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| 1 | IDO1 in cancer: a Gemini of immune checkpoints显示文摘Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as kynurenines.Coincidently,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human cancer.Preclinical studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject survival.Given the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously appreciated.Similar to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive effects.The gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer subtypes.Finally,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。 | Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen Ricky Patel Kristen L Lauing Meijing Wu Derek A Wainwright | 2018 | Cellular & Molecular Immunology2018，15，5： | 17 |
| 2 | Nebulised hypertonic saline solution for acute bronchiolitis in infants显示文摘 | Zhang L Mendoza-Sassi R A Wainwright C | 2013 | Cochrane Database of Systematic Reviews2013，5，3： | 1 |
| 3 | Mast cell de- granulation a mechanism for the anti-arrhythmic effect of endothelin - 1 显示文摘 | Walsh S K Kane K A Wainwright C L | 2009 | Britishi Journal of Pharmacology2009，157，5： | 1 |
| 4 | The complete sequence of the locus for enterocyte effacement ( LEE ) from enteropathogenic Escherichia coli E2348/69 显示文摘 | Elliott S J Wainwright L A McDaniel T K | 1998 | Mol Microbiol1998，28，： | 1 |
| 5 | The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69显示文摘 | Elliott S J Wainwright L A McDaniel T K | 1998 | Mol Microbiol1998，28，： | 1 |
| 6 | Effects of free radical production and scavengers on occlusion-reperfusion induced arrhythmias显示文摘 | Demiryurek A T Cakici I Wainwright C L | 1998 | Pharmacol Res1998，38，6： | 1 |
| 7 | Applying Genetic algorithms to the U-shaped assembly line balanceingproblem显示文摘 | Ajenblit D A Wainwright R L | 1998 | Mathematical and Computer Sciences Department1998，，3： | 1 |
| 8 | Characterization of eDNA encoding molt-inhibiting hormone of the crab, Cancers pagurus, expression of MIH in non-X-Organ tissue 显示文摘 | Lu W Wainwright G Olohan L A | 2001 | Gene2001，278，12： | 1 |
| 9 | U Pb(zircon) and geochemical constraints on the age,orlgin and evolution of Paleozoic arc magmas in the Oyu Tolgoi porphyry Cu-Au dis- trict,southern Mongolia显示文摘 | Wainwright A J Richard M T Joseph L W | 2011 | Gondwana Research2011，，19： | 1 |
| 10 | p21ras activation following hypoxia-ischemia in the newborn rat brain is dependent on nitric oxide synthase activity but p21ras does not contribute to neurologic injury显示文摘 | Wainwright M S Brennan L A Dizon M L Black S M | 2003 | Brain Res Dev Brain Res2003，146，12： | 1 |
| 11 | Mast cell degranulation- a mechanism for the anti-arrhythmic effect of endothelin- 1显示文摘 | Walsh S K Kane K A Wainwright C L | 2009 | Br J Pharmacol2009，157，5： | 1 |
| 12 | U-Pb (zircon) and geochemical constraints on the age, origSn, and evolution of Pa- leozoic arc magmas in the Oyu Tolgoi porphyry Cu-Au district, southern Mongolia显示文摘 | Wainwright A J Tosdal R M Wooden J L | | Gondwana Research0，19，： | 1 |
| 13 | Endothelin and the ischaemic heart显示文摘 | Wainwright C L McCabe C Kane K A | 2005 | Curr Vasc Pharmacol2005，3，4： | 1 |
| 14 | The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69显示文摘 | Wainwright L A McDaniel T K | 1998 | Mol Microbiol1998，28，： | 1 |
| 15 | Dynamic Scheduling of Computer Tasks Using Genetic Algorithms显示文摘 | Pico C A G Wainwright R L | 1994 | IEEE World Congress Computational Intelligence1994，，2： | 1 |
| 16 | A genetic algorithm for packing in three dimensions显示文摘 | Corcoran A L Wainwright R L | 1992 | : 1021-10301992，，： | 1 |
| 17 | The complete sequence of the locus of enterocyte effacement(LEE) from enteropathogenic Escherichia coli E2348/69显示文摘 | Wainwright L A McDaniel T K | 1998 | Mol Microbiol1998，28，： | 1 |
| 18 | A muiticenter, randomized,double-blind,controlled trial of nebulized epinephrine in infants with acute bronchiolftis显示文摘 | Wainwright C A]tamirano L Oheney M et aI | 2005 | N Engl J Med2005，349，1： | 1 |
| 19 | Concepts of hydrological connectivity: Research approaches, pathways and fu- ture agendas显示文摘 | BRACKEN L J WAINWRIGHT J ALl G A | 2013 | Earth-Science Reviews2013，119，： | 1 |
| 20 | Characterization of cDNA encoding molt-inhibiting hormone of the crab,Cancer pagurus;expression of MIH in non-X-organ tissues显示文摘 | Lu W Wainwright G Olohan L A | 2001 | Gene2001，278，12： | 1 |
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