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| 1 | 人不同转移潜能前列腺癌细胞系的放射敏感性异质性及其机理观察显示文摘目的:研究人不同转移潜能前列腺癌细胞系PC-3M-2B4(低转移潜能)和PC-3M-IE8(高转移潜能)放射敏感性异质性及其机理。方法:通过流式细胞仪、荧光显微镜、电镜和Western-blot检测PC-3M-2B4和PC-3M-IE8凋亡能力的差别及凋亡相关蛋白Bcl-2、Bax、Caspase-3表达的差异,来证实人不同转移潜能前列腺癌细胞与放射敏感性的关系。结果:PC-3M-2B4和PC-3M-IE8两种细胞的凋亡率都随着照射后时间的延长而增加,但PC-3M-2B4比PC-3M-IE8凋亡率高,且差异有统计学意义(P<0.05);抗凋亡蛋白Bcl-2表达时间依赖性递减,而促凋亡蛋白Bax和Caspase-3表达明显升高。结论:人不同转移潜能前列腺癌细胞系,其转移能力与放射敏感性有关,转移能力低的对放射敏感性高。 | 陈东波 杨莉萍 | 2014 | 中外医学研究2014，12，23： | 2 |
| 2 | Enhancement of radiosensitivity of MCF-7 breast cancer cells subjected to X-ray or carbon-ion irradiations显示文摘The sensitivity of cancer cells to radiation therapy varies based on cell cycle phase. Here we evaluated the differences between X-ray and carbon-ion irradiation with respect to cellular radiosensitivity and cancer cycle arrest in the breast cancer cell line, MCF-7. The cell survival rate, cell cycle distribution and the presence of apoptosis were measured by clonogenic assay and flow cytometry. BRCA1 and p21 protein levels were analyzed by Western blot, and the levels of human telomerase reverse transcriptase(h TERT) m RNA expression and telomere length were detected with real-time polymerase chain reaction. The results show a significant dose-dependent effects on survival rate, apoptosis and protein levels in the carbon-ion group of MCF-7 cells. Decreased proliferation was not observed at 2 Gy X-ray irradiation. There were significant differences in cellular cycle arrest, apoptosis percentages and BRCA1 and p21 protein expression between X-ray and heavy-ion groups. The results indicatedthat increasing in BRCA1 and p21 expression, and attenuation of h TERT gene expression induced by heavy-ion irradiation in MCF-7 cells might relate to mechanism of cellular radiosensitivity in G2/M arrested phase. | Yi Xie Bing Wang Kaoru Tanaka Hong-Yan Li Qiu-Yue Zhao Hong Zhang | 2016 | Nuclear Science and Techniques2016，27，1： | 0 |
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