|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical outcomes of isolated renal failure compared to other forms of organ failure in patients with severe acute pancreatitis显示文摘AIM To assess differences in clinical outcomes of isolated renal failure(RF) compared to other forms of organ failure(OF) in patients with severe acute pancreatitis(SAP).METHODS Using a prospectively maintained database of patients with acute pancreatitis admitted to a tertiary medical center between 2003 and 2016, those with evidence of persistent OF were classified to renal, respiratory, cardiovascular, or multi-organ(2 or more organs). Data regarding demographics, comorbidities, etiology of acute pancreatitis, and clinical outcomes were prospectively recorded. Differences in clinical outcomes after development of isolated RF in comparison to other forms of OF were determined using independent t and Mann-Whitney U tests for continues variables, and χ~2 test for discrete variables.RESULTS Among 500 patients with acute pancreatitis, 111 patients developed persistent OF: mean age was 54 years, and 75(67.6%) were male. Forty-three patients had isolated OF: 17(15.3%) renal, 25(21.6%) respiratory, and 1(0.9%) patient with cardiovascular failure. No differences in demographics, etiology of acute pancreatitis, systemic inflammatory response syndrome scores, or development of pancreatic necrosis were seen between patients with isolated RF vs isolated respiratory failure. Patients with isolated RF were less likely to require nutritional support(76.5% vs 96%, P = 0.001), ICU admission(58.8% vs 100%, P = 0.001), and had shorter mean ICU stay(2.4 d vs 15.7 d, P < 0.001), compared to isolated respiratory failure. None of the patients with isolated RF or isolated respiratory failure died.CONCLUSION Among patients with SAP per the Revised Atlanta Classification, approximately 15% develop isolated RF. This subgroup seems to have a less protracted clinical course compared to other forms of OF. Isolated RF might be weighed less than isolated respiratory failure in risk predictive modeling of acute pancreatitis. | Amir Gougol Mohannad Dugum Anwar Dudekula Phil Greer Adam Slivka David C Whitcomb Dhiraj Yadav Georgios I Papachristou | 2017 | World Journal of Gastroenterology2017，23，29： | 20 |
| 2 | Significant association between ABO blood group and pancreatic cancer显示文摘AIM:To evaluate whether the ABO blood group is related to pancreatic cancer risk in the general population of the United States.METHODS:Using the University of Pittsburgh's clinicalpancreatic cancer registry,the blood donor database from our local blood bank (Central Blood Bank),and the blood product recipient database from the regional transfusion service (Centralized Transfusion Service) in Pittsburgh,Pennsylvania,we identified 274 pancreatic cancer patients with previously determined serological ABO blood group information.The ABO blood group frequency was compared between these patients and 708842 individual,community-based blood donors who had made donations to Pittsburgh's Central Blood Bank between 1979 and 2009.RESULTS:The frequency of blood group A was statistically significantly higher amongst pancreatic cancer patients compared to its frequency amongst the regional blood donors [47.63% vs 39.10%,odds ratio (OR)=1.43,P=0.004].Conversely,the frequency of blood group O was significantly lower amongst pancreatic cancer patients relative to the community blood donors (32.12% vs 43.99%,OR=0.60,P=0.00007).There were limited blood group B (n=38) and AB (n=17) pancreatic cancer patients;the overall P trend value comparing patient to donor blood groups was 0.001.CONCLUSION:The ABO blood group is associated with pancreatic cancer risk.Future studies should examine the mechanism linking pancreatic cancer risk to ABO blood group. | Julia B Greer Mark H Yazer Jay S Raval M Michael Barmada Randall E Brand David C Whitcomb | 2010 | World Journal of Gastroenterology2010，16，44： | 10 |
| 3 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 4 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 5 | Shipboard Systems Deploy Automated Protection显示文摘 | Butler K L Sarma N D R Whitcomb C A | 1998 | IEEE Computer Applications in Power1998，11，2： | 1 |
| 6 | Phylogeny of the Grassland Leafhopper Genus Flexamia( Homoptera: Cicadellidae)hased on Mitochondrial DNA Sequences显示文摘 | DIETRICH C H WHITCOMB R F BLACK W C | 1997 | Mol Phylogenetic Evol1997，8，2： | 1 |
| 7 | In situ alignment calibration of attitude and doppler sensors for precision underwater vehicle navigation: theory and experiment显示文摘 | Kinsey J C Whitcomb L L | 2007 | IEEE Journal of Oceanic Engineering2007，32，2： | 1 |
| 8 | Genetics and alcohol: a lethal combination in pancreatic disease? 显示文摘 | WHITCOMB D C | 2011 | Alcohol Clin Exp Res2011，35，5： | 1 |
| 9 | lAP Guidelines for the Surgical Management of Acute Pancreatitis显示文摘 | Uhl W Warshaw A Imrie C Bassi C McKay C J Lankisch PG Carter R Di Magno E Banks PA Whitcomb DC | 2002 | Panereatology2002，2，6： | 1 |
| 10 | Performance characteristics of a cascaded two-level converter显示文摘 | Corzine K A Sudhoff S D Whitcomb C A | 1999 | IEEE Transactions on Energy Conversion1999，14，3： | 1 |
| 11 | Imprinted polymers as protecting groups for regioselective modification of polyfunctional substrates显示文摘 | Smith C R Whitcombe M J | 1999 | J Am Chem Soc1999，12，28： | 1 |
| 12 | Predictors of severity and necrosis in acute pancreatictics 显示文摘 | Papachristou G I Whitcomb D C | 2004 | Castroenterol Clin North Am2004，33，4： | 1 |
| 13 | Optimal current control stratagies for suffaco-monnted permanent-magnet synchronous machine drives显示文摘 | CHAPMAN P L SUDHOFF S D WHITCOMB C A | 1999 | IEEE Trans on Energy Convention1999，14，4： | 1 |
| 14 | 查看详情显示文摘 | Alexander C Andersson H S Andersson L I Ansell R J Kirsch N Nicholls I A O'Mahony J Whitcombe M J | | 0，，： | 1 |
| 15 | Genetics of alcoholic and nonalcoholic pancrea- titis显示文摘 | WHITCOMB D C | 2012 | Curr Opin Gastroenterol2012，28，5： | 1 |
| 16 | How to think about SPINK and pancreatitis显示文摘 | David C Whitcomb | 2002 | The American Journal of Gastroenterology2002，，5： | 1 |
| 17 | Molecular imprinting science and technology:a survey of the literature for the years up to and including 2003显示文摘 | ALEXANDER C ANDERSSON H S ANDERSSON L I ANSELL R J KIRSCH N NICHOLLS I A OMAHONY J WHITCOMBE M J | 2006 | J Mol Recognit2006，19，2： | 1 |
| 18 | Alcoholic pancreatitis显示文摘 | Hanck C Whitcomb DC | 2004 | Gastroenterol Clin North Am2004，33，4： | 1 |
| 19 | Genetic risk factors for pancreatic disorders 显示文摘 | WHITCOMB D C | 2013 | Gastroenterology2013，144，6： | 1 |
| 20 | Broad nucleoside reverse-transcriptase inhibitor cross-resistance in human immunodeficiency virus type 1 clinical isolates 显示文摘 | Whitcomb JM Parkin NT Chappey C | 2003 | J Infect Dis2003，188，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员