|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The potential of using blood circular RNA as liquid biopsy biomarker for human diseases显示文摘Circular RNA(circRNA)is a novel class of single-stranded RNAs with a closed loop structure.The majority of circRNAs are formed by a back-splicing process in pre-mRNA splicing.Their expression is dynamically regulated and shows spatiotemporal patterns among cell types,tissues and developmental stages.CircRNAs have important biological functions in many physiological processes,and their aberrant expression is implicated in many human diseases.Due to their high stability,circRNAs are becoming promising biomarkers in many human diseases,such as cardiovascular diseases,autoimmune diseases and human cancers.In this review,we focus on the translational potential of using human blood circRNAs as liquid biopsy biomarkers for human diseases.We highlight their abundant expression,essential biological functions and significant correlations to human diseases in various components of peripheral blood,including whole blood,blood cells and extracellular vesicles.In addition,we summarize the current knowledge of blood circRNA biomarkers for disease diagnosis or prognosis. | Guoxia Wen Tong Zhou Wanjun Gu | 2021 | Protein & Cell2021，12，12： | 8 |
| 2 | Photocatalytic defluorination of perfluorooctanoic acid by surface defective BiOCl:Fast microwave solvothermal synthesis and photocatalytic mechanisms显示文摘There is an urgent need for developing cost-effective methods for the treatment of perfluorooctanoic acid(PFOA)due to its global emergence and potential risks.In this study,taking surface-defective BiOCl as an example,a strategy of surface oxygen vacancy modulation was used to promote the photocatalytic defluorination efficiency of PFOA under simulated sunlight irradiation.The defective BiOCl was fabricated by a fast microwave solvothermal method,which was found to induce more surface oxygen vacancies than conventional solvothermal and precipitation methods.As a result,the asprepared BiOCl showed significantly enhanced defluorination efficiency,which was 2.7 and33.8 times higher than that of BiOCl fabricated by conventional solvothermal and precipitation methods,respectively.Mechanistic studies indicated that the defluorination of PFOA follows a direct hole(h^+)oxidation pathway with the aid of·OH,while the oxygen vacancies not only promote charge separation but also facilitate the intimate contact between the photocatalyst surface and PFOA by coordinating with its terminal carboxylate group in a bidentate or bridging mode.This work will provide a general strategy of oxygen vacancy modulation by microwave-assisted methods for efficient photocatalytic defluorination of PFOA in the environment using sunlight as the energy source. | Yuanyuan Sun Guiying Li Wanjun Wang Wenquan Gu Po Keung Wong Taicheng An | 2019 | Journal of Environmental Sciences2019，31，10： | 7 |
| 3 | Management of Lisfranc injury with anterolateral calcaneal compression fracture显示文摘To the Editor:The mechanism of Lisfranc injury is complex and may cause different patterns of fractures or dislocation of the midfoot complex.Abduction force injury is a special injury pattern,which may cause the fracture or(and)dislocation of the lateral column of the Lisfranc joint,especially the cuboid.[1,2,3]However,the anterolateral calcaneus is less commonly involved.Since the fragment of the calcaneocuboid(CC)joint facet is too uncon-spicuous to manifest on a plain X-ray,and surgeons always pay more attention to the Lisfranc joint,anterolateral calcaneal compression fracture and even Chopart joint injuries are often overlooked,which may lead to a delayed surgical management,chronic foot deformities,and functional disability. | Wenqi Gu Rui Zhang Wanjun Liu Zhongmin Shi Guohua Mei Jianfeng Xue Jian Zou Xiaokang Wang Jiantao Jiang | 2022 | Chinese Medical Journal2022，，6： | 1 |
| 4 | Analysis of synonymous codon usage in H5N1 virus and other influenza A viruses显示文摘 | Tong Zhou Wanjun Gu Jianmin Ma Xiao Sun Zuhong Lu | 2005 | BioSystems2005，，1： | 1 |
| 5 | Identification of repeat structure in large genomes using repeat probability clouds显示文摘 | Gu Wanjun Todd A Castoe Dale J Hedges | 2008 | Analytical Biochemistry2008，380，1： | 1 |
| 6 | cAMP-PGC1α途径诱导的抗Warburg效应驱动胶质母细胞瘤细胞分化为星形胶质细胞显示文摘文章简介多形性胶质母细胞瘤(GBM)是人类最具侵袭性的肿瘤之一。虽然分化治疗已被提出作为治疗GBM的潜在方法,但诱导分化的机制仍然很不清楚。在此,课题组利用c AMP激活剂建立了GBM诱导分化模型,该模型特异性地指导GBM分化为星形胶质细胞。 | Fan Xing Yizhao Luan Jing Cai Sihan Wu Jialuo Mai Jiayu Gu Haipeng Zhang Kai Li Yuan Lin Xiao Xiao Jiankai Liang Yuan Li Wenli Chen Yaqian Tan Longxiang Sheng Bingzheng Lu Wanjun Lu Mingshi Gao Pengxin Qiu Xingwen Su Wei Yin Jun Hu Zhongping Chen Ke Sai Jing Wang Furong Chen Yinsheng Chen Shida Zhu Dongbing Liu Shiyuan Cheng 谢志 朱文博 颜光美 | 2018 | 科学新闻2018，0，4： | 1 |
| 7 | Cluster analysis of the codon use frequency of MHC genes from different species显示文摘 | Zhou Tong Gu Wanjun | 2002 | Bio System2002，65，： | 1 |
| 8 | Ridge Covering High-yield Cultivation Techniques of Jinhong Apple in Cold Region显示文摘After five years of study,it was found that compared with the conventional cultivation techniques,the average yield per plant of3-5-year-old Jinhong apple trees cultivated under the ridge covering mode was increased by 2. 12 times,the stem diameter was increased by20%,the branch number was increased by 73. 5%,and the underground root number was increased by 38. 3%. Under the ridge covering mode,the main distribution area of the underground roots of Jinhong apple trees was moved down to 15-55 cm,the temperature of soil 20 cm beneath the surface of the ridges increased by 1. 3-1. 5℃,the temperature of soil 40 cm beneath the surface of the ridges rose by 0. 9-1. 0℃,and the water content of soil 20-40 cm from the ground was maintained around 5%. Under the ridge covering mode,the Jinhong apple trees grew robustly,began to fruit 3 years later and yielded highly 5 years later. In addition,the ridge covering model also has illumination-enhancing,pest-controlling and tillage-free characteristics. | Chang LIU Zhangli FENG Siyang TANG Haidong BU Minggang XIAO Guangjun GU Xianmin CHENG Wenquan YU Wanjun YE | 2019 | Asian Agricultural Research2019，11，4： | 0 |
| 9 | Super-resolution imaging of the dynamic cleavage of intercellular tunneling nanotubes显示文摘As a new method of cell-cell communication,tunneling nanotubes(TNTs)play important roles in cell-cell signaling and mass exchanges.However,a lack of powerful tools to visualize dynamic TNTs with high temporal/spatial resolution restricts the exploration of their formation and cleavage,hindering the complete understanding of its mechanism.Herein,we present the first example of using stochastic optical reconstruction microscopy(STORM)to observe the tube-like structures of TNTs linking live cells with an easily prepared fluorescent dye.Because of this new imaging microscopy,the cleavage process of TNTs was observed with a high spatial resolution. | Wanjun GONG Wenhui PAN Ying HE Meina HUANG Jianguo ZHANG Zhenyu GU Dan ZHANG Zhigang YANG Junie QU | 2020 | Frontiers of Optoelectronics2020，13，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员