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| 1 | High absorption large-mode area step-index fiber for tandem-pumped high-brightnes shigh-power lasers显示文摘A short absorption length ytterbium(Yb)-doped large-mode area(LMA)fiber is presented as a step forward to mitigate the stern problem of nonlinear scatterings in a tandem pumping scheme adopted for high-power fiber laser.The short absorption length was realized by incorporating high Yb concentration in the fiber core.Furthermore,by replacing the inherent silica cladding with a Ge-doped cladding,we were able to obtain low core numerical aperture(NA)and negate the detrimental effect of index-raising by high Yb concentrations.This overcomes the long-standing limitation in step-index Yb-doped fibers(YDFs)where high cladding absorption inevitably results in high NA,thus hampering single-mode operation.We report an LMA(~575μm^2)YDF with NA of 0.04 and absorption of 27 dB/m at 976 nm both traits promote power scaling of single-mode tandem pumped fiber lasers.To our knowledge,this is the highest cladding absorption attained in a low-NA step-index fiber to date.An all-fiber tandem-pumped amplifier was built using only^14 m of the YDF.The amplifier delivered a near-Gaussian beam(M^i.27)at 836 W output power(pump power limited)with a high slope efficiency of^83%.Thanks to the short length and the tandem pumping,no indication of limiting factors such as stimulated Raman scattering,photodarkening,and transverse mode instability was observed. | KANG-JIE LIM SAMUEL KA-WEN SEAH JOASH YONG'EN YE WENDY WEIYING LIM CHU-PERNG SEAH YUNN-BOON TAN SUTING TAN HUITING LIM RAGHURAMAN SIDHARTHAN ARUMUGAM RAJENDRA PRASADH CHEN-JIAN CHAN SEONGWOO YOO SONG-LIANG CHUA | 2020 | Photonics Research2020，8，10： | 5 |
| 2 | EGFL7 Is Expressed in Bone Microenvironment and Promotes Angiogenesis via ERK, STAT3, and Integrin Signaling Cascades显示文摘 | Shek Man Chim Vincent Kuek Siu To Chow Bay Sie Lim Jennifer Tickner Jinmin Zhao Rosa Chung Yu‐Wen Su Ge Zhang Wendy Erber Cory J. Xian Vicki Rosen Jiake Xu | 2015 | Physiol2015，，1： | 1 |
| 3 | 抗磷脂抗体综合征的诊治—系统综述显示文摘背景:抗磷脂抗体是指可与磷脂结合蛋白发生作用的抗体。抗磷脂抗体综合征(antiphospholipid antibody syndrome,APS)涉及抗磷脂抗体与血栓形成风险或病态妊娠之间的联系。APS患者反复发生动、静脉血栓形成或流产的危险增加。
目的:在抗磷脂抗体阳性或者APS患者中,对血栓形成危险的治疗证据进行系统评估。
证据收集:于MEDLINE(1966年至2005年11月)和Cochrane图书馆电子数据库(2005年)中检索相关随机试验、随机试验汇总分析以及于抗磷脂抗体阳性或APS患者中进行的血栓形成危险治疗前瞻性队列研究。对检出研究的参考文献亦予检索。研究的选择基于临床相关性。
证据综合:在抗磷脂抗体阳性的患者中,既往未发生栓塞事件的健康者新发血栓的绝对危险较低(每年〈1%);既往无血栓形成事件但反复流产的女性新发血栓的危险中度升高(每年10%);有静脉血栓形成史的患者在停止抗凝治疗6个月内危险最高(每年〉10%)。与安慰剂或未治疗对照组相比,无论抗磷脂抗体是否为阳性,中等强度华法令抗凝治疗(调整目标INR为2.0~3.0)均可使复发静脉血栓形成的危险降低80%~90%,并且对预防动脉血栓复发也有效。没有高强度华法令抗凝(目标INR〉3.0)比中等强度华法令抗凝更为有效的证据。对于抗磷脂抗体阳性且既往有脑卒中的患者而言,阿斯匹林与中等强度华法令预防卒中复发的效果相同。临床试验未涉及的治疗问题或者证据不一的问题包括:预防性抗血栓治疗对无栓塞史的抗磷脂抗体阳性患者的作用,非脑血管动脉血栓形成的最佳治疗,华法令治疗后血栓复发以及抗磷脂抗体阳性并反复流产女性的治疗。
结论:对于APS患者而言,中等强度华法令可有效预防静脉血栓复发,对预防动脉血栓形成也可能有效。对于有脑卒中史且抗磷脂抗体阳性的患者,阿斯匹林预防卒中复发的效果与中等强度华法令相同。对于APS患者血栓形成其他方面的最佳治疗,还需要设计良好的前瞻性研究予以阐明。 | Wendy Lim, MD Mark A. Crowther, MD John W. Eikelboom, MBBS 周佳鑫(译) 唐福林(校) | 2007 | 美国医学会杂志(中文版)2007，26，1： | 1 |
| 4 | The ameri- can society of hematology 2011 evidence-based practice guideline for immune thrombocytopenia显示文摘 | Cindy Neunert Wendy Lim Mark Crowther | 2011 | blood2011，117，： | 1 |
| 5 | Clinical guideline update on Immune thrombocytopenia: an evidence based practice guideline developed by the ArncricanSocicty of Hematology 显示文摘 | Cindy Neunert Wendy Lim | 2011 | Blood2011，117，16： | 1 |
| 6 | MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing显示文摘 | Andrew Grimson Kyle Kai-How Farh Wendy K. Johnston Philip Garrett-Engele Lee P. Lim David P. Bartel | 2007 | Molecular Cell2007，，1： | 1 |
| 7 | Has the incidence of deep vein thrombosis in patients undergoing total hip/knee arthroplasty changed over time A systematic review of randomized controlled trials 显示文摘 | Katharine He Xing Gareth Morrison Wendy Lim | 2008 | Thrombosis Re- search2008，123，： | 1 |
| 8 | Antiphospholipid antibody syndrome显示文摘 | Wendy Lim | 2009 | American Society of Hematology2009，，： | 1 |
| 9 | Clinical guideline update on Immune thrombocytopenia: an evidencebased practice guide- line developed by the American Society of Hematology 显示文摘 | Cindy Neunert Wendy Lim Mark Crowther | 2011 | Blood2011，189，16： | 1 |
| 10 | Has the incidence of deep vein thrombosis in patients undergoing total hip/knee arthroplasty changed over time a sys tematic review of randomized controlled trials显示文摘 | KATHARINE HE XING GARETH MORRISON WENDY LIM | 2008 | Thrombosis Research2008，123，： | 1 |
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