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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Partial antagonism of tiletamine-zolaze pam in cheetah显示文摘 | Walzer C Huber C | 2002 | Journal of Wildlife Diseases2002，38，2： | 1 |
| 3 | Thermolysin treatment: a new method for dermo-epidermal separation显示文摘 | Benathan M Frenk E | 1989 | J Invest Dermatol1989，92，1： | 1 |
| 4 | New alterations of serum glycoproteins in alcoholic and cirrhotic patients revealed by high resolution two-dimensional gel electrophoresis显示文摘 | GRAVEL P WALZER C AUBRY C | 1996 | Biochem Biophys Res Commun1996，220，1： | 1 |
| 5 | Thermolysin treatment: a new method for Dermo-epidermal separation显示文摘 | Walzer C Benathan M Frenk E | 1989 | J Invest Dermatol1989，92，1： | 1 |
| 6 | Early neurobehavioral disorders after cardiac surgery:a comparative analysis of coronary artery bypass graft surgery and valve replacement显示文摘 | Ebert AD Walzer TA Huth C | | 0，，： | 1 |
| 7 | Thiolated polymers: development and evaluation of transdermal delivery systems for progesterone显示文摘 | Walzer A Clausen AE Bernkop-Schnurch A | 2001 | Pharm Res2001，18，2： | 1 |
| 8 | Early neurobehavioral disorders after cardiac surgery:a comparative analysis of coronaryartery bypass graft surgery and valve replacement显示文摘 | Ebert AD Walzer TA Huth C | 2001 | J Cardiothorac Vasc Anesth2001，15，1： | 1 |
| 9 | Early neurobehavioral disorders after cardiac surgery : a comparative analysis coronaryarter bypassgraft surgery and value replacement 显示文摘 | Ebert AD Walzer TA Huth C | 2001 | J Cardiothome Vase Anesth2001，15，1： | 1 |
| 10 | Early neurobehavioral disorders after cardiac surgery: A comparative analysis of coronal artery bypass graft surgery and valve replacement 显示文摘 | Ebert A D Walzer T A Huth C | 2001 | Cardiutborac Vase Anesth2001，15，1： | 1 |
| 11 | Scanning tunneling microscopy of self-assembled phenylene ethynylene oligomers on Au (111) substrates显示文摘 | WALZER K MARX E GREENHAM N C | 2004 | J Am Chem Soc2004，126，4： | 1 |
| 12 | Early neurobehavioral disorders after cardiac surgery : a comparative analysis coronaryarter bypassgraft surgery and value replacement 显示文摘 | Ebert AD Walzer TA Huth C | 2001 | J Cardiothome Vase Anesth2001，15，1： | 1 |
| 13 | Imidazoline re- ceptor proteins in brains of patients with alzheimer's disease 显示文摘 | Garcia-Sevilla J A Escriba P V Walzer C | 1998 | Neurosci Lett1998，247，： | 1 |
| 14 | Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling 显示文摘 | Robbins SH Walzer T Dembele D Thibault C Defays A Bessou G | 2008 | Genome Biol2008，9，1： | 1 |
| 15 | Postsynaptic density protein PSD95 expression in Alzheimer's disease and okadaic acid induced neuritic retraction 显示文摘 | Leuba G Walzer C Vernay A | 2008 | Neurobiol Dis2008，30，3： | 1 |
| 16 | Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cells显示文摘 | Vu D Marin P Walzer C | 2003 | Brain Res Mol Brain Res2003，115，2： | 1 |
| 17 | Early neurobehavioral disorders after cardiac surgery: a comparative analysis of coronary artery bypass graft surgery and valve replacement显示文摘 | Walzer TA Huth C | 2001 | J Cardiothorac Vasc Anesth2001，15，1： | 1 |
| 18 | Imidazoline receptor proteins in brains of patients with Alzheimer's disease显示文摘 | Garcia-Sevilla JA Escriba PV Walzer C | 1998 | Neurosci Lett1998，247，23： | 1 |
| 19 | Early neurobehavioral disorders after cardiac surgery: a comparative analysis of coronaryartery bypass graft surgery and valve replacement 显示文摘 | Ebert AD Walzer TA Huth C | 2001 | J Cardio-thorac Vasc Anesth2001，15，1： | 1 |
| 20 | Analysis of the mi- toehondrial genome of cheetahs (Acinonyx jubatus) with neurodegenerative disease 显示文摘 | Burger P A Steinborn R Walzer C | 2004 | Gene2004，338，1： | 1 |
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