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| 1 | Current management of spontaneous intracerebral haemorrhage显示文摘Intracerebral haemorrhage(ICH)is the most devastating and disabling type of stroke.Uncontrolled hypertension(HTN)is the most common cause of spontaneous ICH.Recent advances in neuroimaging,organised stroke care,dedicated Neuro-ICUs,medical and surgical management have improved the management of ICH.Early airway protection,control of malignant HTN,urgent reversal of coagulopathy and surgical intervention may increase the chance of survival for patients with severe ICH.Intensive lowering of systolic blood pressure to<140 mm Hg is proven safe by two recent randomised trials.Transfusion of platelets in patients on antiplatelet therapy is not indicated unless the patient is scheduled for surgical evacuation of haematoma.In patients with small haematoma without significant mass effect,there is no indication for routine use of mannitol or hypertonic saline(HTS).However,for patients with large ICH(volume>30 cbic centmetre)or symptomatic perihaematoma oedema,it may be beneficial to keep serum sodium level at 140–150 mEq/L for 7–10 days to minimise oedema expansion and mass effect.Mannitol and HTS can be used emergently for worsening cerebral oedema,elevated intracranial pressure(ICP)or pending herniation.HTS should be administered via central line as continuous infusion(3%)or bolus(23.4%).Ventriculostomy is indicated for patients with severe intraventricular haemorrhage,hydrocephalus or elevated ICP.Patients with large cerebellar or temporal ICH may benefit from emergent haematoma evacuation.It is important to start intermittent pneumatic compression devices at the time of admission and subcutaneous unfractionated heparin in stable patients within 48 hours of admission for prophylaxis of venous thromboembolism.There is no benefit for seizure prophylaxis or aggressive management of fever or hyperglycaemia.Early aggressive comprehensive care may improve survival and functional recovery. | Cyrus K Dastur Wengui Yu | 2017 | Stroke & Vascular Neurology2017，2，1： | 18 |
| 2 | Stenting for intracranial stenosis:potential future for the prevention of disabling or fatal stroke显示文摘Intracranial stenosis is a common cause of ischaemic strokes,in particular,in the Asian,African and Hispanic populations.The randomised multicentre study Stenting and Aggressive Medical Management for the Prevention of Recurrent stroke in Intracranial Stenosis(SAMMPRIS)showed 14.7% risk of stroke or death in the stenting group versus 5.8% in the medical group at 30 days,and 23% in the stenting group versus 15% in the medical group at a median follow-up of 32.4 months.The results demonstrated superiority of medical management over stenting and have almost put the intracranial stenting to rest in recent years.Of note,16 patients(7.1%)in the stenting group had disabling or fatal stroke within 30 days mostly due to periprocedural complications as compared with 4 patients(1.8%)in the medical group.In contrast,5 patients(2.2%)in the stenting group and 14 patients(6.2%)in the medical group had a disabling or fatal stroke beyond 30 days,indicating significant benefit of stenting if periprocedural complications can be reduced.Recently,the results of the Chinese Angioplasty and Stenting for Symptomatic Intracranial Severe Stenosis trial and the Wingspan Stent System Post Market Surveillance Study(WEAVE trial)showed 2%-2.7% periprocedural complications.It is time to evaluate the role of intracranial stenting for the prevention of disabling or fatal stroke. | Wengui Yu Wei-Jian Jiang | 2018 | Stroke & Vascular Neurology2018，3，3： | 11 |
| 3 | Outcome of patients with 》70% symptomatic intracranial stenosis after wingspan stenting显示文摘 | Jiang Weijian YU Wengui DU Bin | | 0，，05： | 1 |
| 4 | Hypoplasia or Occlusion of the Ipsilateral Cranial Venous Drainage Is Associated With Early Fatal E- dema of Middle Cerebral Artery Infarction 显示文摘 | Wengui Yu Rives J Welch B | 2009 | Stroke2009，40，12： | 1 |
| 5 | Update in the treatment of extracranial atherosclerotic disease for stroke prevention显示文摘Stroke is a leading cause of adult mortality and disability worldwide.Extracranial atherosclerotic disease(ECAD),primarily,carotid artery stenosis,accounts for approximately 18%-25%of ischaemic stroke.Recent advances in neuroimaging,medical therapy and interventional management have led to A significant reduction of stroke from carotid artery stenosis.The current treatment of ECAD includes optimal medical therapy,carotid endarterectomy(CEA)and carotid artery stenting(CAS).The selection of treatments depends on symptomatic status,severity of stenosis,individual factors,efficacy and risk of complications.The aim of this paper is to review current evidence and guidelines on the management of carotid artery stenosis,including the comparison of medical and interventional therapy(CAS and CEA),as well as future directions. | Zhu Zhu Wengui Yu | 2020 | Stroke & Vascular Neurology2020，5，1： | 1 |
| 6 | 急性缺血性脑卒中治疗基准数据的改进研究显示文摘目的尽管组织纤溶酶原激动剂(tPA)静脉溶栓治疗和血管内取栓治疗(EVT)是急性缺血性脑卒中(AIS)的有效治疗手段;但在临床实践中,启动上述治疗时间往往有延误。作者检验了美国单个高级卒中中心的质控数据,以期报道其在急性卒中处理的持续性质控基准数据改进情况。方法本研究纳入2013年1月-2018年12月美国单个高级卒中中心连续性的缺血性脑卒中患者。根据美国心脏协会(AHA)的卒中代码和2015年实施的简明改进协议对脑卒中患者进行管理。人口统计学和临床数据来自遵照指南(GWTG)-卒中登记处和电子病历。按照入院和实施质控改进举措的日期将患者分为3组。使用线性回归模型和Jonckheere-Terpstra检验分析质控指标,质控指标包括静脉tPA溶栓治疗和EVT率、入院-溶栓开始(DTN)时间和入院-动脉穿刺(DTP)时间。结果本研究共纳入1369例发病24h内的卒中患者,2013-2014年、2015-2016年和2017-2018年的静脉tPA溶栓率分别为20%、30%和22%;EVT率分别为9%、14%和15%。根据Jonckheere-Terpstra检验,DTN时间的中位数(57、45、39 min;P<0.001)和DTP时间中位数(172、130、114 min;P=0.009)在以上3个时间段内得到连续性的改善;2017年1月-2018年12月,80%的患者DTN时间≤60 min,63%的患者DTN时间≤45 min。结论遵循AHA指南和简明改进协议后,AIS的静脉溶栓/EVT率和治疗启动时间得到了不断改进。 | 刘诗蒙 Yu Wengui | 2021 | 脑与神经疾病杂志2021，29，11： | 0 |
| 7 | Coagulopathy reversal in intracerebral haemorrhage显示文摘As intracerebral hemorrahge becomes more frequent as a result of an aging population with greater comorbidities,rapid identification and reversal of precipitators becomes increasingly paramount.The aformentioned population will ever more likely be on some form of anticoagulant therapy.Understanding the mechanisms of these agents and means by which to reverse them early on is critical in managing the acute intracerebral hemorrhage. | Alexander Jacob Sweidan Navneet Kaur Singh Joseph Luke Conovaloff Matthew Bower Leonid I Groysman Mohammad Shafie Wengui Yu | 2020 | Stroke & Vascular Neurology2020，5，1： | 0 |
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