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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Effects of spatial variabilily and scale with implication to hydrologic modeling显示文摘 | Wood E F Sivapalan M Bern K J el at | 1988 | Journal of Hydrology1988，102，： | 1 |
| 3 | The use of bivalves as bio-indicators in the assessment of marine pollution along a coastal area 显示文摘 | Yusof A M Yanta N F Wood A K H | 2004 | Journal of Radioanalytical and Nuclear Chemistry2004，259，1： | 1 |
| 4 | Full-scale tests of bridge components strengthened using carbon fiber-reinforced polymer composites显示文摘 | BRENA S F WOOD S L KREGER M E | 2003 | ACI Structural Journal2003，100，6： | 1 |
| 5 | Laparoscopic partial nephrectomy of solid renal masses without hilar clamping using a monopolar radio frequency device显示文摘 | Urena R Meudez F Woods M | 2004 | J Urol2004，171，3： | 1 |
| 6 | Direct myocardial revasularization wihoute edtracorporeal circulation显示文摘 | Benetti F J Naselli G Wood M | 1991 | Chest1991，100，： | 1 |
| 7 | Electrical measurements of the conduction band discontinuity of the abrupt Ge-GaAs (100) heterojunction显示文摘 | Ballingall J M C Wood E C Eastman L F | 1983 | Journal of Vacuum Science & Technology B1983，1，3： | 1 |
| 8 | Backfat composition in pigs: Differences between fat thickness groups and sexes 显示文摘 | WOOD J D ENSER M WHITTINGTON F M | 1989 | Livestock Production Science1989，22，34： | 1 |
| 9 | Disco-vering shared interests u-sing graph analysis显示文摘 | SCHWARTZ M F WOOD D C M | 1993 | Communications of the ACM1993，36，8： | 1 |
| 10 | Chronic, sublethal nickel accli- mation alters the diffusive properties of renal brush border mem- brane vesicles (BBMVs) prepared from the freshwater rainbow trout 显示文摘 | Pane E F Patel M Wood C M | 2006 | Compara Biochem Physiol Part C2006，143，1： | 1 |
| 11 | Increasing flexural capacity of reinforced concrete beams using carbon fibre-reinforced polymer composites 显示文摘 | Brena S F Bramblett R M Wood S L | 2003 | ACI Structure Journal2003，100，1： | 1 |
| 12 | A cardiac prevention and rehabilitation programme for all patients at first presentation with coronary artery disease显示文摘 | Fox K F Nuttall M Wood D A | | 0，，05： | 1 |
| 13 | Influence of tilt and surface roughness on the outflow wind field of an im- pinging jet 显示文摘 | Mason M S Wood G S Fletcher D F | 2009 | Wind and Structures2009，12，3： | 1 |
| 14 | Gold enhanced spectroelectrochemical investigation of 2-mercaptobenzothiazole, isopropyl xanthate and butylethoxycarbonylthiourea adsorption on minerals显示文摘 | HOPE G A BUCKLEY F M MUNCE C G WOODS R | 2007 | Minerals Engineering2007，20，10： | 1 |
| 15 | Dietary chromium picolinate additions improve gain : feed and carcass characteristics in growing - finishing pigs and increase litter size in reproducing sows 显示文摘 | LINDEMANN M D WOOD C M HARPER A F | 1995 | J Anim Sci1995，73，： | 1 |
| 16 | Encapsulation of plant oils in porous starch microspheres显示文摘 | Glenn G M Klamczynski A P Woods D F | 2010 | Journal of Agricultural and Food Chemistry2010，58，7： | 1 |
| 17 | POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells显示文摘 | Marini F Wood RD Seki M | 2003 | Nucleic Acids Res2003，31，21： | 1 |
| 18 | ThermomechanieaI processing and heat treatment of Ti-6AI-2Sn-2Zr-2Cr-2Mo-Si for structural applications 显示文摘 | Wood J P Russo P A Welter M F | 1998 | Mater Sei Eng A1998，243，： | 1 |
| 19 | Surface characterization of untreated and solvent-extracted rice straw显示文摘 | Inglesby M K Gray G M Wood D F | 2005 | Colloids and Surfaces B-Biointerfaces2005，43，2： | 1 |
| 20 | Gas exchange, metabolite status and excess post-exercise oxygen consumption after repetitive bouts of exhaustive exercise in juvenile rainbow trout显示文摘 | Scarabello M Heigenhauser G J F Wood C M | 1992 | J Exp Biol1992，167，： | 1 |
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