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| 1 | Non-genetic contributions of the sperm nucleus to embryonic development显示文摘从几个实验室的最近的数据提供了最新使肥沃的卵母细胞从为合适的胚胎的开发被要求的精子染色质继承 epigenetic 信号的证据。为这评论的目的,术语 epigenetic 被用来描述从精子房间被传给胚胎的分子的信息的所有类型。当在哺乳动物或为为哪个有证据,它可以那么做为合适的 embryogenesis 被要求,有已经被建立了的 epigenetic 信息的至少六种不同形式。这些是(i) DNA methylation;(ii ) 精子特定的 histones,(iii ) 另外的联系染色质的蛋白质;(iv ) perinuclear 膜蛋白质;(v) 精子出生的 RNA 并且,这评论的焦点;并且(vi ) 由精子的 DNA 环领域组织原子矩阵。当为有效授精和随后的胚胎开发作为必要部件为帮助繁殖技术为精子的操作和 cryopreservation 设计协议时,这些 epigenetic 信号应该被考虑。 | Yasuhiro Yamauchi Jeffrey A Shaman W Steven Ward | 2011 | Asian Journal of Andrology2011，13，1： | 6 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | 玻璃基底上水滴稳态蒸发过程中的能量传输机制显示文摘采用理论分析和实验测量相结合的方法研究了水滴在玻璃基底上稳态蒸发时内部能量传输机制。发现了气-液、固-液界面温度不连续现象,且越靠近三相接触线,固-液界面温差越大。固-液界面吸附层的存在导致了该界面温度不连续,从玻璃基底导入的大部分热量通过界面吸附层传向三相接触线,然后通过热毛细对流被带向气液界面以满足液滴蒸发所需热量,而另外一小部分热量则直接通过导热进入液滴内部。 | 吴春梅 李友荣 C A Ward | 2013 | 工程热物理学报2013，34，7： | 4 |
| 4 | Laryngeal and oropharyngeal cancer, and alcohol dehydrogenase 3 and glutathione S-transferase M1 polymorphisms显示文摘 | Coutelle C Ward PJ Fleury B Quattrocchi P Chambrin H Iron A | 1997 | Hum Genet1997，99，3： | 3 |
| 5 | Cancer statistics,2008显示文摘 | Jemal A Siegel R Ward E | | 0，，02： | 2 |
| 6 | FUSARIUM-ID v. 1.0: A DNA Sequence Database for Identifying Fusarium显示文摘 | David M. Geiser María del Mar Jiménez-Gasco Seogchan Kang Izabela Makalowska Narayanan Veeraraghavan Todd J. Ward Ning Zhang Gretchen A. Kuldau Kerry O’donnell | 2004 | European Journal of Plant Pathology (-)2004，，5： | 2 |
| 7 | Factors affecting recovery and quality of oocytes for bovine embryo production in vitro using ovum pick-up technology显示文摘 | Ward F A Lonergan P Enright B P | 2000 | Theriogenology2000，54，： | 2 |
| 8 | Cancer statistics,2009显示文摘 | Jemal A Siegel R Ward E | 2009 | CA:A Cancer Journal for Clinicians2009，，04： | 2 |
| 9 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 10 | Cancer statistics, 2007 显示文摘 | Jemal A Siegel R Ward E | 2007 | CA Cancer J Clin2007，57，1： | 1 |
| 11 | Effect of an angiotensin Ⅱ receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor - beta ( TGF - beta) and alpha - actomyosin ( alpha SMA ), important mediators of radiation - induced pneumopathy and lung fibrosis 显示文摘 | Moheni A Wolfe LF Ward WF | 2007 | Curt Pharm Des2007，13，13： | 1 |
| 12 | Cancer statistics, 2007 显示文摘 | Jemal A Siegel R Ward E | 2007 | CA Cancer J Clin2007，57，1： | 1 |
| 13 | Cancer statistics, 2006 显示文摘 | Jemal A Siegel R Ward E | 2006 | CA Cancer J Clin2006，56，2： | 1 |
| 14 | Cancer statistics, 2007 显示文摘 | Jemal A Siegel R Ward E | 2007 | CA Cancer J Clin2007，57，1： | 1 |
| 15 | Production of high yield of arachidonic acid in a fed batch system by Mortierella alpina ATCC 32222显示文摘 | WARD O P | 1997 | Appl Microbiol Biotechnol1997，48，7： | 1 |
| 16 | Destructible surfactants based on a silicon-oxygen bond显示文摘 | Ward M D | 1982 | J Org Chem1982，47，11： | 1 |
| 17 | Optical harmonics and nonlinear phenomena显示文摘 | Ward J F | 1963 | Rev Mod Phys1963，35，： | 1 |
| 18 | Mammalian keratin gene families: organization for genes coding for the B2 high-sulphur proteins sheep wool 显示文摘 | Powell B C Sleigh M J Ward K A | 1983 | Nucleic Acids Res1983，11，： | 1 |
| 19 | Cancer statistics, 2007 显示文摘 | Jemal A Siegel R Ward E | 2007 | CA Cancer J Clin2007，57，1： | 1 |
| 20 | Cancer statistics,2009显示文摘 | Jemal A Siegel R Ward E | 2009 | CA Cancer J Clin2009，59，4： | 1 |
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