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| 1 | Involvement of the p38 mitogen-activated protein kinase signal transduction pathway in burns-induced lung injury显示文摘Acute lung injury (ALI) is a leading complication in extensively burned patients, especially those with inhalation injury. 1 It can cause hypoxia resulting in injury of remote organs and dysfunction. p38 mitogen-activated protein kinase (p38 MAPK) is a stress activated protein kinase in the MAPK family. 2 Most of the previous studies have demonstrated that p38 MAPK signal transduction pathway mediated ALI in rats with acute severe pancreatitis, sepsis etc. 3-5 However, there is little information regarding the role of p38 MAPK signal transduction pathway in ALI after severe burn trauma. | CHENXu-lin XIAZhao-fan WEIDuo WANGYong-jie WANGChang-rong | 2005 | Chinese Medical Journal2005，，4： | 7 |
| 2 | Excavating bioactivities of nanozyme to remodel microenvironment for protecting chondrocytes and delaying osteoarthritis显示文摘Osteoarthritis(OA)is the main cause of disability in the elderly.Effective intervention in the early and middle stage of osteoarthritis can greatly prevent or slow down the development of the disease,and reduce the probability of joint replacement.However,there is to date no effective intervention for early and middle-stage OA.OA microenvironment mainly destroys the balance of oxidative stress,extracellular matrix synthesis and degradation of chondrocytes under the joint action of biological and mechanical factors.Herein,hollow Prussian blue nanozymes(HPBzymes)were designed via a modified hydrothermal template-free method.The aim of this study was to investigate the effects of HPBzymes on chondrocytes and the progression of OA.The intrinsic bioactivities of HPBzymes were excavated in vitro and in vivo,remodeling microenvironment for significantly protecting chondrocytes and delaying the progression of traumatic OA by inhibiting reactive oxygen species(ROS)and Rac1/nuclear factor kappa-B(NF-κB)signaling in a rat model.HPBzyme significantly diminished interleukin(IL)-1β-stimulated inflammation,extracellular matrix degradation,and apoptosis of human chondrocytes.HPBzyme attenuated the expression of Rac1 and the ROS levels and prevented the release and nuclear translocation of NF-κB.Deeply digging the intrinsic bioactivities of nanozyme with single component to remodel microenvironment is an effective strategy for ROS-associated chronic diseases.This study reveals that excavating the bioactivities of nanomedicine deserves attention for diagnosis and treatment of severe diseases. | Weiduo Hou Chenyi Ye Mo Chen Wei Gao Xue Xie Jianrong Wu Kai Zhang Wei Zhang Yuanyi Zheng Xiaojun Cai | 2021 | Bioactive Materials2021，6，8： | 5 |
| 3 | Hypersonic reentry trajectory planning by using hybrid fractional-order particle swarm optimization and gravitational search algorithm显示文摘This paper proposes a novel hybrid algorithm called Fractional-order Particle Swarm optimization Gravitational Search Algorithm(FPSOGSA)and applies it to the trajectory planning of the hypersonic lifting reentry flight vehicles.The proposed method is used to calculate the control profiles to achieve the two objectives,namely a smoother trajectory and enforcement of the path constraints with terminal accuracy.The smoothness of the trajectory is achieved by scheduling the bank angle with the aid of a modified scheme known as a Quasi-Equilibrium Glide(QEG)scheme.The aerodynamic load factor and the dynamic pressure path constraints are enforced by further planning of the bank angle with the help of a constraint enforcement scheme.The maximum heating rate path constraint is enforced through the angle of attack parameterization.The Common Aero Vehicle(CAV)flight vehicle is used for the simulation purpose to test and compare the proposed method with that of the standard Particle Swarm Optimization(PSO)method and the standard Gravitational Search Algorithm(GSA).The simulation results confirm the efficiency of the proposed FPSOGSA method over the standard PSO and the GSA methods by showing its better convergence and computation efficiency. | Khurram SHAHZAD SANA Weiduo HU | 2021 | Chinese Journal of Aeronautics2021，34，1： | 5 |
| 4 | THE DECOUPLING CONTROL FORAIRCRAFT IN RAPID ROLL显示文摘THEDECOUPLINGCONTROLFORAIRCRAFTINRAPIDROLLHuWeiduo,ZhangMinglian,WenChuanyuan(DepartmentofAutomaticControl,BeijingUniversityo... | Hu Weiduo Zhang Minglian Wen Chuanyuan(Department of Automatic Control,Beijing University of Aeronautics and Astronautics, Beijing, China, 100083) | 1994 | Chinese Journal of Aeronautics1994，7，4： | 2 |
| 5 | Reversing the imbalance in bone homeostasis via sustained release of SIRT-1 agonist to promote bone healing under osteoporotic condition显示文摘The imbalance of bone homeostasis is the root cause of osteoporosis.However current therapeutic approaches mainly focus on either anabolic or catabolic pathways,which often fail to turn the imbalanced bone metabolism around.Herein we reported that a SIRT-1 agonist mediated molecular therapeutic strategy to reverse the imbalance in bone homeostasis by simultaneously regulating osteogenesis and osteoclastogenesis via locally sustained release of SRT2104 from mineral coated acellular matrix microparticles.Immobilization of SRT2104 on mineral coating(MAM/SRT)harnessing their electrostatic interactions resulted in sustained release of SIRT-1 agonist for over 30 days.MAM/SRT not only enhanced osteogenic differentiation and mineralization,but also attenuated the formation and function of excessive osteoclasts via integrating multiple vital upstream signals(β-catenin,FoxOs,Runx2,NFATc1,etc.)in vitro.Osteoporosis animal model also validated that it accelerated osteoporotic bone healing and improved osseointegration of the surrounding bone.Overall,our work proposes a promising strategy to treat osteoporotic bone defects by reversing the imbalance in bone homeostasis using designated small molecule drug delivery systems. | Wei Zhang Xingzhi Zhou Weiduo Hou Erman Chen Chenyi Ye Mo Chen Qian Lu Xiaohua Yu Weixu Li | 2023 | Bioactive Materials2023，，1： | 2 |
| 6 | The Future of Hydrogen Infrastructure for Fuel cell Vehicles in China and a case of Application in Beijing 显示文摘 | Wen Feng Shujuan Wang Weiduo Ni | 2003 | International Journal of Hydrogen Energy2003，，： | 1 |
| 7 | Research on the thermal field and active water cooling system design of an air-core compulsator显示文摘 | Shumei Cui Weiduo Zhao Shaopeng Wu | 2011 | IEEE Transactions on Plasma Science2011，39，1： | 1 |
| 8 | Shift in Global Climate Governance and China's Contributions显示文摘The conclusion of the Paris Agreement struck a balance between interest of various countries in the world and global interest,being a milestone in the process of global climate governance.In the successful conclusion of the Paris Agreement,China played a great promoting role,which fully illustrated China’s determination in partaking in global climate governance and in switch to a new development paradigm of ecological civilization and at the same time | Zhuang Guiyang Zhou Weiduo | 2016 | Contemporary World2016，，2： | 1 |
| 9 | Partitioning of elements from coal by different solvents extraction显示文摘 | Wenfeng Wang Yong Qin Fuchang Qian Longfang Ye Weiduo Hao Li Yuan Fali Jin | 2014 | Fuel2014，，： | 1 |
| 10 | Atomistic Modeling of Lithium Materials from Deep Learning Potential with Ab Initio Accuracy显示文摘Lithium has been paid great attention in recent years thanks to its significant appli-cations for battery and lightweight alloy.Developing a potential model with high ac-curacy and efficiency is impor-tant for theoretical simulation of lithium materials.Here,we build a deep learning potential(DP)for elemental lithium based on a concurrent-learning scheme and DP representation of the density-functional theory(DFT)potential energy surface(PES),the DP model enables material simulations with close-to DFT accuracy but at much lower computational cost.The simulations show that basic parameters,equation of states,elasticity,defects and surface are consistent with the first principles results.More notably,the liquid radial distribution func-tion based on our DP model is found to match well with experiment data.Our results demon-strate that the developed DP model can be used for the simulation of lithium materials. | Haidi Wang Tao Li Yufan Yao Xiaofeng Liu Weiduo Zhu Zhao Chen Zhongjun Li Wei Hu | 2023 | Chinese Journal of Chemical Physics2023，36，5： | 0 |
| 11 | Demagnetization Research on PMs in the Halbach Magnetized Pulsed Alternator显示文摘Demagnetization behavior of Halbach magnetized compensated pulsed alternator(CPA)is studied by using finite element method(FEM)under the different demagnetization factors in this paper.The effect of armature reaction magnetic field and thermal rise on demagnetization of PMs is analyzed.This paper investigates the effect of different demagnetization factors on magnetic field distribution,load current,and no-load phase voltage.A series of dynamic demagnetization points in Halbach array permanent magnet(PM)are evaluated to search the worst working point.Partial demagnetization risk can be represented by the worst working point,and the global demagnetization of the PM is represented by the no-load phase voltage characteristics after discharge.The research results demonstrated that the compensation shield with a certain thickness can increase the discharge current and weaken the demagnetization influence of armature reaction.The demagnetization effect of armature reaction on PMs at high temperatures will be strengthened. | Songlin Wu Shaopeng Wu Weiduo Zhao Shumei Cui | 2019 | CES Transactions on Electrical Machines and Systems2019，3，2： | 0 |
| 12 | 室温电致水结冰:相图中“遗漏”的一个高密度冰相显示文摘水可以根据温度(T)和压力(P)等外部条件冻结成不同的冰形态。分子动力学模拟显示,室温时,在高压和高电场强度的条件下,液态水可以自发形成一种高密度(1.27g/cm^3)的新型铁电冰晶体—“冰x相”。同时,基于爱因斯坦分子自由能计算方法,结果表明:在水相图上的一个高压低温区,冰x相是最稳定的结构。 | Weiduo Zhu Yingying Huang Chongqin Zhu HongHui Wu Lu Wang Jaeil Bai Jinlong Yang Joseph S.Francisco Jijun Zhao Lan-Feng Yuan Xiao Cheng Zeng 李巧红 | 2019 | 家电科技2019，，3： | 0 |
| 13 | Study on Mesenchymal Artery Syndrome and Its Related Anatomy by MDCTA显示文摘Objective: To study the eff ect of MDCTA on the angle and distance of mesenteric artery and abdominal aorta in normal and superior mesenteric artery syndrome and its effect on duodenal level. Materials and Methods: Using MDCTA, retrospective observation of 108 cases of normal and 17 cases of superior mesenteric artery syndrome in patients with superior mesenteric artery and abdominal aortic angle and duodenal level mesenteric artery and abdominal aortic space, and compared. Results: All MDCTA of patients with superior mesenteric artery syndrome showed 'clamp pressure' of the superior mesenteric artery and abdominal aorta in the duodenal segment, causing duodenal obstruction. Among the 108 normal subjects, the angle between the superior mesenteric artery and the abdominal aorta was 46.3 °± 16.5 ° and 14.3 °± 5.6 ° in the superior mesenteric artery syndrome. The normal level of the duodenum was superior to the superior mesenteric artery Arterial distance of 14.7 ± 4.4mm, superior mesenteric artery syndrome in patients with 4.5 ± 0.8mm, the two groups of data have signifi cant statistical diff erences. Conclusion: MDCTA can show the duodenal obstruction caused by the mesenteric artery and the abdominal aorta of the superior mesenteric artery syndrome, and can accurately show the angle between the superior mesenteric artery and the abdominal aorta the reduction of distance, the diagnosis of superior mesenteric artery syndrome has important clinical value. | Zhaoan Hu Weiduo Song Liqiang Liu | 2018 | Anatomical Science2018，1，1： | 0 |
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