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| 1 | Orbit determination and time synchronization for a GEO/IGSO satellite navigation constellation with regional tracking network显示文摘Aiming at regional services,the space segment of COMPASS (Phase I) satellite navigation system is a constellation of Geostationary Earth Orbit (GEO),Inclined Geostationary Earth Orbit (IGSO) and Medium Earth Orbit (MEO) satellites.Precise orbit determination (POD) for the satellites is limited by the geographic distribution of regional tracking stations.Independent time synchronization (TS) system is developed to supplement the regional tracking network,and satellite clock errors and orbit data may be obtained by simultaneously processing both tracking data and TS data.Consequently,inconsistency between tracking system and TS system caused by remaining instrumental errors not calibrated may decrease navigation accuracy.On the other hand,POD for the mixed constellation of GEO/IGSO/MEO with the regional tracking network leads to parameter estimations that are highly correlated.Notorious example of correlation is found between GEO's orbital elements and its clock errors.We estimate orbital elements and clock errors for a 3GEO+2IGSO constellation in this study using a multi-satellite precise orbit determination (MPOD) strategy,with which clock error elimination algorithm is applied to separate orbital and clock estimates to improve numerical efficiency.Satellite Laser Ranging (SLR) data are used to evaluate User Ranging Error (URE),which is the orbital error projected on a receiver's line-of-sight direction.Two-way radio-wave time transfer measurements are used to evaluate clock errors.Experimenting with data from the regional tracking network,we conclude that the fitting of code data is better than 1 m in terms of Root-Mean-Square (RMS),and fitting of carrier phase is better than 1 cm.For orbital evaluation,difference between computed receiver-satellite ranging based on estimated orbits and SLR measurements is better than 1 m (RMS).For clock estimates evaluation,2-hour linear-fitting shows that the satellite clock rates are about 1.E-10 s/s,while receiver clock rates are about 1×10 13-1×10 12 s/s.For the 72-hour POD experiment,the average differences between POD satellite clock rates estimates and clock measurements based on TS system are about 1×10 13 s/s,and for receiver clock rates,the differences are about 1×10 15 s/s. | ZHOU ShanShi HU XiaoGong WU Bin LIU Li QU WeiJing GUO Rui HE Feng CAO YueLing Wu XiaoLi ZHU LingFeng SHI Xin TAN HongLi | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 44 |
| 2 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 3 | Strategies to reduce pulmonary complications after esophagectomy显示文摘Esophagectomy,the surgical removal of all or part of the esophagus,is a surgical procedure that is associated with high morbidity and mortality.Pulmonary complications are an especially important postoperative problem.Therefore,many perioperative strategies to prevent pulmonary complications after esophagectomy have been investigated and introduced in daily clinical practice.Here,we review these strategies,including improvement of patient performance and technical advances such as minimally invasive surgery that have been implemented in recent years.Furthermore,interventions such as methylprednisolone,neutrophil elastase inhibitor and epidural analgesia,which have been shown to reduce pulmonary complications,are discussed.Benefits of the commonly applied routine nasogastric decompression,delay of oral intake and prophylactic mechanical ventilation are unclear,and many of these strategies are also evaluated here.Finally,we will discuss recent insights and new developments aimed to improve pulmonary outcomes after esophagectomy. | Teus J Weijs Jelle P Ruurda Grard AP Nieuwenhuijzen Richard van Hillegersberg Misha DP Luyer | 2013 | World Journal of Gastroenterology2013，19，39： | 17 |
| 4 | Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress显示文摘Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H 2 O 2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H 2 O 2 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Our findings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress. | Tao Lei Haifeng Li Zhen Fang Junbin Lin Shanshan Wang Lingyun Xiao Fan Yang Xin Liu Junjian Zhang Zebo Huang Weijing Liao | 2014 | Neural Regeneration Research2014，9，3： | 17 |
| 5 | Atomic force microscopy imaging and mechanical properties measurement of red blood cells and aggressive cancer cells显示文摘Mechanical properties play an important role in regulating cellular activities and are critical for unlocking the mysteries of life. Atomic force microscopy (AFM) enables researchers to measure mechanical properties of single living cells under physiological conditions. Here, AFM was used to investigate the topography and mechanical properties of red blood cells (RBCs) and three types of aggressive cancer cells (Burkitt's lymphoma Raji, cutaneous lymphoma Hut, and chronic myeloid leukemia K562). The surface topography of the RBCs and the three cancer cells was mapped with a conventional AFM probe, while mechanical properties were investigated with a microsphere glued onto a tip-less cantilever. The diameters of RBCs are significantly smaller than those of the cancer cells, and mechanical measurements indicated that Young's modulus of RBCs is smaller than those of the cancer cells. Aggressive cancer cells have a lower Young's modulus than that of indolent cancer cells, which may improve our understanding of metastasis. | LI Mi LIU LianQing XI Ning WANG YueChao DONG ZaiLi XIAO XiuBin ZHANG WeiJing | 2012 | Science China(Life Sciences)2012，55，11： | 16 |
| 6 | Cancer immunotherapy in clinical practice—the past,present,and future显示文摘Considerable progress has been made in the field of cancer immunotherapy in recent years. This has been made possible in large part by the identification of new immune-based cellular targets and the development of novel approaches aimed at stimulating the immune system. The role played by the immunosuppressive microenvironment in the development of tumors has been established. The success of checkpoint-inhibiting antibodies and cancer vaccines has marked the beginning of a new era in cancer treatment. This review highlights the clinically relevant principles of cancer immunology and various immunotherapeutic approaches that have either already entered mainstream oncologic practice or are currently in the process of being evaluated in clinical trials. Furthermore, the current barriers to the development of effective immunotherapies and the potential strategies of overcoming them are also discussed. | Gaurav Goel Weijing Sun | 2014 | Chinese Journal of Cancer2014，33，9： | 16 |
| 7 | Water-vapor source shift of Xinjiang region during the recent twenty years显示文摘这篇论文的目的是在过去的 20 年期间调查 Xinjiang 区域和他们的移动的气候水蒸汽来源。首先,原则和步粗略地被调整寻求水蒸汽来源。第二,在对流层的静止水蒸汽运输是打算的区分水蒸汽旁边来哪里从的气候 ERA-40 分析。另外,在运输之间的搭配和大气的列水蒸汽内容被分析。结果证明主要蒸汽来自 Xinjiang 的西方方面为季节中间月,除了 7 月当水蒸汽来自北方或西北方向时。水蒸汽来源是不同的不同季节,例如里海和地中海是来源在在 10 月的在 7 月的 1 月和 4 月,北方大西洋和北极海和黑海和里海分别地。在里面最近在 Xinjiang 上面的更多的水蒸汽与全球温暖来自高纬度和北极海的十年,和从与 1973-1986 的案例比较的地中海的更少。事实上,在画热带上的空气变得干燥,异常的水蒸汽运输方向在 1987-2000 期间转到西方或西南。由对比,在中间、高的纬度上的空气以前比 14 年更温暖、湿。 | Dai Xingang Li Weijing Ma Zhuguo Wang Ping | 2007 | Progress in Natural Science:Materials International2007，17，5： | 12 |
| 8 | Interdecadal Variability of the Afro-Asian Summer Monsoon System显示文摘The Afro-Asian summer monsoon is a zonally planetary-scale system, with a large-scale rainbelt covering Africa, South Asia and East Asia on interdecadal timescales both in the past century(1901–2014) and during the last three decades(1979–2014). A recent abrupt change of precipitation occurred in the late 1990 s. Since then, the entire rainbelt of the Afro-Asia monsoon system has advanced northwards in a coordinated way. Consistent increases in precipitation over the Huanghe–Huaihe River valley and the Sahel are associated with the teleconnection pattern excited by the warm phase of the Atlantic Multidecadal Oscillation(AMO). A teleconnection wave train, with alternating cyclones/anticyclones, is detected in the upper troposphere. Along the teleconnection path, the configuration of circulation anomalies in North Africa is characterized by coupling of the upper-level anticyclone(divergence) with low-level thermal low pressure(convergence), facilitating the initiation and development of ascending motions in the Sahel. Similarly, in East Asia, a coupled circulation pattern also excites ascending motion in the Huanghe–Huaihe River valley. The synchronous increase in precipitation over the Sahel and Huanghe–Huaihe River valley can be attributed to the co-occurrences and in-phase changes of ascending motion. On the other hand, the warm phase of the AMO results in significant warming in the upper troposphere in North Africa and the northern part of East Asia. Such warming contributes to intensification of the tropical easterly jet through increasing the meridional pressure gradient both at the entrance region(East Asia) and the exit region(Africa). Accordingly, precipitation over the Sahel and Huanghe–Huaihe River valley intensifies, owing to ageostrophic secondary cells. The results of this study provide evidence for a consistent and holistic interdecadal change in the Afro-Asian summer monsoon. | Yi LI Yihui DING Weijing LI | 2017 | Advances in Atmospheric Sciences2017，34，7： | 12 |
| 9 | Long-term precipitation change by hourly data in Haihe River Basin during 1961–2004显示文摘Hourly summer precipitation data recorded at 21 stations during 1961-2004 in the Haihe River Basin in North China were analyzed. The results show that the precipitation frequency and amount and the morning peak mainly relating to long-duration rainfall events decreased during this period, whereas the normalized afternoon peak mainly relating to short-duration events increased, which may suggest that the proportion of short-duration rainfall has increased as the total summer rainfall has decreased. For short-duration events, the mean intensity and peak intensity increased at most stations and the time to peak intensity decreased, which may be attributable to the higher thermal contrast between the warmer lower surface and cooler upper level. In the case of long-duration events, the total amount was significantly correlated with the East Asian summer monsoon index for the period 1961-2001 (correlation coefficient of 0.63). Although the total amount of rainfall in long-duration events decreased in the basin, the mean intensity and peak intensity, as well as the extreme hourly precipitation, increased in the western basin and decreased in the eastern basin. | YIN ShuiQing GAO Ge LI WeiJing CHEN DeLiang HAO LiSheng | 2011 | Science China Earth Sciences2011，54，10： | 12 |
| 10 | Estimation of ground heat flux and its impact on the surface energy budget for a semi-arid grassland显示文摘Three approaches,i.e.,the harmonic analysis(HA) technique,the thermal diffusion equation and correction(TDEC) method,and the calorimetric method used to estimate ground heat flux,are evaluated by using observations from the Semi-Arid Climate and Environment Observatory of Lanzhou University(SACOL) in July,2008.The calorimetric method,which involves soil heat flux measurement with an HFP01SC self-calibrating heat flux plate buried at a depth of 5 cm and heat storage in the soil between the plate and the surface,is here called the ITHP approach.The results show good linear relationships between the soil heat fluxes measured with the HFP01SC heat flux plate and those calculated with the HA technique and the TDEC method,respectively,at a depth of 5 cm.The soil heat fluxes calculated with the latter two methods well follow the phase measured with the HFP01SC heat flux plate.The magnitudes of the soil heat flux calculated with the HA technique and the TDEC method are close to each other,and they are about 2 percent and 6 percent larger than the measured soil heat flux,respectively,which mainly occur during the nighttime.Moreover,the ground heat fluxes calculated with the TDEC method and the HA technique are highly correlated with each other(R2 = 0.97),and their difference is only about 1 percent.The TDEC-calculated ground heat flux also has a good linear relationship with the ITHP-calculated ground heat flux(R2 = 0.99),but their difference is larger(about 9 percent).Furthermore,compared to the HFP01SC direct measurements at a depth of 5 cm,the ground heat flux calculated with the HA technique,the TDEC method,and the ITHP approach can improve the surface energy budget closure by about 6 percent,7 percent,and 6 percent at SACOL site,respectively.Therefore,the contribution of ground heat flux to the surface energy budget is very important for the semi-arid grassland over the Loess Plateau in China.Using turbulent heat fluxes with common corrections,soil heat storage be-tween the surface and the heat flux plate can improve the surface energy budget closure by about 6 to 7 percent,resulting in a clo-sure of 82 to 83 percent at the SACOL site. | JinQing Zuo JieMin Wang JianPing Huang WeiJing Li GuoYin Wang HongLi Ren | 2011 | Research in Cold and Arid Regions2011，3，1： | 11 |
| 11 | The 2016 Summer Floods in China and Associated Physical Mechanisms:A Comparison with 1998显示文摘The characteristics of droughts and floods in China during the summers(May–August)of 2016 and 1998 were compared in great detail,together with the associated atmospheric circulations and external-forcing factors.Following results are obtained.(1)The precipitation was mostly above normal in China in summer 2016,with two main rainfall belts located in the Yangtze River valley(YRV)and North China.Compared with 1998,a similar rainfall belt was located over the YRV,with precipitation 100%and more above normal.However,the seasonal processes of Meiyu were different.A typical'Secondary Meiyu'occurred in 1998,whereas dry conditions dominated the YRV in2016.(2)During May–July 2016,the Ural high was weaker than normal,but it was stronger than normal in 1998.This difference resulted from fairly different distributions of sea surface temperature anomalies(SSTAs)over the North Atlantic Ocean during the preceding winter and spring of the two years.(3)Nonetheless,tropical and subtropical circulation systems were much more similar in May–July of 2016 and 1998.The circulation systems in both years were characterized by a stronger than normal and more westward-extending western Pacific subtropical high(WPSH),a weaker than normal East Asian summer monsoon(EASM),and anomalous convergence of moisture flux in the mid and lower reaches of the YRV.These similar circulation anomalies were attributed to the similar tropical SSTA pattern in the preceding seasons,i.e.,the super El Ni?o and strong warming in the tropical Indian Ocean.(4)Significant differences in the circulation pattern were observed in August between the two years.The WPSH broke up in August 2016,with its western part being combined with the continental high and persistently dominating eastern China.The EASM suddenly became stronger,and dry conditions prevailed in the YRV.On the contrary,the EASM was weaker in August 1998 and the'Secondary Meiyu'took place in the YRV.The Madden–Julian Oscillation(MJO)was extremely active in August 2016 and stayed in western Pacific for 25 days.It triggered frequent tropical cyclone activities and further influenced the significant turning of tropical and subtropical circulations in August2016.In contrast,the MJO was active over the tropical Indian Ocean in August 1998,conducive to the maintenance of a strong WPSH.Alongside the above oceanic factors and atmospheric circulation anomalies,the thermal effect of snow cover over the Qinghai–Tibetan Plateau from the preceding winter to spring in 2016 was much weaker than that in 1998.This may explain the relatively stronger EASM and more abundant precipitation in North China in 2016than those in 1998. | Yuan YUAN Hui GAO Weijing LI Yanju LIU Lijuan CHEN Bin ZHOU Yihui DING | 2017 | Journal of Meteorological Research2017，31，2： | 11 |
| 12 | Why Is the East Asian Summer Monsoon Extremely Strong in 2018?——Collaborative Effects of SST and Snow Cover Anomalies显示文摘In 2018,summer precipitation was above normal in North and Northwest China and below normal around the Yangtze River valley,due to an extremely strong East Asian summer monsoon(EASM).The atmospheric circulation anomalies in East Asia and key external forcing factors that influence the EASM in 2018 are explored in this paper.The results show that there existed an anomalous cyclonic circulation near the Philippines,while the western Pacific subtropical high was located more northward than its normal position.In the mid–high latitudes,a negative geopotential height anomaly center was found near the Ural Mountains,suppressing the blocking activity.Under such a circulation pattern,precipitation near the Yangtze River valley decreased because local divergence and subsidence intensified,whereas precipitation in northern China increased due to large amounts of water vapor transport by anomalously strong southerly winds.Further analyses reveal that the strong EASM circulation in 2018 might result from the joint influences of several external forcing factors.The weak La Ni?a event that started from October 2017,the positive North Atlantic Tripolar mode(NAT)in spring 2018,and the reduced snow cover over the Tibetan Plateau in winter 2017/18 all collaboratively contributed to formation of the cyclonic circulation anomaly near the Philippines,leading to the extremely strong EASM.Especially,the positive NAT and the reduced Tibetan snow cover may have caused the negative geopotential height anomaly near the Ural Mountains,in favor of a strong EASM.The above external factors and their reinforcing impacts on the EASM are further verified by two groups of similar historical cases. | Lijuan CHEN Wei GU Weijing LI | 2019 | Journal of Meteorological Research2019，33，4： | 11 |
| 13 | Observed Trends in Various Aspects of Compound Heat Waves across China from 1961 to 2015显示文摘Based on combined thresholds of daily maximum and minimum temperatures, a compound heat wave is defined,and then changes in multiple aspects of such heat waves in China are estimated between 1961 and 2015. Our results intriguingly indicate that severe compound heat waves in northern China are characterized by excessively high intensity within short duration, while long duration determines great disaster-causing potential of severe events in the south. In the past few decades, large areas of China have experienced longer, stronger, and more frequent compound heat waves. Northern China has witnessed dramatic intensity increases, with a maximum amplification over 5°C decade^(–1); while remarkable lengthening in duration has been mostly recorded in the south, with a maximum trend over 1day decade^(–1). The spatial extent affected by compound heat waves has significantly expanded since the 1960 s, with the largest expanding rate over 6% decade^(–1) detected in North China and Northeast China. These systematic assessments serve to deepen our understanding of observed changes in compound heat waves across China, and may further shed some light on future adaptations and mitigations against an increasingly warming climate. | Yi LI Yihui DING Weijing LI | 2017 | Journal of Meteorological Research2017，31，3： | 10 |
| 14 | Gastric cancer: current and evolving treatment landscape显示文摘Gastric(including gastroesophageal junction) cancer is the third leading cause of cancer-related death in the world.In China,an estimated 420,000 patients were diagnosed with gastric cancer in 2011,ranking this malignancy the second most prevalent cancer type and resulting in near 300,000 deaths.The treatment landscape of gastric cancer has evolved in recent years.Although systemic chemotherapy is still the mainstay treatment of metastatic disease,the introduction of agents targeting human epidermal growth factor receptor 2 and vascular endothelial growth factor/vascular endothelia growth factor receptor has brought this disease into the molecular and personalized medicine era.The preliminary yet encouraging clinical efficacy observed with immune checkpoint inhibitors,e.g.,anti-programmed cell death protein 1/programmed death-ligand 1,will further shape the treatment landscape for gastric cancer.Molecular characterization of patients will play a critical role in developing new agents,as well as in implementing new treatment options for this disease. | Weijing Sun Li Yan | 2016 | Chinese Journal of Cancer2016，35，8： | 9 |
| 15 | Effects of riparian land use on water quality and fish communities in the headwater stream of the Taizi River in China显示文摘 | Sen DING Yuan ZHANG Bin LIU Weijing KONG Wei MENG | 2013 | Frontiers of Environmental Science & Engineering2013，7，5： | 8 |
| 16 | Tropospheric biennial oscillation of the western Pacific subtropical high and its relationships with the tropical SST and atmospheric circulation anomalies显示文摘There is the significant period of tropospheric biennial Oscillation(TBO)over East Asian monsoon region at the interannual timescales,which has the important influences on East China climate.Based on a set of reconstructed indices which describes the western Pacific subtropical high(WPSH)objectively,this paper focuses on the TBO component of WPSH,one of the key members of the East Asian Monsoon system,and its relationships with the tropical SST and atmospheric circulation anomalies.It is found that(1)As an important interannual component of WPSH,the time series of TBO has the obvious transition in the late1970s,and the variability of the WPSH’s TBO component is more significant after the late 1970s.(2)The time-lag correlations between the WPSH’s TBO and the tropical sea surface temperature(SST)anomalies in several key ocean regions are more significant and have longer correlation duration than the raw data.The response of the western boundary index to ENSO is earlier than the intensity index,and the time-lag correlations of them are up to maximum when lagging ENSO by 3–5 months and 5–6months,respectively.(3)In the course of the WPSH’s TBO cycle,the occurrence of the El Ni o-like anomaly in the tropical central-eastern Pacific in winter is always coupled with the weak East Asian winter monsoon,with the most significant enhancing phase of the WPSH’TBO.In contrast,the La Ni a-like anomaly in the central-eastern Pacific in winter is coupled with the strong East Asian winter monsoon,with the most weakening phase of the WPSH’s TBO.(4)The distribution of the tropical SST and atmospheric circulations anomalies are asymmetric in the TBO cycle.The WPSH’s TBO is more significant in the period of the developing El Ni o-like anomaly in central-eastern Pacific than in the period of the developing La Ni a-like anomaly.Therefore,during the period of developing El Ni o-like anomaly,more attention should be paid to the interannual component of TBO signal in the short-term climate prediction. | LIU YunYun DING YiHui GAO Hui LI WeiJing | 2013 | Chinese Science Bulletin2013，58，30： | 8 |
| 17 | Influence of Late Springtime Surface Sensible Heat Flux Anomalies over the Tibetan and Iranian Plateaus on the Location of the South Asian High in Early Summer显示文摘Variation in the location of the South Asian High(SAH) in early boreal summer is strongly influenced by elevated surface heating from the Tibetan Plateau(TP) and the Iranian Plateau(IP). Based on observational and ERA-Interim data,diagnostic analyses reveal that the interannual northwestward–southeastward(NW–SE) shift of the SAH in June is more closely correlated with the synergistic effect of concurrent surface thermal anomalies over the TP and IP than with each single surface thermal anomaly over either plateau from the preceding May. Concurrent surface thermal anomalies over these two plateaus in May are characterized by a negative correlation between sensible heat flux over most parts of the TP(TPSH)and IP(IPSH). This anomaly pattern can persist till June and influences the NW–SE shift of the SAH in June through the release of latent heat(LH) over northeastern India. When the IPSH is stronger(weaker) and the TPSH is weaker(stronger)than normal in May, an anomalous cyclone(anticyclone) appears over northern India at 850 hPa, which is accompanied by the ascent(descent) of air and anomalous convergence(divergence) of moisture flux in May and June. Therefore, the LH release over northeastern India is strengthened(weakened) and the vertical gradient of apparent heat source is decreased(increased)in the upper troposphere, which is responsible for the northwestward(southeastward) shift of the SAH in June. | Haoxin ZHANG Weiping LI Weijing LI | 2019 | Advances in Atmospheric Sciences2019，36，1： | 8 |
| 18 | Mapping CD20 molecules on the lymphoma cell surface using atomic force microscopy显示文摘Atomic force microscopy (AFM) was used to locate CD20 molecules on the surface of lymphoma Raji cells. Rituximab (a monoclonal antibody against CD20) molecules were linked onto the AFM tip via a polyethylene glycol (PEG) linker. Raji cells were adsorbed onto glass slides coated with poly-L-lysine. First, the CD20 distribution in a local area of the cell surface was visualized using the AFM lift scan mode. Second, 16 × 16 force curves were obtained from the same cell area to construct the CD20-rituximab binding force map. Finally, free rituximab was added to block the CD20 molecules on the cell surface and the lift phase image and CD20-rituximab force map were obtained again. The experimental results indicated that when the lift height was greater than the length of the PEG linker, no recognition sites were observed in the lift phase image. However, as the lift height decreased to the length of the PEG linker, some recognition sites were observed in the lift phase image and these sites were generally consistent with the pixels in the force map. After blocking, both the recognition sites in the lift phase image and the gray pixels in the binding force map decreased markedly. These results can improve our understanding of the distribution of protein molecules on the cell surface and facilitate further investigations into cellular functions. | LI Mi LIU LianQing XI Ning WANG YueChao DONG ZaiLi XIAO XiuBin ZHANG WeiJing | 2013 | Chinese Science Bulletin2013，58，13： | 6 |
| 19 | Laparoscopic total gastrectomy versus open total gastrectomy for cancer: a systematic review and meta-analysis显示文摘 | Leonie Haverkamp Teus J. Weijs Pieter C. Sluis Ingeborg Tweel Jelle P. Ruurda Richard Hillegersberg | 2013 | Surgical Endoscopy2013，，5： | 6 |
| 20 | Forming proper ensemble forecast initial members with four-dimensional variational data assimilation method显示文摘A method has been presented to improve ensemble forecast by utilizing these initial members generated by four-dimensional variational data assimilation (4-D VDA), to conquer limitation of those initial members generated by Monte Carlo forecast (MCF) or lagged average forecast (LAF). This method possesses significant statistical characteristic of MCF, and by virtue of LAF that contains multi-time information and its initial members are harmonic with | Jiandong Gong Weijing Li Jifan Chou | 1999 | Chinese Science Bulletin1999，44，16： | 6 |
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