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| 1 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 2 | Comparative transcriptomics of Central Asian Vitis vinifera accessions reveals distinct defense strategies against powdery mildew显示文摘Grape powdery mildew(PM),caused by the biotrophic ascomycete Erysiphe necator,is a devastating fungal disease that affects most Vitis vinifera cultivars.We have previously identified a panel of V.vinifera accessions from Central Asia with partial resistance to PM that possess a Ren1-like local haplotype.In this study,we show that in addition to the typical Ren1-associated late post-penetration resistance,these accessions display a range of different levels of disease development suggesting that alternative alleles or additional genes contribute to determining the outcome of the interaction with the pathogen.To identify potential Ren1-dependent transcriptional responses and functions associated with the different levels of resistance,we sequenced and analyzed the transcriptomes of these Central Asian accessions at two time points of PM infection.Transcriptomes were compared to identify constitutive differences and PM-inducible responses that may underlie their disease resistant phenotype.Responses to E.necator in all resistant accessions were characterized by an early up-regulation of 13 genes,most encoding putative defense functions,and a late down-regulation of 32 genes,enriched in transcriptional regulators and protein kinases.Potential Ren1-dependent responses included a hotspot of co-regulated genes on chromosome 18.We also identified 81 genes whose expression levels and dynamics correlated with the phenotypic differences between the most resistant accessions‘Karadzhandahal’,DVIT3351.27,and O34-16 and the other genotypes.This study provides a first exploration of the functions associated with varying levels of partial resistance to PM in V.vinifera accessions that can be exploited as sources of genetic resistance in grape breeding programs. | Katherine C H Amrine Barbara Blanco-Ulate Summaira Riaz Dániel Pap Laura Jones Rosa Figueroa-Balderas M Andrew Walker Dario Cantu | 2015 | Horticulture Research2015，2，1： | 3 |
| 3 | Beyond first-line chemotherapy for advanced pancreatic cancer:An expanding array of therapeutic options?显示文摘While an increasing number of therapeutic options are now available for the first-line treatment of locally advanced or metastatic pancreatic cancer,the optimal choice for treatment in the second-line setting and beyond is less well defined.A variety of cytotoxic agents,either alone or in combination,have been evaluated,although primarily in the context of small single-arm or retrospective studies.Most regimens have been associated with median progression-free survival rates in the range of 2-4 mo and overall survival rates between 4-8mo,highlighting the very poor prognosis of patients who are candidates for such treatment.Targeted therapies studied in this chemotherapy-refractory setting,meanwhile,have produced even worse efficacy results.In the current article,we review the clinical evidence for treatment of refractory disease,primarily in patients who have progressed on front-line gemcitabine-based chemotherapy.In the process,we highlight the limitations of the available data to date as well as some of the challenges in designing appropriate clinical trials in this salvage setting,including how to select an appropriate control arm given the absence of a wellestablished reference standard,and the importance of incorporating predictive biomarkers and quality of life measures whenever possible into study design. | Evan J Walker Andrew H Ko | 2014 | World Journal of Gastroenterology2014，20，9： | 2 |
| 4 | 文化、不平等性与卫生服务提供显示文摘1动态不平等性对基层医疗卫生人力的影响
政治、社会、文化、专业群体皆建立在一致且常规的人类行为之上。当遭受巨大变革和内外压力时,这些群体会变得十分脆弱。尤其在动荡时期,这些群体往往更关注社会和文化的差异性,而非二者的一致性。尽管社会中的个体思维和行为会呈现较大的差异,但对健康的感知具有统一性,并在更广范围人群内尤为突出,这主要归因于文化价值观的作用。广义的文化心态会随着时间和地理位置的不同而不同,就像健康的社会决定因素也会因文化类型的不同而产生差异。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，3： | 2 |
| 5 | Rangeland ecology: understanding and managing ehange显示文摘 | Walker B H | 1993 | A Journal of Human Environment1993，22，： | 1 |
| 6 | Analysis and purification of modified methoxy polyethylene glycol compounds of similar molecular mass by high-performance liquid chromatography显示文摘 | Weaner L E Walker D G | 1995 | J chromatogr A1995，704，： | 1 |
| 7 | General population and medical student perceptions of good and bad doctors in Mozambique 显示文摘 | Pfeiffer A Noden B H Walker Z A | 2011 | Educ Health (Abingdon)2011，24，1： | 1 |
| 8 | Detection of cerebral hypoperfusion during trial carotid occlusion with reversal following extracranialintracranial bypass prior to permanent occlusion显示文摘 | Walker BS Mathews D Batjer H | 1994 | Clin Nucl Med1994，19，： | 1 |
| 9 | Cationic polymerization of emulsified epoxy resins 显示文摘 | Walker F H Dickenson J B Hegedus C R | 2002 | Prog Organ Coat2002，45，23： | 1 |
| 10 | The predictive value of hierachical cytogenetic classification in older adults with acute myeloid leukemia (AML) :analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial 显示文摘 | Grimwade D Walker H Harrison G | 2001 | Blood2001，98，： | 1 |
| 11 | Opportunistic management for rangelands not at equilibrium显示文摘 | Westoby M Walker B H Noy-Mier I | 1989 | J Range Manage1989，42，4： | 1 |
| 12 | Visualising and mapping stakeholder influence 显示文摘 | Bourne L Walker D H T | 2005 | Management Decision2005，43，5： | 1 |
| 13 | The predictive value of hierarchical cytogenetic classification in older aduhs with acute myeloid leukemia a (AML):analysis of 1065 patients entered into the United Kingdom Medical Research Council AML 11 trial显示文摘 | Grimwade D Walker H Harrison G | 2001 | Blood2001，98，5： | 1 |
| 14 | A revision of the eastern Asiatic Myrsinaceae显示文摘 | WALKER E H | | 0，，1： | 1 |
| 15 | Relationships amongancestral species of sugarcane revealed with RFLP using singlecopy maize nuclear probes显示文摘 | Lu Y h D'hont A Walker Dit | 1994 | Euphytica1994，78，12： | 1 |
| 16 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 17 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 18 | 医疗卫生保健文化的反思及促进健康与文化融合的建议显示文摘1医疗卫生保健文化的反思1.1健康文化与医学知识如果医务人员有充足的时间对患者进行诊断并帮助患者进行社区护理,就可在节省卫生费用的同时改善健康结果。整合型社区护理能缩小不同文化背景和群体健康需求的差异。然而,全球范围内对整合型社区护理的投入较少,原因之一就是20世纪对临床服务的重视弱化了卫生服务提供过程中的同情心理。当然,患者也对医学知识存在显性和隐性的影响(特别是当其因不遵医嘱而受到指责时)。 | Napier A D Ancarno C Butler B Calabrese J Chater A Chatterjee H Guesnet F Horne R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams A C Willott C Wilson JWoolf K | 2016 | 中国卫生政策研究2016，9，4： | 1 |
| 19 | Identification of potential therapeutic drugs for Huntington's disease using Caenorhabditis elegans 显示文摘 | Voisine C Varma H Walker N | 2007 | PLoS One2007，2，： | 1 |
| 20 | Land Use Rights Reform and Real Estate Market in China显示文摘 | Walker A Li L H | 1994 | Journal of Real Estate Literature1994，，2： | 1 |
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