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| 1 | Apoptosis and Proinflammatory Cytokine Responses of Primary Mouse Microglia and Astrocytes Induced by Human H1N1 and Avian H5N1 Influenza Viruses显示文摘Patients with an influenza virus infection can be complicated by acute encephalopathy and encephalitis. To investigate the immune reactions involved in the neurocomplication,mouse microglia and astrocytes were isolated,infected with human H1N1 and avian H5N1 influenza viruses,and examined for their immune responses. We observed homogeneously distributed viral receptors,sialic acid (SA)-α2,3-Galactose (Gal) and SA-α2,6-Gal,on microglia and astrocytes. Both viruses were replicative and productive in microglia and astrocytes. Virus-induced apoptosis and cytopathy in infected cells were observed at 24 h post-infection (p.i.). Expression of IL-1β,IL-6 and TNF-α mRNA examined at 6 h and 24 h p.i. was up-regulated,and their expression levels were considerably higher in H5N1 infection. The amounts of secreted proinflammatory IL-1β,IL-6 and TNF-α at 6 h and 24 h p.i. were also induced,with greater induction by H5N1 infection. This study is the first demonstration that both human H1N1 and avian H5N1 influenza viruses can infect mouse microglia and astrocytes and induce apoptosis,cytopathy,and proinflammatory cytokine production in them in vitro. Our results suggest that the direct cellular damage and the consequences of immunopathological injury in the CNS contribute to the influenza viral pathogenesis. | Gefei Wang Juan Zhang Weizhong Li Yun Su Yuanli Gao Heng Zhang Guimei Lin Xiaoyang Jiao Kangsheng Li | 2008 | Cellular & Molecular Immunology2008，5，2： | 28 |
| 2 | Comparison of the effect and safety of Kuntai capsule and hormone replacement therapy in patients with perimenopausal syndrome:a systematic review and Meta-analysis显示文摘OBJECTIVE: To assess the effectiveness and safety of Kuntai capsule and hormone replacement therapy in treatment of perimenopausal syndrome.METHODS: Articles were retrieved from the databases Cochrane Database of Systematic Reviews,Pub Med, Chinese National Knowledge Infrastructure, China Science and Technology Journal Database, and Wanfang Database. Only randomized controlled trials were included; 15 trials involving1243 patients were identified from January 2005 to April 2015. A systemic review and Meta-analysis of publications was performed. The review was limit-ed to randomized controlled trials that compared Kuntai capsule and hormone replacement therapy to treat perimenopausal syndrome for at least 3months. The primary outcome assessed was the treatment efficacy at 3 months, including effective rate of Kupperman menopausal scores, Kupperman menopausal scores, and blood estradiol(E2) or blood follicle stimulating hormone(FSH) levels.Other outcomes assessed were safety or adverse events, such as gastrointestinal complaints, breast distending pain, or vaginal bleeding.RESULTS: Kupperman menopausal scores showed no significant difference in effective rate [odds ratio(OR): 1.05, 95% confidence intervals(CI): 0.71 to1.55] and changes in FSH level [mean difference(MD): 2.14, 95% CI:-2.36 to 6.65]. There was a significant statistical difference in Kupperman menopausal scores(MD:-1.14, 95% CI:-2.03 to-0.25)and changes in E2level(MD:-16.41, 95% CI:-18.83to-13.69). There were fewer adverse events in the Kuntai capsule group than in the hormone replacement therapy group(OR: = 0.35, 95% CI: 0.25 to0.48, P < 0.01).CONCLUSION: Compared with hormone replacement therapy, Kuntai capsule can improve perimenopausal symptoms and blood E2 levels, and reduce the incidence of adverse events. | Du Xiaoqin Xu Lin Wang Lijun Heng Mingli Bu Huaien Hao Yu Tian Jinhui | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 28 |
| 3 | High entropy defective fluorite structured rare-earth niobates and tantalates for thermal barrier applications显示文摘Rare-earth tantalates and niobates(REjTaO7 and REjNbO7)have been considered as promising candidate thermal barrier coating(TBC)materials in next generation gas-turbine engines due to their ultra-low thermal conductivity and better thermal stability than yttria-stabilized zirconia(YSZ).However,the low Vickers hardness and toughness are the main shortcomings of RE;TaO-and REjNbOr that limit their applications as TBC materials.To increase the hardness,high entropy(Yu3Ybu3Er/3)sTaOr,(Y13YbnErns)NbO,and(Sm1/6Eu1/6Y 1/6Yb1/6Lu1/6Er1/6)3(Nb1/2Ta1/2)O7 are designed and synthesized in this study.These high entropy ceramics exhibit high Vickers hardness(10.912.0 GPa),close thermal expansion coefficients to that of single-principal-component RE3TaO,and RE;NbO,(7.9×10^-6-10.8×10-6 C-1 at room temperature),good phase stability,and good chemical compatibility with thermally grown Al2O3,which make them promising for applications as candidate TBC materials. | Zifan ZHAO Heng CHEN Huimin XIANG Fu-Zhi DAI Xiaohui WANG Wei XU Kuang SUN Zhjjian PENG Yanchun ZHOU | 2020 | Journal of Advanced Ceramics2020，9，3： | 27 |
| 4 | Hypoxic preconditioning attenuates hypoxia/reoxygenation-induced apoptosis in mesenchymal stem cells显示文摘目的: 间充质的干细胞(MSC ) 是心脏的代替治疗的一个有希望的候选人。然而,因为差的血供给, ischemia-reperfusion,和煽动性的因素,移植 MSC 的多数乐意地在移植以后被失去。我们试图在 MSC.Methods 的 hypoxia/reoxygenation-induced apoptosis 上学习组织缺氧 preconditioning ( HPC )的效果: MSC 的三代被划分成 6 个组包括正常的组, hypoxia-reoxygenation ( H/R )组, cyclosporine A ( CsA ),和 HPC 10 min , 20 min ,并且 30 min 组织。 apoptotic 索引,房间生存能力, mitochondrial 膜电位, Bcl-2 和 bax 的易位,细胞外的调整激酶(英皇家空军之阶级最低之兵), Akt ,组织缺氧可诱导的因素 1-alpha ,并且脉管的内皮生长因素( VEGF )在 H/R treatment.Results 以后被测试: HPC 减少了 apoptotic 索引并且增加了 H/R.Moreover 导致的生存能力, HPC 显著地稳定了 mitochondrial 膜电位在调整 Bcl-2 和 VEGF 表达式上面,并且增加了英皇家空军之阶级最低之兵和 Akt.As 的磷酸化积极控制, CsA 有象 HPC 的一样的函数,除了支持英皇家空军之阶级最低之兵和 Akt 磷酸化并且在调整 VEGF.Conclusion 上面: HPC 对 H/R 经由稳定 mitochondrial 膜电位导致的 MSC apoptosis 有保护的效果在调整 Bcl-2 和 VEGF 上面,并且支持英皇家空军之阶级最低之兵和 Akt phosphorylation.HPC 为新奇干细胞protective 策略的开发有含意。 | Jian-an WANG Tie-long CHEN Jun JIANG Heng SHI Chun GUI Rong-hua LUO Xiao-jie XIE Mei-xiang XIANG Xing ZHANG | 2008 | Acta Pharmacologica Sinica2008，29，1： | 25 |
| 5 | Detection of RASSF1A promoter hypermethylation in serum from gastric and colorectal adenocarcinoma patients显示文摘AIM:To evaluate the diagnostic role of serum RASSF1A promoter hypermethylation in gastric and colorectal ad- enocarcinoma. METHODS:Methylation-specific polymerase chain reac- tion (MSPCR) was used to examine the promoter meth- ylation status of the serum RASSF1A gene in 47 gastric adenocarcinoma patients, 45 colorectal adenocarcinoma patients, 60 patients with benign gastrointestinal dis- ease (30 with benign gastric disease and 30 with benign colorectal disease), and 30 healthy donor controls. Apaired study of RASSF1A promoter methylation status in primary tumor, adjacent normal tissue, and postopera- tive serum were conducted in 25 gastric and colorectal adenocarcinoma patients who later were underwent sur- gical therapy. RESULTS:The frequencies of detection of serum RASSF1A promoter hypermethylation in gastric (34.0%) and colorectal (28.9%) adenocarcinoma patients were significantly higher than those in patients with benign gastric (3.3%) or colorectal (6.7%) disease or in healthy donors (0%) (P < 0.01). The methylation status of RASSF1A promoter in serum samples was consistent with that in paired primary tumors, and the MSPCR results for RASSF1A promoter methylation status in paired preoperative samples were consistent with those in postoperative serum samples. The serum RASSF1A promoter hypermethylation did not correlate with patient sex, age, tumor differentiation grade, surgical therapy, or serum carcinoembryonic antigen level. Although the serum RASSF1A promoter hypermethylation frequency tended to be higher in patients with distant metastases, there was no correlation between methylation status and metastasis. CONCLUSION:Aberrant CpG island methylation within the promoter region of RASSF1A is a promising biomark- er for gastric and colorectal cancer. | Yu-Cai Wang Zheng-HongYu Chang Liu Li-Zhi Xu Wen Yu Jia Lu Ren-Min Zhu Guo-Li Li Xin-Yi Xia Xiao-Wei Wei Hong-Zan Ji Heng Lu Yong Gao Wei-Min Gao Long-Bang Chen | 2008 | World Journal of Gastroenterology2008，14，19： | 26 |
| 6 | The antitumor effect of tanshinone IIA on antiproliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line显示文摘The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were investigated.The exploration of the interaction between tanshinone IIA and its target proteins provides a feasible platform for studying the anticancer mechanism of active components of herbs.The CCK-8 assay was used to evaluate the proliferative activity of A549 cells treated with tanshinone IIA(2.5 80 μmol/L) for 24,48 and 72 h,respectively.Flow cytometry was used for the detection of cell apoptosis and cell cycle perturbation.VEGF and VEGFR2 expression were studied by Western blotting.The binding mode of tanshinone IIA within thecrystal structure of the VEGFR2 protein was evaluated with molecular docking analysis by use of the CDOCKER algorithm in Discovery Studio 2.1.The CCK-8 results showed that tanshinone IIA can significantly inhibit A549 cell proliferation in a dose-and time-dependent manner.Flow cytometry results showed that the apoptosis rate of tested group was higher than the vehicle control,and tanshinone IIAtreated cells accumulated at the S phase,which was higher than the vehicle control.Furthermore,the expression of VEGF and VEGFR2 was decreased in Western blot.Finally,molecular docking analysis revealed that tanshinone IIA could be stably docked into the kinase domain of VEGFR2 protein with its unique modes to form H-bonds with Cys917 and π–π stacking interactions with Val848.In conclusion,tanshinone IIA may suppress A549 proliferation,induce apoptosis and cell cycle arrest at the S phase.This drug may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2. | Jun Xie Jiahui Liu Heng Liu Shihui Liang Meigui Lin Yueyu Gu Taoli Liu Dongmei Wang Hui Gee Sui-lin Mo | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 26 |
| 7 | Posterior scleral reinforcement for the treatment of pathological myopia显示文摘AIM: To investigate the effects of posterior scleral reinforcement(PSR) in the treatment of pathological myopia.·METHODS: The study included 52 eyes in 43 patients with pathological myopia who underwent PSR(PSR group), and 52 eyes in 36 age- and myopia-matched patients who did not undergo such treatment as control group. Axial length, refraction error, best corrected visual acuity(BCVA), and macular scans by optical coherence tomography(OCT) were recorded at baseline, 6mo, 1, 3and 5y after the surgery, and the complications were noted.·RESULTS: There were no statistical differences in axial length, refractive error, or BCVA between the PSR group and the control group at baseline. At the end of the follow-up, the mean axial length was 29.79 ±1.26 mm in the PSR group, which was significantly shorter than that in the control group(30.78±1.30 mm)(P <0.01), and the mean refractive error was-16.86 ±2.53 D in the PSR group, which was significantly lower than that in the control group(-19.18 ±2.12 D)(P <0.01). A statistically significant difference in BCVA was found between the PSR group(0.51 ±0.25 log MAR) and the control group(0.62±0.26 log MAR) at the postoperative 5-year follow-up(P <0.01). There were no serious complications during the 5-year follow-up period.·CONCLUSION: PSR can prevent axial elongation and myopia progression in eyes with pathological myopia. | Xiu-Juan Li Xiao-Peng Yang Qiu-Ming Li Yu-Ying Wang Yuan Wang Xiao-Bei Lyu Heng Jia | 2016 | International Journal of Ophthalmology(English edition)2016，9，4： | 21 |
| 8 | Application of an acrylic vessel supported by a stainless-steel truss for the JUNO central detector显示文摘在 Daya 海湾实验的成功以后, Jiangmen 地下的中微子天文台(Jupiter 之妻) 被发射测量中微子团层次和摆动参数并且学习另外的中微子物理。它的中央察觉者从反应堆,地球,空气,和阳光被放为反中微子。中央察觉者的主要要求是液体闪烁器的 20 kt 的抑制,作为目标团,和 3% 精力分辨率。它关于有它的内部表面上的 PMT 的 75% 范围的 38.5 m 的一个球形状察觉者。因为它必须为物理测量的几种不同类型满足要求并且在它的结构和工程拥有可行性和可靠性,如此的一个巨大的察觉者的设计是大挑战,都在合理时间和费用。为 JUNO 中央察觉者的一种选择是超丙烯酸的球在水里沉没了防护背景。这份报纸为如此的一个丙烯酸的球建议一个结构的计划那被支持由一不锈钢捆绑,在土木工程由支持点的眼镜窗帘墙启发了。计划的初步的设计被有限元素(FE ) 用 ABAQUS 完成并且验证方法。FE 分析证明计划能在 5 ~ 10 MPa 的限制以内控制丙烯酸的球的压力水平,根据中央察觉者的设计目的需求。计划具有突出的全球稳定性并且在本地连接上允许各种各样的选择。我们证明计划可行性好并且应该是为中央察觉者的一种合理选择。 | WANG Yuan Qing ZONG Liang HENG Yue Kun WANG Zong Yi ZHOU Yan HOU Shao Jing QIN Zhong Hua MA Xiao Yan | 2014 | Science China(Technological Sciences)2014，57，12： | 19 |
| 9 | The cloning of 3'-truncated preS/S gene from HBV genomic DNA and its expression in transgenic mice显示文摘INTRODUCTIONHepatitis B virus (HBV) is regarded as one of themain etiologic factors involved in the developmentof human hepatocellular carcinoma (HCC).The open reading frame (orf)of X gene of HBVencoded a transactivating factor is the evidence thatstrongly supported the notion that the X gene ofHBV DNA integrated in HCC genomic DNA couldcontribute to the carcinogenesis of liver cells byactivation of some related cellular genes | Yi Ping Hu~1 Yu Cheng Yao~1 Jian Xiu Li~1 Xin Min Wang~1 Hong Li~2 Zhong Hua Wang~1 Zhang Heng Lei~3 1 Department of Cell Biology,Second Military Medical University,Shanghai 200433,China 2 Department of Biology,Department of Basic Medicine,West-China University of Medical Sciences,Chengdu 610041,China 3 Department of Biology,North Sichuan Medical College,Nanchong 637007,China | 2000 | World Journal of Gastroenterology2000，6，5： | 18 |
| 10 | Clogging behavior of submerged entry nozzles for Ti-bearing IF steel显示文摘如果钢被 metallographic 分析学习,堵塞 忍受Ti 的行为的嘴,扫描电子 microscopySEM ,精力散 spectroscopyEDS ,和X光检查 diffractionXRD.According 到试验性的结果,嘴堵塞首先出现三 layers.There 是在内部层的很多大尺寸的铁粒子并且主要起炉渣在中间、外部的 layers.The 主管的阶段堵塞内部层的成分是松开的氧化铝簇包括和小粒的塑造的氧化铝包括中间的层的 clog 成分主要是主要阶段在嘴堵塞存在是的树突氧化铝 inclusions.The FeO 牯慭楴湯戬晥牯 ? 敢湩 ? 潳癬摥渠浵牥捩污祬戠 ? 桴 ? 桳潯楴杮洠瑥潨 ? 潂桴愠獳獩楴杮愠摮漠灰獯湩 ? 畢祯湡 ? 汦睯? 敷敲挠湯楳敤敲 ? 瑉椠 ? 潦湵 ? 桴瑡搠慵 ? s 羰 ? 羰 ? | Heng Cui Yan-ping Bao Min Wang Wei-shuang Wu | 2010 | International Journal of Minerals,Metallurgy and Materials2010，17，2： | 17 |
| 11 | ‘Size effect’ related bending formability of thin-walled aluminum alloy tube显示文摘Aluminum alloy (Al-alloy) thin-walled (D/t > 20, diameter D, wall thickness t) bent tubes have attracted increasing applications in many industries with mass quantities and diverse specifications due to satisfying high strength to weigh ratio requirements of product manufacturing. However, due to nonlinear nature of bending with coupling effects of multiple factors, the similarity theory seems not applicable and there occurs a challenge for efficient and reliable evaluation of the bending formability of thin-walled tube with various bending specifications. Considering the unequal deformation and three major instabilities, the bending formability of thin-walled Al-alloy tube in changing tube sizes such as D and t are clarified via both the analytical and FE modeling/ simulations. The experiments of rotary draw bending are conducted to validate the theoretical models and further confirm 'size effect' related bending formability. The major results show that (1) The anti-wrinkling capability of tube decreases with the larger D and smaller t, and the effect significance of t is larger than that of D even under rigid supports; (2) The wall thinning increases with the larger D and smaller t, and this tendency becomes much more obvious under rigid supports; (3) The cross-section deformation increases with the larger D and smaller t according to the analytical model obtained intrinsic relationship, while this tendency becomes opposite due to the nonlinear role of mandrel die; (4) The size factor D/t can be used as a nondimensional index to evaluate both the bending formability regarding the wall thinning and cross-section deformation. | Li Heng Yang He Zhang Zhiyong Wang Zekang | 2013 | Chinese Journal of Aeronautics2013，26，1： | 16 |
| 12 | Advanced glycation end products promote human aortic smooth muscle cell calcification in vitro via activating NF-KB and down-regulating IGFIR expression显示文摘 | Yi WANG Zhen-yu ZHANG Xiao-qing CHEN Xiang WANG Heng CAO Shao-wen LIU | 2013 | Acta Pharmacologica Sinica2013，34，4： | 16 |
| 13 | Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis显示文摘AIM: To investigate the effect of emodin on expression of claudin4, claudin5 and occludin, as well as the alveolar epithelial barrier in rats with pancreatitis induced by sodium taurocholate. METHODS: Experimental pancreatitis was induced by retrograde injection of 5% sodium taurocholate into the biliopancreatic duct. Emodin was injected via the external jugular vein 3 h after induction of acute pancreatitis. Rats from sham operation group and acute pancreatitis group were injected with normal saline (an equivalent volume as emodin) at the same time point. Samples of lung and serum were obtained 6 h after drug administration. Pulmonary morphology was examined with HE staining. Pulmonary edema was estimated by measuring water content in lung tissue samples. Tumor necrosis factorα (TNFα) and interleukin6 (IL6) level were measured by enzymelinked immunospecific assay. Serum amylase and pulmonary myeloperoxidase (MPO) activity were detected by spectrophotometry. Alveolar epithelial barrier was assessed by pulmonary dye extravasation. Expression of claudin4, claudin5 and occludin in lung tissue samples was examined by immunohistology, quantitative realtime reverse transcription polymerase chain reaction and Western blotting analysis, respectively.RESULTS: Pancreatitis-associated lung injury was char-acterized by pulmonary edema, leukocyte infiltration, alveolar collapse, and elevated serum amylase level. The pulmonary damage, pulmonary pathological scores, serum amylase and MPO activity, TNF-α and IL-6 levels, and wet/dry ratio were decreased in rats after treatment with emodin. Immunostaining of claudin-4, claudin-5 and occludin was detected in lung tissue samples from rats in sham operation group, which was distributed in alveolar epithelium, vascular endothelium, and bron-chial epithelium, respectively. The mRNA and protein expression levels of claudin-4, claudin-5 and occludin in lung tissue samples were markedly decreased, the expression level of claudin-4, claudin-5 and occluding was increased, and the pulmonary dye extravasation was reduced in lung tissue samples from rats with acute pancreatitis after treatment with emodin.CONCLUSION: Emodin attenuates pulmonary edema and inflammation, enhances alveolar epithelial barrier function, and promotes expression of claudin-4, claudin-5 and occludin in lung tissue samples from rats with acute pancreatitis. | Xia, Xian-Ming Wang, Fang-Yu Wang, Zhen-Kai Wan, Hai-Jun Xu, Wen-An Lu, Heng | 2010 | World Journal of Gastroenterology2010，16，24： | 15 |
| 14 | A Novel Chloroplast-Localized Pentatricopeptide Repeat Protein Involved in Splicing Affects Chloroplast Development and Abiotic Stress Response in Rice显示文摘Pentatricopeptide 重复(PPR ) 蛋白质在更高的植物包括一个大家庭并且在 organellar RNA 新陈代谢的各种各样的方面调制 organellar 基因表示 byparticipating。在米饭,家庭包含他们的功能仍然是的 477 个成员,和 majorityof 不清楚。在这研究,我们孤立并且描绘米饭变异的、白条纹叶(wsl ) ,它在开发早的显示萎黄病有条纹或刻痕之状态。基于地图的克隆表明 WSL 编码指向叶绿体的最新识别的米饭 PPR 蛋白质。在 wsl 异种,锐气依赖者质体基因表示是显著地下面调整的,并且质体 rRNAs 和翻译 productsaccumulate 到很底层。一致地与观察, wsl 在叶绿体抄本 rpl2 拼接显示出一个强壮的缺点,在异种导致异常抄本累积和它的产品减小。wsl 显示出提高的敏感到骆驼毛的织物,咸度,和糖,并且它积累更多的 H 2 O 2 比野类型。这些结果建议减少的翻译效率可以影响异种的反应到 abioticstress.Key 词: | Junjie Tan Zhenhua Tan Fuqing Wu Peike Sheng Yueqin Heng Xinhua Wang Yulong Ren Jiulin Wang Xiuping Guo Xin Zhang Zhijun Cheng Ling Jiang Xuanming Liu Haiyang Wang Jianmin Wan | 2014 | Molecular Plant2014，7，8： | 15 |
| 15 | (La0.2Ce0.2Nd0.2Sm0.2Eu0.2)PO4: A high-entropy rare-earth phosphate monazite ceramic with low thermal conductivity and good compatibility with Al2O3显示文摘Low thermal conductivity, matched thermal expansion coefficient and good compatibility are general requirements for the environmental/thermal barrier coatings(EBCs/TBCs) and interphases for Al2O3 f/Al2O3 composites. In this work, a novel high-entropy(HE) rare-earth phosphate monazite ceramic (La0.2Ce0.2Nd0.2Sm0.2Eu0.2)PO4 is designed and successfully synthesized. This new type of HE rare-earth phosphate monazite exhibits good chemical compatibility with Al2O3, without reaction with Al2O3 as high as 1600℃ in air. Moreover, the thermal expansion coefficient(TEC) of HE (La0.2Ce0.2Nd0.2Sm0.2Eu0.2)PO4(8.9 × 10^-6/℃ at 300–1000℃) is close to that of Al2O3. The thermal conductivity of HE (La0.2Ce0.2Nd0.2Sm0.2Eu0.2)PO4 at room temperature is as low as 2.08 W·m^-1·K^-1, which is about 42% lower than that of La PO4. Good chemical compatibility, close TEC to that of Al2O3, and low thermal conductivity indicate that HE (La0.2Ce0.2Nd0.2Sm0.2Eu0.2)PO4 is suitable as a candidate EBC/TBC material and an interphase for Al2O3 f/Al2O3 composites. | Zifan Zhao Heng Chen Huimin Xiang Fu-Zhi Dai Xiaohui Wang Zhijian Peng Yanchun Zhou | 2019 | Journal of Materials Science & Technology2019，35，12： | 15 |
| 16 | Inherent mechanism of breakdown in laminar-turbulent transition of plane channel flows显示文摘Laminar-turbulent transition is an old yet unsolved problem. Notwithstanding the great effort made, there is an important question that seems not to have been addressed yet, that is, what is the inherent mechanism of breakdown that eventually leads to transition? The conventional idea is that the transition starts from the amplification of disturbances, and when the disturbances become larger, higher harmonics will be generated due to nonlinear effect, making the flow more and more complicated, and finally turbulent. Though the scenario seems clear, yet there is a missing link, that is, what happens in the breakdown process. Here we show by analyzing the results from direct numerical simulations that the change of stability characteristics of the mean flow profile plays a key role in the breakdown process. | LUO Jisheng, WANG Xinjun & ZHOU Heng Department of Mechanics, Tianjin University Liu-Hui Center of Mathematics, Nankai and Tianjin University, Tianjin 300071, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，2： | 14 |
| 17 | Scour and silting evolution and its influencing factors in Inner Mongolian Reach of the Yellow River显示文摘有河的平衡的河被床变丑调整描绘。在剖面图的侵蚀免职区域反映这个特征,它是研究河的一个底搜索并且由时间系列分析的免职进化。与在这篇论文建议的一个侵蚀免职区域指示物方法,在 Bygl 和 Shhk 车站的侵蚀免职区域数量的时间系列从 1976 ~ 2006 与 31 年的系列持续时间被获得。在它的趋势和变化的分析以后,关于进化的三个不同趋势通过快速的收缩从伪平衡阶段一般来说被观察到最后的新伪平衡。一旦大洪水发生在一些支流,侵蚀免职区域系列的趋势将变化,这也被发现一旦大洪水发生在一些支流,并且它的曾经更大的影响由于有在上游的水库的结束的洪水的减少。几乎所有转弯的点与超沉积洪水发生在一些支流的时间是重合的。与清楚的变化的时间系列自从 1990 年代末,内部蒙古的活动范围在一个新平衡阶段。这能在二个方面被结束。1。从在河收缩的支流结果的大洪水和沉积交通的缺席,并且重获隧道在内部蒙古的活动范围的带流动的能力大洪水高山峰分泌物并且过长的间隔被需要破坏新平衡。2。因为它能在数量表明生气的节的实时变丑,侵蚀免职区域指示物的建议方法具有到隧道搜索免职进化分析的大帮助。 | QIN Yi ZHANG Xiaofang WANG Fenglong YAN Heng HAN Haijun | 2011 | Journal of Geographical Sciences2011，21，6： | 14 |
| 18 | Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice显示文摘瞄准:最近的研究证明中国植物 Polygalae 根值的摘录在老鼠和人施加提高认知的行动。这研究的目的是描绘从 Polygalae Radix.Methods 提取的活跃混合物的药理学侧面:二部分 P3 和 P6 和二混合物 PTM-15 和 polygalasaponin XXXII (PGS32 ) 被准备。Neuroprotective 效果在暴露于高集中 glutamate,浆液缺乏或 H 2 O 2 。反痴呆行动用走彻底地回避测试和隧道水迷宫测试在老鼠在导致莨菪胺的健忘被估计。在进行隧道水迷宫测试以后,在老鼠马头鱼尾的怪兽的 TrkB phosphorylation 用西方的弄污被检测。长期的 potentiation (LTP ) 在成年老鼠在有牙齿的回转被导致;PGS32 (5 μ L 400 μ mol/L ) 被注入侧面的服的室在高频率刺激(HFS ) 以后的 20 min .Results:在老鼠在导致莨菪胺的健忘比作部分 P6,显示出的更突出的 neuroprotective 在 vitro 完成的部分 P3 和提高认知的效果。在部分 P3 的一活跃复合 PGS32 施加了有势力提高认知的行动:PGS32 的口头的管理(0.125 mg·为 19 天的 kg −1·d−1) 在老鼠废除了导致莨菪胺的记忆缺陷。而且, PGS32 (0.5 和 2 mg· kg −1·d−1) 显著地在马头鱼尾的怪兽刺激了 TrkB 的 phosphorylation。PGS32 的 Intracerebroventricular 注射显著地在 rats.Conclusion 的有牙齿的回转提高了导致 HFS 的 LTP:PGS32 在老鼠稀释导致莨菪胺的认知缺陷,建议它有为认知机能障碍和痴呆的处理的一个潜力。 | Heng ZHOU Wei XUE Shi-feng CHU Zhen-zhen WANG Chuang-jun LI Yi-na JIANG Lin-ming LUO Piao LUO Gang LI Dong-ming ZHANG Nai-hong CHEN | 2016 | Acta Pharmacologica Sinica2016，37，8： | 12 |
| 19 | Distribution,Frequency and Variation of Stripe Rust Resistance Loci Yr10,Lr34/Yr18 and Yr36 in Chinese Wheat Cultivars显示文摘Wheat stripe rust is a devastating disease in many regions of the world.In wheat,49 resistance genes for stripe rust have been officially documented,but only three genes are cloned,including the race-specific resistance Yr10 candidate gene(Yr10_(CG)) and slow-rusting genes Lr34/Yr18(hereafter designated as Yr18) and Yr36.In this study,we developed gene-specific markers for these genes and used them to screen a collection of 659 wheat accessions,including 485 Chinese cultivars.Thirteen percent and eleven percent of the tested Chinese cultivars were positive for the markers for Yr10_(CG) and Yr18_(RH)(the resistant haplotype of Yr18),respectively,but none were positive for the Yr36 marker.Since there is a limited use of the Yr10 gene in Chinese wheat,the relatively high frequency of wheat varieties with the Yr10_(CG) marker suggests that the identity of the Yr10 gene is unknown.With regards to the Yr18 gene,29%of the tested cultivars that are used in the Middle and Lower Yangtze Valleys' winter wheat zone were positive for Yr18_(RH) markers.A non-functional allele of Yr18_(RH) was identified in 'Mingxian 169',a commonly used susceptible check for studying stripe rust.The data presented here will provide useful information for marker-assisted selection for wheat stripe rust resistance. | Cuiling Yuan Hui Jiang Honggang Wang Kun Li Heng Tang Xianbin Li Daolin Fu | 2012 | Journal of Genetics and Genomics2012，39，11： | 12 |
| 20 | Effects of combined drip irrigation and sub-surface pipe drainage on water and salt transport of saline-alkali soil in Xinjiang, China显示文摘Developing effective irrigation and drainage strategies to improve the quality of saline-alkali soil is vital for enhancing agricultural production and increasing economic returns. In this study, we explored how irrigation and drainage modes (flood irrigation, drip irrigation, and sub-surface pipe drainage under drip irrigation) improve the saline-alkali soil in Xinjiang, China. We aimed to study the transport characteristics of soil water and salt under different irrigation and drainage modes, and analyze the effects of the combination of irrigation and drainage on soil salt leaching, as well as its impacts on the growth of oil sunflower. Our results show that sub-surface pipe drainage under drip irrigation significantly reduced the soil salt content and soil water content at the 0–200 cm soil depth. Under sub-surface pipe drainage combined with drip irrigation, the mean soil salt content was reduced to below 10 g/kg after the second irrigation, and the soil salt content decreased as sub-surface pipe distance decreased. The mean soil salt content of flood irrigation exceeded 25 g/kg, and the mean soil desalination efficiency was 3.28%, which was lower than that of drip irrigation. The mean soil desalination rate under drip irrigation and sub-surface pipe drainage under drip irrigation was 19.30% and 58.12%, respectively. After sub-surface drainage regulation under drip irrigation, the germination percentage of oil sunflower seedlings was increased to more than 50%, which further confirmed that combined drip irrigation and sub-surface pipe drainage is very effective in improving the quality of saline-alkali soil and increasing the productivity of agricultural crops. | HENG Tong LIAO Renkuan WANG Zhenhua WU Wenyong LI Wenhao ZHANG Jinzhu | 2018 | Journal of Arid Land2018，10，6： | 12 |
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