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| 1 | Gastrointestinal perforation in metastatic colorectal cancer patients with peritoneal metastases receiving bevacizumab显示文摘AIM:To investigate the safety and efficacy of adding bevacizumab to first-line chemotherapy in metastatic colorectal cancer patients with peritoneal disease.METHODS:We compared rates of gastrointestinal perforation in patients with metastatic colorectal cancer and peritoneal disease receiving first-line chemotherapy with and without bevacizumab in three distinct cohorts:(1) the AGITG MAX trial(Phase Ⅲ randomised clinical trial comparing capecitabine vs capecitabine and bevacizumab vs capecitabine,bevacizumab and mitomycin C);(2) the prospective Treatment of Recurrent and Advanced Colorectal Cancer(TRACC) registry(any first-line regimen ± bevacizumab);and(3) two cancer centres in New South Wales,Australia [Macarthur Cancer Therapy Centre and Liverpool Cancer Therapy Centre(NSWCC) from January 2005 to Decenber 2012,(any first-line regimen ± bevacizumab).For the AGITG MAX trial capecitabine was compared to the other two arms(capecitabine/bevacizumab and capecitabine/bevacizumab/mitomycin C).In the AGITG MAX trial and the TRACC registry rates of gastrointestinal perforation were also collected in patients who did not have peritoneal metastases.Secondary endpoints included progression-free survival,chemotherapy duration,and overall survival.Time-toevent outcomes were estimated using the Kaplan-Meier method and compared using the log-rank test.RESULTS:Eighty-four MAX,179 TRACC and 69 NSWCC patients had peritoneal disease.There were no gastrointestinal perforations recorded in either the MAX subgroup or the NSWCC cohorts.Of the patients without peritoneal disease in the MAX trial,4/300(1.3%) in the bevacizumab arms had gastrointestinal perforations compared to 1/123(0.8%) in the capecitabine alone arm.In the TRACC registry 3/126(2.4%) patients who had received bevacizumab had a gastrointestinal perforation compared to 1/53(1.9%) in the chemotherapy alone arm.In a further analysis of patients without peritoneal metastases in the TRACC registry,the rate of gastrointestinal perforations was 9/369(2.4%) in the chemotherapy/bevacizumab group and 5/177(2.8%) in the chemotherapy alone group.The addition of bevacizumab to chemotherapy was associated with improved progression-free survival in all three cohorts:MAX 6.9 m vs 4.9 m,HR = 0.64(95%CI:0.42-1.02);P = 0.063;TRACC 9.1 m vs 5.5 m,HR = 0.61(95%CI:0.37-0.86);P = 0.009;NSWCC 8.7 m vs 6.8 m,HR = 0.75(95%CI:0.43-1.32);P = 0.32.Chemotherapy duration was similar across the groups.CONCLUSION:Patients with peritoneal disease do not appear to have an increased risk of gastrointestinal perforations when receiving first-line therapy with bevacizumab compared to systemic therapy alone. | Aflah Roohullah Hui-Li Wong Katrin M Sjoquist Peter Gibbs Kathryn Field Ben Tran Jeremy Shapiro Joe Mckendrick Desmond Yip Louise Nott Val Gebski Weng Ng Wei Chua Timothy Price Niall Tebbutt Lorraine Chantrill | 2015 | World Journal of Gastroenterology2015，21，17： | 3 |
| 2 | 权重式多Agent作业计划及其在Job Shop中的应用显示文摘提出了一种新的分布式多Agent通用作业计划编制体系。为体系中每个设备、任务和控制中心设计了计划编制Agent,以计算竞争作业的评价指数 ,根据车间的特征决定各Agent的权重 ,并用加权平均方式确定各竞争作业的最终评价指数。将这种一般策略应用于JobShop生产系统的最小交工延迟问题 ,与以往的启发式算法相比 。 | 任海英 Weng M X | 2004 | 中国机械工程2004，15，6： | 3 |
| 3 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 4 | Electronic structure and optical properties of the Co-doped anatase TiO2 studied from first principles 显示文摘 | Weng H M Yang X P Dong J M | 2004 | Phys Rev2004，69，12： | 1 |
| 5 | HT-7U TF and PF conductor design显示文摘 | Weng P D Bi Y F Chen Z M | 2000 | Cryogenics2000，40，810： | 1 |
| 6 | Comparative studies on the hypolipidemic and growth suppressive effects of oolong, black, pu-erh, and green tea leaves in rats显示文摘 | Kuo K L Weng M S Chiang C T | 2005 | Journal of Agricultural and Food Chemistry2005，53，2： | 1 |
| 7 | Size- and density-controlled synthesis of TiO2 nanodots on a substrate by phase-separation-induced self-assembly 显示文摘 | LUO M CHENG K WENG W J | 2009 | Nanotechnology2009，20，21： | 1 |
| 8 | Video object tracking using adaptive Kalman filter显示文摘 | WENG S K KUO C M TU S K | 2006 | Journal of Visual Communication and Image Representation2006，17，6： | 1 |
| 9 | Improved high Q value of MgTiO3-CaTiO3 microwave dielectric ceramics at low sintering temperature显示文摘 | Weng M H | 2001 | Materials Research Bulletin2001，36，： | 1 |
| 10 | Pu-erh tea supple-mentation suppresses fatty acid synthase expression in the rat liverthrough downregulating Akt and JNK signalings as demonstrated inhuman hepatoma HepG2 cells显示文摘 | CHIANG C T WENG M S LIN-SHIAU S Y | 2006 | Oncology Research Featuring Pre-clinical and Clinical Cancer Therapeutics2006，16，3： | 1 |
| 11 | Effects of additives on micro-structures and microwave dielectric properties of (Zr,Sn)TiO4 ceramics显示文摘 | Huang C L Weng M H Chen H L | 2001 | Mater Chem Phys2001，71，： | 1 |
| 12 | Effects of addtives on microstructure and microwave dielectric properties of (Zr,Sn) TiO4 ceramics显示文摘 | HUANG C L WENG M H CHEN H L | 2001 | Mater Chem Phys2001，71，： | 1 |
| 13 | Wavelets period doubling and timefrequency localization with applleatlon to organization of con vection over the tropical western Pacific显示文摘 | Hengyi Weng K M Lau | 1994 | J Atmos Sci1994，51，17： | 1 |
| 14 | Camera calibration with distortion models and accuracy evaluation 显示文摘 | WENG J COHEN P HERNIOU M | 1992 | PAMI1992，14，10： | 1 |
| 15 | Genetic variation of Zoysia as revealed by Random Amplified Polymorphic DNA ( RAPD) and Isozyme pattern 显示文摘 | Weng J H Fan M J Lin Y | 2007 | Planttion Science2007，10，： | 1 |
| 16 | Identification and expression cloning of a leptin receptor, OB - R 显示文摘 | TARTAGLIA L A DEMBSKI M WENG X | 1995 | Cell1995，83，7： | 1 |
| 17 | Antiviral effect of epigallocatechin gallate on enterovirus 71显示文摘 | Ho H Y Cheng M L Weng S F | | 0，，14： | 1 |
| 18 | Prevalence of diabetes among men and women in China显示文摘 | Yang W Y Lu J M Weng J P | 2010 | New England Journal of Medicine2010，362，： | 1 |
| 19 | HT-7U TF and PF conductor design显示文摘 | Weng P D Bi Y F Chen Z M | 2000 | Cryogenics2000，40，8： | 1 |
| 20 | Assessment of tobacco heating system 2.4 on osteogenic differentiation of mesenchymal stem cells and primary human osteoblasts compared to conventional cigarettes显示文摘BACKGROUND Cigarette smoking(CS)is the most common method of consuming tobacco.Deleterious effects on bone integrity,increased incidence of fractures,and delayed fracture healing are all associated with CS.Over 150 of the 6500 molecular species contained in cigarette smoke and identified as toxic compounds are inhaled by CS and,via the bloodstream,reach the skeletal system.New technologies designed to develop a reduced-risk alternative for smokers are based on electronic nicotine delivery systems,such as e-cigarettes and tobacco heating systems(THS).THS are designed to heat tobacco instead of burning it,thereby reducing the levels of harmful toxic compounds released.AIM To examine the effects of THS on osteoprogenitor cell viability and function compared to conventional CS.METHODS Human immortalized mesenchymal stem cells(n=3)and primary human preosteoblasts isolated from cancellous bone samples from BG Unfall Klinik Tübingen(n=5)were osteogenically differentiated in vitro with aqueous extracts generated from either the THS 2.4“IQOS”or conventional“Marlboro”cigarettes for up to 21 d.Cell viability was analyzed using resazurin conversion assay(mitochondrial activity)and calcein-AM staining(esterase activity).Osteogenic differentiation and bone cell function were evaluated using alkaline phosphatase(AP)activity,while matrix formation was analyzed through alizarin red staining.Primary cilia structure was examined by acetylatedα-tubulin immunofluorescent staining.Free radical production was evaluated with 2’,7’-dichlorofluoresceindiacetate assay.RESULTS Our data clearly show that THS is significantly less toxic to bone cells than CS when analyzed by mitochondrial and esterase activity(P<0.001).No significant differences in cytotoxicity between the diverse flavors of THS were observed.Harmful effects from THS on bone cell function were observed only at very high,non-physiological concentrations.In contrast,extracts from conventional cigarettes significantly reduced the AP activity(by two-fold)and matrix mineralization(four-fold)at low concentrations.Additionally,morphologic analysis of primary cilia revealed no significant changes in the length of the organelle involved in osteogenesis of osteoprogenitor cells,nor in the number of ciliated cells following THS treatment.Assessment of free radical production demonstrated that THS induced significantly less oxidative stress than conventional CS in osteoprogenitor cells.CONCLUSIONTHS was significantly less harmful to osteoprogenitor cells during osteogenesisthan conventional CS. Additional studies are required to confirm whether THS isa better alternative for smokers to improve delays in bone healing followingfracture. | Romina H Aspera-Werz Sabrina Ehnert Monja Müller Sheng Zhu Tao Chen Weidong Weng Johann Jacoby Andreas K Nussler | 2020 | World Journal of Stem Cells2020，12，8： | 1 |
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