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| 1 | 单纯支架治疗梭形动脉瘤的计算机仿真及血流动力研究显示文摘目的血流导向是治疗颅内梭形或宽颈动脉瘤的重要概念。本研究拟通过计算机仿真技术,探讨单纯多支架治疗梭形动脉瘤的血流导向作用。方法选用病例特异性的椎动脉梭形动脉瘤CFD模型。使用快速虚拟支架植入法植入1~3枚Enterprise支架。使用ICEMCFD软件进行网格化处理,ANSYS软件进行血流动力学分析,比较不同数量支架植入后的各项血流动力学参数的变化。结果虚拟支架植入后支架位置良好、贴壁满意。虚拟植入1~3枚支架后,梭形动脉瘤壁的平均瘤壁面切应力(WSS)分别下降了10%、20.4%和28.3%;经过瘤体最大截面的血流量分别下降了9.6%、21%和32.6%;相对滞留时间延长至支架植入前的1.45倍、2.07倍和2.79倍;动脉瘤壁平均压力变化不大。结论单纯支架治疗颅内梭形动脉瘤具有血流导向作用,随着支架数量增加,上述作用明显增强。快速虚拟支架植入法仿真度高、操作时间短,是适用于临床的虚拟支架植入技术。 | 方亦斌 Larrabide. I. 徐瑾瑜 于瀛 黄清海 王盛章 Wakhloo A. J. 刘建民 | 2012 | 中华脑血管病杂志(电子版)2012，6，6： | 2 |
| 2 | From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer’s and Parkinson’s diseases显示文摘Two of the most common neurodegenerative disorders-Alzheimer’s and Parkinson’s diseases-are characterized by synaptic dysfunction and degeneration that culminate in neuronal loss due to abnormal protein accumulation.The intracellular aggregation of hyper-phosphorylated tau and the extracellular aggregation of amyloid beta plaques form the basis of Alzheimer’s disease pathology.The major hallmark of Parkinson’s disease is the loss of dopaminergic neurons in the substantia nigra pars compacta,following the formation of Lewy bodies,which consists primarily of alpha-synuclein aggregates.However,the discrete mechanisms that contribute to neurodegeneration in these disorders are still poorly understood.Both neuronal loss and impaired adult neurogenesis have been reported in animal models of these disorders.Yet these findings remain subject to frequent debate due to a lack of conclusive evidence in post mortem brain tissue from human patients.While some publications provide significant findings related to axonal regeneration in Alzheimer’s and Parkinson’s diseases,they also highlight the limitations and obstacles to the development of neuroregenerative therapies.In this review,we summarize in vitro and in vivo findings related to neurogenesis,neuroregeneration and neurodegeneration in the context of Alzheimer’s and Parkinson’s diseases. | Debia Wakhloo Jane Oberhauser Angela Madira Sameehan Mahajani | 2022 | Neural Regeneration Research2022，17，12： | 2 |
| 3 | Stenting and sec ondary coiling of intracranial internal carotid artery aneurysm:technical case report 显示文摘 | Mericle RA Lanzino G Wakhloo AK | 1998 | Neurosurgery1998，43，5： | 1 |
| 4 | Alteration of hemodynamics in aneurysm models by stenting: Influence of stent porosity显示文摘 | Lieber BB Stancampiano AP Wakhloo AK | 1997 | Ann Biomed Eng1997，25，： | 1 |
| 5 | Modeling of flow in a straight stented and nonstented side wal aneurysm model显示文摘 | Aenis M Stancampiano AP Wakhloo AK | | 0，，02： | 1 |
| 6 | Stent-assisted reconstructive endovascular repair of cranial fusiform atherosclerotic and dissecting aneurysms: long-term clinical and angiographic follow-up显示文摘 | Wakhloo AK Mandell J Gounis MJ | 2008 | Stroke2008，39，： | 1 |
| 7 | Transradial ap- proach for vertebral artery stenting: technical easereport显示文摘 | Fessler RD Wakhloo AK Lanzino G | 2000 | Neuosurgery2000，46，6： | 1 |
| 8 | Dawning of a new era for acute stroke therapy显示文摘 | Fisher M Wakhloo A | 2015 | Stroke2015，46，： | 1 |
| 9 | Brain aneurysms and arteriovenous malformations:advancements and emerging treatments in endovascular embolization显示文摘 | Linfante I Wakhloo AK | 2007 | Stroke2007，38，： | 1 |
| 10 | Intra-arterial fibrinolysis in central artery occlusion显示文摘 | Schumacher M Schmidt D Wakhloo AK | 1991 | Radiology1991，31，： | 1 |
| 11 | Efficacy and current limitations of intravascular stents for intracranial internal carotid,vertebral,and basilar artery aneurysms显示文摘 | Lanzino G Wakhloo AK Fessler | 1999 | J Neurosurg1999，91，： | 1 |
| 12 | Advances in interventional neurora-diology显示文摘 | Wakhloo AK Deleo MJ Brown MM | 2009 | Stroke2009，40，1： | 1 |
| 13 | Temporary balloon protection as an adjunct to endovaccular coiling of wide-necked cerebral aneurysms:techni cal note显示文摘 | Wakhloo AK Rodriguez R | 1997 | Neurosurery,1997，41，： | 1 |
| 14 | Efficacy and current limitation of intravascular stent for intracranial internal carotid,vertebral,and basilar artery aneurysms显示文摘 | Wakhloo AK Fessler RD | 1999 | J Neurosurg1999，91，： | 1 |
| 15 | Complex-shaped platinum coils for brain aneurysms:higher packing density,improved biomechani-cal stability,and midterm angiographic outcome显示文摘 | Wakhloo AK Gounis MJ Sandhu JS | 2007 | AJNR Am J Neu-roradiol2007，28，1： | 1 |
| 16 | Identification of Patients at Risk for Periprocedural Neurological Deficits Associated With Carotid Angioplasty and Stenting显示文摘 | Adnan I. Qureshi Andreas R. Luft Vallabh Janardhan M. Fareed K. Suri Mudit Sharma Giuseppe Lanzino Ajay K. Wakhloo Lee R. Guterman L. Nelson Hopkins | 2000 | Stroke: Journal of the American Heart Association2000，，2： | 1 |
| 17 | Morphological age-dependent development of the human carotid bifurcation显示文摘 | Lieber BB Wakhloo AK | 2005 | J Biomech2005，38，： | 1 |
| 18 | Transradial approach for vertebral artery stenting:technical case report显示文摘 | Fessler RD Wakhloo AK Lanzino G | 2000 | Neurosurgery2000，46，： | 1 |
| 19 | Immunomodulatory effects of two sapogenins 1 and 2 isolated from luffa cylindrica in Balb/C mice显示文摘 | Khajuria A Gupta A Garai S Wakhloo B P | 2007 | Bioorganic and Medicinal Chemistry Letters2007，17，6： | 1 |
| 20 | Cerebral oedema associated with WHO- Ⅰ, WHO- Ⅱ , and WHO-Ⅲ-meningiomas: correlation of clinical, computed tomographic, operative and histological findings 显示文摘 | de Vries J Wakhloo AK | 1993 | Acta Neurochir (Wien)1993，125，14： | 1 |
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