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| 1 | Analysis of reference gene expression for real-time PCR based on relative quantitation and dual spike-in strategy in the silkworm Bombyx mori显示文摘为即时量的聚合酶链反应(qPCR ) ,一般来说,正规化策略把引用基因用作控制并且不应该响应改变条件变化避免这基因的试验性的错误表示的介绍。然而,许多参考基因的表示被报导了更加变化,没有适当正规化,目标基因的表示侧面能被曲解。在这研究,七的表达式层次通常使用了引用基因(行为, GAPDH, 28srRNA, RPL3, -tubulin, UBC,和 TBP ) 与 20-hydroxyecdysone (20E ) 并且与卢丁在不同开发时间点并且响应处理被检测。表示稳定性用 geNorm 和 NormFinder 软件被分析。重要变化在正常纸巾之中并且在试验性地对待的纸巾之间被发现。双刺在里面策略也在正常纸巾之中并且在试验性地对待的纸巾之间揭示了参考基因的表示层次的重要变化。Glutathione-S-transferase 西格马 1 (GSTs1 ) ,它在胖身体有高表达式水平并且与抵抗的机制有关,被用作目标基因验证这二条途径的可行性和差别。 | Ran Peng Yuanfen Zhai Hua Ding Tianyuan Di Ting Zhang Bing Li Weide Shen Zhengguo Wei | 2012 | Acta Biochimica et Biophysica Sinica2012，44，7： | 8 |
| 2 | An Innovated Integrated Model Using Singular Spectrum Analysis and Support Vector Regression Optimized by Intelligent Algorithm for Rainfall Forecasting显示文摘Rainfall forecasting is becoming more and more significant and precipitation anomalies would lead to droughts and floods disasters.However,because of the complexity and non-stationary of rainfall data,it is difficult to forecast.In this paper,a novel hybrid model to forecast rainfall is developed by incorporating singular spectrum analysis (SSA) and dragonfly algorithm (DA) into support vector regression (SVR) method.Firstly,SSA is used for extracting the trend components of the hydrological data.Then,SVR is utilized to deal with the volatility and irregularity of the precipitation series.Finally,the parameter of SVR is optimized by DA.The proposed SSA-DA-SVR method is used to forecast the monthly precipitation for Songbai,Panshui,Lanma and Jiulongchi stations.To validate the efficiency of the method,four compared models,DA-SVR,SSA-GWO-SVR,SSA-PSO-SVR and SSA-CS-SVR are established.The result shows that the proposed method has the best performance among all five models,and its prediction has high precision and accuracy. | Weide Li Juan Zhang | 2019 | Journal of Autonomous Intelligence2019，2，1： | 4 |
| 3 | One-pot solvothermal synthesis of three-dimensional (3D) BiOI/BiOCl composites with enhanced visible-light photocatalytic activities for the degradation of bisphenol-A显示文摘 | Xin Xiao Rong Hao Min Liang Xiaoxi Zuo Junmin Nan Laisheng Li Weide Zhang | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 4 | Dry-period irrigation and fertilizer application affect water use and yield of spring wheat in semi-arid regions显示文摘 | Li Zizhen Li Weide Li Wenlong | 2004 | Agricultural Water Management2004，65，2： | 1 |
| 5 | Expression and localization of mesothelin in developing rat pancreas显示文摘 | Liang‐QinHou Yin‐HeWang Li‐JieLiu JingGuo Li‐PingTeng Li‐HuaCao HuiShi LiYuan WeiDe | 2008 | Development Growth & Differentiation2008，，7： | 1 |
| 6 | Irrigation and fertilizer effects on water use and yield of spring wheat in semi-arid regions显示文摘 | Wenlong Li Weide Li Zizhen Li | 2004 | Agricultural Water Management2004，67，： | 1 |
| 7 | Irrigation and fertilizer effects on water use and yield of spring wheat in semiarid regions显示文摘 | Li Wenlong Li Weide Li Zizhen | 2004 | Agricultural Water Management2004，67，： | 1 |
| 8 | A microfluidic cell chip for virus isolation via rapid screening for permissive cells显示文摘Virus identification is a prerequisite not only for the early diagnosis of viral infectious diseases but also for the effective prevention of epidemics.Successful cultivation is the gold standard for identifying a virus,according to the Koch postulates.However,this requires screening for a permissive cell line,which is traditionally time-,reagent-and labor-intensive.Here,a simple and easy-to-operate microfluidic chip,formed by seeding a variety of cell lines and culturing them in parallel,is reported for use in virus cultivation and virus-permissive host-cell screening.The chip was tested by infection with two known viruses,enterovirus 71(EV71)and influenza virus H1N1.Infection with EV71 and H1N1 caused significant cytopathic effects(CPE)in RD and MDCK cells,respectively,demonstrating that virus cultivation based on this microfluidic cell chip can be used as a substitute for the traditional plate-based culture method and reproduce the typical CPE caused by virus infection.Using this microfluidic cell chip method for virus cultivation could make it possible to identify an emerging virus in a highthroughput,automatic,and unprecedentedly fast way. | Weide Su Jingjiang Qiu Ying Mei Xian-En Zhang Yong He Feng Li | 2022 | Virologica Sinica2022，37，4： | 1 |
| 9 | Decision analysis of emergency ventilation and evacuation strategies against suddenly released contaminant indoors by considering the uncertainty of source locations显示文摘 | CAI Hao LONG Weiding LI Xianting | 2010 | Journal of Hazardous Materials2010，178，123： | 1 |
| 10 | Irrigation and fertilizer effects on water use and yield of spring wheat in semi-arid regions显示文摘 | Li Wenlong Li Weide Li Zizhen | 2004 | Agricultural Water Management2004，67，1： | 1 |
| 11 | Effect of the niche-fitness at different water supply and fertilization on yield of spring wheat in farmland of semi-arid areas显示文摘 | Wenlong Li Zizhen Li Weide Li | 2004 | Agricultural Water Management2004，，1： | 1 |
| 12 | Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer显示文摘The therapeutic efficacy of metformin in prostate cancer(PCa)appears uncertain based on various clinical trials.Metformin treatment failure may be attributed to the high frequency of transcriptional dysregulation,which leads to drug resistance.However,the underlying mechanism is still unclear.In this study,we found evidences that metformin resistance in PCa cells may be linked to cell cycle reactivation.Super-enhancers(SEs),crucial regulatory elements,have been shown to be associated with drug resistance in various cancers.Our analysis of SEs in metformin-resistant(MetR)PCa cells revealed a correlation with Prostaglandin Reductase 1(PTGR1)expression,which was identified as significantly increased in a cluster of cells with metformin resistance through single-cell transcriptome sequencing.Our functional experiments showed that PTGR1 overexpression accelerated cell cycle progression by promoting progression from the G0/G1 to the S and G2/M phases,resulting in reduced sensitivity to metformin.Additionally,we identified key transcription factors that significantly increase PTGR1 expression,such as SRF and RUNX3,providing potential new targets to address metformin resistance in PCa.In conclusion,our study sheds new light on the cellular mechanism underlying metformin resistance and the regulation of the SE-TFs-PTGR1 axis,offering potential avenues to enhance metformin’s therapeutic efficacy in PCa. | Jianheng Ye Shanghua Cai Yuanfa Feng Jinchuang Li Zhiduan Cai Yulin Deng Ren Liu Xuejin Zhu Jianming Lu Yangjia Zhuo Yingke Liang Jianjiang Xie Yanqiong Zhang Huichan He Zhaodong Han Zhenyu Jia Weide Zhong | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 13 | Characteristics of Water Environment in Regions of Zhaling and Eling Lakes near Waterhead of Yellow River显示文摘Conditions of the water environment in the region of the Zhaling and Eling lakes, which are located in the frozen earth zone on the Qingzang plateau, are unique. The equilibrium of the water quantity of the two lakes is maladjustment under the condition of a dry and cold climate in which evaporation is greater than precipitation. The Zhaling and Eling lakes have been atrophying, leaving three lake terraces and star studded lagoons around the two lakes since Holocene. When these lagoons were separated from the original lakes, they became cut lake basins, and were transformed from fresh water lakes into salt water lakes, salt lakes or salt playas owing to strong evaporation. This kind of evolutionary process will continue in the future. | Cao Wenbing Wan Li Hu Fusheng Shen Zhaoli Department of Water Resources and Environmental Engineering, China University of Geosciences, Beijing 100083 Yan Weide Qinghai Exploring Institute of Hydrogeology and Engineering Geology, Ledu 810700 | 2001 | Journal of China University of Geosciences2001，12，2： | 0 |
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