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| 1 | National Epidemiology and Evolutionary History of Four Hand, Foot and Mouth Disease-Related Enteroviruses in China from 2008 to 2016显示文摘Hand, foot and mouth disease(HFMD) is a major public health concern in China. The most predominant enteroviruses that cause HFMD have traditionally been attributed to enterovirus A71(EVA71) and coxsackievirus A16(CVA16). Since its first large outbreak in 2008, the dominant HFMD pathogens are constantly changing. In 2013 and 2015, CVA6 exceeded both EVA71 and CVA16 to become the leading cause of HFMD in some provinces. However, there still lacks a comprehensive overview on the molecular epidemiology and evolution of HFMD-related enteroviruses at the national level. In this study, we performed systematic epidemiological analyses of HFMD-related enteroviruses using the data of 64 published papers that met the inclusion criteria, and conducted phylogenetic analyses based on 12,080 partial VP1 sequences identified in China before 31 st June 2018. We found that EVA71 prevalence has decreased sharply but other enteroviruses have increased rapidly from 2008 to 2016 and that one subtype of each enterovirus is represented during the epidemic. In addition, four genotypes EVA71_C4, CVA16_B1, CVA6_D and CVA10_C are the most predominant enterovirus strains and collectively they cause over 90% of all HFMD cases in China according to the phylogenetic trees using representative partial VP1 sequences. These four major enterovirus genotypes have different geographical distributions, and they may cocirculate with other genotypes and serotypes. These results suggest that more molecular epidemiological studies should be performed on several enteroviruses simultaneously, and such information should have implications for virological surveillance, disease management, vaccine development and policy-making on the prevention and control of HFMD. | Xuemin Fu Zhenzhou Wan Yanpeng Li Yihong Hu Xia Jin Chiyu Zhang | 2020 | Virologica Sinica2020，35，1： | 31 |
| 2 | Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells显示文摘AIM:To investigate the potential mechanism of ArgGly-Asp(RGD) peptide-labeled liposome loading oxymatrine(OM) therapy in CCl 4-induced hepatic fibrosis in rats.METHODS:We constructed a rat model of CCl 4 induced hepatic fibrosis and treated the rats with different formulations of OM.To evaluate the antifibrotic effect of OM,we detected levels of alkaline phosphatase,hepatic histopathology(hematoxylin and eosin stain and Masson staining) and fibrosis-related gene expression of matrix metallopeptidase(MMP)-2,tissue inhibitor of metalloproteinase(TIMP)-1 as well as type Ⅰ procollagen via quantitative real-time polymerase chain reaction.To detect cell viability and apoptosis of hepatic stellate cells(HSCs),we performed 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-diphenytetrazoliumromide assay and flow cytometry.To reinforce the combination of oxymatrine with HSCs,we constructed fluorescein-isothiocyanate-conjugated Arg-Gly-Asp peptide-labeled liposomes loading OM,and its targeting of HSCs was examined by fluorescent microscopy.RESULTS:OM attenuated CCl 4-induced hepatic fibrosis,as defined by reducing serum alkaline phosphatase(344.47 ± 27.52 U/L vs 550.69 ± 43.78 U/L,P < 0.05),attenuating liver injury and improving collagen deposits(2.36% ± 0.09% vs 7.70% ± 0.60%,P < 0.05) and downregulating fibrosis-related gene expression,that is,MMP-2,TIMP-1 and type Ⅰ procollagen(P < 0.05).OM inhibited cell viability and induced apoptosis of HSCs in vitro.RGD promoted OM targeting of HSCs and enhanced the therapeutic effect of OM in terms of serum alkaline phosphatase(272.51 ± 19.55 U/L vs 344.47 ± 27.52 U/L,P < 0.05),liver injury,collagen deposits(0.26% ± 0.09% vs 2.36% ± 0.09%,P < 0.05) and downregulating fibrosis-related gene expression,that is,MMP-2,TIMP-1 and type Ⅰ procollagen(P < 0.05).Moreover,in vitro assay demonstrated that RGD enhanced the effect of OM on HSC viability and apoptosis.CONCLUSION:OM attenuated hepatic fibrosis by inhibiting viability and inducing apoptosis of HSCs.The RGD-labeled formulation enhanced the targeting efficiency for HSCs and the therapeutic effect. | Ning-Li Chai Qiang Fu Hui Shi Chang-Hao Cai Jun Wan Shi-Ping Xu Ben-Yan Wu | 2012 | World Journal of Gastroenterology2012，18，31： | 27 |
| 3 | Histological Subtypes of Lung Cancer in Chinese Males from 2000 to 2012显示文摘Objective To characterize the histological and epidemiological features of male lung cancer patients in China. Methods The demographic and histological information about male lung cancer patients identified from 2000-01-01 to 2012-12-31,was collected from the Cancer Hospital of the Chinese Academy of Medical Sciences. Relative frequencies(RF) were estimated for major histological subtypes and compared according to the years of diagnosis and birth. Results The RF of adenocarcinoma(ADC) increased from 21.96% to 43.36% and the RF of squamous cell carcinoma(SCC) decreased from 39.11% to 32.23% from 2000 to 2012 in the 15 427 male lung cancer patients included in this study(Z=17.909,P<0.0001; Z=-6.117,P<0.0001). The RF of ADC increased from 28.72% in 2000-2004,36.88% in 2005-2008 to 48.61% in 2009-2012 in patients born after 1960. The age-adjusted RF of ADC in 2007-2012 increased consistently in all the investigated areas. Conclusion The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors. Smoke-free policies rather than modifying tobacco products should be enforced. | ZOU Xiao Nong LIN Dong Mei WAN Xia CHAO Ann FENG Qin Fu DAI Zhen YANG Gong Huan LV Ning | 2014 | Biomedical and Environmental Sciences2014，27，1： | 19 |
| 4 | Humoral and cellular immunogenecity of DNA vaccine based on hepatitis B core gene in rhesus monkeys显示文摘INTRODUCTIONHepatitis B virus (HBV) is the most commonetiologic agent for infectious liver diseases. It isestimated that there are more than 250 millionchronic HBV carriersin the world today and thereis a significant association among persistentinfection, liver cirrhosis and hepatocellularcarcinoma[1-3]. | Zu Hu Huang1 Hui Zhuang2 Shan Lu3 Ren Hua Guo1 Guo Min Xu2 Jie Cai1 Wan Fu Zhu2 1Department of Infectious Diseases. The First Affiliated Hospital of Nanjing Medical University, Nenjing 210029, Jiangsu Province. China2Faculty of Microbiology, Beijing University, Beijing 100000, China3University of Massachusetts Medical Center | 2001 | World Journal of Gastroenterology2001，7，1： | 19 |
| 5 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 6 | The China Multi-Model Ensemble Prediction System and Its Application to Flood-Season Prediction in 2018显示文摘Multi-model ensemble prediction is an effective approach for improving the prediction skill short-term climate prediction and evaluating related uncertainties. Based on a combination of localized operation outputs of Chinese climate models and imported forecast data of some international operational models, the National Climate Center of the China Meteorological Administration has established the China multi-model ensemble prediction system version 1.0 (CMMEv1.0) for monthly-seasonal prediction of primary climate variability modes and climate elements. We verified the real-time forecasts of CMMEv1.0 for the 2018 flood season (June-August) starting from March 2018 and evaluated the 1991-2016 hindcasts of CMMEv1.0. The results show that CMMEv1.0 has a significantly high prediction skill for global sea surface temperature (SST) anomalies, especially for the El Nino-Southern Oscillation (ENSO) in the tropical central-eastern Pacific. Additionally, its prediction skill for the North Atlantic SST triple (NAST) mode is high, but is relatively low for the Indian Ocean Dipole (IOD) mode. Moreover, CMMEv1.0 has high skills in predicting the western Pacific subtropical high (WPSH) and East Asian summer monsoon (EASM) in the June-July-August (JJA) season. The JJA air temperature in the CMMEv1.0 is predicted with a fairly high skill in most regions of China, while the JJA precipitation exhibits some skills only in northwestern and eastern China. For real-time forecasts in March-August 2018, CMMEv1.0 has accurately predicted the ENSO phase transition from cold to neutral in the tropical central-eastern Pacific and captures evolutions of the NAST and IOD indices in general. The system has also captured the main features of the summer WPSH and EASM indices in 2018, except that the predicted EASM is slightly weaker than the observed. Furthermore, CMMEv1.0 has also successfully predicted warmer air temperatures in northern China and captured the primary rainbelt over northern China, except that it predicted much more precipitation in the middle and lower reaches of the Yangtze River than observation. | Hong-Li REN Yujie WU Qing BAO Jiehua MA Changzheng LIU Jianghua WAN Qiaoping LI Xiaofei WU Ying LIU Ben TIAN Joshua-Xiouhua FU Jianqi SUN | 2019 | Journal of Meteorological Research2019，33，3： | 16 |
| 7 | Colonoscopic screening and follow-up for coiorectal cancer in the elderly显示文摘AIM: To improve the prevention and treatment of senilepatients with colorectal cancer by evaluating the importanceof colonoscopy in clinical screening and follow-up.METHODS: Clinical screening of colonoscopy wasperformed for 2196 patients aged 60-90 years old accordingto the protocol,and 174lO of them (79.2 %) were followed-up.RESULTS: Colorsctal cancer was found in 52 patients, and the detectable rate was 2. 4 %. Among them, 19 werediagnosed as early colorectsl cancer, accounting for 36. 5 %of the detected colorectal cancer. Among the followed-uppatients, early colorectsl cancer was found in 9, accountingfor 45.0 % of the detected colorsctal cancer. The resectsblerate and 5 years survival rate of colorectsl cancer were 97.7% and 80.9 % respectively. The incidence of complicationwas 0.05 %, and the successful rate of cecum intubationwas 98.9 %.CONCLUSION: Colonuscopic screening and follow-up of theelderly for colorectsl cancer and pre-cancerous lesion(adenomatoid polyp) can increase the detectable rate ofearly colorectal cancer and improve its prevention andtreatment. | Jun Wan Zi-Qi Zhang Cheng Zhu Meng-Wei Wang Dong-Hai Zhao Yong-He Fu Jian-Ping Zhang Ya-Hong Wang Ben-Yan Wu,Department of Gastroenterology,General Hospital of the Chinese PLA,Beijing 100853,China | 2002 | World Journal of Gastroenterology2002，8，2： | 14 |
| 8 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 9 | First report of the South American tomato leafminer, Tuta absoluta (Meyrick), in China显示文摘Tuta absoluta(Meyrick) originated in South America and is one of the most serious pests of tomatoes. It is also known to attack other solanaceous crops, including potato, eggplant, pepper, tobacco, and weedy species such as black nightshade. After accidental introduction into Spain in 2006, this pest spread rapidly throughout Afro-Eurasia and has become a major threat to tomato production worldwide. Here, we report the first record of T. absoluta as an invasive pest in China. It was found in tomato fields in Ili Kazakg Autonomous Prefecture, Xinjiang Uygur Autonomous Region(Ili, Xinjiang), China, and its occurrence was confirmed by both morphological and molecular approaches. In Ili, T. absoluta has been found to attack eggplant, potato, and black nightshade. We found the larvae generally mining and feeding on leaves and boring into tomato fruits, with multiple larvae sometimes observed in a single fruit. Its infestation levels differ among the tomato fields and host species. In all of the surveyed tomato fields, T. absoluta infested 100% of plants. In some of the fields, up to 90% of the eggplant and 100% of the potato plants were infested. Since no natural enemies were found under field conditions, suitable management practices are urgently needed to stop the further spread of this destructive pest in China. | ZHANG Gui-fen MA De-ying WANG Yu-sheng GAO You-hua LIU Wan-xue ZHANG Rong FU Wen-jun XIAN Xiao-qing WANG Jun KUANG Meng WAN Fang-hao | 2020 | Journal of Integrative Agriculture2020，19，7： | 12 |
| 10 | In vitro and in vivo antibacterial activity of Pogostone显示文摘 | Peng Fu Wan Feng Xiong Liang Peng Cheng Dai Min Chen Jianping | 2014 | Chinese Medical Journal2014，，23： | 11 |
| 11 | Epidemiological Investigation and Genome Analysis of Duck Circovirus in Southern China显示文摘Duck circovirus (DuCV),a potential immunosuppressive virus,was investigated in Southern China from March 2006 to December 2009 by using a polymerase chain reaction (PCR) based method.In this study,a total of 138 sick or dead duck samples from 18 different farms were examined with an average DuCV infection rate of ~35%.It was found that ducks between the ages of 40~60 days were more susceptible to DuCV.There was no evidence showing that the DuCV virus was capable of vertical transmission.Farms with positive PCR results exhibited no regularly apparent clinical abnormalities such as feathering disorders,growth retardation or lower-than-average weight.The complete genomes of 9 strains from Fujian Province and 1 from Zhejiang Province were sequenced and analyzed.The 10 DuCV genomes,compared with others genomes downloaded from GenBank,ranged in size from 1988 to 1996 base pairs,with sequence identities ranging from 83.2% to 99.8%.Phylogenetic analysis based on genome sequences demonstrated that DuCVs can be divided into two distinct genetic genotypes,GroupⅠ(the Euro-USA lineage) and GroupⅡ(the Taiwan lineage),with approximately 10.0% genetic difference between the two types.Molecular epidemiological data suggest there is no obvious difference among DuCV strains isolated from different geographic locations or different species,including Duck,Muscovy duck,Mule duck,Cheery duck,Mulard duck and Pekin duck. | Chun-he Wan Guang-hua Fu Shao-hua Shi Long-fei Cheng Hong-mei Chen Chun-xiang Peng Su Lin Yu Huang | 2011 | Virologica Sinica2011，26，5： | 10 |
| 12 | A cross-sectional study on HGV infection in a rural population显示文摘AbstractAIMTodeterminetheepidemiologicalcharacteristicsandclinicalsignificanceofHGVinfection,andtocomparewithHBVandHCVinfecti... | LING Bin Hua 1, ZHUANG Hui 1, CUI Yi Hui 1, AN Wen Feng 1, LI Zhi Jie 1, WANG Shu Ping 2 and ZHU Wan Fu 2 | 1998 | World Journal of Gastroenterology1998，4，6： | 10 |
| 13 | Domestic versus imported drug-eluting stents for the treatment of patients with acute coronary syndrome显示文摘BACKGROUND:The application of coronary stents,especially drug-eluting stents(DESs),has made percutaneous coronary intervention(PCI) one of important therapeutic methods for CHD. DES has reduced the in-stent restenosis to 5%–9% and signifi cantly improved the long-term prognosis of patients with CHD. The study aimed to investigate the long-term eff icacy and safety of domestic drugeluting stents(DESs) in patients with acute coronary syndrome(ACS).METHODS:All patients with ACS who had undergone successful percutaneous coronary intervention(PCI) in the First Aff iliated Hospital of Zhengzhou University from July 2009 to December 2010 were included in this study. Patients were excluded from the study if they were implanted with bare metal stents or different stents(domestic and imported DESs) simultaneously. The included patients were divided into two groups according to different stents implanted:domestic DESs and imported DESs.RESULTS:In the 1 683 patients of this study,1 558(92.6%) patients were followed up successfully for an average of(29.1±5.9) months. 130(8.3%) patients had major adverse cardiovascular events(MACEs),including cardiac death in 32(2.1%) patients,recurrent myocardial infarction in 16(1%),and revascularization in 94(6%). The rates of cardiac death,recurrent myocardial infarction,revascularization,in-stent restenosis,stent thrombosis and other MACEs were not signif icantly different between the two groups(all P>0.05). Multivarite logistic regression revealed that diabetes mellitus(OR=1.75,95%CI:1.09–2.82,P=0.021),vascular numbers of PCI(OR=2.16,95%CI:1.22–3.83,P=0.09) and PCI with left main lesion(OR=9.47,95%CI:2.96–30.26,P=0.01) were independent prognostic factors of MACEs. The Kaplan-Meier method revealed that there was no significant difference in cumulative survival rates and survival rates free from clinical events between the two groups(all P>0.05).CONCLUSIONS:The incidences of clinical events and cumulative survival rates are not statistically different between domestic DESs and imported DESs. Domestic DES is effective and safe in the treatment of patients with ACS. | Hai-mu Yao Tong-wen Sun You-dong Wan Xiao-juan Zhang Xin Fu De-liang Shen Jin-ying Zhang Ling Li | 2014 | World Journal of Emergency Medicine2014，5，3： | 9 |
| 14 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 15 | Fourth C hinese National Consensus Report on the management of H elicobacter pylori infection显示文摘 | Wen Zhong Liu Yong Xie Hong Cheng Nong Hua Lu Fu Lian Hu Wan Dai Zhang Li Ya Zhou Ye Chen Zhi Rong Zeng Chong Wen Wang Shu Dong Xiao Guo Zong Pan Pin Jin Hu | 2013 | Journal of Digestive Diseases2013，，5： | 9 |
| 16 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 17 | XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells显示文摘Autophagy 被激活响应滋养的饥饿维持细胞的精力动态平衡。然而, autophagy 固执地没被激活,它糟糕在机械学的水平被理解。这里,我们报导 FoxO1 的那周转涉及夫酸安饥饿引起的动态 autophagic 过程。X-box-binding protein-1u (XBP-1u ) 由招募在 FoxO1 降级有一个关键角色 FoxO1 到 20S proteasome。另外,由 Ser61 和 Ser176 上的细胞外的调整蛋白质 kinases1/2 (ERK1/2 ) 的 XBP-1u 的 phosphorylation 被发现在夫酸安饥饿之上为在 XBP-1u 和 FoxO1 之间的增加的相互作用批评。而且,引起 FoxO1 的持续水平和 autophagy 的坚持的激活的 XBP-1u 击倒,在房间生存能力导致重要减少。最后,在 XBP-1u 之间的反的关联和 FoxO1 表示同意很好,表示侧面在许多人的癌症纸巾观察了。因此,我们的调查结果连接到 XBP-1u-induced FoxO1 的 autophagy 的动态过程降级。 | Ying Zhao Xue Li Mu-Yan Cai Ke Ma Jing Yang Jingyi Zhou Wan Fu Fu-Zheng Wei Lina Wang Dan Xie Wei-Guo Zhu | 2013 | Cell Research2013，23，4： | 8 |
| 18 | Improving the stability of LiNi_(0.80)Co_(0.15)Al_(0.05)O_2 by AlPO_4 nanocoating for lithium-ion batteries显示文摘Nickel-rich layered materials,such as LiNi_(0.8)0Co_(0.15)Al_(0.05)O_2(NCA),have been considered as one alternative cathode materials for lithium-ion batteries(LIBs) due to their high capacity and low cost.However,their poor cycle life and low thermal stability,caused by the electrode/electrolyte side reaction,prohibit their prosperity in practical application.Herein,AlPO4 has been homogeneously coated on the surface of NCA via wet chemical method towards the target of protecting NCA from the attack of electrolyte.Compared with the bare NCA,NCA@AlPO_4 electrode delivers high capacity without sacrificing the discharge capacity and excellent cycling stability.After 150 cycles at 0.5 C between 3.0-4.3 V,the capacity retention of the coated material is 86.9%,much higher than that of bare NCA(66.8%).Furthermore,the thermal stability of cathode is much improved due to the protection of the uniform coating layer on the surface of NCA.These results suggest that AlPO4 coated NCA materials could act as one promising candidate for next-generation LIBs with high energy density in the near future. | Ran Qi Ji-Lei Shi Xu-Dong Zhang Xian-Xiang Zeng Ya-Xia Yin Jian Xu Li Chen Wei-Gui Fu Yu-Guo Guo Li-Jun Wan | 2017 | Science China Chemistry2017，60，9： | 8 |
| 19 | Targeted bile acids and gut microbiome profiles reveal the hepatoprotective effect of WZ tablet(Schisandra sphenanthera extract) against LCA-induced cholestasis显示文摘Cholestasis is caused by the obstacle of bile formation or secretion and can develop into severe liver diseases. We previously reported the ethanol extract of Schisandra sphenanthera(Wuzhi tablet, WZ) can significantly protect against lithocholic acid(LCA)-induced intrahepatic cholestasis in mice, partially due to the activation of PXR pathway and promotion of liver regeneration.However, the effect of WZ on the bile acids profile and gut microbiome in cholestastic mice remain unknown. In this study, the effect of WZ against LCA-induced liver injury was evaluated and its effect on the bile acids metabolome and gut microbiome profiles in cholestastic mice was further investigated. Targeted metabolomics analysis was performed to examine the change of bile acids in the serum, liver, intestine and feces. The change of intestinal flora were detected by the genomics method. Targeted metabolomics analysis revealed that WZ enhanced the excretion of bile acids from serum and liver to intestine and feces. Genomics analysis of gut microbiome showed that WZ can reverse LCA-induced gut microbiome disorder to the normal level. In conclusion, WZ protects against LCAinduced cholestastic liver injury by reversing abnormal bile acids profiles and alteration of gut microbiome. | LI Dong-Shun HUANG Quan-Fei GUAN Li-Huan ZHANG Hui-Zhen LI Xi FU Kai-Li CHEN Yi-Xin WAN Jian-Bo HUANG Min BI Hui-Chang | 2020 | Chinese Journal of Natural Medicines2020，18，3： | 7 |
| 20 | Enhanced anti-sunward flow near local noon during a period of horizontal IMF and high solar wind velocity V_Y显示文摘It is believed that a southward interplanetary magnetic field (IMF) is mainly responsible for the energy input from solar wind into the magnetosphere.This paper presents an unusual case of strong anti-sunward plasma flow (up to 2 km/s) in the polar cap ionosphere and large cross-polar cap potential (CPCP) during a period of horizontal IMF (|BZ| < 2 nT) observed by both ACE (at the L1 point) and Geotail (on the dusk flank of the magnetosheath).The CPCP is even higher than that under preceding BZ ≈-23 nT.Furthermore,GOES8 observed that the magnetosheath field turns northward as the anti-sunward plasma flow and CPCP start to increase,which implies that the magnetosheath field interacting with the Earth's magnetopause has significantly rotated and differs from the IMF observed by ACE and Geotail.In accordance with previous theoretical work,we suggest that the magnetic field line draping produces a southward magnetosheath field and enhances anti-sunward plasma flow and the CPCP. | WEI Yong ZONG QiuGang PU ZuYin WAN WeiXing LIU JianJun FU SuiYan SHI QuanQi | 2011 | Chinese Science Bulletin2011，56，11： | 7 |
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