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| 1 | Inflammatory bowel disease serology in Asia and the West显示文摘AIM:To study serological antibodies in Caucasians and Asians,in health and inflammatory bowel disease(IBD),in Australia and Hong Kong(HK).METHODS:Anti-glycan antibodies[anti-chitobioside(ACCA),anti-laminaribioside(ALCA)],and anti-mannobioside(AMCA),anti-Saccharomyces cervisiae(gASCA);and atypical perinuclear anti-neutrophil cytoplasmic antibody(pANCA)were tested in IBD patients,their unaffected relatives,and healthy controls in Australia and HK(China).Antibody status(positive or negative)and titre was compared between subjects of different geography,ethnicity and disease state.RESULTS:Ninety subjects were evaluated:21 Crohn’s disease(CD),32 ulcerative colitis(UC),29 healthy controls,and 8 IBD patient relatives.Forty eight subjects were Australian(29 Caucasian and 19 ethnic Han Chinese)and 42 were from HK(all Han Chinese).Caucasian CD patients had a significantly higher antibody prevalence of gASCA(67%vs 3%,P<0.001),ALCA(44%vs 6%,P=0.005),and AMCA(67%vs 15%,P=0.002),whereas HK CD patients had a higher prevalence of only AMCA(58%vs 25%,P=0.035),when compared with UC and healthy subjects in both countries.Caucasian CD had significantly higher gASCA prevalence(67%vs 0%,P<0.001)and titre(median59 vs 9,P=0.002)than HK CD patients.Prevalence and titres of ALCA,ACCA and AMCA did not differ between CD in the two countries.Presence of at least one antibody was higher in Caucasian than HK CD patients(100%vs 58%,P=0.045).pANCA did not differ between countries or ethnicity.CONCLUSION:Serologic CD responses differ between HK Asian and Australian Caucasian patients.Different genetic,environmental or disease pathogenic factors may account for these differences. | Lani Prideaux Michael A Kamm Peter De Cruz Daniel R van Langenberg Siew C Ng Iris Dotan | 2013 | World Journal of Gastroenterology2013，19，37： | 10 |
| 2 | Ni2 revisited: Reassignment of the ground electronic state显示文摘 | Pinegar J C Langenberg J D Arrington C A | 1994 | J Chem Phys1994，102，： | 1 |
| 3 | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk显示文摘 | Dupuis J Langenberg C Prokopenko I | 2010 | Nat Genet2010，42，2： | 1 |
| 4 | Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon-γ-dependent mechanism显示文摘 | Netea M G Azam T Lewis E C Joosten L A Wang M Langenberg D Meng X Chan E D Yoon D Y Ottenhoff T Kim S H and Dinarello C A | | 0，，08： | 1 |
| 5 | Genetic evidence that raised sex hormone binding globulin (SHBG)levels reduce the risk of type 2 diabetes 显示文摘 | Perry JR Weedon MN Langenberg C | 2010 | Hum Mol Genet2010，19，3： | 1 |
| 6 | Seropositivityand Higher Immunoglobulin G Antibody Levels Against Cytomega-lovirus Are Associated With Mortality in the Population-Based Eu-ropean Prospective Investigation of Cancer-Norfolk Cohort 显示文摘 | Gkrania-Klotsas E Langenberg C Sharp SJ | 2013 | Clin Infect Dis2013，56，10： | 1 |
| 7 | Renal blood flow in sepsis 显示文摘 | Langenberg C Bellomo R May C | 2005 | Crit Care2005，9，4： | 1 |
| 8 | Urinary biomarkers in septic acute kidney injury 显示文摘 | Bagshaw S Langenberg C Haase M | 2007 | Intensive Care Med2007，33，7： | 1 |
| 9 | Renal blood flow in sepsis显示文摘 | Langenberg C Bellomo R May C | 2005 | Crit Care2005，9，4： | 1 |
| 10 | Liver metastases of colorectaI cancer: US, CT or MR? 显示文摘 | Schima W Kulinna C Langenberger H | 2005 | Cancer Imaging2005，，5： | 1 |
| 11 | Renal blood flow and function during recovery from experimental显示文摘 | Langenberg C Wan L Egi M | 2007 | Intensive Care Med2007，33，9： | 1 |
| 12 | Cardiovascular death and the metabolic syndrome: role of adiposity-sigllaling hormones and inflammation markers 显示文摘 | Langenberg C Bergstrom J Scheidt-Nave C | 2006 | Diabetes Care2006，29，： | 1 |
| 13 | Regional evaluation of the coal bed-methane potential of the foothills/ mountains of Alberta, Canada 显示文摘 | Langenberg C W Beaton A Berhane H | 2006 | International Journal of Coal Geology2006，65，12： | 1 |
| 14 | Variants in MTNR1B influence fasting glueose levels显示文摘 | Prokopenko I Langenberg C Florez JC | | Nat Genet0，2，1： | 1 |
| 15 | Regional evaluation of the combed methane potential of the Foothills/Mountains of Alberta, Canada显示文摘 | Langenberg C W Beatona Berhaneh | 2006 | International Journal of Coal Geology2006，65，1： | 1 |
| 16 | Birthweight, childhood growth, and blood pressure at 43 yeat in a British birth cohort显示文摘 | Hardy R Wadsworlh ME Langenberg C | 2004 | Int J Epidemiol2004，33，： | 1 |
| 17 | Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy : a prospective British birth cohort study 显示文摘 | Kuh D Langenberg C Hardy R | 2005 | BJOG2005，112，4： | 1 |
| 18 | Renal histopathology during experimental septic acute kidney injury and recovery显示文摘 | Langenberg C Gobe G Hood S | 2014 | Crit Care Med2014，42，1： | 1 |
| 19 | Variants in MTNR1B influence fasting glucose levels显示文摘 | Prokopenko I Langenberg C Florez JC | 2009 | Nat Genet2009，41，1： | 1 |
| 20 | Regional evaluationof the coal bed-methane potential of the foothills/mountainsof Alberta, Canada 显示文摘 | Langenberg C W Beaton A Berhane H | 2006 | International Journal of Coal2006，65，12： | 1 |
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