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| 1 | Rotational assisted endoscopic retrograde cholangiopancreatography in patients with reconstructive gastrointestinal surgical anatomy显示文摘AIM: To evaluate the success rates of performing therapy utilizing a rotational assisted enteroscopy device in endoscopic retrograde cholangiopancreatography(ERCP) in surgically altered anatomy patients. METHODS: Between June 1, 2009 and November 8, 2012, we performed 42 ERCPs with the use of rotational enteroscopy for patients with altered anatomy(39 with gastric bypass Roux-en-Y, 2 with Billroth Ⅱ gastrectomy, and 1 with hepaticojejunostomy associated with liver transplant). The indications for ERCP were: choledocholithiasis: 13 of 42(30.9%), biliary obstruction suggested on imaging: 20 of 42(47.6%), suspected sphincter of Oddi dysfunction: 4 of 42(9.5%), abnormal liver enzymes: 1 of 42(2.4%), ascending cholangitis: 2 of 42(4.8%), and bile leak: 2 of 42(4.8%). All procedures were completed with the Olympus SIF-Q180 enteroscope and the Endo-Ease Discovery SB overtube produced by Spirus Medical. RESULTS: Successful visualization of the major ampulla was accomplished in 32 of 42 procedures(76.2%). Cannulation of the bile duct was successful in 26 of 32 procedures reaching the major ampulla(81.3%). Successful therapeutic intervention was completed in 24 of 26 procedures in which the bileduct was cannulated(92.3%). The overall intention to treat success rate was 64.3%. In terms of cannulation success, the intention to treat success rate was 61.5%. Ten out of forty two patients(23.8%) required admission to the hospital after procedure for abdominal pain and nausea, and 3 of those 10 patients(7.1%) had a diagnosis of post-ERCP pancreatitis. The average hospital stay was 3 d.CONCLUSION: It is reasonable to consider an attempt at rotational assisted ERCP prior to a surgical intervention to alleviate biliary complications in patients with altered surgical anatomy. | Majed El Zouhairi James B Watson Svetang V Desai David K Swartz Alejandra Castillo-Roth Mahfuzul Haque Paul S Jowell Malcolm S Branch Rebecca A Burbridge | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，3： | 10 |
| 2 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 3 | MicroRNA profile in neosquamous esophageal mucosa following ablation of Barrett's esophagus显示文摘AIM To investigate the micro RNA expression profile in esophageal neosquamous epithelium from patients who had undergone ablation of Barrett's esophagus.METHODS High throughput screening using Taq Man~ Array Human Micro RNA quantitative PCR was used to determine expression levels of 754 micro RNAs in distal esophageal mucosa(1 cm above the gastro-esophageal junction) from 16 patients who had undergone ablation of non-dysplastic Barrett's esophagus using argon plasma coagulation vs pretreatment mucosa, posttreatment proximal normal non-treated esophageal mucosa, and esophageal mucosal biopsies from 10 controls without Barrett's esophagus. Biopsies of squamous mucosa were also taken from 5 cm above the pre-ablation squamo-columnar junction. Predicted m RNA target pathway analysis was used to investigate the functional involvement of differentially expressed micro RNAs.RESULTS Forty-four micro RNAs were differentially expressed between control squamous mucosa vs post-ablation neosquamous mucosa. Nineteen micro RNAs were differentially expressed between post-ablation neosquamous and post-ablation squamous mucosa obtained from the more proximal non-treated esophageal segment. Twelve microRNAs were differentially expressed in both neosquamous vs matched proximal squamous mucosa and neosquamous vs squamous mucosa from healthy patients. Nine micro RNAs(mi R-424-5p, mi R-127-3p, mi R-98-5p, mi R-187-3p, mi R-495-3p, mi R-34c-5p, mi R-223-5p, mi R-539-5p, mi R-376a-3p, mi R-409-3p) were expressed at higher levels in post-ablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These micro RNAs were also more highly expressed in Barrett's esophagus mucosa than matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in the regulation of cell survival signalling pathways. Three micro RNAs(mi R-187-3p, mi R-135b-5p and mi R-31-5p) were expressed at higher levels in postablation neosquamous mucosa than in matched proximal squamous and healthy squamous mucosa. These mi RNAs were expressed at similar levels in preablation Barrett's esophagus mucosa, matched proximal squamous and squamous mucosa from controls. Target prediction and pathway analysis suggests that these micro RNAs may be involved in regulating the expression of proteins that contribute to barrier function.CONCLUSION Neosquamous mucosa arising after ablation of Barrett's esophagus expresses micro RNAs that may contribute to decreased barrier function and micro RNAs that may be involved in the regulation of survival signaling pathways. | Loveena Sreedharan George C Mayne David I Watson Timothy Bright Reginald V Lord Alfiya Ansar Tingting Wang Jakob Kist David StJ Astill Damian J Hussey | 2017 | World Journal of Gastroenterology2017，23，30： | 3 |
| 4 | Objective assessment of the perineural vascular plexus as a landmark for the horizontal part of the facial nerve in middle ear and mastoid surgery 显示文摘 | Paleri V Watson C | 2005 | Otol Neurotol2005，26，2： | 1 |
| 5 | Graphite fiber brush anodes for increased power production in air- cathode microbial fuel cells显示文摘 | Logan B E Cheng S Watson V | 2007 | Environ Sci Technol2007，41，9： | 1 |
| 6 | Objective assessment of the perineural vascular plexus as a landmark for the horizontal part of the facial nerve in middle ear and mastoid surgery显示文摘 | Paleri V Watson C | 2005 | Otol Neurotol2005，26，2： | 1 |
| 7 | Measurement issues in the sonographic assessment of tennis elbow显示文摘 | Poltawski L Jayaram V Watson T | 2010 | J Clin Ultrasound2010，38，4： | 1 |
| 8 | A landscape of driver mutations in melanoma显示文摘 | Hodis E Watson I R Kryukov G V | 2012 | Cell2012，150，2： | 1 |
| 9 | Combining Kohonen maps with ARIMA time series models to forecast traffic flow 显示文摘 | Voort M V D Dougherty M Watson S | 1996 | Transportation Research Part C1996，4，5： | 1 |
| 10 | Renal replacement therapy for a- cute renal failure in children:European guidelines显示文摘 | Strazdins V Watson AR Harvey B | 2004 | Pediatr Neph- rol2004，19，2： | 1 |
| 11 | Bisphenol S disrupts estradiol - induced nongenomic signaling in a rat pituitary cell line: Effects on cell functions 显示文摘 | Ren6 V Watson C S | 2013 | Environmental Health Perspectives2013，1210，： | 1 |
| 12 | Graphite fiber brush anodes for increased power production in air-cathede microbial fuel cells 显示文摘 | Logan B E Cheng S Watson V | 2007 | Environ Sci Technol2007，41，9： | 1 |
| 13 | Heat shock proteins Hsp27, Hsp 60, Hsp70, and Hsp90: expression in bladder carcinoma 显示文摘 | Labret T Watson RW Molinie V | 2003 | Cancer2003，98，5： | 1 |
| 14 | Mapping the Proteome of Barrel Medic (Medicago truncatula)显示文摘 | Watson B S Asirvatham V S Wang L J | 2003 | Plant Physiology2003，131，： | 1 |
| 15 | Troponin for prediction of cardiovascular collapse in acute colchicine overdose 显示文摘 | Heyningen C V Watson I D | 2005 | Emerg Med J2005，22，8： | 1 |
| 16 | Limitations on gas turbine performance imposed by large turbine cooling flows 显示文摘 | Horlock J H Watson D T Jones T V | 2001 | Journal of Engineering for Gas Turbines and Power2001，123，7： | 1 |
| 17 | Studies on the mode of action of spinosad:the internal effective concentration and the concentration dependence on neural excitation显示文摘 | Salgado V L Sheets J J Watson G B | | 0，，2： | 1 |
| 18 | Graphilc fiber brush anodes for increased power production in air-calhode microbial tirol cells显示文摘 | Logan B E Cheng S Watson V ct al | 2007 | Environ Sci technol2007，41，9： | 1 |
| 19 | Adaptive experimental design for construction of response surface approximations 显示文摘 | Perez V M Renaud J E Watson L W | 2002 | AIAA Journal2002，40，12： | 1 |
| 20 | The longitudinal effects ofphysical activity and dietary calcium on bone mass accrual across stagesof pubertal development 显示文摘 | Lappe JM Watson P Gilsanz V | 2015 | J Bone Miner R es2015，30，1： | 1 |
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