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| 1 | Outcomes of furazolidone-and amoxicillin-based quadruple therapy for Helicobacter pylori infection and predictors of failed eradication显示文摘AIM To evaluate the outcomes of furazolidone-and amoxicillin-based quadruple therapy for treatment of Helicobacter pylori(H. pylori) infection and identify predictors of failed eradication.METHODS Patients with H. pylori infection treated with furazolidone, amoxicillin, bismuth, and proton pump inhibitor therapy(January 2015 to December 2015) who received the ^(13)C-urea breath test > 4 wk after treatment were evaluated. Demographic and clinical data including prior H. pylori treatment attempts, medication adherence, alcohol and cigarette consumption during therapy, and treatment-related adverse events were recorded by reviewing medical records and telephone surveys. H. pylori eradication rates for overall and subgroups were evaluated. Multivariate analysis was performed to identify independent predictors of failed H. pylori eradication.RESULTS Of the 992 patients treated and retested for H. pylori infection, the overall eradication rate was 94.5% [95% confidence interval(CI): 94.1%-95.9%]. H. pylori eradication rate of primary therapy was 95.0%(95%CI: 93.5%-96.5%), while that of rescue therapy was 91.3%(95%CI: 86.8%-95.8%). Among the 859 patients who completed the study protocol, 144(17%) reported treatment-related adverse events including 24(3%) leading to premature discontinuation. On multivariate analysis, poor medication adherence [adjusted odds ratio(AOR) = 6.7, 95%CI: 2.8-15.8], two or more previous H. pylori treatments(AOR = 7.4, 95%CI: 2.2-24.9), alcohol consumption during therapy(AOR = 4.4, 95%CI: 1.5-12.3), and possibly smoking during therapy(AOR = 1.9, 95%CI: 0.9-4.3) were associated with failed H. pylori eradication. CONCLUSION Furazolidone-and amoxicillin-based quadruple therapy for H. pylori infection in an area with a high prevalence of clarithromycin resistance demonstrated high eradication rates as primary and rescue therapies with a favorable safety profile. Patient education targeting abstinence from alcohol during therapy and strict medication adherence may further optimize H. pylori eradication. | Ya-Wen Zhang Wei-Ling Hu Yuan Cai Wen-Fang Zheng Qin Du John J Kim John Y Kao Ning Dai Jian-Min Si | 2018 | World Journal of Gastroenterology2018，24，40： | 18 |
| 2 | Old age security in rural China: there is a long way to go显示文摘 | DAI Bao-zhen ZHOU Lu-lin Y John Mei | 2013 | Chinese Medical Journal2013，，22： | 8 |
| 3 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 4 | Cyclic adenosine 3',5'-monophosphate induces differentiation of mouse embryonic stem cells into cardiomyocytes显示文摘 | Chen Y Shao JZ Xiang LX Guo J Zhou Q J Yao X Dai LC Lu YL | 2006 | 中国生物学文摘2006，20，7： | 5 |
| 5 | Isolation and characterization of neural stem cells from human fetal striatum显示文摘 | Li X Xu J Bai Y Wang X Dai X Liu Y Zhang J Zou J Shen L Li L | 2006 | 中国生物学文摘2006，20，5： | 3 |
| 6 | Simplification, expansion and enhancement of direct interior point algorithm for power system maximum loadability 显示文摘 | Dai Y McCalley J D Vittal V | 2000 | IEEE Trans on Power Systems2000，15，3： | 2 |
| 7 | Characterization of soil organic matter fractions of tundra soils in Arctic Alaska by carbon 13 nuclear magnetic resonance spectroscopy 显示文摘 | Dai X Y Ping C L Candler R | 2001 | Soil Science Society of America Journal2001，65，： | 2 |
| 8 | Landslide risk assessment and management:an overview显示文摘 | F C Dai C F Lee Y Y Ngai | 2002 | Engineering Geology2002，64，： | 2 |
| 9 | 收缩压和舒张压变异性对脑卒中患者血管事件的不同影响显示文摘较高的血压变异性(blood pressure variability,BPV)是心血管病的危险因素。然而,在引发不同的血管事件时,收缩压变异性(systolic blood pressure variability,SBPV)和舒张压变异性(diastolic blood pressure variability,DBPV)是否存在不同作用仍不清楚。本研究旨在探讨SBPV或DBPV对急性缺血性脑卒中(acute ischaemic stroke,IS)或短暂性脑缺血发作(transient ischaemic attack,TIA)患者血管事件的作用是否存在区别。 | 周卫(译) 袁源(摘) 叶鹏(审校) Dai L Cheng A Hao X Xu J Zuo Y Wang A Meng X Li H Wang Y Zhao X Wang Y | 2020 | 中华高血压杂志2020，28，11： | 2 |
| 10 | 显示文摘 | Zhao B Cheng P Dai Y | 2003 | Angew Chem Int Ed2003，42，8： | 1 |
| 11 | Triterpenoids from the stems of Myricaria paniculata 显示文摘 | Li S Dai S J Chen R Y | 2005 | J Asian Nat Prod Res2005，7，3： | 1 |
| 12 | Distribution of time between failures of machining center based on type Ⅰ censored data显示文摘 | Dai Y Zhou Y F Jia Y Z | 2003 | Reliability Engineering and System Safety2003，79，3： | 1 |
| 13 | Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain-potential function of a novel receptor 显示文摘 | Hong Y Dai P Jiang J Zeng X | 2004 | Br J Pharmacol2004，141，： | 1 |
| 14 | l Medicalapplication of NiTi shape memory alloy in China显示文摘 | Y CHU K DAI M ZHU eta | 2000 | Materials Science Forum2000，，327： | 1 |
| 15 | A Nonlinear Conjugate Gradient with a Strong Global Convergence Property 显示文摘 | Dai Y H Yuan Y X | 2000 | SIAM Journal of Optimization2000，10，： | 1 |
| 16 | Soil nutrient factors related to salidroside production of rhodiola sachalinensis distributed in chang bai mountain显示文摘 | YAN X F WU S X WANG Y SHANG X H DAI S J | 2004 | Environmental and Experimental Botsny2004，52，： | 1 |
| 17 | HIF-1alpha induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemia显示文摘 | Dai Y Xu M Wang Y | 2007 | J Mol Cell Cardiol2007，42，11： | 1 |
| 18 | Genetic polymorphisms of cytokine genes and risk for trichloroethylene-induced severe generalized dermatitis: a case-control study 显示文摘 | DAI Y LENG S LI L | 2004 | Biomarkers2004，9，6： | 1 |
| 19 | Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients显示文摘 | Dai Y Sui W Lan H | 2009 | Rheumatol Int2009，29，7： | 1 |
| 20 | Superhydrophobic surfaces prepared from water glass and non-fluorinated alkylsilane on cotton substrates显示文摘 | Li Z Xing Y Dai J J | | Applied Surface Science0，254，7： | 1 |
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