautam Yinxiao Xiang Josh Lamstein Yi Liang Anna Bezryadina Guo Liang Tobias Hansson Benjamin Wetzel Daryl Preece Adam White Matthew Silverman Susan Kazarian Jingjun Xu Roberto Morandotti Zhigang Chen | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 4 | A comparison of intercell metrics on discrete global grid systems显示文摘 | Matthew J. Gregory A. Jon Kimerling Denis White Kevin Sahr | 2007 | Computers, Environment and Urban Systems2007，，3： | 1 |
| 5 | Aeees- sing Web Database Using OGSA-DAI in BDWorld 显示文摘 | Shirley Crompton Brian Matthews Alex Gray Andrew Jones and Richard White | 2007 | Knowledge and data management in GRIDS2007，，： | 1 |
| 6 | A randomised crossover trial of chemotherapy in the home: patient preferences and cost analysis显示文摘 | Rischin D White MA Matthews JP | 2000 | Med J Australia2000，173，3： | 1 |
| 7 | Overcoming Supply Chain Failure in the Agri -food Sector: A Case Study from Moldova显示文摘 | Gorton Matthew Dumitrashko Mikhail White John | 2006 | Food Policy2006，31，1： | 1 |
| 8 | A randomised crossover trial of chemotherapy in the home: patient preferences and cost analysis显示文摘 | Rischin D White MA Matthews JP | 2000 | Med J Aust2000，173，3： | 1 |
| 9 | Evidence-Based Surgical Management of Substernal Goiter显示文摘 | Matthew L. White Gerard M. Doherty Paul G. Gauger | 2008 | World Journal of Surgery2008，，7： | 1 |
| 10 | Overcoming supply chain failure in the agri-food sector: A case study from Moldova显示文摘 | Matthew Gorton Mikhail Dumitrashko John White | 2006 | Food Policy2006，，31： | 1 |
| 11 | Ethanol, memory, and hippocampal function: a review of recent findings显示文摘 | White AM Matthews DB Best PJ | 2002 | Hippocampus2002，10，1： | 1 |
| 12 | Pre-harvest foliar ap- plication of Prohexadione-Ca and gibberellins modify canopy source-sink relations and improve quality and shelf-life of 'Bing' sweet cherry 显示文摘 | Zhang Caixi Whiting Matthew | 2011 | Plant Growth Regalation2011，65，1： | 1 |
| 13 | Advances in Biochemical Screening for Phaeochromocytoma using Biogenic Amines显示文摘 | Malcolm J Whiting Matthew P | 2009 | Clin Biochem Rev2009，30，1： | 1 |
| 14 | Dynamic responses of sweet cherry trees under vibratory excitations显示文摘 | Xiaoqiang Du Du Chen Qin Zhang Patrick A. Scharf Matthew D. Whiting | 2012 | Biosystems Engineering2012，，3： | 1 |
| 15 | Neurovascular injuries of the spinal cord显示文摘 | White Matthew L Khoury E | 2002 | Eur J Radiol2002，42，2： | 1 |
| 16 | The role of radiologic studies in the evaluation and management of primary hyperaldosteronism显示文摘 | Matthew L. White Paul G. Gauger Gerard M. Doherty Kyung J. Cho Norman W. Thompson Gary D. Hammer Barbra S. Miller | 2008 | Surgery2008，，： | 1 |
| 17 | Neurovascular injuries of the spinal cord显示文摘 | White Matthew L EI Khoury George Y | 2002 | Eur J Radiol2002，42，2： | 1 |
| 18 | IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis显示文摘 | Colin D. White Matthew D. Brown David B. Sacks | 2009 | FEBS Letters2009，，12： | 1 |
| 19 | SAMHD1 Restricts Herpes Simplex Virus 1 in Macrophages by Limiting DNA Replication显示文摘 | Eui Tae Kim Tommy E. White Alberto Brandariz-Nú?ez Felipe Diaz-Griffero Matthew D. Weitzman | 2013 | Journal of Virology2013，，23： | 1 |
| 20 | The impact and outcomes of establishing an integrated interdisciplinary surgical team to care for the diabetic foot显示文摘 | David G. Armstrong Manish Bharara Matthew White Brian Lepow Sugam Bhatnagar Timothy Fisher Heather R. Kimbriel Jodi Walters Kaoru R. Goshima John Hughes Joseph L. Mills | 2012 | Diabetes Metab Res Rev2012，，6： | 1 |
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