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| 1 | Superior growth performance in broiler chicks fed chelated compared to inorganic zinc in presence of elevated dietary copper显示文摘Background: The goal of this study was to compare the antagonism of elevated dietary Cu(250 mg/kg) from Cu SO4 on three different Zn sources(Zn SO4· H2O; [Zn bis(-2-hydroxy-4-(methylthio)butanoic acid)], Zn(HMTBa)2,a chelated Zn methionine hydroxy analogue; and Zn-Methionine), as measured using multiple indices of animal performance in ROSS 308 broilers.Methods: Three experiments were conducted in broiler chicks fed a semi-purified diet. Al birds were fed a Zn-deficient diet(8.5 mg/kg diet) for 1 wk, and then provided with the experimental diets for 2 wks.Results: Experiment 1 was a 2 × 2 factorial design with two levels of Cu(8 vs. 250 mg/kg diet from Cu SO4) and two Zn sources at 30 mg/kg [Zn SO4· H2 O vs. Zn(HMTBa)2]. Elevated Cu impaired growth performance only in birds fed Zn SO4.Compared to Zn SO4· H2 O, Zn(HMTBa)2improved feed intake(12 %; P < 0.001) and weight gain(12 %, P < 0.001) and the benefits were more pronounced in the presence of 250 mg/kg diet Cu. Experiment 2 was a dose titration of Zn SO4· H2 O and Zn(HMTBa)2at 30, 45, 60, and 75 mg/kg diet in the presence of 250 mg/kg Cu SO4. Feed:gain was decreased and tibia Zn was increased with increasing Zn levels from 30 to 75 mg/kg. Birds fed Zn(HMTBa)2consumed more food and gained more weight compared to birds fed Zn SO4, especially at lower supplementation levels(30 and45 mg/kg; interaction P < 0,05). Experiment 3 compared two organic Zn sources(Zn(HMTBa)2vs. Zn-Methionine)at 30 mg/kg with or without 250 mg/kg Cu SO4. No interactions were observed between Zn sources and Cu levels on performance or tissue mineral concentrations. High dietary Cu decreased weight gain(P < 0.01). Tibia Cu and liver Cu were significantly increased with 250 mg/kg dietary Cu supplementation(P < 0.01). No difference was observed between the two Zn sources.Conclusions: Dietary 250 mg/kg Cu significantly impaired feed intake and weight gain in birds fed Zn SO4· H2 O,but had less impact in birds fed Zn(HMTBa)2. No difference was observed between the two organic zinc sources.These results are consistent with the hypothesis that chelated organic Zn is better utilized than inorganic zinc in the presence of elevated Cu. | Junmei Zhao Robert B. Shirley Julia J. Dibner Karen J. Wedekind Frances Yan Paula Fisher Thomas R. Hampton Joseph L. Evans Mercedes Vazquez-Anon | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 6 |
| 2 | Methodology for assessing zinc bioavailability: efficacy estimates for zinc-methionine, zinc sulfate, and zinc oxide显示文摘 | Wedekind K J Hortin A E Baker D H | 1992 | Journal of Animal Science1992，70，1： | 1 |
| 3 | Cardiac arrhythmias and sudden death in infancy: implication for the medicalegal investigation显示文摘 | Wedekind H Schulze-Bahr E Debus V | 2007 | Int J Legal Med2007，121，4： | 1 |
| 4 | Experimental hypervelocity impact into quartz sand:Distribution and shock metamorphism of ejecta显示文摘 | Stffler D Gault D E Wedekind J | 1975 | Journal of Geophysical Research1975，80，： | 1 |
| 5 | Cooperation through image scoring in humans显示文摘 | Wedekind C Milinski M | 2000 | Science2000，288，5467： | 1 |
| 6 | Sudden infant death syndrome and long QT syndrome: an epidemialogical and genetic study显示文摘 | Wedekind H Bajanowski T Friederich P | 2006 | Int J Legal Med2006，120，3： | 1 |
| 7 | Zinc bioavailability in feed-grade sources of zinc显示文摘 | Wedekind K J Baker D H | 1990 | Journal of Animal Science1990，68，： | 1 |
| 8 | MHC-linked susceptibi-lity to a bacterial infection, but no MHC-linked cryptic female choice in whitefish 显示文摘 | Wedekind C Walker M Portmann J | 2004 | J Evol Biol2004，17，1： | 1 |
| 9 | Gamma ? radiation monitoring network at sea 显示文摘 | Wedekind Ch Schilling G Grufettmufeller M | 1999 | Applied Radiation and Isotopes1999，50，4： | 1 |
| 10 | Trauma to the pontomesencephalic brainstem-a major clue to the prognosis of severe traumatic brain injury显示文摘 | Wedekind C Hesselmann V Lippert-Gruner M | 2002 | Br J Neurosurg2002，16，3： | 1 |
| 11 | Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity显示文摘 | WEDEKIND J E TRAME C B DORYWALSKA M | 2001 | J Mol Bid2001，314，4： | 1 |
| 12 | Early traumatic life events, parental rearingstyles, family history of mental disorders,and birth risk factors in patients with social anxietydisorder 显示文摘 | Bandelow B Charomo Torrent A Wedekind D | 2004 | Eur Arch Psychiatry ClinNeurosci2004，254，6： | 1 |
| 13 | Tumor gene therapy made easy: allogeneic major histocompatibility complex in the C6 rat glioma model 显示文摘 | Banck MS Wedekind D | 1999 | Hum Gene Ther1999，10，1： | 1 |
| 14 | The selenium requirement of the puppy显示文摘 | Wedekind K J S Yu G F Combs | 2003 | Journal of Animal Physiology and Animal Nutrition2003，88，： | 1 |
| 15 | An experimental Investigation into the Oscillatory Motion of the Mixture Vapor,Transition Point in Horizontal Evaporating Flow显示文摘 | Wedekind G L | 1971 | Transaction of ASME Journal of Heat Transfer1971，，2： | 1 |
| 16 | Methodology for as- sessing zinc bioavailability:efficacy estimates for zinc-methi- onine, zinc sulfate, and zinc oxide 显示文摘 | Wedekind K J Hortin A E Baker D H | 1992 | Journal of Animal Science1992，70，1： | 1 |
| 17 | High levels of circulating early apoptotic peripheral blood mononuclear cells in systemic lupus erythematosus 显示文摘 | PERIOK A WEDEKIND F HERRMANN M | 1998 | Lupus1998，7，2： | 1 |
| 18 | Methodology forassessing Zinc bioavailability efficacy estimates for Zinc- 2 methionihe,Zinc Sulfate,and Zinc Oxide 显示文摘 | Wedekind K J A E Hortin DH Baker | 1992 | J A nim Sci1992，70，： | 1 |
| 19 | Outcome of prolonged coma following severe traumatic brain injury显示文摘 | Lippert-Gruner M Wedekind C Klug N | 2003 | Brain Inj2003，17，1： | 1 |
| 20 | Bioavailability of zinc inoraganic and organic sources for pigs fed corn-soybean mealdiets显示文摘 | Wedekind K J 1994 | 1994 | J Anim Sci1994，72，： | 1 |
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