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| 1 | Dynamic changes in blood cytokine levels as clinical indicators in severe acute respiratory syndrome显示文摘Objective To investigate the dynamic changes observed in serum levels of interleukins (ILs), tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in severe acute respiratory syndrome (SARS) patients.Methods Sixty-one cases of SARS with positive antibodies to SARS coronavirus (SARS-CoV) were classified into the following categories: initial stage (3-7 days), peak stage (8-14 days), and remission and recovery stage (15-27 days). Forty-four healthy individuals were used as controls. Serum levels of ILs, TNF-α and TGF-β1 were measured in all subjects. Serum antibodies to SARS-CoV were detected only in SARS cases. Results The mean concentration of serum IL-6 in SARS patients did not differ from that in the control group in initial and peak stages, but became significantly higher in remission and recovery stage compared with the control group, initial and peak stages (P<0.01). The mean concentration of serum IL-8 in SARS patients did not differ from that of the control group in initial stage, but was significantly higher than control group in peak stage and remission and recovery stage (P<0.05). And it was more significantly higher in remission and recovery stage than in peak stage (P<0.01). The mean concentrations of IL-16 and TNF-α in SARS patients were higher than those of the control group for every length of the clinical courses investigated, and were especially high in remission and recovery stage (P<0.01). SARS patients experienced higher concentration of serum IL-13 compared with the controls in initial stage (P<0.01), but returned to normal levels in peak stage and in remission and recovery stage. The mean concentration of serum IL-18 in SARS patients was significantly lower than that of the control group during all clinical courses (P<0.05). The mean concentration of serum TGF-β1 in SARS patients was higher than that of the control group during all clinical courses. Although TGF-β1 in serum decreased in remission and recovery stage in SARS patients, the average was still higher than that of the control group (P<0.01).Conclusions Most proinflammatory cytokines and TGF-β1 were elevated during the early phase of SARS, which may be associated with lung infiltration and proliferation. Concurrently, the mean concentration of serum IL-13 decreased gradually, and the mean concentration of serum IL-18 level in SARS patients was lower than that of the control group during all the courses of SARS, suggesting that the immune state of the patients with SARS was obviously abnormal. Observing the dynamic changes in blood cytokine levels can provide a scientific basis to assess pathogenesis and efficacy of clinical treatment of SARS. | PangBS WangZ ZhangLM TongZH XuLL HuangXX GuoWJ ZhuM WangC LiXW HeZP LiHX ZhaoFJ | 2003 | Chinese Medical Journal2003，，9： | 12 |
| 2 | Unsedated transnasal esophagogastroduodenoscopy for the evaluation of dysphagia following treatment for previous primary head and neck cancer显示文摘 | WANGC P LEE Y C LOU P J | 2009 | Oral Oncol2009，45，： | 1 |
| 3 | Synthesis of PbS nanocubes using an ionic liquid as the solvent显示文摘 | ZhaoX L WangC X Hao XP | 2007 | Mater Lett2007，61，26： | 1 |
| 4 | High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets显示文摘 | WangC Sanders CM Yang Q | 2010 | Proc Natl Acad Sci U S A2010，107，： | 1 |
| 5 | Dynamic sensing of the localized corrosion at the metal/solution interface显示文摘 | LI W YUAN B Y WANGC | | 0，，04： | 1 |
| 6 | Open reduction of irreducible atlantoaxial dislocation by transoral anterior atlantoaxial release and posterior internal fixation 显示文摘 | WangC YanY ZhouHT | 2006 | Spine2006，31，11： | 1 |
| 7 | Probing the microenvironmentof an oligo-(p-phenylene vinylene)derivative encapsulated in polymer-impregnated sol-gel silica matrix显示文摘 | TANGJun DUChuang YUXiaoqiang ZHANGGuo WANGCe | 2004 | Chinese Science Bulletin2004，49，18： | 1 |
| 8 | Treatment with total alkaloids from Radix Linderae reduces inflammation and joint destruction in type Ⅱ collagen-induced model for rheumatoid arthritis显示文摘 | WANGC DAI Y YANG J | 2007 | Journal of Ethnopharmacology2007，111，2： | 1 |
| 9 | Exploring Chinese users' acceptance of instant messaging using the theory of planned behavior, the technology acceptance model, and the flow theory显示文摘 | Yaobin Lu Tao Zho Bin Wangc | 2009 | Computers in Human Behavior2009，，25： | 1 |
| 10 | Molecularepidemiologyofpor-cineepidemicdiarrheavirusinChina显示文摘 | ChenJ WangC ShiH etal | 2010 | ArchVirol2010，155，： | 1 |
| 11 | Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadalmen显示文摘 | WangC SwerdloffRS IranmaneshA | 2000 | J Clin Endocrinol Metab2000，85，8： | 1 |
| 12 | Hormesis effects and impli-cative application in assessment of lead-contaminated soils inroots of Vicia faba seedlings显示文摘 | WangC R Tian Y Wang X R | 2010 | Chemosphere2010，80，9： | 1 |
| 13 | Preparations and properties of maleic acid and maleic anhydride functionalized multiwall carbon nanotube/poly (urea urethane) nanocomposites显示文摘 | Wu H L WangC H MaCCM etal | 2007 | Comps Sci Techn2007，67，9： | 1 |
| 14 | Prevalenceofchronic obstructive pulmonary disease in China: a large,population-basedsurvey显示文摘 | ZHONGNS WANGC YAOW Z etal | 2007 | Am JRespirCritCareMed2007，176，8： | 1 |
| 15 | Decomposition of Energy Related C02 Emissions in China: 1957-2000 显示文摘 | WangC Chen J Zou J | 2005 | Energy2005，30，： | 1 |
| 16 | A new approa:h to attribute reduction of consistent and inconsistent eowring decision systems with covering rough sets 显示文摘 | CHEN DG WANGC Z HU Q H | 2007 | lntbrma- tion Seiences2007，177，17： | 1 |
| 17 | Separation, Characteristics and biological activities of phenolics in Areca fruit显示文摘 | WangC K Lee W H | 1996 | Journal of Agricultural andFood Chemistry1996，4，8： | 1 |
| 18 | Production of hydrogen-rich gas from plant biomass by catalytic pyrolysis at low temperature显示文摘 | Hao Q L WangC Lu D Q | 2010 | International Journal of Hydrogen Energy2010，35，17： | 1 |
| 19 | Both low and high temperature may increase the risk of stroke mortality显示文摘 | ChenR WangC MengX | 2013 | Neurology2013，81，10： | 1 |
| 20 | Expression of cathepsinD , stromelysin-3, and urokinase by reactine stromal cells on breast carcinoma prognosis显示文摘 | Tetub Brisson J Wangcs | 2001 | Cancer2001，92，11： | 1 |
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