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| 1 | Different contributions of STAT3, ERK1/2, and PI3-K signaling to cardiomyocyte hypertrophy by cardiotrophin-1显示文摘AIM: To assess the contribution of signal transducer and activator of transcription 3(JAK-STAT3) pathway, extracellular signal-regulated kinases1/2 (ERK1/2) pathway, and phosphatidylinositol 3-kinase (PI3-K) pathway to cardiomyocytes hypertrophy induced by cardiotrophin-1 (CT-1), a new member of interleukin-6 (IL-6) family of cytokines. METHODS: STAT3, ERK1/2, and PI3-K were assessed by Western blot analysis. Activity of ERK1/2 was also confirmed by in-gel kinase assay. Hypertrophy of cardiomyocyte was evaluated by [^3H]leucine incorporation and cellular protein-to-DNA ratio. RESULTS: CT-1 simultaneously activated phosphorylation of STAT3, ERK1/2, and PI3-K in rat cardiomyocytes. Parthenolide, an inhibitor of STAT, suppressed CT-1-induced [^3H]leucine incorporation by 88.3% and protein-to-DNA ratio by 75.0%. U0126, an MEK1/2 inhibitor, increased CT-1-induced the phosphorylation of STAT3 in a dose-dependent manner and, consistently, augmented CT-1-induced increase in [^3H]leucine incorporation and cellular protein-to-DNA ratio by 17.6% and 16.3%, respectively. Wortmannin, a PI3-K inhibitor, did not influence CT-1-induced [^3H]leucine incorporation and cellular protein-to-DNA ratio. CONCLUSION: The hypertrophic effect of CT-1 was essentially mediated by STAT3, independent of PI3-K, and negatively regulated by ERK1/2 via inhibiting the phosphorylation of STAT3. The interaction between STAT3 and ERK1/2 in CT-1-induced signaling contributes to development of cardiac hypertrophy. | Ze-junTIAN WeiCUI Yong-junLI Yu-mingHAO JunDU FanLIU HuiZHANG Xiu-guangZU Su-yunLIU LiCHEN WeiAN | 2004 | Acta Pharmacologica Sinica2004，25，9： | 16 |
| 2 | The Late Carboniferous–Early Permian Ocean-Continent Transition in the West Junggar,Central Asian Orogenic Belt: Constraints from Columnar Jointed Rhyolite显示文摘The West Junggar of the western Central Asian Orogenic Belt is one of the typical regions in the term of ocean subduction, contraction and continental growth in the Late Paleozoic. However, it is still controversial on the exact time of ocean-continent transition so far. This study investigates rhyolites with columnar joint in the West Junggar for the first time.Based on zircon U-Pb dating, we determined that the ages of the newly-discovered rhyolites are between 303.6 and 294.5 Ma, belonging to Late Carboniferous–Early Permian, which is the oldest rhyolite with columnar joint preserved in the world at present. Geochemical results show that the characteristics of the major element compositions include a high content of SiO_2(75.78–79.20 wt%) and a moderate content of Al_2O_3(12.21–13.19 wt%). The total alkali content(K_2O +Na_2O) is 6.14–8.05 wt%, among which K_2O is 2.09–4.72 wt% and the rate of K_2O/Na_2O is 0.38–3.05. Over-based minerals such as Ne, Lc, and Ac do not appear. The contents of TiO_2(0.09–0.24 wt%), CaO(0.15–0.99 wt%) and MgO(0.06–0.18 wt%) are low. A/CNK=0.91–1.68, A/NK=1.06–1.76, and as such, these are associated with the quasi-aluminum-weak peraluminous high potassium calc-alkaline and some calc-alkaline magma series. These rhyolites show a significant negative Eu anomaly with relative enrichment of LREE and LILE(Rb, Ba, Th, U, K) and depletion of Sr, HREE and HFSE(Nb, Ta, Ti, P). These rhyolites also have the characteristics of an A2-type granite, similar to the Miaoergou batholith,which indicates they both were affected by post-orogenic extension. Combining petrological, zircon U-Pb dating and geochemical characteristics of the rhyolites, we conclude that the specific time of ocean-continent transition of the West Junggar is the Late Carboniferous–Early Permian. | XU Shenglin CHEN Xuanhua LI Tingdong SHI Jianjie DING Weicui LI Bing HUANG Penghui ZHANG Yiping ZHANG Yaoyao MA Feizhou | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 9 |
| 3 | Construction of the Continental Asia in Phanerozoic:A Review显示文摘This is a review of the formation and tectonic evolution of the continental Asia in Phanerozoic.The continental Asia has formed on the bases of some pre-Cambrian cratons,such as the Siberia,India,Arabia,North China,Tarim,South China,and Indochina,through multi-stage plate convergence and collisional collages in Phanerozoic.The north-central Asia had experienced the expansion and subduction of the Paleo-Asian Ocean(PAO)in the early Paleozoic and the closure of the PAO in the late Paleozoic and early Mesozoic,forming the PAO regime and Central Asian orogenic belt(CAOB).In the core of the CAOB,the Mongol-Okhotsk Ocean(MOO)opened with limited expansion in the Early Permian and finally closed in the Late Jurassic–Early Cretaceous.The south-central Asia had experienced mainly multi-stage oceanic opening,subduction and collision evolution in the Tethys Ocean,forming the Tethys regime and Himalaya-Tibetan orogenic belt.In eastern Asia,the plate subduction and continental margin orogeny on western margin of the Pacific Ocean,forms the West Pacific regime and West Pacific orogenic belt.The PAO,Tethys,and West Pacific regimes,together with Precambrian cratons among or surrounding them,made up the major tectonic and dynamic systems of the continental Asia in Phanerozoic.Major tectonic events,such as the Early Paleozoic Qilian,Uralian,and Dunhuang orogeneses,the late Paleozoic East Junggar,Tianshan and West Junggar orogeneses,the Middle to Late Permian Ailaoshan orogeny and NorthSouth Lhasa collision,the early Mesozoic Indochina-South China and North-South China collisions,the late Mesozoic Mongolia-Okhotsk orogeny,Lhasa-Qiangtang collision,and intra-continental Yanshanian orogeny,and the Cenozoic IndoAsian,Arab-Asian,and West Pacific margin collisions,constrained the formation and evolution of the continental Asia.The complex dynamic systems have left large number of deformation features,such as large-scale strike-slip faults,thrustfold systems and extensional detachments on the continental Asia.Based on past tectonics,a future supercontinent,the Ameurasia,is prospected for the development of the Asia in ca.250 Myr. | CHEN Xuanhua DONG Shuwen SHI Wei DING Weicui ZHANG Yiping LI Bing SHAO Zhaogang WANG Ye | 2022 | Acta Geologica Sinica(English Edition)2022，96，1： | 3 |
| 4 | Digital Geological Mapping of Sinus Iridum Area of the Moon Based on the Chang'E-I Data显示文摘Based on the CCD images,IIM data and DEM data of China’s lunar exploration project(Chang’E-I)and related processed and analytic results,an integrated study of regional geology of Sinus Iridum and its adjacent area was conducted,and a series of relevant researches and analyses were carried out,including analysis of impact craters and their extrusive and accumulative materials,division of stratigraphic and tectonic units and classification of rock types,integrated analysis of chronology and lunar evolution history.In consideration of crater’s shape features,quantity and preserving status of filling materials,the lunar impact craters can be divided into 7 types and 11 subtypes,and the accumulative materials of craters are divided into 6 types and 9 accumulative groups.According to the content and distribution of TiO2and image characteristics,the basalts are divided into high-TiO2,medium-TiO2and low-TiO2basalts.Discussion was made on division of tectonic units and evolution features in the study area.The geological map of the Sinus Iridum Quadrangle(LQ-4)at a scale of 1:2.5 M was preliminarily compiled with the ArcGIS system,and the spatial database of the map was established.Related technical specification,procedure and method for lunar geological mapping have been worked out,so as to lay a foundation for the forthcoming geological mapping of the global Moon in China by using the data of Chang’E-II and also for comprehensive study and geological mapping of other celestial bodies in the future. | DING Xiaozhong HAN Kunying PANG Jianfeng WANG Liang HAN Tonglin JU Yuanjing DING Weicui | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 3 |
| 5 | Late Paleozoic Element Migration and Accumulation under Intracontinental Sinistral Strike-slip Faulting in the West Junggar Orogenic Belt, NW China显示文摘The migration,accumulation and dispersion of elements caused by tectonic dynamics have always been a focus of attention,and become the basis of tectono-geochemistry.However,the effects of faulting,especially strike-slip faulting,on the adjustment of geochemical element distribution,are still not clear.In this paper,we select the West Junggar Orogenic Belt(WJOB),NW China,as a case study to test the migration behavior of elements under tectonic dynamics.The WJOB is dominated by NE-trending large-scale sinistral strike-slip faults such as the Darabut Fault,the Mayile Fault,and the Baerluke Fault,which formed during the intracontinental adjustment under N-S compression during ocean-continental conversion in the Late Paleozoic.Geochemical maps of 13 elements,Al,W,Sn,Mo,Cu,Pb,Zn,As,Sb,Hg,Fe,Ni,and Au,are analyzed for the effects of faulting and folding on element distribution at the regional scale.The results show that the element distribution in the WJOB is controlled mainly by two mechanisms during tectonic deformation:first is the material transporting mechanism,where the movement of geological units is consistent with the direction of tectonic movement;second is the diffusion mechanism,especially by tectonic pressure dissolution driven by tectonic dynamics,where the migration of elements is approximately perpendicular or opposite to the direction of tectonic movement.We conclude that the adjustment of element distributions has been determined by the combined actions of transporting and diffusion mechanisms,and that the diffusion mechanism plays an important role in the formation of geochemical Au blocks in the WJOB. | WANG Ye CHEN Xuanhua NIE Lanshi DING Weicui WANG Xueqiu XU Shenglin MA Feizhou HAN Lele | 2020 | Acta Geologica Sinica(English Edition)2020，94，6： | 1 |
| 6 | Monitoring stress levels on rice with heavy metal pollution from hyperspectral reflectance data using wavelet-fractal analysis显示文摘 | Meiling Liu Xiangnan Liu Weicui Ding Ling Wu | 2010 | International Journal of Applied Earth Observations and Geoinformation2010，，2： | 1 |
| 7 | Intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis: An observational study and review of the literature显示文摘 | Marwan S.Abougergi ApoorvBroor WeiCui Bernard G.Jaar | 2010 | J Hosp Med2010，，1： | 1 |
| 8 | Fe(III)?loaded activated carbon as catalyst to improveomethoate degradation by ozone in water显示文摘 | LING Weicui QIANG Zhimin SHI Yanwei | 2011 | Journal ofMolecular Catalysis A:Chemical2011，34，： | 1 |
| 9 | Ultrafine Fe/Fe3C decorated on Fe-N_(x)-C as bifunctional oxygen electrocatalysts for efficient Zn-air batteries显示文摘Efficient bifunctional oxygen electrocatalysts for ORR and OER are fundamental to the development of high performance metal-air batteries.Herein,a facile cost-efficient two-step pyrolysis strategy for the fabrication of a bifunctional oxygen electrocatalyst has been proposed.The efficient non-preciousmetal-based electrocatalyst,Fe/Fe_(3)C@Fe-N_(x)-C consists of highly curved onion-like carbon shells that encapsulate Fe/Fe_(3)C nanoparticles,distributed on an extensively porous graphitic carbon aerogel.The obtained Fe/Fe_(3)C@Fe-N_(x)-C aerogel exhibited superb electrochemical activity,excellent durability,and high methanol tolerance.The experimental results indicated that the assembly of onion-like carbon shells with encapsulated Fe/Fe_(3)C yielded highly curved carbon surfaces with abundant Fe-Nxactive sites,a porous structure,and enhanced electrocatalytic activity towards ORR and OER,hence displaying promising potential for application as an air cathode in rechargeable Zn-air batteries.The constructed Zn-air battery possessed an exceptional peak power density of~147 mW cm^(-2),outstanding cycling stability(200 cycles,1 h per cycle),and a small voltage gap of 0.87 V.This study offers valuable insights regarding the construction of low-cost and highly active bifunctional oxygen electrocatalysts for efficient air batteries. | Lingbo Zong Xin Chen Siliang Liu Kaicai Fan Shuming Dou Jie Xu Xiaoxian Zhao Wenjun Zhang Yaowen Zhang Weicui Wu Fenghong Lu Lixiu Cui Xiaofei Jia Qi Zhang Yu Yang Jian Zhao Xia Li Yida Deng Yanan Chen Lei Wang | 2021 | Journal of Energy Chemistry2021，30，5： | 1 |
| 10 | Differentiation of Human Embryonic Stem Cells to Neural Lineages in Adherent Culture by Blocking Bone Morphogenetic Protein Signaling显示文摘 | LesleyGerrard LeighRodgers WeiCui | 2009 | STEM CELLS2009，，9： | 1 |
| 11 | Diabetes: An Accomplice to Cancer显示文摘Worldwide, cancer and diabetes are two major chronic diseases that have great impacts on human health. Clinical and basic research studies have shown that diabetes, especially type 2 diabetes mellitus (T2DM), can promote the incidence and development of colon, pancreatic, breast, liver and bladder cancers. Hyperglycemia, chronic inflammation and abnormal metabolism are considered to be major risk factors involved in the development of cancer. Notably, some treatments used for diabetes, such as maintenance of a healthy diet and the use of hypoglycemic drugs to control blood glucose levels, may decrease the risk of cancer. On the other hand, metabolic disorders and the organ damage caused by cancer can also promote or accelerate the progression of diabetes. By reviewing the relevant literature, we found that diabetes can promote the occurrence and development of some cancers, and cancer can, in turn, influence diabetes. We herein discuss and summarize the mechanisms underlying the relationship between diabetes and cancer and the new therapeutic strategies based on this relationship. | Ting WenGe You XiYu Lu Cai Jiu WeiCui | 2019 | Journal of Nutritional Oncology2019，4，1： | 0 |
| 12 | Fluoridation routes,function mechanism and application of fluorinated/fluorine-doped nanocarbon-based materials for various batteries:A review显示文摘With the popularity and widespread applications of electronics,higher demands are being placed on the performance of battery materials.Due to the large difference in electronegativity between fluorine and carbon atoms,doping fluorine atoms in nanocarbon-based materials is considered an effective way to improve the performance of used battery.However,there is still a blank in the systematic review of the mechanism and research progress of fluorine-doped nanostructured carbon materials in various batteries.In this review,the synthetic routes of fluorinated/fluorine-doped nanocarbon-based(CF_x)materials under different fluorine sources and the function mechanism of CF_x in various batteries are reviewed in detail.Subsequently,judging from the dependence between the structure and electrochemical performance of nanocarbon sources,the progress of CF_x based on different dimensions(0D–3D)for primary battery applications is reviewed and the balance between energy density and power density is critically discussed.In addition,the roles of CF_x materials in secondary batteries and their current applications in recent years are summarized in detail to illustrate the effect of introducing F atoms.Finally,we envisage the prospect of CF_x materials and offer some insights and recommendations to facilitate the further exploration of CF_x materials for various high-performance battery applications. | Weicui Liu Nanping Deng Gang Wang Ruru Yu Xiaoxiao Wang Bowen Cheng Jingge Ju Weimin Kang | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
| 13 | 3D spiny AlF_(3)/Mullite heterostructure nanofiber as solid-state polymer electrolyte fillers with enhanced ionic conductivity and improved interfacial compatibility显示文摘Lithium metal batteries assembled with solid-state electrolyte can offer high safety and volumetric energy density compared to liquid electrolyte.The polymer solid-state electrolytes of poly(ethylene oxide)(PEO)are widely used in lithium metal solid-state batteries due to their unique properties.However,there are still some defects such as low ionic conductivity at room temperature and weak inhibition of lithium dendrite growth.Herein,the spiny inorganic nanofibers heterostructure with mullite whiskers grown on the surface of aluminum fluoride(AlF_(3))nanofibers are introduced into the PEOLi TFSI electrolytes for the first time to prepare composite solid-state electrolytes.The AlF_(3)as a strong Lewis acid can adsorb anions and promote the dissociation of Li salts.Besides,the specially threedimensional(3D)structure enlarges the effective contacting interface with the PEO polymer,which allows the lithium ions to be transported not only along the large aspect ratio of AlF3nanofibers,but also along the mullite phase in the transmembrane direction rapidly.Thereby,the transport channel of lithium ions at the spiny inorganic nanofibers-polymer interface is further improved.Benefiting from these advantages,the obtained composite solid-state electrolyte has a high ionic conductivity of 1.58×10^(-4)S cm^(-1)at 30℃and the lithium ions transfer number of 0.53.In addition,the AlF3has strong binding energy with anions,low electronic conductivity and wide electrochemical stability window,and reduced nucleation overpotential of lithium during cycling,which is positive for lithium dendrite suppression in solid-state electrolytes.Thus,the assembled symmetric Li/Li symmetric batteries exhibit stable cycling performance at different area capacities of 0.15,0.2,0.3 and 0.4 m A h cm^(-2).More importantly,the LiFePO_(4)(LFP)/Li battery still has 113.5 m A h g-1remaining after 400 cycles at 50℃and the Coulomb efficiency is nearly 100%during the long cycle.Overall,the interconnected structure of 3D spiny inorganic heterostructure nanofiber constitutes fast and uninterrupted lithium ions transport channels,maximizing the synergistic effect of interfacial transport of inorganic fillers and reducing PEO crystallinity,thus providing a novel approach to high performance solid-state electrolytes. | Weicui Liu Lingshuai Meng Xueqiang Liu Lu Gao Xiaoxiao Wang Junbao Kang Jingge Ju Nanping Deng Bowen Cheng Weimin Kang | 2023 | Journal of Energy Chemistry2023，，1： | 0 |
| 14 | Yu's Wavelet-a New Wavelet Used to Improve Resolution in Seismic Data Processing显示文摘Yu'sWavelet-aNewWaveletUsedtoImproveResolutioninSeismicDataProcessing￥FanWeicuiandLiuJirenKeywords:Wavelet,Processing.Resolut... | Fan Weicui and Liu Jiren. | 1996 | China Oil & Gas1996，3，2： | 0 |
| 15 | Early Cretaceous Thrust and Nappe Tectonics in North Qilian Shan,Northern Tibetan Plateau:Evidence from Field Mapping,Geochronology,and Deep Structural Analysis显示文摘The North Qilian Shan fold and thrust belt,located at the northern Tibetan Plateau and southern margin of the Hexi Corridor,is a key tectonic unit to decode the formation and expansion of the plateau.Previous studies emphasize the Cenozoic deformation due to the far-field response to the Indo-Asian collision,but the Mesozoic deformations are poorly constrained in this area.We conducted detailed field mapping,structural analysis,geochronology,and structural interpretation of deep seismic reflectional profiling and magnetotelluric(MT)sounding,to address the superposed results of the Mesozoic and Cenozoic deformation.The results recognized the North Qilian thrust and nappe system(NQTS),the root and the frontal belt are the North Qilian thrust(NQT),and the Yumu Shan klippe(YK),respectively.The middle belt is located between the NQT and the YK.Monzonitic granite zircon U-Pb dating from the middle belt yields an age of ca.415 Ma,which is similar to south NQT.The thrusting displacement is estimated at ca.48 km by structural interpretation of deep profiles.The timing is constrained in the early stage of the Early Cretaceous by the formation of simultaneous growth strata.We suggest that the NQTS has resulted from the far-field effect of the Lhasa-Qiangtang collision,and the Yumu Shan is uplifted by the superposed Cenozoic deformation. | HAN Lele DING Weicui CHEN Xuanhua SHAO Zhaogang ZHANG Da XIAO Yongjun HE Chengguang WANG Zengzhen LI Bing ZHANG Yiping XU Shenglin WANG Ye | 2023 | Acta Geologica Sinica(English Edition)2023，97，4： | 0 |
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