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| 1 | Compound Gaoziban tablet(复方高滋斑片) alleviates depression via toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B pathway显示文摘OBJECTIVE: To evaluate the effect of compound Gaoziban tablet(复方高滋斑片, CGZBT) on depression, and to investigate the underlying mechanism. METHODS: The components of CGZBT were analysed by high-performance liquid chromatography. Then, we assessed the effects of varying doses of CGZBT on an established chronic unpredictable mild stress(CUMS) model in rats. Whether animals were depressed was evaluated by sucrose preference test, open field test and forced swimming test. Neurotransmitters of hippocampus were detected by liquid chromatography-mass spectrometry. Serum levels of tumor necrosis factor-alpha(TNF-α), interleukin(IL)-1β, IL-6, IL-4, and IL-10 were measured by enzyme-linked immunosorbent assay. Expressions of toll-like receptor 4(TLR4), myeloid differentiation factor 88(My D88), phospho-nuclear factorkappa B(p-NF-κB), cyclooxygenase-2(COX-2), ionized calcium binding adapter molecule-1(IBA-1) were assessed by immunohistochemical staining and western blotting. RESULTS: Eight compounds were identified from CGZBT, moreover, our results showed that CGZBT effectively reversed the CUMS-induced decrease in sucrose preference, shortened the movement distance and prolonged immobility time. CGZBT significantly increased levels of 5-hydroxytryptamine, dopamine, norepinephrine, 5-hydroxyindoleacetic acid levels, and reduced the expression of TNF-α, IL-1β, IL-6, yet increased IL-4 and IL-10. Furthermore, the expressions of TLR4, My D88, COX-2, p-NF-κB and IBA-1 in hippocampus were effectively reversed after treatment with CGZBT. CONCLUSIONS: These results indicated that CGZBT could, at least in part, alleviate depression induced by CUMS via the TLR4/My D88/NF-κB pathway, suggesting its potential as an antidepressant drug. | ZOU Xinshuang SHI Lei YIN Hailong LI Haiping WANG Mengheng SONG Wanci LUO Laichun WU Hezhen YANG Yanfang ZAN Junfeng LIU Yanwen DAN Hanxiong YIN Qiang YOU Pengtao | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 2 |
| 2 | Expanded graphite-A new kind ofbiomedical material显示文摘 | Shen Wanci | 1999 | Carbon1999，，37： | 1 |
| 3 | Percutaneous transhepatic intrahepatic portosystemic shunt for variceal bleeding: A series of six cases and literature review显示文摘Objectives:To present a case series of modified transjugular intrahepatic portosystemic shunts(TIPS) and percutaneous transhepatic intrahepatic portosystemic shunts(PTIPS) in cirrhotic patients with variceal bleeding(VB).In addition,the scientific literature pertaining to PTIPS was reviewed.Methods:This retrospective clinical case series included six cirrhotic patients with VB who were treated with PTIPS after the failure of endoscopic band ligation or endoscopic injection sclerotherapy combined with vasoactive drugs.The treatment was conducted between January 2017 and June 2019 at a single institution.Three patients suffered from severe atrophy of the right or left lobar of the liver as well as the main right or left branch of the portal vein.The remaining three patients showed severe atrophy of the whole liver and portal vein,resulting in widening of the liver fissure.A paired t-test was used to compare the changes in portal pressure gradient between before and after the PTIPS operation.The rebleeding rate,treatment efficacy,complications,and technical success rate were all assessed during follow-up.Results:All six PTIPS procedures were performed successfully,with no severe procedural-related complications observed.None of the patients experienced VB during a mean follow-up of 22.8(range,18.0-28.0) months.The mean portosystemic pressure gradient decreased from 28.3 ± 4.3 mmHg pre-procedure to 12.3 ± 2.6 mmHg immediately post-procedure(P <0.001).At follow-up,one patient was found to have developed grade 2 hepatic encephalopathy thrice during the first year,according to the West Haven criteria.However,this was resolved following medical treatment.Conclusions:When the patient’s portal venous anatomy is unconducive to the performance of TIPS using the transjugular approach,PTIPS can be considered as a safe,effective complementary surgical approach for patients with VB. | Hang Du Binyan Zhong Peng Zhang Wansheng Wang Jian Shen Shuai Zhang Wanci Li Haohuan Tang Linfeng Zhou Weihao Yang Xiaoli Zhu | 2021 | Journal of Interventional Medicine2021，4，1： | 1 |
| 4 | Expanded Graphite-A New Kind of Biomedical Material显示文摘 | Shen Wanci | 1999 | Carbon1999，，37： | 1 |
| 5 | Microstructures of surface white layer and internal white adiabatic shear band 显示文摘 | Zhang Baofa shen Wanci Liu Yingjie | 1997 | Wear1997，211，： | 1 |
| 6 | Modified natural flake graphite with high cycle performance as anode material in lithium ion batteries显示文摘 | Lin Zou Feiyu Kang Yong-Ping Zheng Wanci Shen | 2009 | Electrochimica Acta2009，，15： | 1 |
| 7 | Investigations on the modified natural graphite as anode materials in lithium ion battery显示文摘 | Lin Zou Feiyu Kang Xinlu Li Yong-Ping Zheng Wanci Shen Jing Zhang | 2007 | Journal of Physics and Chemistry of Solids2007，，5： | 1 |
| 8 | Flexible asymmetric supercapacitor based on MnO_2 honeycomb structure显示文摘A flexible asymmetric supercapacitor with high energy density was constructed by using a flexible substrate of carbonized silk-fabrics decorated with carbon nanotube, electroplating MnO_2 nanosheets and dip-coating activated carbon powders as the positive and the negative electrodes, respectively. By controlling the electroplating time, the MnO_2 nanosheets can be self-assembled to honeycomb structure and showed excellent electrochemical performance in 1 mol/L Na_2SO_4 electrolyte with SC950-EP30 performing the best. It exhibited a high specific capacitance(1110.85 F/g at a current density of 1 A/g based on the mass of MnO_2) and superior rate capability(77.44% capacity retention from 1 A/g to 10 A/g).Thus, the optimal asymmetric device assembled with this material as positive electrode can deliver a maximum energy density of 43.84 Wh/kg and a maximum power density of 6.62 kW/kg. | Yuling Chen Chao Chen Ruitao Lv Wanci Shen Feiyu Kang Nyanhwa Tai Zhenghong Huang | 2018 | Chinese Chemical Letters2018，29，4： | 0 |
| 9 | Environment-friendly preparation of exfoliated graphite and functional graphite sheets显示文摘Exfoliated graphite(EG)is promising oil sorbent as well as an intermediate product for the preparation of flexible graphite films(FGFs).It has been a critical challenge to energy conservation and pollution abatement for the traditional EG production technique.Here,we propose a simple and effective preparation method to acquire EG in which flake graphite is intercalated and exfoliated at room temperature,not involving any pollutant emission.The influence factors in the preparation process were explored,such as the amount of H_(2)SO_(4)and H_(2)O_(2),the temperature for the preparation of room temperature exfoliated graphite(RTEG).In contrast to the EG by high temperature exfoliation(HTEG),RTEG exhibits a homogeneous structure and a significantly increased volume and surface area.Moreover,EG blocks with high oil sorption capacity and excellent reuse performance can be obtained by RTEG method.Especially,FGFs fabricated by RTEG has high flexibility,thermal conductivity and electrical conductivity.It suggests that this environment-friendly technology is suitable for large-scale industrial implementation of graphite-based oil sorbents and flexible materials. | Shiyu Hou Shuaijie He Tianle Zhu Jihui Li Liqiang Ma Hongda Du Wanci Shen Feiyu Kang Zheng-Hong Huang | 2021 | Journal of Materiomics2021，7，1： | 0 |
| 10 | g-C_(3)N_(4) templated mesoporous carbon with abundant heteroatoms as high-rate anode material for dual-carbon sodium ion hybrid capacitors显示文摘Sodium ion hybrid capacitors(SIHCs)are regarded as advanced power supply systems.Nevertheless,the kinetics imbalance of cathode and anode suppresses the further performance improvement of SIHCs.The carbonaceous anode materials are promising and many strategies have been utilized to increase the capacity of sloping region or accelerate the reaction rate of plateau region.However,it is still challenging to simultaneously realize high mesopore/micropore volume ratio,large interlayer distance(>0.37 nm),and abundant and favorable heteroatoms-doping by a simple method.Herein,we report N,P,O ternarydoped mesoporous carbon(PNPOC-T,T=700,800 or 900)with large interlayer distance(~0.4 nm)as anode materials.The PNPOC-T were prepared by a simple in-situ polymerization of aniline and phytic acid on the exfoliated graphitic nitrogen carbide(g-C3N4)and subsequent carbonization.The obtained PNPOC-800 exhibits an excellent rate performance(101.5 mA·h·g^(-1) at 20 A·g^(-1)),which can be attributed to the high surface-controlled capacitive behavior ratio and rapid ion diffusion.The optimum SIHCs display a high energy density of 105.48 W·h·kg^(-1) and a high power density of 13.59 kW$kg1.Furthermore,the capacitance retention rate of SIHCs can reach 87.43%after 9000 cycles at 1 A·g^(-1). | Chong Wang Qingtao Yu Ning Zhao Bohan Li Wanci Shen Feiyu Kang Zheng-Hong Huang Ruitao Lv | 2022 | Journal of Materiomics2022，8，6： | 0 |
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