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| 1 | Effect of Microstructure Refinement on the Strength and Toughness of Low Alloy Martensitic Steel显示文摘马氏体的微观结构在熄灭,有从 6 亩 m 到 199 亩 m 的优先的奥氏体谷物尺寸的 tempered 17CrNiMo6 钢被光金属组织学( OM )描绘了,与各种各样的优先的奥氏体谷物尺寸扫描电子显微镜学( SEM )和传动电子显微镜学( TEM ) .Theyield 强度和钢的坚韧被测试并且与微观结构特征相关。结果证明在 17CrNiMo6 钢的优先的奥氏体谷物尺寸和马氏体的包尺寸与收益强度跟随一种 Hall-Petch 关系。当优先的奥氏体谷物尺寸从 199 亩 m 被精制到 6 亩 m 时,收益强度由 235 MPa 增加了,当在 77 K 的 Charpy U槽口冲击能多于 8times 改善了时,显示那微观结构精炼在比在增加强度改进抵抗到劈开骨折是更有效的。破裂表面暗示为劈开骨折的联合起来的裂缝路径作为是包被识别。 | Chunfang WANG Maoqiu WANG Jie SHI Weijun HUI Han DONG | 2007 | Journal of Materials Science & Technology2007，23，5： | 50 |
| 2 | Anti-inflammatory effect of resveratrol through the suppression of NF-KB and JAK/STAT signaling pathways显示文摘 | Chunfang Ma Yin Wang Lei Dong Minjing Li Wanru Cai | 2015 | Acta Biochimica et Biophysica Sinica2015，47，3： | 17 |
| 3 | Recombinant CC16 protein inhibits the production of pro-inflammatory cytokines via NF-KB and p38 MAPK pathways in LPS-activated RAW264,7 macrophages显示文摘积累的证据显示克莱拉房间 protein-16 (CC16 ) 有反煽动性的功能,尽管深奥分子的小径完全没被阐明。这里,我们评估了效果肿瘤坏死因素 alpha (TNF-) 的表示上的 recombinant 老鼠 CC16 (rCC16 ) , interleukin-6 (IL-6 ) ,和在 lipopolysaccharide (LPS ) 的 IL-8 刺激了老鼠巨噬细胞(RAW264.7 房间) 并且探索了内在的分子的机制。rCC16 在两个禁止了导致 LPS 的 TNF- , IL-6,和 IL-8 表示,这被发现送信人 ribonucleicacid (mRNA ) 水平和蛋白质以一种集中依赖者方式铺平,由即时反向的 transcriptase 聚合酶链反应和连接酶的 immunosorbent 试金示威了。如此的镇压效果被 transcriptional 活动和原子因素(NF ) 的脱氧核糖核酸酸绑定活动的抑制伴随 -B 然而并非使活跃之物蛋白质(AP )-1。西方的污点分析进一步表明 rCC16 禁止了原子 NF-B 和 NF-B 禁止的蛋白质 IB,和 p38 的 cytosolic NF-B, phosphorylation 和减小的减小的增加激活 mitogen 的蛋白质 kinase (MAPK ) 依赖者由在它的 p65 子单元的 Ser276 的 phosphorylation 的 NF-B 激活。而且, rCC16 被发现没另外在c6月N终端 kinase ,c6月,或c-Jun.的原子 translocation 的 phosphorylation 上有效果,TNF-的减小, IL-6 ,并且 IL-8 被颠倒内长的uteroglobin有约束力的蛋白质的水平什么时候被 RNA 干扰在 对待rCC16 、 对待LPS 的 RAW264.7 房间减少。我们的数据建议 rCC16 由在 RAW264.7 房间使 NF-B 和 p38 MAPK 然而并非 AP-1 失去活性压制调停 LPS 的煽动性的调停人 TNF- , IL-6,和 IL-8 生产。 | Min Pang Yangyang Yuan Dong Wang Ting Li Dan Wang Xiaohong Shi Min Guo Chunfang Wang Xinri Zhang Guoping Zheng Baofeng Yu Hailong Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 14 |
| 4 | Cold acclimation improves photosynthesis by regulating the ascorbate–glutathione cycle in chloroplasts of Kandelia obovata显示文摘As the most northerly mangrove species in China, Kandelia obovata may undergo extreme cold event stress. Enhancing the cold tolerance of this species is crucial to its successful afforestation. This study aimed to determine the resistance of K. obovata seedlings to low temperature stress by cold acclimation and to explain the mechanisms for alleviating cold injury. To understand these mechanisms, seedlings that were acclimatized and not acclimatized were exposed to 5℃/- 2℃(day/night)for 48 h.Results showed that low temperature stress reduced leaf photosynthesis of non-acclimatized seedlings by inducing oxidative stress and structural damage to chloroplasts. These phenomena were shown by increasing levels of malondialdehyde (MDA), O2-and H2O2, as well as decreasing enzyme activities in the ascorbate–glutathione (AsA-GSH) cycle. However, cold-acclimatized seedlings had improved photosynthetic rates and efficiency of photosystem II (PSII) under low temperature stress. Compared with non-acclimatized seedlings, leaves of coldacclimatized seedlings under low temperature stress for 48 h exhibited higher anti-oxidative enzyme activities, lower levels of O2^- and H2O2, less damage to chloroplast structure, and removed 33.7% of MDA at low temperature stress for 48 h. The data indicate that cold acclimation enhances photosynthetic capacity by effectively regulating activation in the PSII electron transport and the AsA–GSH cycle to scavenge excess ROS in chloroplasts, while the latter is more important. | Weicheng Liu Chunfang Zheng Jinong Chen Jianbiao Qiu Zhixing Huang Qi Wang Yong Ye | 2019 | Journal of Forestry Research2019，30，3： | 11 |
| 5 | SCM-198 protects endometrial stromal cells from oxidative damage through Bax/Bcl-2 and ERK signaling pathways显示文摘In creasi ng amounts of evidence dem on strated that accumulative reactive oxyge n species (ROS) and apoptosis of human endometrial stromal cells (ESCs) are closely associated with endometrial dysfunction induced by oxidative stress, which plays an important role in the pathological process of multiple gyn ecological and reproduction-related diseases. SCM-198, an alkaloid active component of Leonurus japonicas Houtt, has been reported to have anti-oxidative activity. However, the specific mechanisms of SCM-198 in the prevention of endometrial damage remain unknown. In the present study, we assessed the effect of SCM-198 on hydrogen peroxide (H2O2Hnduced oxidative injury in ESCs. ESCs were pretreated with SCM-198 for 4 h and then challenged with H2O2.Morphology ch a nges, apoptosis rate, and intracellular ROS producti on were measured to assess the level of oxidative injury. Flow cytometry and western blot analysis were performed to detect the expression levels of Bax, Bcl-2, active-caspase-3, and mitogen-activated protein kinases pathways. Classic inflammation cytokines were measured by real-time polymerase chain reactions. Our results showed that SCM-198 attenuated apoptosis and ROS generation of ESCs induced by H2O2. H2O2 induced the apparent apoptotic characteristics, including fragmentation of DNA, upregulation of Bax/Bcl2, activation of caspase-3, and secretion of inflammation cytokines, which were all ameliorated by SCM-198. Furthermore, H2O2-induced apoptosis-related ERK1/2 pathway activation was restrained by SCM-198 pretreatme nt. These fin dings suggested that SCM-198 could protect ESCs from oxidative injury, mainly by inhibiting oxidative stress and reducing apoptosis. | Yunyun Li Yikong Lin Xixi Huang Chunfang Xu Xinhua Liu Li Wang Min Yu Dajin Li Yizhun Zhu Meirong Du | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 10 |
| 6 | Image universal steganalysis based on best wavelet packet decomposition显示文摘Based on the best wavelet packet decomposition of images, a new universal steganalysis method with high detection correct ratio is proposed. First, the best wavelet packet decomposition of image based on the Shannon entropy information cost function is made. Second, high order absolute characteristic function moments of histogram extracted from the coefficient subbands obtained by best wavelet packet decomposition are regarded as features. Finally, these features are processed and a back-propagation (BP) neural network is designed to classify original and stego images. Three different steganalysis algorithms for three different cases of background and application condition are presented. To validate the performance of the proposed method, a series of experiments are made for six kinds of typical steganography methods, i.e. LSB, LTSB, PMK, Jsteg, F5 and JPHide. Results show that, the average detection accuracy of the proposed method exceeds at least 6.4% and up to 15.4% and has a better universal performance than its closest competitors. Furthermore, the proposed method can provide reference for designing the pattern recognition and classification algorithm based on best wavelet packet decomposition. | LUO XiangYang LIU FenLin YANG ChunFang WANG DaoShun | 2010 | Science China(Information Sciences)2010，53，3： | 9 |
| 7 | Laboratory Characterizations on 2007 Cases of Monoclonal Gammopathies in East China显示文摘Monoclonal gammopathies are characterized by the presence of monoclonal immunoglobulin in patients with or without evidence of multiple myeloma (MM),macroglobulinemia,amyloidosis (AL),or a related plasma cell proliferative disorder. This study aims to evaluate laboratory diagnostic characters of monoclonal gammopathies and investigates the correlation between monoclonal gammopathies and transforming growth factor β1 (TGFβ1). Immunofixation electrophoresis (IFE),serum protein electrophoresis (SPE),nephelometry and urine light chain ELISA were used for laboratory identification of monoclonal immunoglobulins. Plasma TGFβ1 was detected with double-antibodies ELISA. Lightcycler was used for single nucleotide polymorphism (SNP) analysis. Totally 2,007 cases of monoclonal immunoglobulin (M protein) were identified in 10,682 samples. The isotypes of M protein were IgG type 47.1%,IgA 23.0%,IgM 8.7%,IgD 5.3%,free light chain κ 6.1%,λ 9.8%. In reference to IFE,the coherency of diagnosis was serum light chain ratio (κ/λ) 94.4%,quantitation of Igs 83%,light chain quantitation 80.9%,and urine light chain ratio (κ/λ) 58.0%. Plasma TGFβ1 was elevated significantly compared to normal control. The allelic frequency of codon 10 (C > T) was neither associated with the existence of the M protein nor with the M protein isotype. Monoclonal gammopathies can be identified with the combination of IFE,SPE,Igs quantitaion and urine light chain determination. Although TGFβ1,an important cytokine in immune regulation,was elevated in monoclonal gammopathies,the SNPs in coding region of TGFβ1 gene did not confer susceptibility to the development of monoclonal gammopathies in this study. | Hao Wang Chunfang Gao Lingling Xu Zaixing Yang Wenjing Zhao Xiantao Kong | 2008 | Cellular & Molecular Immunology2008，5，4： | 8 |
| 8 | Studies on Fatty Acid Composition in the Oil of Momordica cochinchinensis显示文摘对木鳖子油中脂肪酸组成进行分析 ,采用石油醚提取脂肪油 ,快速甲酯化法制备成甲酯衍生物 ,GC- MS联用技术分析其中的脂肪酸组成和相对百分含量 ,鉴定了 8种脂肪酸成分 ,为开发利用木鳖子资源提供了依据。 | Shang Huijuan Yuan Chunfang Wang Yuguang Gao Qipin Wang Wei Niu Zhiduo Wang Yongqi | 2000 | 中草药2000，31，10： | 5 |
| 9 | Fine Mapping of RppP25, a Southern Rust Resistance Gene in Maize显示文摘Southern rust (Puccinia polysora Underw.) is a major disease that can cause severe yield losses in maize (Zea mays L.). In our previous study, a major gene RppP25 that confers resistance to southern rust was identified in inbred line P25. Here, we report the fine mapping and candidate gene analysis of RppP25 from the near-isogenic line F939, which harbors RppP25 in the genetic background of the susceptible inbred line F349. The inheritance of resistance to southern rust was investigated in the BC1F1 and BC3F1 populations, which were derived from a cross between F939 and F349 (as the recurrent parent). The 1:1 segregation ratio of resistance to susceptible plants in these two populations indicated that the resistance is controlled by a single dominant gene. Ten markers, including three simple sequence repeat (SSR) markers and seven insertion/deletion (InDel) markers, were developed in the RppP25 region. RppP25 was delimited to an interval between P091 and M271, with an estimated length of 40 kb based on the physical map of B73. In this region, a candidate gene was identified that was predicted to encode a putative nucleotide-binding site leucine-rich repeat (NBS-LRR) protein. Two co-segregated markers will aid in pyramiding diverse southern rust resistance alleles into elite materials, and thereby improve southern rust resistance worldwide. | Panfeng Zhao Guobin Zhang Xiaojun Wu Na Li Dianyi Shi Dengfeng Zhang Chunfang Ji Mingliang Xu Shoucai Wang | 2013 | Journal of Integrative Plant Biology2013，55，5： | 5 |
| 10 | Redox condition during Ediacaran–Cambrian transition in the Lower Yangtze deep water basin, South China: constraints from iron speciation and δ^(13) Corg in the Diben section, Zhejiang显示文摘Cherts of the Piyuancun Formation and black mudstones of the Hetang Formation in Diben Town, Kaihua County, Zhejiang were deposited in a deep water basin of the Lower Yangtze area during the Ediacaran–Cambrian transition(E–C transition), offering an opportunity to reconstruct the ancient redox condition of the deep water basin. Total 53 samples were collected and analyzed for iron speciation, including pyrite iron(FePy), carbonate associated iron(FeCarb), iron oxide and hydroxide(FeOx),magnetite iron(FeMag) and total iron(FeT) as well as d13 Corgto gain a deeper understanding of specific redox condition during the period. The results show that(1) most samples have pyrite concentration \1 %, with the FePy/FeHR ratio ranging from \0.01 to 0.81(mostly \0.5), and the FeHR/FeT ratio between 0.39 and 0.93(mostly [0.5).(2) The E–C boundary in the Diben section occurred at the maximum negative excursion of organic carbon isotope within the Piyuancun Formation, which can be correlated with other sections by using d13 Corg. We thus concluded that the relatively high content of highly reactive iron and low content of pyrite iron in the Diben section indicate a minor occurrence of H2 S and a predominance of anoxic and ferruginous environment, which is similar to other reported sections such as the Longbizui and Yanwutan sections, western Hunan. In addition, oxygen concentration in sea water showed an increasing trend in the interval corresponding to the bottom and upper layer of the Hetang Formation as indicated by the FeHR/FeT ratio, which decreased from 0.7 to 0.38, however, it was not great enough to oxidize the whole deep water. Therefore, during the E–C transition deep water basin in South China was most likely an anoxic and ferruginous enrironment, which prevented metazoon from the evolution in the deep water basin. Our work offers an important reference to better understanding of the spatiotemporal occurrence and dynamic processes of the ‘‘Cambrian Explosion''. | Yuyang Yuan Chunfang Cai Tiankai Wang Lei Xiang Lianqi Jia Yan Chen | 2014 | Chinese Science Bulletin2014，59，28： | 5 |
| 11 | Dynamic blood single-cell immune responses in patients with COVID-19显示文摘The 2019 coronavirus disease(COVID-19)outbreak caused by the SARS-CoV-2 virus is an ongoing global health emergency.However,the virus'pathogenesis remains unclear,and there is no cure for the disease.We investigated the dynamic changes of blood immune response in patients with COVID-19 at different stages by using 5'gene expression,T cell receptor(TCR),and B cell receptors(BCR)V(D)J transcriptome analysis at a single-cell resolution.We obtained single-cell mRNA sequencing(scRNA-seq)data of 341,420 peripheral blood mononuclear cells(PBMCs)and 185,430 donotypic T cells and 28,802 donotypic B cells from 25 samples of 16 patients with COVID-19 for dynamic studies.In addition,we used three control samples.We found expansion of dendritic cells(DCs),CD14+monocytes,and megakaryocytes progenitor cells(MP)/platelets and a reduction of naive CD4+T lymphocytes in patients with COVID-19,along with a significant decrease of CD8+T lymphocytes,and natural killer cells(NKs)in patients in critical condition.The type I interferon(IFN-I),mitogen-activated protein kinase(MAPK),and ferroptosis pathways were activated while the disease was active,and recovered gradually after patient conditions improved.Consistent with this finding,the mRNA level of IFN-I signal-induced gene IFI27 was significantly increased in patients with COVID-19 compared with that of the controls in a validation cohort that included 38 patients and 35 controls.The concentration of interferon-a(IFN-a)in the serum of patients with COVID-19 increased significantly compared with that of the controls in an additional cohort of 215 patients with COVID-19 and 106 controls,further suggesting the important role of the IFN-I pathway in the immune response of COVID-19.TCR and BCR sequences analyses indicated that patients with COVID-19 developed specific immune responses against SARS-CoV-2 antigens.Our study reveals a dynamic landscape of human blood immune responses to SARS-CoV-2 infection,providing clues for therapeutic potentials in treating COVID-19. | Lulin Huang Yi Shi Bo Gong Li Jiang Zhixin Zhang Xiaoqi Liu Jialiang Yang Yongquan He Zhilin Jiang Ling Zhong Juan Tang Chunfang You Qi Jiang Bo Long Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Shuqiang Wang Xingxiang Yang Zhenglin Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 4 |
| 12 | Effects of compound microbial inoculant treated wastewater irrigation on soil nutrients and enzyme activities显示文摘Wastewater treated by compound microbial inoculant(CMI)in agricultural irrigation can enrich soil fertility and decompose the possible pollutants.In this study,a greenhouse experiment using tomato as the model crop was performed to investigate the effects of treated wastewater irrigation on soil nutrients and enzymes.For this purpose,certain parameters were measured,including soil total nitrogen(N),nitrate N,total phosphorus(P),available potassium(K)and the activities of the enzymes urease,acid phosphatase and catalase in soils irrigated with fresh water,wastewater and CMI-treated wastewater under three amount of irrigation water.The results showed that irrigation with both treated and untreated wastewater significantly increased soil total N,total P,and available K,however the treated wastewater showed higher effects on soil enrichment,especially on available K.The activity of soil urease and acid phosphatase reached highest with treated wastewater irrigation,whereas wastewater irrigation increased the activity of catalase obviously.Soil enzyme and nutrient with fresh water irrigation decreased with increasing water amount;the content of soil urease,nitrate-nitrogen,total N and total P in treated wastewater and wastewater irrigation rose with increasing water amount,but the highest activity of acid phosphatase and the lowest activity of catalase were found in medium irrigation water amount.Under the condition of tomato cultivation,total N,nitrate N and total P were closely correlated with soil urease and catalase;there were significant positive correlation among soil urease,catalase,total N,nitrate N and total P;there existed significantly positive correlation between acid phosphatase and all measured soil nutrient indexes.The results suggested that irrigation with CMI-treated wastewater is a security and effective strategy to agricultural land management. | Wang Chunfang Shao Xiaohou Xu Huilian Chang Tingting Wang Weina | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 4 |
| 13 | Dynamic Analysis of Supply and Demand Coupling of Ecosystem Services in Loess Hilly Region:A Case Study of Lanzhou,China显示文摘The relationship between the supply and demand for ecosystem services(ESs)is a key issue for the rational allocation of natural resources and optimisation of sustainable development capacity.This paper investigateed the dynamic evolution features of supply and demand of four ESs in Lanzhou of China,namely,water supply,food supply,carbon fixation and soil retention services.The crosssectional data of 2005 and 2017 were used for calculating ESs value and its supply and demand through ArcGIS software,InVEST model,elastic coefficient model and coupling coordination model.Results showed that:1)from 2005 to 2017,the supply of water supply services increased,the demand of soil retention services decreased,and the supply and demand of food supply and carbon fixation services increased.The high-value areas of service supply were mainly distributed in the rocky mountain areas in the southeast and northwest with high vegetation coverage,while the high-value areas of demand were mainly distributed in the urban areas and surrounding areas with high population density.2)There were five different types of coupling relations.Water supply service was dominated by a negative coupling type D,which means that the decrease in demand for ESs has had a positive response on the supply of ESs.Negative coupling type C was the main type of food supply and carbon fixation services,which means that the increase in demand for ESs has had a negative response on the supply of ESs.All three services were supplemented by a positive coupling type A,which means that the increase in demand for ESs has had a positive response on the supply of ESs.Soil retention service generally exhibits a positive coupling type B,which means that the decrease in demand for ESs has had a negative response on the supply of ESs.3)Over the past 12 yr,the coordination degree of supply and demand of water supply,food supply and soil retention services decreased,and the coordination degree of carbon fixation service increased.Various types of ES had a low degree of coupling and coordination,showing different characteristics of temporal and spatial evolution.The areas with imbalanced ESs supply and demand were mainly distributed in urban areas dominated by construction land.The research results are valuable to the optimisation of urban and rural ecological environments and the sustainable development of territory space under the framework of ecological civilisation,including similar ecologically vulnerable areas in other developing countries. | LI Pengjie LIU Chunfang LIU Licheng WANG Weiting | 2021 | Chinese Geographical Science2021，31，2： | 3 |
| 14 | Expressions of cyclooxygenase-2 and matrix metalloproteinase-9 in cervical carcinoma and their clinical significance显示文摘Objective: To investigate the expressions of cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 in cervical carcinoma and their clinical significance. Methods: Immunohistochemistry SP method was used to detect the expres- sions of COX-2 and MMP-9 in 72 cases of invasive carcinoma of cervix (ICC) and 16 cases of normal cervical epithelium remote from tumor (NCE). The relationships between the expressions of COX-2, MMP-9 in ICC and some characteristics relating to clinical pathology of cervical carcinoma such as histological grading, lymph node metastasis, stromal invasion and FIGO stage were analyzed statistically. Results: The rates of the positive expressions of COX-2 and MMP-9 in ICC were significantly higher than those in NCE. COX-2: 88.9% (64/72) in group ICC and 12.5% (2/16) in group NCE, P = 0.000; MMP-9: 94.4% (68/72) in group ICC and 43.8% (7/16) in group NCE, P = 0.000. The expression of COX-2 was positively correlated with lymph node metastasis (r = 0.296, P = 0.012) and stromal invasion (r = 0.257, P = 0.029). The expression of MMP-9 was positively correlated with FIGO stage (r = 0.329, P = 0.005) and histological grading (r = 0.351, P = 0.003). The expression of COX-2 was positively correlated with the expression of MMP-9 in ICC (r = 0.297, P = 0.011). Conclusion: The overexpressions of COX-2 and MMP-9 were closely related to the invasion and growth of cervical carcinoma. The tissue with the overexpression of COX-2 had strong invasion ability. COX-2 and MMP-9 had synergistic effect on proliferation, invasion and metastasis of cancer cells. Detecting the coexpression of COX-2 and MMP-9 may be of value in further understanding the biological behavior and predicting the prognosis of cervical carcinoma. | Chunfang Luo Runqing Zhu Hui Wang Yulan Lu | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，1： | 3 |
| 15 | New β-delayed Proton Precursor ^(135)Gd显示文摘Newβ-delayedProtonPrecursor^(135)Gd￥XuShuwei;XieYuanxiang;LiZhankui;MaRuichang;GeYuanxiu;WangChunfang;GuoBing;XingJianping;Hu?.. | Xu Shuwei Xie Yuanxiang Li Zhankui Ma Ruichang Ge Yuanxiu Wang Chunfang Guo Bing Xing Jianping Huang Wenxue Zhang Tianmei Liu Zhong Zhu Shaofei Jin Genming and Luo Yixiao | 1996 | IMP & HIRFL Annual Report1996，，1： | 2 |
| 16 | Sufficient conditions for super k-restricted edge connectivity in graphs of diameter 2显示文摘 | WANG SHIYING LIN SHANGWEI LI CHUNFANG | 2009 | Discrete Math2009，309，4： | 1 |
| 17 | Preparation and Characterization of Natural Rubber/Silica Nanocomposites using Rule of Similarity in Latex显示文摘Rule of similarity and latex compounding techniques were combined for the first time to prepare natural rubber/nanosilica(NR/SiO2) nanocomposite with core-shell nanosilica-poly(methyl methacrylate)(SiO2-PMMA) particles and PMMA-modified natural rubber matrix(NR-PMMA).The microstructure of SiO2 and nanocomposites with different SiO2 contents was characterized by fourier transform infrared spectroscopy(FTIR);the morphology of nanocomposites was investigated with scanning electron microscopy(SEM);the tensile strength was characterized by tensile testing machine and the thermal stability of composites was studied by thermal gravimetric analysis.Results showed that PMMA chains have successfully grafted onto the surface of SiO2,and the core-shell SiO2-PMMA nanoparticles and NR-PMMA latex have been perfectly incorporated.SiO2-PMMA nanoparticles are evenly distributed over the NR matrix with an average size in the range of 60-100 nm at the low content(SiO2 ≤ 3 wt%),while aggregations are apparently observed when 5 wt% SiO2 is loaded.In addition,NR/SiO2 composities possess a considerable improvement in ageing resistance compared with the pure NR.The tensile strength of composite increases from 6.99 to 12.72 MPa,reaching the highest value at a 0.5 wt% SiO2 loading,and then the figure decreases gradually because of the aggregation of SiO2 nanoparticles.It is anticipated that the reported process is to provide a simple and economic way for preparing NR composites. | 罗勇悦 FENG Chunfang WANG Qinghuang YI Zhifeng QIU Quanfang Kong LX 彭政 | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，5： | 1 |
| 18 | Association between time in range and cancer mortality among patients with type 2 diabetes:a prospective cohort study显示文摘Background:Little was known about the association among time in range(TIR),time above range(TAR),time below range(TBR),and cancer mortality among patients with type 2 diabetes.We aimed to investigate the association among TIR,TAR,TBR,and the risk of cancer mortality among patients with type 2 diabetes.Methods:A total of 6225 patients with type 2 diabetes were prospectively recruited in Shanghai,China.TIR was measured with continuous glucose monitoring at baseline and was defined as the average percentage of time in the target glucose range during a 24 h period.Cox proportion hazard regression analysis was used to determine the association between TIR and the risk of cancer mortality.Results:During a mean follow-up of 7.10 years,we confirmed 237 death events related to cancer.The multivariable-adjusted hazard ratio(HR)for cancer mortality was 1.32(95%confidence interval[CI]:1.01-1.75)in patients with TIR≤70%compared with those with TIR>70%.When TIR was considered as a continuous variable,the multivariable-adjusted HR for cancer mortality associated with each 10%decrease in TIR was 1.07(95%CI:1.02-1.14).In the site-specific analysis,a significant association between TIR as a continuous variable and the risk of hepatocellular cancer was found(HR:1.24;95%CI:1.09-1.41).However,no relationship between hemoglobin A1c and cancer mortality was observed(HR:1.04;95%CI:0.97-1.10).Conclusions:The present study found an inverse association of TIR with the risk of cancer mortality among patients with type 2 diabetes.New evidence of TIR was added into the clinical practice that TIR may be an optimal target of glycemic control among patients with type 2 diabetes. | Yun Shen Chunfang Wang Yaxin Wang Jingyi Lu Lei Chen Lei Zhang Wei Lu Wei Zhu Gang Hu Tian Xia Jian Zhou | 2022 | Chinese Medical Journal2022，，3： | 1 |
| 19 | Biological effects of extract from newborn porcine liver on hepatocytes,hepatic stellate cells,and hepatoma cell line显示文摘Objective: Porcine liver extract has been shown to be effective in the clinical treatment of severe hepatitis. The aim of the present study was to study its antifibrotic as well as immune regulatory effect in vitro. Methods: Hepatocytes, hepatic stellate cells (HSCs), hepatoma cell line (HepG2) and human peripheral blood mononuclear cells (PMNCs) were studied with respect to proliferation, extracellular matrix production and apoptotic activities by proliferation assay, radioimmunoassay, gene transfection, reporter gene analysis and flow cytometry, respectively. Results: A strong stimulatory proliferation effect was observed in hepatocytes, and an inhibitory effect was found in HSCs. Hyaluronic acid (HA) production and reporter gene activities driven by various α1(I) procollagen gene promoters in HSC-T6 were significantly decreased after treatment with the extract. Fluo-Anexin V binding apoptotic HepG2 cells were more prominent in the presence of 60 μg/ml extract. More CD4+/CD69+ positive T lymphocytes existed in the presence of the extract. Conclusion: Porcine liver extract is effective for antifibrogenesis via hepatocyteregeneration, HSC and hepatoma cell inhibition in vitro. The elevation of active T lymphocytes is helpful for immune surveillance. Fine mapping of the extract is necessary in order to get definite molecules which are essential in all described functions. | Zhou Changlin Zhou Feiguo Gao Chunfang Wang Hao Xu Lingling Zhang Lingzheng Chen Jie | 2008 | Journal of Medical Colleges of PLA(China)2008，23，6： | 1 |
| 20 | Feedingrates affect heat shock protein levels in liver of larval white stur-geon(Acipenser transmontanus)显示文摘 | Deng Dongfang Wang Chunfang Lee Seunghyung | 2009 | Aquaculture2009，287，： | 1 |
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