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| 1 | Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes显示文摘This review aims to outline the most up-to-date knowledge of pancreatic adenocarcinoma risk, diagnostics, treatment and outcomes, while identifying gaps that aim to stimulate further research in this understudied malignancy. Pancreatic adenocarcinoma is a lethal condition with a rising incidence, predicted to become the second leading cause of cancer death in some regions. It often presents at an advanced stage, which contributes to poor five-year survival rates of 2%-9%, ranking firmly last amongst all cancer sites in terms of prognostic outcomes for patients. Better understanding of the risk factors and symptoms associated with this disease is essential to inform both health professionals and the general population of potential preventive and/or early detection measures. The identification of high-risk patients who could benefit from screening to detect pre-malignant conditions such as pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms is urgently required, however an acceptable screening test has yet to be identified. The management of pancreatic adenocarcinoma is evolving, with the introduction of new surgical techniques and medical therapies such as laparoscopic techniques and neo-adjuvant chemoradiotherapy, however this has only led to modest improvements in outcomes. The identification of novel biomarkers is desirable to move towards a precision medicine era, where pancreatic cancer therapy can be tailored to the individual patient, while unnecessary treatments that have negative consequences on quality of life could be prevented for others. Research efforts must also focus on the development of new agents and delivery systems. Overall, considerable progress is required to reduce the burden associated with pancreatic cancer. Recent, renewed efforts to fund large consortia and research into pancreatic adenocarcinoma are welcomed, but further streams will be necessary to facilitate the momentum needed to bring breakthroughs seen for other cancer sites. | Andrew McGuigan Paul Kelly Richard C Turkington Claire Jones Helen G Coleman R Stephen McCain | 2018 | World Journal of Gastroenterology2018，24，43： | 140 |
| 2 | Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells显示文摘 | Arnold Isabelle C Dehzad Nina Reuter Sebastian Martin Helen Becher Burkhard Taube Christian Müller Anne | 2011 | Journal of Clinical Investigation2011，，8： | 4 |
| 3 | Chronic overexpression of PNPLA3^sup I148M^ in mouse liver causes hepatic steatosis显示文摘 | Li John Zhong Huang Yongcheng Karaman Ruchan Ivanova Pavlina T Brown H Alex Roddy Thomas Castro-Perez Jose Cohen Jonathan C Hobbs Helen H | 2012 | EN2012，，11： | 3 |
| 4 | Hepatotoxicity of anti-inflammatory and analgesic drugs:ultrastructural aspects显示文摘与导致药的肝疾病的增加的发生,正在被尝试更好在这些经常危及生活的反应后面理解机制。止痛剂和反煽动性的药是展出 hepatotoxicity 的一个主要的组。我们考察关于这些反应的研究,集中于极端结构的调查结果,它可以贡献理解和导致药的肝疾病的可能的回避。我们也在与抗氧化剂 N-acetylcysteine 或 P-glycoprotein 禁止者 verapamil 独自或在联合暴露于 acetaminophen 的临床的材料和有教养的房间上介绍一些原来的观察。 | Irena MANOV Helen MOTANIS Idan FRUMIN Theodore C IANCU | 2006 | Acta Pharmacologica Sinica2006，27，3： | 2 |
| 5 | Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake显示文摘Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit quality.Actinidia chinensis var.deliciosa‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is unclear.In this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit DM.During fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate supply.We showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate limited.Enhanced glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after anthesis.Transcipt analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate supply.At standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch degradation.When carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase genes.We conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited. | Simona Nardozza Helen L Boldingh Mark W Wohlers Andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C Richardson | 2017 | Horticulture Research2017，4，1： | 2 |
| 6 | Codon usage and gene function are related in sequences of Arabidopsis thaliana 显示文摘 | Helene C Fred6rique L Michel C Alain H | 1998 | Gene1998，209，： | 1 |
| 7 | Social support in later life : examining the roles of childhood and adulthood cognition 显示文摘 | Bourne V J Helen C Fox B | 2007 | Personal Individ Dif- fer2007，43，： | 1 |
| 8 | Studies of microstructural and mechanical properties of Nylon/glass composite显示文摘 | Cartledge Caroline A B | 1999 | Journal of Materials Science1999，34，： | 1 |
| 9 | Comparison between different LiFePO4 synthesis routes and their influence on its physico-chemical properties显示文摘 | SLVSIN F FREDEREC L C CAROLE B HELENE R | 2003 | J Power Source2003，，： | 1 |
| 10 | Three-Dimensional Culture of Annulus Fibrosus Cells within PDLLA/Bioglass ? Composite Foam Scaffolds; Assessment of Cell Attachment, Proliferation and Extracellular Matrix Production 显示文摘 | Helen W Merry C L R Blaker J J | 2007 | Biomaterials2007，28，11： | 1 |
| 11 | 基于G-蛋白偶联受体激酶2抑制剂治疗心力衰竭的合理药物设计(英文)显示文摘G protein-coupled receptors(GPCRs)convert extracellular stimuli in the form of hormones,odorants and light into profound changes in cell homeostasis.Their timely desensitization is critical for cells to rapidly respond to changes in their environment and to avoid damage from sustained signaling.Seven GPCR kinases(GRKs)phosphorylate and regulate the activity of most of the^800 GPCRs in the human genome.Although GRKs normally play an adaptive role,in conditions such as chronic heart failure they are overexpressed and linked to disease progression.GRK2 and GRK5 have thus become important targets for the treatment of heart failure and pathological cardiac hypertrophy,respectively.Our lab has determined atomic structures representing all three vertebrate GRK subfamilies,and is now in the midst of a campaign to develop selective inhibitors of these enzymes using structure-based rational design.We have identified the FDA approved drug paroxetine as a selective GRK2 inhibitor,determined the crystal structure of the GRK2·paroxetine complex and,in collaboration with the Koch lab,showed that the drug improves contractility in myocytes and,most impressively,recovery in postmyocardial infarcted mice.Since then,we have identified additional chemical scaffolds that exhibit even higher potency and/or selectivity for GRK5.Using a'hybrid'inhibitor design approach we have generated GRK selective chemical probes that exhibit improved potency and stability and are able to increase inotropy and dampen the hypertrophic response in cardiomyocytes and small animal models.Structural analysis has revealed the molecular basis for selectivity and potency in many of these compounds,allowing for the design of future generations of GRK chemical probes. | John J TESMER Helen V WALDSCHMIDT Marie C CATO Renee BOULEY Osvaldo CRUZ-RODRIGUEZ Scott D LARSEN | 2017 | 中国药理学与毒理学杂志2017，31，10： | 1 |
| 12 | Physiological responses of cabbage to incipient copper toxicity显示文摘 | Penelope A R Helen C H Kenneth L S | 1989 | J Amer Soc Hor Sci1989，114，1： | 1 |
| 13 | Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma显示文摘 | Deirdre T Helen C Andrew G J | 2008 | Vaccine2008，26，35： | 1 |
| 14 | Cotton (Gossypium hirsutum) MatP6 and MatP7 Oleosin Genes 显示文摘 | D Wayne Hughes Helen Y C Wang Clenn A Calau | 1993 | Plant Physiology1993，101，： | 1 |
| 15 | Drugs used for parenteral sedation in dental practice显示文摘 | Raymond A Dionne DDS Helen C | 1988 | Anesth Prog1988，35，5： | 1 |
| 16 | The anti-gene strategy: control of gene expression by triplex-forming-oligonucleotides显示文摘 | Helene C | 1991 | Anti-cancer Drug Des1991，6，： | 1 |
| 17 | Effect of third strand composition on triple helix formation: purine versus pyrimidine oligodeoxynucleotides显示文摘 | Faucon B Mergny J L Helene C | 1996 | Nucleic Acids Res1996，24，10： | 1 |
| 18 | Mosaic SCN1A mutation in famlial severe myoclonic epilepsy of infancy显示文摘 | Marini C Mei D Helen Cross J | 2006 | Epilepsia2006，47，10： | 1 |
| 19 | Diversity of cycloidea-like genes in Gesneriaceae in relation to Floral symmetry显示文摘 | Helene L Citeme Michael Moller Quentin C B Cronk | 2000 | Annals of Botany2000，86，： | 1 |
| 20 | G-quadruplex DNA: a target for drug design显示文摘 | MERGNY J L HELENE C | 1998 | Nat Meal1998，4，： | 1 |
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