|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 2 | Educated consumers don't believe artificial meat is the solution to the problems with the meat industry显示文摘The production of in vitro meat by cell culture has been suggested by some scientists as one solution to address the major challenges facing our society. Firstly, consumers would like the meat industry to reduce potential discomfort of animals on modern farms, or even to avoid killing animals to eat them. Secondly, citizens would like meat producers to reduce potential environmental deterioration by livestock and finally, there is a need to reduce world hunger by increasing protein resources while the global population is predicted to grow rapidly. According to its promoters, artificial meat has a potential to make eating animals unnecessary, to reduce carbon footprint of meat production and to satisfy all the nutritional needs and desires of consumers and citizens. To check these assumptions, a total of 817 educated people(mainly scientists and students) were interviewed worldwide by internet in addition to 865 French educated people. We also interviewed 208 persons(mainly scientists) after an oral presentation regarding artificial meat. Results of the three surveys were similar, but differed between males and females. More than half of the respondents believed that 'artificial meat' was feasible and realistic. However, there was no majority to think that artificial meat will be healthy and tasty, except respondents who were in favour of artificial meat. A large majority of the respondents believed that the meat industry is facing important problems related to the protection of the environment, animal welfare or inefficient meat production to feed humanity. However, respondents did not believe that artificial meat will be the solution to solve the mentioned problems with the meat industry, especially respondents who were against artificial meat. The vast majority of consumers wished to continue to eat meat even they would accept to consume less meat in a context of increasing food needs. Only a minority of respondents(from 5 to 11%) would recommend or accept to eat in vitro meat instead of meat produced from farm animals. Despite these limitations, 38 to 47% of the respondents would continue to support research on artificial meat, but a majority of them believed that artificial meat will not be accepted by consumers in the future, except for respondents who were in favour of artificial meat. We speculated that the apparent contradictory answers to this survey expressed the fact that people trust scientists whoare supposed to continuously discover new technologies potentially useful in a long term future for the human beings, but people also expressed concern for their health and were not convinced that artificial meat will be tasty, safe and healthy enough to be accepted by consumers. | Aurélie Hocquette Carla Lambert Clémentine Sinquin Laure Peterolff Zoé Wagner Sarah P F Bonny André Lebert Jean-Franois Hocquette | 2015 | Journal of Integrative Agriculture2015，14，2： | 11 |
| 3 | Minimization vs tailoring:Where do we stand with personalized immunosuppression during renal transplantation in 2015?显示文摘The introduction of novel immunosuppressive agents over the last two decades and the improvement of our diagnostic tools for early detection of antibodymediated injury offer us an opportunity, if not a mandate, to better match the immunosuppression needs of the individual patients with side effects of the therapy. However, immunosuppressive regimens in the majority of programs remain mostly protocol-driven, with relatively little inter-program heterogeneity in certain areas of the world. Emerging data showing different outcomes with a particular immunosuppressive strategy in populations with varying immunological risks underscore a real potential for 'personalized medicine' in renal transplantation. Studies demonstrating marked differences in the adverse-effect profiles of individual drugs including the risk for viral infections, malignancy and renal toxicity call for a paradigm shift away from a 'one size fits all' approach to an individually tailored immunosuppressive therapy for renal transplant recipients, assisted by both screening for predictors of graft loss and paying close attention to dose or class-related adverse effects. Our paper explores some of the opportunities during the care of these patients. Potential areas of improvements may include:(1) a thorough assessment of immunological and metabolic risk profile of each renal transplant recipient;(2) screening for predictors of graft loss and early signs of antibody-mediated rejection with donor-specific antibodies, protocol biopsies and proteinuria(including close follow up of adverse effects with dose adjustments or conversions as necessary); and(3) increased awareness of the possible link between poor tolerance of a given drug at a given dose and non-adherence with the prescribed regimen. Altogether, these considerations may enable the most effective use of the drugs we already have. | Lajos Zsom László Wagner Tibor Fül?p | 2015 | World Journal of Transplantation2015，5，3： | 3 |
| 4 | Bilateral vs unilateral laparoscopic intrafascial nerve-sparing radical prostatectomy:evaluation of surgical and functional outcomes in 457 patients显示文摘 | Greco F Hoda MR Wagner S | 2011 | British Journal of Urology International2011，，04： | 2 |
| 5 | Challenges for fuel cells in transport applications显示文摘 | Chalk S G Miller J F Wagner F W | 2000 | Journal of Power Sources2000，86，： | 2 |
| 6 | 氮素改变辣椒初级代谢和薄壁组织厚度调控比叶面积研究显示文摘比叶面积(SLA)是影响植物光截获和光利用效率的关键性状,常常影响植物的生长和产量。SLA是解释不同植物在不同环境下生长差异的一个关键性状。光照和氮素供应都是决定SLA的重要因素。为了更好地了解辐照度和氮素对辣椒(Capsicum chinense)SLA的影响,研究对两个中国辣椒商品种(Biquinho和Habanero)的初级代谢产物和形态特征进行了分析。两种基因型辣椒的SLA随着遮阴而增加,但随氮供应量的增加而下降;在氮素供应由缺乏到充足的范围内Habanero品种的SLA表现稳定。相关分析表明,高氮供应导致SLA降低是因为氨基酸、蛋白质和淀粉含量的调节,从而影响叶片密度。此外,在中度缺氮到充足供氮范围内,两种基因型辣椒的SLA表现出响应差异,Biquinho和Habanero分别在栅栏和海绵状薄壁组织上表现出差异。总之,结果表明,SLA对氮供应的反应是由某些代谢物含量和依赖于基因型的影响叶片厚度及密度的薄壁组织变化平衡调节的。 | Lucas de ávila Silva Rebeca P.Omena-Garcia Jorge A.Condori-Apfata Paulo Mafra de Almeida Costa Natália Machado Silva Fábio M.Da Matta Agustin Zsogon Wagner L.Araújo Edgard A.de Toledo Picoli Ronan Sulpice Adriano Nunes-Nesi 沈凌峰 吉雪花(译) | 2021 | 辣椒杂志2021，，3： | 2 |
| 7 | p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis显示文摘成红血球细胞的 Enucleation 对哺乳动物在终端区别期间唯一。尽管 erythroid enucleation 广泛地被学习了,包括 retinoblastoma 蛋白质(Rb ) ,仅仅一些基因被识别了调整原子挤出。它由哪个仍然保持大部分未定义发信号的分子,外来的刺激例如 erythropoietin (Epo ) ,是 transduced 导致 enucleation。这里,我们显示出那 p38α,激活 mitogen 的蛋白质 kinase (MAPK ) ,为 erythroid enucleation 被要求。在包含高 Epo 层次并且模仿的一个前 vivo 区别系统强调红血球生成, p38α在 erythroid 区别期间被激活。p38α 的损失;完全堵住主要成红血球细胞的 enucleation。而且, p38α在胎儿、贫血的压力红血球生成期间在 vivo 以一种房间自治的方式调整成红血球细胞 enucleation。显著地, p38α 的损失;导致 p21 目标 Rb 的 p21,和减少的激活的 downregulation,哪个是成红血球细胞 enucleation 的重要管理者。这研究表明那 p38α在压力红血球生成期间是为成红血球细胞 enucleation 的一个关键发信号分子。 | Simon M Schultze Andreas Mairhofer Dan Li Jin Cen Hartmut Beug Erwin F Wagner Lijian Hui | 2012 | Cell Research2012，22，3： | 2 |
| 8 | Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests显示文摘 | Richard F A Logan Julietta Patnick Claire Nickerson Lynn Coleman Matt D Rutter Christian von Wagner | 2012 | Gut2012，，10： | 2 |
| 9 | Comparative characteristics of mesenehymal stern cells from human bone marrow, adipose tissue, and umbilical cord blood 显示文摘 | Wagner W Wein F Seckinger A | 2005 | Exp Hematol2005，33，11： | 1 |
| 10 | Auger and photoelection line energy erlation ships in aluminum-oxygen and Silicon-oxygen compounds显示文摘 | Wagner C D Passoja D E Hillery H F | 1982 | J Vac Sci Technol1982，21，： | 1 |
| 11 | Characterization of the horse (Equus caballus) IGHA gene显示文摘 | Wagner B Greiser-Wilke I Antczak D F | 2003 | Immunogenetics2003，，8： | 1 |
| 12 | Effect of combined use of nonionic surfactant on formation of oil-in-water mlcroemulsions显示文摘 | Li P Ghosh A Wagner R F | 2005 | Int J Pharm2005，288，1： | 1 |
| 13 | BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia显示文摘 | Hantschel O Warsch W Eckelhart E Kaupe I Grebien F Wagner K-U | 2012 | Nature chemical biology2012，8，： | 1 |
| 14 | Statistics of speckle in ultrasound B-scans 显示文摘 | Wagner R F Smith S W Sandrik J M | 1983 | IEEE Transactions on Sonics and Ultrasonics1983，30，3： | 1 |
| 15 | Effects of topographic variability on the scaling of plant species richness in gradient dominated landscapes 显示文摘 | Hofer G Wagner H H Herzog F Edwards PJ | 2008 | Ecography2008，31，： | 1 |
| 16 | Soluble urokinase plasminogen activator receptor predicts mortality in patients with systemic inflammatory response syndrome显示文摘 | Raggam R B Wagner J Pruller F | 2014 | J Intern Med2014，276，6： | 1 |
| 17 | Simultaneous cellu- lose degradation and electricity production by Enterobacter cloacae in a microbial fuel cell显示文摘 | Rezaei F Xing D Wagner R | 2009 | Appl Environ Microbiol2009，75，： | 1 |
| 18 | Papillary glioneuro-nal tumor--a new tumor entity 显示文摘 | Broholm H Madsen F F Wagner A A | 2002 | Clin Neuropathol2002，21，1： | 1 |
| 19 | Signal integration byJNK and p38MAPK pathway in cancer development显示文摘 | Wagner E F Nebreda A R | 2009 | Nat Rev Cancer2009，9，8： | 1 |
| 20 | Cognitive Neuroscience of Self-regulation Failure显示文摘 | Heatherton T F Wagner D D | 2011 | Trends in Cognitive Sciences2011，，15： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员