|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | 人类组织中未识别的间质结构及其分布显示文摘基于探针的共聚焦激光显微镜(pCLE)是一种体内实时成像技术,通常在静脉注射荧光素后,对深度60~70μm的人体组织进行结构评估。在未知解剖关系的肝外胆管pCLE检查中,充满荧光素的窦隙由20μm宽的黑暗分支带围绕大的多边形空间,呈现网状模式(reticular pattern),冷冻活检证实为黏膜下层的一部分。 | 张仕强 方三高 Benias P C Wells R G Sackey-Aboagye B | 2018 | 临床与实验病理学杂志2018，34，11： | 7 |
| 3 | Gamma knife stereotactic radiosurgery for the management of incidentally-identified brain metastasis from non-small cell lung cancer显示文摘 | Marko NF Suh JH Chao ST Barnett GH Vogelbaum MA Toms S Well R J Angelov L | 2011 | 中国神经肿瘤杂志2011，9，1： | 4 |
| 4 | Faecalibacterium prausnitzii and human intestinal health显示文摘 | S Miquel R Martín O Rossi LG Bermúdez-Humarán JM Chatel H Sokol M Thomas JM Wells P Langella | 2013 | Current Opinion in Microbiology2013，，： | 3 |
| 5 | Importance of left atrial appendage flow as a predictor of thromboembolic events in patients with atrial fibrillation显示文摘 | Kamp O Verhorst P M J Welling R C | 1999 | Eur Heart J1999，20，13： | 1 |
| 6 | Application of pressurized liquid extraction technology to pharmaceutical solid dosage from analysis显示文摘 | Hoang TH Farkas R Wells C | 2002 | Journal of Chromatography A2002，968，： | 1 |
| 7 | Reducing bladder artifactsin clinical pelvic SPECT Images显示文摘 | Wells R G Farncombe T Chang E | 2004 | The Journal of Nuclear Medicine2004，45，： | 1 |
| 8 | A network meta-analysis ofrandomized controlled trials of biologies for rheumatoid arthritis: aCochrane overview显示文摘 | Singh JA Christensen R Wells GA^ | 2009 | CMAJ2009，181，11： | 1 |
| 9 | Derivation of a simple clinical model to categorize patients probalfility of pulmonary embolism:increasing the models utility with the SimpliRed D-Dimmer显示文摘 | Wells P S Anderson D R Rodger M | 2000 | Thromb Haemost2000，83，： | 1 |
| 10 | Evaluation of time- temperature related quality changes in icecream during storage 显示文摘 | DOLAN K D SINGH R P WELLS J H | 1985 | Journal of Food Processing and Preservation1985，9，： | 1 |
| 11 | Factors associated with pressure ulcers in adults in acute care hospitals显示文摘 | FISH ER A R WELL S G HARRISON M B | 2004 | Holist Nurs Pract2004，18，5： | 1 |
| 12 | Transport of genistein-7-glucoside by human intestinal Caco-2 cells: poteintial role for MRP2 显示文摘 | Wells U K French K L Walgren R A | 1999 | Res Comm Mole Pathol Pharm1999，103，1： | 1 |
| 13 | Optimization of a bath for electroless plating and its use for the produc- tion of nickel - phosphorus - silicon carbide coatings 显示文摘 | Kalantary M R Holbrook K A Wells P B | 1993 | Transaction of Institute of Metal Finishing1993，71，2： | 1 |
| 14 | Adaptive segmentation of MRI data 显示文摘 | Wells W Grimson W Kikinis R | 1996 | IEEE Transactions on Medical Imaging1996，15，4： | 1 |
| 15 | Two sesquiterpene furans with new carbocyclic ringsystems and related thiol acetates from a species of thesponge genus Dysidea显示文摘 | KAZLAUSKAS R MURPHY P T WELLS R J | 1978 | Tetrahedron Lett1978，49，： | 1 |
| 16 | Cardiac resynchronization therapy: a meta-analysis of randomized controlled trials显示文摘 | Wells G Parkash R Healey JS | | CMAJ0，183，42： | 1 |
| 17 | Seasonal Fluctuation in ^15N of groundwater nitrate in a mantled karst aquifer due to macropore transport of fertilize-derived nitrate显示文摘 | Wells E R Krothe N C | 1989 | J Hydrol1989，112，： | 1 |
| 18 | Correlation of time temperature indicator response with microbial growth in pasteurized milk 显示文摘 | GRISIUS R WELLS J H BARRET E L | 1987 | Journal of Food Processing and Preservation1987，11，： | 1 |
| 19 | Semiparametric inference for a quantile comparison function with applications to receiver operating characteristic curves 显示文摘 | Li G Tiwari R C and Wells M T | 1999 | Biometrika1999，86，： | 1 |
| 20 | Function of the hemoglobin and the gas bubble in the back- swimmer Anisops assimilis ( Hemiptera: Notonectidae )显示文摘 | WELLS R M G HUDSON M J BRITFAIN T | 1981 | Comp Physiol B Biochem Syst Environ Physiol1981，142，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员