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| 1 | Molecular alterations in gastric cancer with special reference to the early-onset subtype显示文摘Currently, gastric cancer(GC) is one of the most frequently diagnosed neoplasms, with a global burden of 723000 deaths in 2012. It is the third leading cause of cancer-related death worldwide. There are numerous possible factors that stimulate the procarcinogenic activity of important genes. These factors include genetic susceptibility expressed in a singlenucleotide polymorphism, various acquired mutations(chromosomal instability, microsatellite instability, somatic gene mutations, epigenetic alterations) and environmental circumstances(e.g., helicobcter pylori infection, EBV infection, diet, and smoking). Most of the aforementioned pathways overlap, and authors agree that a clear-cut pathway for GC may not exist. Thus, the categorization of carcinogenic events is complicated. Lately, it has been claimed that research on early-onset gastric carcinoma(EOGC) and hereditary GC may contribute towards unravelling some part of the mystery of the GC molecular pattern because young patients are less exposed to environmental carcinogens and because carcinogenesis in this setting may be more dependent on genetic factors. The comparison of various aspects that differ and coexist in EOGCs and conventional GCs might enable scientists to: distinguish which features in the pathway of gastric carcinogenesisare modifiable, discover specific GC markers and identify a specific target. This review provides a summary of the data published thus far concerning the molecular characteristics of GC and highlights the outstanding features of EOGC. | Malgorzata Skierucha Anya NA Milne G Johan A Offerhaus Wojciech P Polkowski Ryszard Maciejewski Robert Sitarz | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 2 | Gastroenterostoma after Billroth antrectomy as a premalignant condition显示文摘Gastric stump carcinoma(GSC) following remote gastric surgery is widely recognized as a separate entity within the group of various types of gastric cancer.Gastrectomy is a well established risk factor for the development of GSC at a long time after the initial surgery.Both exoas well as endogenous factors appear to be involved in the etiopathogenesis of GSC,such as achlorhydria,hypergastrinemia and biliary reflux,Epstein-Barr virus and Helicobacter pylori infection,atrophic gastritis,and also some polymorphisms in interleukin-1 and maybe cyclo-oxygenase-2.This review summarizes the literature of GSC,with special reference to reliable early diagnostics.In particular,dysplasia can be considered as a dependable morphological marker.Therefore,close endoscopic surveillance with multiple biopsies of the gastroenterostomy is recommended.Screening starting at 15 years after the initial ulcer surgery can detect tumors at a curable stage.This approach can be ofspecial interest in Eastern European countries,where surgery for benign gastroduodenal ulcers has remained a practice for a much longer time than in Western Europe,and therefore GSC is found with higher frequency. | Robert Sitarz Ryszard Maciejewski Wojciech P Polkowski G Johan A Offerhaus | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 3 | Pharmacokineties of taerolimus in liver transplant patients 显示文摘 | William JJ Wojciech P Goran BK | 1995 | Clin Pharmacol Ther1995，57，： | 1 |
| 4 | Parallel tabu search algorithm for the hybrid flow shop problem 显示文摘 | Wojciech B Jaroslaw P Czeslaw S | 2013 | Computer and Industrial Engineering2013，65，3： | 1 |
| 5 | Hyperbaric oxygen therapy(HBOT)in case of hemorrhagic cystitis after radiotherapy显示文摘 | Wojciech K Alicja P Marcin K | 2012 | Central Eur J Urol2012，65，4： | 1 |
| 6 | DFT studies on tautomerism of C5-substituted 1,2,3-triazoles显示文摘 | Wojciech P O Jan Cz D Aleksander P M | 2003 | J Mol Struct2003，，： | 1 |
| 7 | P- selectin and its role in some diseases显示文摘 | Alicja P Wojciech S Joanna MK | 2009 | Postepy Hig Med Dosw2009，63，： | 1 |
| 8 | Hip Resurfacing Arthroplasty in Treatment of Avascular Necrosis of the Femoral Head显示文摘 | Michat P Bogdan K Wojciech W | 2015 | Med Sci Monit2015，21，6： | 1 |
| 9 | Synthesis of reactive UV absorbers, derivatives of monoehlorotriazine, for improvement in protecting properties of cellulose fabrics 显示文摘 | WOJCIECH C JOANNA P ROLAND S | 2006 | Dyes and Pigments2006，71，： | 1 |
| 10 | Brugada Phenocopy: New Terminology and Proposed Classification显示文摘 | Adrian Baranchuk Timothy Nguyen Min Hyung Ryu Francisco Femenía Wojciech Zareba Arthur A.M. Wilde Wataru Shimizu Pedro Brugada Andrés R. Pérez‐Riera | 2012 | Annals of Noninvasive Electrocardiology2012，，4： | 1 |
| 11 | Current electrocardiographic criteria for diagnosis of Brugada pattern: a consensus report显示文摘 | Antonio Bayés de Luna Josep Brugada Adrian Baranchuk Martin Borggrefe Guenter Breithardt Diego Goldwasser Pier Lambiase Andrés Pérez Riera Javier Garcia-Niebla Carlos Pastore Giuseppe Oreto William McKenna Wojciech Zareba Ramon Brugada Pedro Brugada | 2012 | Journal of Electrocardiology2012，，5： | 1 |
| 12 | Learning of fuzzy cognitive maps using density estimate显示文摘 | Wojciech S Witold P Lukasz A K | 2012 | IEEE Transactions on Systems Man and Cybernetics-Part B: Cybernetics2012，42，3： | 1 |
| 13 | Effect of erbium concentration on physical properties of fluoroindate glass显示文摘 | WOJCIECH A P JOANNA P WITOLD R R | 2003 | Chem Phys Lett2003，308，： | 1 |
| 14 | Somatic embryogenesis and in vitro culture of Huperzia selago shoots as a potential source of huperzine A 显示文摘 | Wojciech S Agnieszka P Piotr S | 2005 | Plant Sci2005，168，6： | 1 |
| 15 | Pattern electro- retinogram(PERG) and pattern visual evoked potential(PVEP) in the early stages of Alzheimer' s disease显示文摘 | Kamila K Wojciech L Andrzej P Krystyna H | 2010 | Doc Ophthalmol2010，，： | 1 |
| 16 | 查看详情显示文摘 | Wu J S Wojciech P Klaus M | | 0，，： | 1 |
| 17 | Continuous veno-venous hemodiafiltration in children after cardiac surgery显示文摘 | Anna Jander Marcin Tkaczyk Izabela P?gowska-Klimek Witold Pietrzykowski Jacek Moll Wojciech Krajewski Micha? Nowicki | 2007 | European Journal of Cardio-Thoracic Surgery2007，，6： | 1 |
| 18 | Robust stability and stabilization of 2-D discrete state-delayed systems 显示文摘 | Wojciech P James L Krzysztof G | 2004 | Systems & Control Letters2004，51，2： | 1 |
| 19 | Fuzzy Random Fields and Unsupervised Image Segmentation 显示文摘 | Helene C Alain H Wojciech P | 1993 | IEEE Trans Geosci Remot Sensing1993，31，4： | 1 |
| 20 | Thermal decomposition of the non Interstitial hydrides for the storage and production of hydrogen显示文摘 | Wojciech Grochala Peter P Edwards | 2004 | Chem Rev2004，104，： | 1 |
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