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| 1 | 从附睾到卵子:CRISP蛋白在哺乳动物受精过程中的作用显示文摘哺乳动物的受精过程涉及精卵结合的很多步骤,是一个非常复杂的过程,其分了机制亟待阐明。此篇综述主要论述了CRISP(富含半胱氨酸的分泌蛋白)作为模型分子在哺乳动物受精过程中的价值。大量的体外实验和基因敲出模型研究显示,附睾内的CRISP1以两种不同的亲和力结合于精子表面,参与精子获能、精子-透明带结合、精卵融合的调控。这些研究成果可以延伸至人类。我们住研究中发现,人类具有与啮齿类同源的CRISP(hCRISP1),同样参与受精过样。CRISP家族的其他成员(睾丸内CRISP2、附挈内CRISP3—4、射精时的CRISP3)也参与了精卵结合的过程,提示同源分子间的相互协同有助于受精的成功。另外,我们的研究显示,CRISP蛋白伴随精子穿越男性及女性生殖管道的全过程。我们推测CRISP不仅参与了受精过程,而且可能成为不育和避孕研究的新靶点。 | Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone Nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D Gomez-Elias Debora J Cohen Patricia S Cuasnicu | 2015 | Asian Journal of Andrology2015，17，5： | 5 |
| 2 | The ABCs of floral homeotic genes显示文摘 | WEIGEL D MEYEROWITZ E M | 1994 | Cell1994，78，： | 1 |
| 3 | Diffusion tensor imaging and white matter tractography in patients with brainstem lesions 显示文摘 | Chert X Weigel D Ganslandt O | 2007 | Acta Neurochir (Wien)2007，149，11： | 1 |
| 4 | Independent regulation of flowering by phytochrome B and gibberellins in Arabidopsis显示文摘 | Blazquez M A Weigel D | 1999 | Plant Physiol1999，120，： | 1 |
| 5 | Gene silencing in plants using artificial microRNAs and other small RNAs 显示文摘 | Ossowski S Schwab R Weigel D | 2008 | Plant J2008，53，4： | 1 |
| 6 | Differential screening and suppression snbtractive hybridazation identified genes differentially expressed in an estrogen receptor-positive breast carcinoma cell line 显示文摘 | Kuang W W Thompson D A Hoeh R V Weigel R J | 1998 | Nucleic Acids Res1998，26，： | 1 |
| 7 | Agenetic framework for floral patterning显示文摘 | Parcy F Nilsson O Busch M A Lee I Weigel D | 1998 | Nature1998，395，： | 1 |
| 8 | LEAFY controls floral meristem identity in Arabidopsis显示文摘 | Weigel D Alvarez J Smyth D R | 1992 | Cell1992，69，： | 1 |
| 9 | Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus 显示文摘 | Weigel L M Clewell D B Gill S R | 2003 | Science2003，302，5650： | 1 |
| 10 | Product configuration frameworks-A survey显示文摘 | Sabin D Weigel R | 1998 | IEEE Intelligent Systems & Their Applications1998，13，4： | 1 |
| 11 | Product Configuration Frameworks:A Survey显示文摘 | Sabin D Weigel R | 1998 | IEEE Intelligent Systems1998，13，4： | 1 |
| 12 | A developmental switch sufficient for flower initiation in diverse plants显示文摘 | Weigel D Nillson O | 1995 | Nature1995，377，： | 1 |
| 13 | Circadian clock adjustment to plant iron status depends on chloroplast and phytochrome function 显示文摘 | SALOME P A OLIVA M WEIGEL D | 2013 | EMBO J2013，32，4： | 1 |
| 14 | Diffusion tensor imaging and white matter tractography in patients with brainstem lesions 显示文摘 | Chen X Weigel D Ganslandt 0 | 2007 | Acta Neurochir (Wien)2007，149，11： | 1 |
| 15 | Exfoliative cheilitis (EC) in AIDS: association with Candida infection 显示文摘 | Reichart PA Weigel D Schmidt -Westhausen A | 1997 | Jour- nal of oral pathology & medicine: official publication of the Interna- tional Association of Oral Pathologists and the American Academy of Oral Pathology1997，26，6： | 1 |
| 16 | A thermosensory pathway controlling flowering time in Arabidopsis thaliana显示文摘 | Blazquez MA Ahn JH Weigel D | | 0，，02： | 1 |
| 17 | Activation tagging in Arabidopsis 显示文摘 | WEIGEL D AHN J H BLAZQUEZ M A | 2000 | Plant Physiol2000，122，4： | 1 |
| 18 | A developmental switch sufficient for flower initiation in diverse plant显示文摘 | NISSEN O | 1995 | Nature1995，377，： | 1 |
| 19 | A mutation associated with fluoroquinolone resistance in eigth species of Enterobacteriaceae 显示文摘 | Weigel L M Steward C D Tenover gyr F C | 1998 | Antimicrobial Agents and Chemotherapy1998，42，： | 1 |
| 20 | Regulatory elements of the floral homeotie gene AGAMOUS identified by phylogenetic footprinting and shadowing显示文摘 | HONG R L HAMAGUCHI L H BUSCH M A WEIGEL D | 2003 | The Plant Cell2003，15，： | 1 |
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